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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CYP27A1 1593 cytochrome P450, family 27, subfamily A, polypeptide 1  2CTX, CP27 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17875655   2007Cell line : -

Source : University of Illinois at Chicago (UIC) Gastrointestinal Tumor Bank.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

ImmunohistochemistryUp-regulation--


Gene Details



NC_000002.11 (219646472..219680016)

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Gene Type protein coding
Gene Family Cytochrome P450s
Description This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q35
Start 219646472  
End 219680016  
Strand +  
Gene Sequence

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Length 33545  
OMIM ID 606530   
HGNC ID HGNC:2605   
Unigene ID Hs.516700   
Ensembl ID ENSG00000135929   
PharmGKB ID PA135   

mRNA Information


mRNA ID NM_000784.3
Exon join(1..689,27829..28019,30474..30673,30804..31001, 31176..31348,32273..32439,32632..32710,32797..33009, 33163..33545)  
mRNA Sequence

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Length 2388  



CDS Information


   
Location435..2030
CDS Sequence

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CCDS ID CCDS2423.1



Protein Information


      
Protein IDNP_000775.1
Protein Namecytochrome P450, family 27, subfamily A, polypeptide 1
Molecular Wt. (Da)0
Protein Sequence

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Length 531  
Uniprot IDP27986
Ensembl Protein ID ENSP00000323512  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation321

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                  
Pathway Name Pathway ID
Metabolic pathways hsa01100
PPAR signaling pathway hsa03320
Primary bile acid biosynthesis hsa00120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0006761-526  p450
cl1207861-526  p450 superfamily
COG2124147-518  CypX
PLN02687318-502  PLN02687
PLN03195181-503  PLN03195
PLN02655310-507  PLN02655
PTZ00404331-499  PTZ00404
PLN00110329-497  PLN00110
PLN02183144-494  PLN02183
PLN0311291-498  PLN03112
PLN02987287-505  PLN02987
PLN02426145-505  PLN02426
PLN02936283-503  PLN02936
PLN02196332-498  PLN02196
PLN02971314-502  PLN02971
PLN0016860-498  PLN00168
PLN02302332-499  PLN02302
PLN03018269-508  PLN03018
PLN0323460-497  PLN03234
PLN0239482-508  PLN02394
PLN02500263-502  PLN02500
PLN0296688-501  PLN02966
PLN02169332-497  PLN02169
PLN02774282-498  PLN02774
PLN02290335-498  PLN02290
TIGR04538319-498  P450_cycloAA_1
PLN03141283-500  PLN03141
PLN02648348-450  PLN02648
TIGR04458405-497  CYP450_TxtE
PLN02738111-503  PLN02738
TIGR04515311-493  P450_rel_GT_act


Ontology Information


   
HPRD ID3031
Molecular ClassEnzyme: Oxidoreductase
Molecular FunctionIsomerase activity (GO:0016853)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091); Regulation of cell cycle (GO:0000074)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q02318DB00082PegvisomantBiotechDrug
Q02318DB00153ErgocalciferolSmallMoleculeDrug
Q02318DB00169CholecalciferolSmallMoleculeDrug
Q02318DB06777Chenodeoxycholic acidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO