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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CYP1B1 1545 cytochrome P450, family 1, subfamily B, polypeptide 1  2CP1B 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
16289386   2005Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 231 colonic tissues including 97 adenocarcinomas, 85 adenomas and 49 non-neoplastic colons

Stage : TNM Stage I-III

ImmunohistochemistryUp-regulation-A screening panel of CYP1B1 in combination with nuclear beta-catenin was the most suitable marker pair to screen for colorectal carcinoma based on this study.

Expressions of CYP1B1, p53, nuclear beta-catenin and bcl-2 were significantly associated with colorectal carcinogenesis (p<0.01 for the trend test). The overexpression rates for CYP1B1, p53, nuclear beta-catenin and bcl-2 were significantly higher in the adenoma and carcinoma groups than in the non-neoplastic colon group (p<0.05).


Gene Details



Chromosome 2 - NC_000002.12 (38067603..38076181, complement)

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Gene Type protein coding
Gene Family Cytochrome P450s
Description This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.  
Chromosome 2
Location 2p22.2
Start 38067603  
End 38076181  
Strand -  
Gene Sequence

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Length 8579  
OMIM ID 601771   
HGNC ID HGNC:2597   
Unigene ID Hs.154654   
Ensembl ID ENSG00000138061   
PharmGKB ID -   

mRNA Information


mRNA ID NM_000104.3
Exon join(1..402,793..1836,4872..8579)  
mRNA Sequence

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Length 5160  



CDS Information


   
Locationjoin(794..1836,4872..5460)
CDS Sequence

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CCDS ID CCDS1793.1



Protein Information


      
Protein IDNP_000095.2
Protein Namecytochrome P450, family 1, subfamily B, polypeptide 1
Molecular Wt. (Da)60715
Protein Sequence

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Length 543  
Uniprot IDP15170
Ensembl Protein ID ENSP00000399539  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


   
EC1.14.14.1???
Nameunspecific monooxygenase
microsomal monooxygenase
xenobiotic monooxygenase
aryl-4-monooxygenase
aryl hydrocarbon hydroxylase
microsomal P-450
flavoprotein-linked monooxygenase
flavoprotein monooxygenase
ClassOxidoreductases
Sysnamesubstrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)  
SubstrateRH [CPD:C01371]; reduced flavoprotein [CPD:C03024]; O2 [CPD:C00007]  
ProductROH [CPD:C01335]; oxidized flavoprotein [CPD:C03161]; H2O [CPD:C00001]  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                    
Pathway Name Pathway ID
Chemical carcinogenesis hsa05204
Metabolism of xenobiotics by cytochrome P450 hsa00980
MicroRNAs in cancer hsa05206
Ovarian steroidogenesis hsa04913
Steroid hormone biosynthesis hsa00140
Tryptophan metabolism hsa00380


Structure Information


PDB ID3PM0
Resolution2.7
MethodX-RAY DIFFRACTION
Chains A  
Molecule Cytochrome P450 1B1  
Model View



Domain Information




ID Location Description
pfam0006751-520  p450
cl1207851-520  p450 superfamily
PTZ0040452-523  PTZ00404
PLN0311251-514  PLN03112
PLN0268751-512  PLN02687
PLN0011051-512  PLN00110
PLN0239449-472  PLN02394
PLN0218351-489  PLN02183
PLN0296651-480  PLN02966
PLN0323451-514  PLN03234
PLN0297151-480  PLN02971
COG212451-523  CypX
PLN0265550-526  PLN02655
PLN0016851-499  PLN00168
PLN0301851-485  PLN03018
PLN02936330-528  PLN02936
PLN0219651-490  PLN02196
PLN0229053-523  PLN02290
PLN02302291-498  PLN02302
PLN02426330-510  PLN02426
PLN02169330-494  PLN02169
PLN02987330-524  PLN02987
PLN02774383-484  PLN02774
TIGR04538387-487  P450_cycloAA_1
PLN03141406-489  PLN03141
PLN03195330-502  PLN03195
PLN02738330-523  PLN02738


Ontology Information


   
HPRD ID712
Molecular ClassEnzyme: Oxidoreductase
Molecular FunctionGlutathione transferase activity (GO:0004364)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q16678DB00121BiotinSmallMoleculeDrug
Q16678DB00201CaffeineSmallMoleculeDrug
Q16678DB00277TheophyllineSmallMoleculeDrug
Q16678DB00338OmeprazoleSmallMoleculeDrug
Q16678DB00363ClozapineSmallMoleculeDrug
Q16678DB00396ProgesteroneSmallMoleculeDrug
Q16678DB00448LansoprazoleSmallMoleculeDrug
Q16678DB00499FlutamideSmallMoleculeDrug
Q16678DB00526OxaliplatinSmallMoleculeDrug
Q16678DB00530ErlotinibSmallMoleculeDrug
Q16678DB00613AmodiaquineSmallMoleculeDrug
Q16678DB00624TestosteroneSmallMoleculeDrug
Q16678DB00655EstroneSmallMoleculeDrug
Q16678DB00675TamoxifenSmallMoleculeDrug
Q16678DB00694DaunorubicinSmallMoleculeDrug
Q16678DB00783EstradiolSmallMoleculeDrug
Q16678DB00818PropofolSmallMoleculeDrug
Q16678DB00997DoxorubicinSmallMoleculeDrug
Q16678DB01026KetoconazoleSmallMoleculeDrug
Q16678DB01065MelatoninSmallMoleculeDrug
Q16678DB01087PrimaquineSmallMoleculeDrug
Q16678DB01168ProcarbazineSmallMoleculeDrug
Q16678DB01169Arsenic trioxideSmallMoleculeDrug
Q16678DB01174PhenobarbitalSmallMoleculeDrug
Q16678DB01204MitoxantroneSmallMoleculeDrug
Q16678DB01229PaclitaxelSmallMoleculeDrug
Q16678DB01234DexamethasoneSmallMoleculeDrug
Q16678DB01248DocetaxelSmallMoleculeDrug
Q16678DB01254DasatinibSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO