Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CYP7A1 | 1581 | cytochrome P450, family 7, subfamily A, polypeptide 1 | 8 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21537451 | 2010 | Cell line : - Source : Aichi Cancer Center Sample Type : CRC tumor and normal tissues No. of Sample : 96 cases of proximal colon cancer, 357 of distal colon/rectal cancer and 961matched non-cancer controls Stage : - | Determination of CYP7A1 loci genotype,Exposure data | Polymorhpism | - | CYP7A1 plays a role in the carcinogenesis of colorectal cancer specifically in the proximal colon. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cytochrome P450s |
| Description | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010] | Chromosome | 8 |
| Location | 8q11-q12 |
| Start | 59402737 |
| End | 59412720 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9984 |
| OMIM ID | 118455 |
| HGNC ID | HGNC:2651 |
| Unigene ID | Hs.1644 |
| Ensembl ID | ENSG00000167910 |
| PharmGKB ID | PA132 |
mRNA Information
| mRNA ID | NM_000780.3 |
|---|---|
| Exon | join(799..941,2491..2731,3770..4356,6324..6454,8432..8607, 9186..10782) | mRNA Sequence | Download Select all |
| Length | 2875 |
Protein Information
| Protein ID | NP_000771.2 |
|---|---|
| Protein Name | cytochrome P450, family 7, subfamily A, polypeptide 1 |
| Molecular Wt. (Da) | 57530 |
| Protein Sequence | Download Select all |
| Length | 504 |
| Uniprot ID | P42338 |
| Ensembl Protein ID | ENSP00000289153 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 266 |
| S | Phosphorylation | 268 |
| T | Phosphorylation | 269 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bile secretion | hsa04976 |
| Metabolic pathways | hsa01100 |
| PPAR signaling pathway | hsa03320 |
| Primary bile acid biosynthesis | hsa00120 |
| Steroid hormone biosynthesis | hsa00140 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00067 | 32-497 | p450 |
| cl12078 | 32-497 | p450 superfamily |
| PLN02196 | 16-473 | PLN02196 |
| COG2124 | 52-472 | CypX |
| PLN02302 | 2-468 | PLN02302 |
| PLN02687 | 296-473 | PLN02687 |
| PLN02394 | 291-485 | PLN02394 |
| PLN02987 | 3-465 | PLN02987 |
| PLN02655 | 184-473 | PLN02655 |
| PLN02936 | 271-473 | PLN02936 |
| PLN00110 | 277-472 | PLN00110 |
| TIGR04538 | 310-454 | P450_cycloAA_1 |
| PLN03234 | 248-472 | PLN03234 |
| PLN02971 | 249-482 | PLN02971 |
| PLN02774 | 207-472 | PLN02774 |
| PLN00168 | 296-474 | PLN00168 |
| PLN03018 | 296-492 | PLN03018 |
| PLN02966 | 269-464 | PLN02966 |
| PTZ00404 | 296-473 | PTZ00404 |
| PLN02290 | 296-465 | PLN02290 |
| PLN02648 | 313-418 | PLN02648 |
| PLN02426 | 288-477 | PLN02426 |
| PLN03112 | 296-446 | PLN03112 |
| PLN02183 | 296-472 | PLN02183 |
| PLN02500 | 394-471 | PLN02500 |
| PLN03141 | 304-458 | PLN03141 |
| PLN02738 | 296-480 | PLN02738 |
Ontology Information
| HPRD ID | 3135 |
|---|---|
| Molecular Class | Enzyme: Hydroxylase |
| Molecular Function | Lipid kinase activity (GO:0001727) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.