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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CYP1A2 1544 cytochrome P450, family 1, subfamily A, polypeptide 2  15P3-450, CP12 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24527758   2014Cell line : -

Source : Turkish population

Sample Type : Population based case control study

No. of Sample : -

Stage : -

Haplotype-based analysisPolymorhpism-CYP1A1 haplotype C6235-A2455 might be associated with the development of CRC


Gene Details



NC_000015.9 (75041184..75048941)

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Gene Type protein coding
Gene Family Cytochrome P450s
Description This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q24.1
Start 75041184  
End 75048941  
Strand +  
Gene Sequence

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Length 7758  
OMIM ID 124060   
HGNC ID HGNC:2596   
Unigene ID Hs.1361   
Ensembl ID ENSG00000140505   
PharmGKB ID PA27093   

mRNA Information


mRNA ID NM_000761.4
Exon join(1..55,888..1727,2347..2467,2923..3012,3282..3405, 4342..4428,5949..7758)  
mRNA Sequence

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Length 3127  



CDS Information


   
Location65..1615
CDS Sequence

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CCDS ID CCDS32293.1



Protein Information


      
Protein IDNP_000752.2
Protein Namecytochrome P450, family 1, subfamily A, polypeptide 2
Molecular Wt. (Da)58277
Protein Sequence

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Length 516  
Uniprot IDO75747
Ensembl Protein ID ENSP00000266497  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation82

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5447POR485NP_000932.3in vitro9398194   


Pathway Information


                                                      
Pathway Name Pathway ID
Caffeine metabolism hsa00232
Chemical carcinogenesis hsa05204
Drug metabolism - cytochrome P450 hsa00982
Linoleic acid metabolism hsa00591
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Retinol metabolism hsa00830
Steroid hormone biosynthesis hsa00140
Tryptophan metabolism hsa00380


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0006742-494  p450
cl1207842-494  p450 superfamily
PLN0311214-503  PLN03112
PLN0011013-502  PLN00110
PLN0268712-502  PLN02687
PTZ0040445-503  PTZ00404
PLN0239415-492  PLN02394
PLN021833-502  PLN02183
PLN0323414-499  PLN03234
PLN0016811-492  PLN00168
COG212433-511  CypX
PLN0296623-503  PLN02966
PLN0265543-498  PLN02655
PLN0297115-484  PLN02971
PLN0301842-477  PLN03018
PLN021969-483  PLN02196
PLN02936317-492  PLN02936
PLN02290164-497  PLN02290
PLN02302305-476  PLN02302
PLN02774282-472  PLN02774
PLN0298714-472  PLN02987
PLN02169317-502  PLN02169
TIGR04538299-479  P450_cycloAA_1
PLN02500248-472  PLN02500
PLN02426317-468  PLN02426
PLN03141211-472  PLN03141
PLN03195317-501  PLN03195
PLN02648302-437  PLN02648
TIGR04458374-495  CYP450_TxtE
PLN02738297-492  PLN02738


Ontology Information


   
HPRD ID4234
Molecular ClassEnzyme: Oxygenase
Molecular FunctionLipid kinase activity (GO:0001727)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P05177DB00030Insulin RegularBiotechDrug
P05177DB00046Insulin LisproBiotechDrug
P05177DB00047Insulin GlargineBiotechDrug
P05177DB00071Insulin, porcineBiotechDrug
P05177DB00170MenadioneSmallMoleculeDrug
P05177DB00176FluvoxamineSmallMoleculeDrug
P05177DB00184NicotineSmallMoleculeDrug
P05177DB00188BortezomibSmallMoleculeDrug
P05177DB00191PhentermineSmallMoleculeDrug
P05177DB00195BetaxololSmallMoleculeDrug
P05177DB00199ErythromycinSmallMoleculeDrug
P05177DB00201CaffeineSmallMoleculeDrug
P05177DB00207AzithromycinSmallMoleculeDrug
P05177DB00208TiclopidineSmallMoleculeDrug
P05177DB00213PantoprazoleSmallMoleculeDrug
P05177DB00215CitalopramSmallMoleculeDrug
P05177DB00220NelfinavirSmallMoleculeDrug
P05177DB00238NevirapineSmallMoleculeDrug
P05177DB00246ZiprasidoneSmallMoleculeDrug
P05177DB00257ClotrimazoleSmallMoleculeDrug
P05177DB00261AnagrelideSmallMoleculeDrug
P05177DB00262CarmustineSmallMoleculeDrug
P05177DB00268RopiniroleSmallMoleculeDrug
P05177DB00277TheophyllineSmallMoleculeDrug
P05177DB00281LidocaineSmallMoleculeDrug
P05177DB00286Conjugated EstrogensSmallMoleculeDrug
P05177DB00296RopivacaineSmallMoleculeDrug
P05177DB00297BupivacaineSmallMoleculeDrug
P05177DB00300TenofovirSmallMoleculeDrug
P05177DB00313Valproic AcidSmallMoleculeDrug
P05177DB00315ZolmitriptanSmallMoleculeDrug
P05177DB00316AcetaminophenSmallMoleculeDrug
P05177DB00321AmitriptylineSmallMoleculeDrug
P05177DB00325NitroprussideSmallMoleculeDrug
P05177DB00333MethadoneSmallMoleculeDrug
P05177DB00334OlanzapineSmallMoleculeDrug
P05177DB00338OmeprazoleSmallMoleculeDrug
P05177DB00339PyrazinamideSmallMoleculeDrug
P05177DB00356ChlorzoxazoneSmallMoleculeDrug
P05177DB00357AminoglutethimideSmallMoleculeDrug
P05177DB00363ClozapineSmallMoleculeDrug
P05177DB00368NorepinephrineSmallMoleculeDrug
P05177DB00370MirtazapineSmallMoleculeDrug
P05177DB00377PalonosetronSmallMoleculeDrug
P05177DB00379MexiletineSmallMoleculeDrug
P05177DB00381AmlodipineSmallMoleculeDrug
P05177DB00384TriamtereneSmallMoleculeDrug
P05177DB00388PhenylephrineSmallMoleculeDrug
P05177DB00396ProgesteroneSmallMoleculeDrug
P05177DB00397PhenylpropanolamineSmallMoleculeDrug
P05177DB00398SorafenibSmallMoleculeDrug
P05177DB00400GriseofulvinSmallMoleculeDrug
P05177DB00401NisoldipineSmallMoleculeDrug
P05177DB00412RosiglitazoneSmallMoleculeDrug
P05177DB00418SecobarbitalSmallMoleculeDrug
P05177DB00420PromazineSmallMoleculeDrug
P05177DB00425ZolpidemSmallMoleculeDrug
P05177DB00428StreptozocinSmallMoleculeDrug
P05177DB00435Nitric OxideSmallMoleculeDrug
P05177DB00448LansoprazoleSmallMoleculeDrug
P05177DB00458ImipramineSmallMoleculeDrug
P05177DB00461NabumetoneSmallMoleculeDrug
P05177DB00467EnoxacinSmallMoleculeDrug
P05177DB00468QuinineSmallMoleculeDrug
P05177DB00472FluoxetineSmallMoleculeDrug
P05177DB00476DuloxetineSmallMoleculeDrug
P05177DB00477ChlorpromazineSmallMoleculeDrug
P05177DB00487PefloxacinSmallMoleculeDrug
P05177DB00499FlutamideSmallMoleculeDrug
P05177DB00501CimetidineSmallMoleculeDrug
P05177DB00502HaloperidolSmallMoleculeDrug
P05177DB00503RitonavirSmallMoleculeDrug
P05177DB00518AlbendazoleSmallMoleculeDrug
P05177DB00523AlitretinoinSmallMoleculeDrug
P05177DB00526OxaliplatinSmallMoleculeDrug
P05177DB00530ErlotinibSmallMoleculeDrug
P05177DB00537CiprofloxacinSmallMoleculeDrug
P05177DB00539ToremifeneSmallMoleculeDrug
P05177DB00540NortriptylineSmallMoleculeDrug
P05177DB00544FluorouracilSmallMoleculeDrug
P05177DB00549ZafirlukastSmallMoleculeDrug
P05177DB00553MethoxsalenSmallMoleculeDrug
P05177DB00564CarbamazepineSmallMoleculeDrug
P05177DB00568CinnarizineSmallMoleculeDrug
P05177DB00571PropranololSmallMoleculeDrug
P05177DB00572AtropineSmallMoleculeDrug
P05177DB00575ClonidineSmallMoleculeDrug
P05177DB00586DiclofenacSmallMoleculeDrug
P05177DB00604CisaprideSmallMoleculeDrug
P05177DB00605SulindacSmallMoleculeDrug
P05177DB00607NafcillinSmallMoleculeDrug
P05177DB00615RifabutinSmallMoleculeDrug
P05177DB00619ImatinibSmallMoleculeDrug
P05177DB00623FluphenazineSmallMoleculeDrug
P05177DB00625EfavirenzSmallMoleculeDrug
P05177DB00629GuanabenzSmallMoleculeDrug
P05177DB00633DexmedetomidineSmallMoleculeDrug
P05177DB00655EstroneSmallMoleculeDrug
P05177DB00661VerapamilSmallMoleculeDrug
P05177DB00668EpinephrineSmallMoleculeDrug
P05177DB00673AprepitantSmallMoleculeDrug
P05177DB00675TamoxifenSmallMoleculeDrug
P05177DB00678LosartanSmallMoleculeDrug
P05177DB00679ThioridazineSmallMoleculeDrug
P05177DB00682WarfarinSmallMoleculeDrug
P05177DB00694DaunorubicinSmallMoleculeDrug
P05177DB00696ErgotamineSmallMoleculeDrug
P05177DB00697TizanidineSmallMoleculeDrug
P05177DB00705DelavirdineSmallMoleculeDrug
P05177DB00724ImiquimodSmallMoleculeDrug
P05177DB00730ThiabendazoleSmallMoleculeDrug
P05177DB00737MeclizineSmallMoleculeDrug
P05177DB00738PentamidineSmallMoleculeDrug
P05177DB00740RiluzoleSmallMoleculeDrug
P05177DB00744ZileutonSmallMoleculeDrug
P05177DB00745ModafinilSmallMoleculeDrug
P05177DB00752TranylcypromineSmallMoleculeDrug
P05177DB00758ClopidogrelSmallMoleculeDrug
P05177DB00763MethimazoleSmallMoleculeDrug
P05177DB00772MalathionSmallMoleculeDrug
P05177DB00773EtoposideSmallMoleculeDrug
P05177DB00778RoxithromycinSmallMoleculeDrug
P05177DB00783EstradiolSmallMoleculeDrug
P05177DB00788NaproxenSmallMoleculeDrug
P05177DB00794PrimidoneSmallMoleculeDrug
P05177DB00806PentoxifyllineSmallMoleculeDrug
P05177DB00818PropofolSmallMoleculeDrug
P05177DB00829DiazepamSmallMoleculeDrug
P05177DB00831TrifluoperazineSmallMoleculeDrug
P05177DB00850PerphenazineSmallMoleculeDrug
P05177DB00851DacarbazineSmallMoleculeDrug
P05177DB00857TerbinafineSmallMoleculeDrug
P05177DB00863RanitidineSmallMoleculeDrug
P05177DB00882ClomifeneSmallMoleculeDrug
P05177DB00898EthanolSmallMoleculeDrug
P05177DB00904OndansetronSmallMoleculeDrug
P05177DB00908QuinidineSmallMoleculeDrug
P05177DB00917DinoprostoneSmallMoleculeDrug
P05177DB00918AlmotriptanSmallMoleculeDrug
P05177DB00921BuprenorphineSmallMoleculeDrug
P05177DB00924CyclobenzaprineSmallMoleculeDrug
P05177DB00934MaprotilineSmallMoleculeDrug
P05177DB00951IsoniazidSmallMoleculeDrug
P05177DB00953RizatriptanSmallMoleculeDrug
P05177DB00967DesloratadineSmallMoleculeDrug
P05177DB00969AlosetronSmallMoleculeDrug
P05177DB00972AzelastineSmallMoleculeDrug
P05177DB00974Edetic AcidSmallMoleculeDrug
P05177DB00976TelithromycinSmallMoleculeDrug
P05177DB00978LomefloxacinSmallMoleculeDrug
P05177DB00980RamelteonSmallMoleculeDrug
P05177DB00988DopamineSmallMoleculeDrug
P05177DB00998FrovatriptanSmallMoleculeDrug
P05177DB01002LevobupivacaineSmallMoleculeDrug
P05177DB01007TioconazoleSmallMoleculeDrug
P05177DB01012CinacalcetSmallMoleculeDrug
P05177DB01013Clobetasol propionateSmallMoleculeDrug
P05177DB01026KetoconazoleSmallMoleculeDrug
P05177DB01028MethoxyfluraneSmallMoleculeDrug
P05177DB01029IrbesartanSmallMoleculeDrug
P05177DB01037SelegilineSmallMoleculeDrug
P05177DB01041ThalidomideSmallMoleculeDrug
P05177DB01045RifampicinSmallMoleculeDrug
P05177DB01056TocainideSmallMoleculeDrug
P05177DB01058PraziquantelSmallMoleculeDrug
P05177DB01059NorfloxacinSmallMoleculeDrug
P05177DB01065MelatoninSmallMoleculeDrug
P05177DB01075DiphenhydramineSmallMoleculeDrug
P05177DB01087PrimaquineSmallMoleculeDrug
P05177DB01094HesperetinSmallMoleculeDrug
P05177DB01095FluvastatinSmallMoleculeDrug
P05177DB01097LeflunomideSmallMoleculeDrug
P05177DB01100PimozideSmallMoleculeDrug
P05177DB01104SertralineSmallMoleculeDrug
P05177DB01110MiconazoleSmallMoleculeDrug
P05177DB01115NifedipineSmallMoleculeDrug
P05177DB01118AmiodaroneSmallMoleculeDrug
P05177DB01129RabeprazoleSmallMoleculeDrug
P05177DB01131ProguanilSmallMoleculeDrug
P05177DB01136CarvedilolSmallMoleculeDrug
P05177DB01137LevofloxacinSmallMoleculeDrug
P05177DB01142DoxepinSmallMoleculeDrug
P05177DB01151DesipramineSmallMoleculeDrug
P05177DB01156BupropionSmallMoleculeDrug
P05177DB01165OfloxacinSmallMoleculeDrug
P05177DB01166CilostazolSmallMoleculeDrug
P05177DB01171MoclobemideSmallMoleculeDrug
P05177DB01174PhenobarbitalSmallMoleculeDrug
P05177DB01182PropafenoneSmallMoleculeDrug
P05177DB01184DomperidoneSmallMoleculeDrug
P05177DB01191DexfenfluramineSmallMoleculeDrug
P05177DB01200BromocriptineSmallMoleculeDrug
P05177DB01211ClarithromycinSmallMoleculeDrug
P05177DB01217AnastrozoleSmallMoleculeDrug
P05177DB01223AminophyllineSmallMoleculeDrug
P05177DB01241GemfibrozilSmallMoleculeDrug
P05177DB01242ClomipramineSmallMoleculeDrug
P05177DB01254DasatinibSmallMoleculeDrug
P05177DB01283LumiracoxibSmallMoleculeDrug
P05177DB01303OxtriphyllineSmallMoleculeDrug
P05177DB01306Insulin AspartBiotechDrug
P05177DB01307Insulin DetemirBiotechDrug
P05177DB01309Insulin GlulisineBiotechDrug
P05177DB01355HexobarbitalSmallMoleculeDrug
P05177DB01367RasagilineSmallMoleculeDrug
P05177DB01403MethotrimeprazineSmallMoleculeDrug
P05177DB01407ClenbuterolSmallMoleculeDrug
P05177DB01412TheobromineSmallMoleculeDrug
P05177DB01418AcenocoumarolSmallMoleculeDrug
P05177DB01424AminophenazoneSmallMoleculeDrug
P05177DB01435AntipyrineSmallMoleculeDrug
P05177DB01544FlunitrazepamSmallMoleculeDrug
P05177DB01558BromazepamSmallMoleculeDrug
P05177DB01601LopinavirSmallMoleculeDrug
P05177DB01621PipotiazineSmallMoleculeDrug
P05177DB01623ThiothixeneSmallMoleculeDrug
P05177DB01628EtoricoxibSmallMoleculeDrug
P05177DB04574EstropipateSmallMoleculeDrug
P05177DB04841FlunarizineSmallMoleculeDrug
P05177DB04871LorcaserinSmallMoleculeDrug
P05177DB04920ClevidipineSmallMoleculeDrug
P05177DB04946IloperidoneSmallMoleculeDrug
P05177DB05271RotigotineSmallMoleculeDrug
P05177DB05278inhaled insulinSmallMoleculeDrug
P05177DB05812AbirateroneSmallMoleculeDrug
P05177DB06148MianserinSmallMoleculeDrug
P05177DB06210EltrombopagSmallMoleculeDrug
P05177DB06216AsenapineSmallMoleculeDrug
P05177DB06290SimeprevirSmallMoleculeDrug
P05177DB06292DapagliflozinSmallMoleculeDrug
P05177DB06413ArmodafinilSmallMoleculeDrug
P05177DB06589PazopanibSmallMoleculeDrug
P05177DB06594AgomelatineSmallMoleculeDrug
P05177DB06605ApixabanSmallMoleculeDrug
P05177DB06626AxitinibSmallMoleculeDrug
P05177DB06712NilvadipineSmallMoleculeDrug
P05177DB06770Benzyl alcoholSmallMoleculeDrug
P05177DB06774CapsaicinSmallMoleculeDrug
P05177DB06803NiclosamideSmallMoleculeDrug
P05177DB06820SulconazoleSmallMoleculeDrug
P05177DB08864RilpivirineSmallMoleculeDrug
P05177DB08867UlipristalSmallMoleculeDrug
P05177DB08881VemurafenibSmallMoleculeDrug
P05177DB08910PomalidomideSmallMoleculeDrug
P05177DB09330OsimertinibSmallMoleculeDrug
P05177DB09570IxazomibSmallMoleculeDrug
P05177DB00951IsoniazidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO