Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CYR61 | 3491 | cysteine-rich, angiogenic inducer, 61 | 1 | GIG1, CCN1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21081514 | 2011 | Cell line : HT29, Caco 2 Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 39 Stage : Dukes Stage A,C, B | RT-PCR, Real-time PCR, Immunohistochemistry | Up-regulation | - | Upregulation of Cyr61 and CTGF gene expression in colorectal cancer suggests they have a role in tumour initiation or development. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] | Chromosome | 1 |
| Location | 1p22.3 |
| Start | 86046444 |
| End | 86049650 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3207 |
| OMIM ID | 602369 |
| HGNC ID | HGNC:2654 |
| Unigene ID | Hs.8867 |
| Ensembl ID | ENSG00000142871 |
| PharmGKB ID | PA27126 |
mRNA Information
| mRNA ID | NM_001554.4 |
|---|---|
| Exon | join(1..287,605..818,1168..1524,1656..1864,1980..3207) | mRNA Sequence | Download Select all |
| Length | 2295 |
Protein Information
| Protein ID | NP_001545.2 |
|---|---|
| Protein Name | cysteine-rich, angiogenic inducer, 61 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 381 |
| Uniprot ID | Q15465 |
| Ensembl Protein ID | ENSP00000297261 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3685 | ITGAV | 1903 | NP_002201.1 | in vitro;in vivo | 1 082 183 511 287 410 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00007 | 293-375 | Cys_knot |
| cl21545 | 293-375 | GHB_like superfamily |
| smart00041 | 292-360 | CT |
| smart00214 | 100-159 | VWC |
| cl17735 | 100-159 | VWC superfamily |
| pfam00219 | 32-78 | IGFBP |
| cl02472 | 32-78 | IGFBP superfamily |
| pfam00093 | 100-160 | VWC |
| smart00121 | 32-84 | IB |
| pfam00090 | 232-272 | TSP_1 |
| cl15278 | 232-272 | TSP_1 superfamily |
| smart00209 | 232-272 | TSP1 |
Ontology Information
| HPRD ID | 184 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Sialyltransferase activity (GO:0008373) |
| Biological Process | Lymphocyte activation (GO:0046649); Lymphocyte proliferation (GO:0046651); Embryonic development (GO:0009790) |
Drug Information
No matching records could be found.