Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CYP2W1 | 54905 | Cytochrome P450, family 2, subfamily W, polypeptide 1 | 7 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17979506 | 2007 | Cell line : HepG2,Caco 2TC7 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 39 Stage : - | real time RT- PCR, Western blotting, Sodium bisulfite sequencing method. | Hypomethylation | - | The expression of CYP2W1 is colon tumor-specific and is associated with methylation status of the CYP2W1 gene. |
| 20602611 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 162 Stage : - | Amplification Restriction method | Polymorhpism | - | CYP2W1 variant alleles are common among Caucasian individuals and, of these, the CYP2W1 G541A (Ala181Thr) polymorphism is associated with increased colorectal cancer risk. |
| 19118998 | 2009 | Cell line : HEK 293, HepG 2, and Caco 2TC7 Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | Expression of CYP2W1 is an independent prognostic factor in patients with stages II and III colorectal cancer. |
| 20805301 | 2010 | Cell line : MDA-MB-468, MCF 7, KM 12 and HCC 2998 Source : ATCC Sample Type : - No. of Sample : - Stage : - | N-Glycosylation, DNA Constructs and Mutagenesis, Cell Transfections, Western Blotting. | Up-regulation | - | Cytochrome P450 2W1 (CYP2W1) is expressed at high levels in colorectal cancer cells. The analysis of colorectal normal and cancer tissues and CYP2W1 overexpressing human embryonic kidney (HEK) 293 cells showed that a fraction of CYP2W1 is modified by N-glycosylation. |
| 21831963 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 235 Stage : TNM Stage II,III | Cell lines and cell culture, MTT cell proliferation assay, real time RT-PCR, Western blotting | Up-regulation | - | CYP2W1 is important for bioactivation of GW-610 in CRC cells. Because CYP2W1 is highly expressed in colorectal tumors, GW-610 represents a promising agent for CRC therapy. |
| 22993331 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 150 colorectal patients and 263 controls Stage : - | Immunohistochemisry | Up-regulation | - | The CYP2W1 enzyme might be used as a novel drug target for the treatment of colon cancer. CYP2W1 expression was an independent prognostic factor in the subgroup of patients with colon cancer stage III. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cytochrome P450s |
| Description | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008] | Chromosome | 7 |
| Location | 7p22.3 |
| Start | 983156 |
| End | 989640 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6485 |
| OMIM ID | |
| HGNC ID | HGNC:20243 |
| Unigene ID | Hs.272795 |
| Ensembl ID | ENSG00000073067 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011515441.1 |
|---|---|
| Exon | join(1..230,1257..1419,1795..1944,2011..2168,3469..3642, 3952..4090,4192..4376,5122..5263,5480..5552,5806..6063) | mRNA Sequence | Download Select all |
| Length | 1672 |
CDS Information
| Location | join(57..230,1257..1419,1795..1944,2011..2168,3469..3642, 3952..4090,4192..4376,5122..5263,5480..5552,5970..6306) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_060251.2 |
|---|---|
| Protein Name | Cytochrome P450, family 2, subfamily W, polypeptide 1 |
| Molecular Wt. (Da) | 51544 |
| Protein Sequence | Download Select all |
| Length | 490 |
| Uniprot ID | O15520 |
| Ensembl Protein ID | ENSP00000264664 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00067 | 32-479 | p450 |
| cl12078 | 32-479 | p450 superfamily |
| PLN02394 | 20-470 | PLN02394 |
| COG2124 | 32-477 | CypX |
| PLN02687 | 22-490 | PLN02687 |
| PTZ00404 | 33-456 | PTZ00404 |
| PLN02183 | 31-490 | PLN02183 |
| PLN03112 | 28-490 | PLN03112 |
| PLN03234 | 30-486 | PLN03234 |
| PLN00168 | 29-489 | PLN00168 |
| PLN02966 | 30-488 | PLN02966 |
| PLN02655 | 33-435 | PLN02655 |
| PLN00110 | 25-462 | PLN00110 |
| PLN02302 | 291-458 | PLN02302 |
| PLN02987 | 30-458 | PLN02987 |
| PLN02936 | 291-461 | PLN02936 |
| PLN02196 | 32-456 | PLN02196 |
| PLN02290 | 296-480 | PLN02290 |
| PLN03018 | 32-479 | PLN03018 |
| PLN03141 | 26-455 | PLN03141 |
| PLN02971 | 292-479 | PLN02971 |
| PLN02426 | 295-464 | PLN02426 |
| PLN02500 | 291-455 | PLN02500 |
| PLN02774 | 293-455 | PLN02774 |
| PLN02169 | 291-454 | PLN02169 |
| PLN03195 | 274-454 | PLN03195 |
| TIGR04538 | 238-455 | P450_cycloAA_1 |
| PLN02738 | 293-490 | PLN02738 |
Ontology Information
| HPRD ID | 3902 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.