CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
16569639	2006	Cell line : HEK 293T, HCT 116, DLD 1, SW 480 Source : - Sample Type : - No. of Sample : - Stage : -	Immunoprecipitation and Western Blotting, Immunofluorescence, Transactivation Assay.	Down-regulation	-	Daxx, a human cell death-associated protein, was isolated as a Tcf4-interacting protein. The evidence suggests a possible physiological function of Daxx, via interaction with Tcf4, to regulate proliferation and differentiation of colon cells. A reduction in Daxx protein expression was observed in colon adenocarcinoma tissue when compared with normal colon tissue.
17848589	2007	Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO). Sample Type : - No. of Sample : - Stage : -	Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry	Down-regulation	0.862	-
10698492	2000	Cell line : DLD 1 Source : ATCC Sample Type : - No. of Sample : - Stage : -	Two hybrid system, Cloning and plasmid construct, Indirect immune-staining, GST pull-down assays.	Mutation & Deletion	-	EAP1/Daxx and ETS1 are co- localized in the nucleus of mammalian cells. DAXX c terminal 173 amino acid region binds to N-terminal 139 aminoacid region of ETS1 that region of ETS1 called DAXX interaction domain(DID). Interaction of EAP1/Daxx with ETS1 causes the repression of transcriptional activation of the MMP1 and BCL2 genes. All experi-ments were performed in the yeast reporter strain EGY48 yeast cells and Transfection were done in COS-1 and the human colon cancer DLD1 (human colon carcinoma cell, ATCC-CCL221).Yeast reporter strain EGY48 yeast cells and COS1 and DLD1 cell lines used.

Gene Details

Chromosome: 6; NC_000006.11 (33286335..33290793, complement)
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Gene Type	protein coding
Gene Family	-
Description	This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Chromosome	6
Location	6p21.3
Start	33318558
End	33323016
Strand	-
Gene Sequence	>gi\|568815592:c33323016-33318558 Homo sapiens chromosome 6, GRCh38.p2 Primary Assembly ACGACAATATGGCGGCGCTTAGTTGCATGAAGGCGGAAACTCTGTGACTTCCGGTCCGTAGTGGGGCCTG CGGTGGGAGTGGGAAGGAAGGCGGAGGGAACCATGCGAGGTTCTGAGAATTGCGGCGAGGGTCGCCTCGA GAGACGGTTTCTGAGGTGGGGGCCGGACGGTGCGGGGATCAGAGGCGGGGGCGGGGATATAGAGGGAGAG GTATTGGGGAGAGCTGGGCGCTGAGTCTGAGGGGAAAGCTGTGGTACCTTCCTGTCCCTGAAAGGGAGTG GAGCGGCCGGGGGCTGAACTGGGGGAGGGGGATTTGGCGGGAAGCGCATCTAGCGGACCGGCCGGACCCA CGGTTGGGATCTAAGAGGAATCGCGAGAGCGTAGCGCGGTGCGGGGGGACTTTTGATCAGTTACGGGTCA CCGAGAGAATGGGGAAAATTAGGGTGGGGTGAAAGGGAGGGGACTTGGGTAAAATATCTTCAACCTAAAG CCCCAGTTTGAGGAGACTCATCGGAGGGTGAAATATGGAGATAATTCAAGGAGGAGAAAAGAGAACGGAC TGTTGGGAGGGAACCTCTTTCACCTCAGAGAGTCTAGGAGTTGGGGTGATCATTCAGGATAGGGTGGGTG TGGGGTTGACTTGTTTGAGAGCAGAGGGGGCAAACACATGAGGTGGCGCCCACAGGAGTGTGTTGTCTGT GCAAGGGGGTGTCAGGACGATTTGGGGTGCAGTGTGGGAGGAAGAATCAACTTGCCAACTCTAAGAAATA GGGGGGAAATGCAACAGAAAGACCGGAAATCGACGTGAGGGGTGGAGCAGAAGGTGGCAACTTAAGGTGT GGGGGTGGTTTGCCCCCCCCCCACACCACTTGAAGGGCCCCAAAAAGCATATAGAACTAATGGTTATTGA AATCAGGTGGTGAAGACAGTGTTGGTCAGGGCTGGATGTTACTGAAACCCAAGGAGTTCAGAAAATGTGT GAGGTGAAGGGATGGGGCTATGCTGGAGGGGCTCATTCTGAGGCCCCATCCCCTTCCAGCAGGAATTCTG AAATCCCCACCACTTCCTCCCTCCGGGGGATTTGATCCCCTATGGCCACCGCTAACAGCATCATCGTGCT GGATGATGATGACGAAGATGAAGCAGCTGCTCAGCCAGGGCCCTCCCACCCACTCCCCAATGCGGCCTCA CCTGGGGCAGAAGCCCCTAGCTCCTCTGAGCCTCATGGGGCCAGAGGAAGCAGTAGTTCGGGCGGCAAGA AATGCTACAAGCTGGAGAATGAGAAGCTGTTCGAAGAGGTGAGCTTTAGCGGGGAAGATTGTTGTACCCC AGGGAGGGGGATGGCTGACTGGTTCTCCTGTCCTTTCTTTCCCACTAACCCCACCTCCCCTTTCTCTCAA CCCCCTCCCTTGTCTCTCTTCCCCTTCCTTCTTCCCCTGAACCTTCTAGTTCCTTGAACTTTGTAAGATG CAGACAGCAGACCACCCTGAGGTGGTCCCATTCCTCTATAACCGGCAGCAACGTGCCCACTCTCTGTTTT TGGCCTCGGCGGAGTTCTGCAACATCCTCTCTAGGGTCCTGTCTCGGGCCCGGAGCCGGCCAGCCAAGCT CTATGTCTACATCAATGAGCTCTGCACTGTTCTCAAGGCCCACTCAGCCAAAAAGAAGCTGAACTTGGCC CCTGCCGCCACCACCTCCAATGAGCCCTCTGGGAATAACCCTCCCACACACCTCTCCTTGGACCCCACAA ATGCTGAAAACACTGCCTCTCAGTCTCCAAGGACCCGTGGTTCCCGGCGGCAGATCCAGCGTTTGGAGCA GCTGCTGGCGCTCTATGTGGCAGAGATCCGGCGGCTGCAGGAAAAGGAGTTGGATCTCTCAGAATTGGAT GACCCAGACTCCGCATACCTGCAGGAGGCACGGTTGAAGCGTAAGCTGATCCGCCTCTTTGGGCGACTAT GTGAGCTGAAAGACTGCTCTTCACTGACCGGCCGTGTCATAGAGCAGCGCATCCCCTACCGTGGCACCCG CTACCCAGAGGTTAACAGGCGCATTGAGCGGCTCATCAACAAGCCAGGGCCTGATACCTTCCCTGACTAT GGGGATGTGCTTCGGGCTGTAGAGAAGGCAGCTGCCCGACACAGCCTTGGCCTCCCCCGACAGCAGCTCC AGCTCATGGCTCAGGATGCCTTCCGAGATGTGGGCATCAGGTTACAGGAGCGACGTCACCTCGATCTCAT CTACAACTTTGGCTGCCACCTCACAGATGACTATAGGCCAGGTAGGGGGTTGGTGGGATGCCTCTCAGTG ACCCTTATATGTCAGGTATGAGGCGGATGGGGCATCTCTCTAGTCCTTTCTAGGGTTTTTACTCTTCTAG TCCCTTCAAGGGCTGAGTGCTCTGACTTTATGTCTTCCCACGTAGGCGTTGACCCTGCACTATCAGATCC TGTGTTGGCCCGGCGCCTTCGGGAAAACCGGAGTTTGGCCATGAGTCGGCTGGATGAGGTCATCTCCAAA TATGCAATGTTGCAAGACAAAAGTGAGGAGGGCGAGAGAAAAAAGAGAAGAGCTCGGCTCCAAGGCACCT CTTCCCACTCTGCAGACACCCCCGAAGCCTCCTTGGATTCTGGTGAGGTGTGGATGGGGTACAGCCTTCA GAGAGACATTGTCCTTCCCCTGCACTGGCCACCAGGGAGTCCAGGTTGACTGATGGGGGAGCATGAGAAG GAAAGCAAGAACCAAACCCTCTGGGGCAAGGGATTCCTTAGAGAAACTTCTTTGTCTCCCAGGGCCCTAG TGGAATGGCATCCCAGGGGTGCCCTTCTGCCTCCAGAGCTGAGACAGATGACGAAGACGATGAGGAGAGT GATGAGGAAGAGGAGGAGGAGGAGGAAGAAGAAGAGGAGGAGGCCACAGATTCTGAAGAGGAGGAGGATC TGGAACAGATGCAGGAGGGTCAGGAGGATGATGAAGAGGAGGACGAAGAGGAAGAAGCAGCAGCAGGTAT GTCAAGGGAACATTCTCCTCACCTGTCATTTCTGTTTTGTTAGGCATGAGCCACCTGTTTGAAACCTTTC CCTTCCTCCTCCTAGTGTCCTCTCAGCAGTATTTTTTCCCCCTCATTCTCAGGCTACCCTCTCCCCTTTT CTTCTTTTCCAGGTAAAGATGGAGACAAGAGCCCCATGTCCTCACTACAGATCTCCAATGAAAAGAACCT GGAACCTGGCAAACAGATCAGCAGATCTTCAGGGGAGCAGCAAAACAAAGGACGCATAGTGTCACCATCG TTACTGTCAGAAGAACCCCTGGCCCCCTCCAGCATAGATGCTGAAAGCAATGGAGAACAGCCTGAGGAGC TGACCCTGGAGGAAGAAAGCCCTGTGTCTCAGCTCTTTGAGCTAGAGATTGAAGCTTTGCCCCTGGATAC CCCTTCCTCTGTGGAGACGGACATTTCCTCTTCCAGGAAGCAATCAGAGGAGCCCTTCACCACTGTCTTA GAGAATGGAGCAGGCATGGTCTCTTCTACTTCCTTCAATGGAGGCGTCTCTCCTCACAACTGGGGAGATT CTGGTCCCCCCTGCAAAAAATCTCGGAAGGAGAAGAAGCAAACAGGATCAGGGCCATTAGGAAACAGGTA ATAACAAGAGGAGGAGGAAGAGGGAAGCCAAGGAGGGATTGCAGGGGACTTTCGGAGAGCAATACTGGGG AACTGAGTCTGCTGGGAGAGACTGGACTGCCCCCCTCCAGCCTCAGTCTTCCCGTACCCCTCCACATATT TATGTTTCTGTTTCTAGCTATGTGGAAAGGCAAAGGTCAGTGCATGAGAAGAATGGGAAAAAGATATGTA CCCTGCCCAGCCCACCTTCCCCCTTGGCTTCCTTGGCCCCAGTTGCTGATTCCTCCACGAGGGTGGACTC TCCCAGCCATGGCCTGGTGACCAGCTCCCTCTGCATCCCTTCTCCAGCCCGGCTGTCCCAAACCCCCCAT TCACAGCCTCCTCGGCCTGGTACTTGCAAGGTAAGAAGGGGAGGGCGTGTTTCCTCTGACAATTTGTTCT CTTTCATTGGCTGTTTCAGCTGCTCTGTCTGAATATTCCACGTGCCACATCCTGTCTCTTCCTTTTTCCC ACCCATTTTATCCTCTAAATCCTCCTGTTTCTTTTCTCCTGTACTCCAGATCTCTTTGACTCTTTGTCTC TCACTTCCCTGCAGACAAGTGTGGCCACACAATGCGATCCAGAAGAGATCATCGTGCTCTCAGACTCTGA TTAGCTGCCTCCCCTTCTCCCTGCCTCCAGAATGTTCTGGGATAACATTTGGAGGAAGGTGGGAAGCAGA TGACTGAGGAAGGGATGGACTAAGCTAATCCCCTTTTGGTGGTGTTTCTTTAAAAAAAAAAAAAAGCTTA AGTTTTACACAGAAACATTAATAAACAATAAAGTTCTTTTCTTACTGTA Download Select all
Length	4459
OMIM ID	603186
HGNC ID	HGNC:2681
Unigene ID	Hs.336916
Ensembl ID	ENSG00000204209
PharmGKB ID	PA27148

mRNA Information

mRNA ID	NM_001254717.1
Exon	join(1..155,1450..2281,2426..2637,2793..3006,3163..3637, 3798..4020,4215..4459)
mRNA Sequence	>1616 ACGACAATATGGCGGCGCTTAGTTGCATGAAGGCGGAAACTCTGTGACTTCCGGTCCGTAGTGG GGCCTGCGGTGGGAGTGGGAAGGAAGGCGGAGGGAACCATGCGAGGTTCTGAGAATTGCGGCGA GGGTCGCCTCGAGAGACGGTTTCTGAGTTCCTTGAACTTTGTAAGATGCAGACAGCAGACCACC CTGAGGTGGTCCCATTCCTCTATAACCGGCAGCAACGTGCCCACTCTCTGTTTTTGGCCTCGGC GGAGTTCTGCAACATCCTCTCTAGGGTCCTGTCTCGGGCCCGGAGCCGGCCAGCCAAGCTCTAT GTCTACATCAATGAGCTCTGCACTGTTCTCAAGGCCCACTCAGCCAAAAAGAAGCTGAACTTGG CCCCTGCCGCCACCACCTCCAATGAGCCCTCTGGGAATAACCCTCCCACACACCTCTCCTTGGA CCCCACAAATGCTGAAAACACTGCCTCTCAGTCTCCAAGGACCCGTGGTTCCCGGCGGCAGATC CAGCGTTTGGAGCAGCTGCTGGCGCTCTATGTGGCAGAGATCCGGCGGCTGCAGGAAAAGGAGT TGGATCTCTCAGAATTGGATGACCCAGACTCCGCATACCTGCAGGAGGCACGGTTGAAGCGTAA GCTGATCCGCCTCTTTGGGCGACTATGTGAGCTGAAAGACTGCTCTTCACTGACCGGCCGTGTC ATAGAGCAGCGCATCCCCTACCGTGGCACCCGCTACCCAGAGGTTAACAGGCGCATTGAGCGGC TCATCAACAAGCCAGGGCCTGATACCTTCCCTGACTATGGGGATGTGCTTCGGGCTGTAGAGAA GGCAGCTGCCCGACACAGCCTTGGCCTCCCCCGACAGCAGCTCCAGCTCATGGCTCAGGATGCC TTCCGAGATGTGGGCATCAGGTTACAGGAGCGACGTCACCTCGATCTCATCTACAACTTTGGCT GCCACCTCACAGATGACTATAGGCCAGGCGTTGACCCTGCACTATCAGATCCTGTGTTGGCCCG GCGCCTTCGGGAAAACCGGAGTTTGGCCATGAGTCGGCTGGATGAGGTCATCTCCAAATATGCA ATGTTGCAAGACAAAAGTGAGGAGGGCGAGAGAAAAAAGAGAAGAGCTCGGCTCCAAGGCACCT CTTCCCACTCTGCAGACACCCCCGAAGCCTCCTTGGATTCTGGTGAGGGCCCTAGTGGAATGGC ATCCCAGGGGTGCCCTTCTGCCTCCAGAGCTGAGACAGATGACGAAGACGATGAGGAGAGTGAT GAGGAAGAGGAGGAGGAGGAGGAAGAAGAAGAGGAGGAGGCCACAGATTCTGAAGAGGAGGAGG ATCTGGAACAGATGCAGGAGGGTCAGGAGGATGATGAAGAGGAGGACGAAGAGGAAGAAGCAGC AGCAGGTAAAGATGGAGACAAGAGCCCCATGTCCTCACTACAGATCTCCAATGAAAAGAACCTG GAACCTGGCAAACAGATCAGCAGATCTTCAGGGGAGCAGCAAAACAAAGGACGCATAGTGTCAC CATCGTTACTGTCAGAAGAACCCCTGGCCCCCTCCAGCATAGATGCTGAAAGCAATGGAGAACA GCCTGAGGAGCTGACCCTGGAGGAAGAAAGCCCTGTGTCTCAGCTCTTTGAGCTAGAGATTGAA GCTTTGCCCCTGGATACCCCTTCCTCTGTGGAGACGGACATTTCCTCTTCCAGGAAGCAATCAG AGGAGCCCTTCACCACTGTCTTAGAGAATGGAGCAGGCATGGTCTCTTCTACTTCCTTCAATGG AGGCGTCTCTCCTCACAACTGGGGAGATTCTGGTCCCCCCTGCAAAAAATCTCGGAAGGAGAAG AAGCAAACAGGATCAGGGCCATTAGGAAACAGCTATGTGGAAAGGCAAAGGTCAGTGCATGAGA AGAATGGGAAAAAGATATGTACCCTGCCCAGCCCACCTTCCCCCTTGGCTTCCTTGGCCCCAGT TGCTGATTCCTCCACGAGGGTGGACTCTCCCAGCCATGGCCTGGTGACCAGCTCCCTCTGCATC CCTTCTCCAGCCCGGCTGTCCCAAACCCCCCATTCACAGCCTCCTCGGCCTGGTACTTGCAAGA CAAGTGTGGCCACACAATGCGATCCAGAAGAGATCATCGTGCTCTCAGACTCTGATTAGCTGCC TCCCCTTCTCCCTGCCTCCAGAATGTTCTGGGATAACATTTGGAGGAAGGTGGGAAGCAGATGA CTGAGGAAGGGATGGACTAAGCTAATCCCCTTTTGGTGGTGTTTCTTTAAAAAAAAAAAAAAGC TTAAGTTTTACACAGAAACATTAATAAACAATAAAGTTCTTTTCTTACTGTAAAAAAAAAAAAA A Download Select all
Length	2369

CDS Information

Location	join(103..155,1109..1298,1450..2281,2426..2637,2793..3006, 3163..3637,3798..4020,4215..4274)
CDS Sequence	>gi\|359843218:174-2171 Homo sapiens death-domain associated protein (DAXX), transcript variant 4, mRNA ATGCAGACAGCAGACCACCCTGAGGTGGTCCCATTCCTCTATAACCGGCAGCAACGTGCCCACTCTCTGT TTTTGGCCTCGGCGGAGTTCTGCAACATCCTCTCTAGGGTCCTGTCTCGGGCCCGGAGCCGGCCAGCCAA GCTCTATGTCTACATCAATGAGCTCTGCACTGTTCTCAAGGCCCACTCAGCCAAAAAGAAGCTGAACTTG GCCCCTGCCGCCACCACCTCCAATGAGCCCTCTGGGAATAACCCTCCCACACACCTCTCCTTGGACCCCA CAAATGCTGAAAACACTGCCTCTCAGTCTCCAAGGACCCGTGGTTCCCGGCGGCAGATCCAGCGTTTGGA GCAGCTGCTGGCGCTCTATGTGGCAGAGATCCGGCGGCTGCAGGAAAAGGAGTTGGATCTCTCAGAATTG GATGACCCAGACTCCGCATACCTGCAGGAGGCACGGTTGAAGCGTAAGCTGATCCGCCTCTTTGGGCGAC TATGTGAGCTGAAAGACTGCTCTTCACTGACCGGCCGTGTCATAGAGCAGCGCATCCCCTACCGTGGCAC CCGCTACCCAGAGGTTAACAGGCGCATTGAGCGGCTCATCAACAAGCCAGGGCCTGATACCTTCCCTGAC TATGGGGATGTGCTTCGGGCTGTAGAGAAGGCAGCTGCCCGACACAGCCTTGGCCTCCCCCGACAGCAGC TCCAGCTCATGGCTCAGGATGCCTTCCGAGATGTGGGCATCAGGTTACAGGAGCGACGTCACCTCGATCT CATCTACAACTTTGGCTGCCACCTCACAGATGACTATAGGCCAGGCGTTGACCCTGCACTATCAGATCCT GTGTTGGCCCGGCGCCTTCGGGAAAACCGGAGTTTGGCCATGAGTCGGCTGGATGAGGTCATCTCCAAAT ATGCAATGTTGCAAGACAAAAGTGAGGAGGGCGAGAGAAAAAAGAGAAGAGCTCGGCTCCAAGGCACCTC TTCCCACTCTGCAGACACCCCCGAAGCCTCCTTGGATTCTGGTGAGGGCCCTAGTGGAATGGCATCCCAG GGGTGCCCTTCTGCCTCCAGAGCTGAGACAGATGACGAAGACGATGAGGAGAGTGATGAGGAAGAGGAGG AGGAGGAGGAAGAAGAAGAGGAGGAGGCCACAGATTCTGAAGAGGAGGAGGATCTGGAACAGATGCAGGA GGGTCAGGAGGATGATGAAGAGGAGGACGAAGAGGAAGAAGCAGCAGCAGGTAAAGATGGAGACAAGAGC CCCATGTCCTCACTACAGATCTCCAATGAAAAGAACCTGGAACCTGGCAAACAGATCAGCAGATCTTCAG GGGAGCAGCAAAACAAAGGACGCATAGTGTCACCATCGTTACTGTCAGAAGAACCCCTGGCCCCCTCCAG CATAGATGCTGAAAGCAATGGAGAACAGCCTGAGGAGCTGACCCTGGAGGAAGAAAGCCCTGTGTCTCAG CTCTTTGAGCTAGAGATTGAAGCTTTGCCCCTGGATACCCCTTCCTCTGTGGAGACGGACATTTCCTCTT CCAGGAAGCAATCAGAGGAGCCCTTCACCACTGTCTTAGAGAATGGAGCAGGCATGGTCTCTTCTACTTC CTTCAATGGAGGCGTCTCTCCTCACAACTGGGGAGATTCTGGTCCCCCCTGCAAAAAATCTCGGAAGGAG AAGAAGCAAACAGGATCAGGGCCATTAGGAAACAGCTATGTGGAAAGGCAAAGGTCAGTGCATGAGAAGA ATGGGAAAAAGATATGTACCCTGCCCAGCCCACCTTCCCCCTTGGCTTCCTTGGCCCCAGTTGCTGATTC CTCCACGAGGGTGGACTCTCCCAGCCATGGCCTGGTGACCAGCTCCCTCTGCATCCCTTCTCCAGCCCGG CTGTCCCAAACCCCCCATTCACAGCCTCCTCGGCCTGGTACTTGCAAGACAAGTGTGGCCACACAATGCG ATCCAGAAGAGATCATCGTGCTCTCAGACTCTGATTAG Download Select all
CCDS ID	-

Protein Information

Protein ID	NP_001135442.1
Protein Name	Death-associated protein 6
Molecular Wt. (Da)	82746
Protein Sequence	>1616 MRGSENCGEGRLERRFLSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSS SGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRA RSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPR TRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKD CSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQ LQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRL DEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETD DEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSL QISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVS QLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPP CKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHG LVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD Download Select all
Length	752
Uniprot ID	O00327
Ensembl Protein ID	ENSP00000374357

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	671
K	Sumoylation	630
K	Sumoylation	631
S	Phosphorylation	495;-
S	Phosphorylation	668;-
S	Phosphorylation	712;-
T	Phosphorylation	709;-
S	Phosphorylation	737;-
S	Phosphorylation	739;-
T	Phosphorylation	169
T	Phosphorylation	174
S	Phosphorylation	176
S	Phosphorylation	178
S	Phosphorylation	213
S	Phosphorylation	688
S	Phosphorylation	702
S	Phosphorylation	690
Y	Phosphorylation	648
S	Phosphorylation	424
K	Acetylation	512
Y	Phosphorylation	379
S	Phosphorylation	515
T	Phosphorylation	665
S	Phosphorylation	675
S	Phosphorylation	697
S	Phosphorylation	97
S	Phosphorylation	498
S	Phosphorylation	499
S	Phosphorylation	682

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
355	FAS	609	NP_000034.1	in vitro;in vivo;yeast 2-hybrid	11 193 028 921 562 900 000 000
356	FASLG	610	NP_000630.1	in vitro;in vivo	9215629
546	ATRX	2069	NP_000480.2	in vitro	12953102
1060	CENPC1	315	NP_001803.2	in vivo;yeast 2-hybrid	9645950
1786	DNMT1	532	NP_001124295.1	in vivo	10444590
2113	ETS1	1260	NP_001137292.1	in vitro;yeast 2-hybrid	10698492
3065	HDAC1	3143	NP_004955.2	in vivo	10669754
3066	HDAC2	5521	NP_001518.2	in vitro	10669754
3297	HSF1	778	NP_005517.1	in vivo;yeast 2-hybrid	15016915
4193	MDM2	1272	NP_002383.2	in vitro;in vivo	16845383
4217	MAP3K5	3904	NP_005914.1	in vitro;in vivo;yeast 2-hybrid	974 350 111 003 656
4599	MX1	919	NP_002453.2	in vitro;yeast 2-hybrid	11716541
5079	PAX5	1334	NP_057953.1	in vitro;in vivo;yeast 2-hybrid	11799127
5371	PML	23	NP_150241.2	in vitro;in vivo;yeast 2-hybrid	1 068 485 510 669 750 000 000 000 000 000 000 000 000
6517	SLC2A4	688	NP_001033.1	in vitro;yeast 2-hybrid	11842083
6934	TCF7L2	3751	NP_110383.2	in vivo;yeast 2-hybrid	16569639
7040	TGFB1	1821	NP_000651.3	in vivo;yeast 2-hybrid	11483955
7048	TGFBR2	1823	NP_001020018.1	in vivo;yeast 2-hybrid	11483955
7157	TP53	1859	NP_000537.3	in vitro;in vivo;yeast 2-hybrid	12954772
7161	TP73	3587	NP_005418.1	in vitro;in vivo;yeast 2-hybrid	12954772
7251	TSG101	3229	NP_006283.1	in vivo;yeast 2-hybrid	15033475
7874	USP7	3950	NP_003461.2	in vitro;in vivo	16845383
8841	HDAC3	8950	NP_003874.2	in vitro	10669754
10114	HIPK3	5111	NP_005725.3	in vitro	11034606
22938	SNW1	4340	NP_036377.1	in vitro;in vivo;yeast 2-hybrid	1 587 816 315 604 090

Pathway Information

Pathway Name	Pathway ID
Amyotrophic lateral sclerosis (ALS)	hsa05014
Herpes simplex infection	hsa05168
MAPK signaling pathway	hsa04010

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd13150	183-387	DAXX_histone_binding
cl18941	183-387	DAXX_histone_binding superfamily
cd13151	57-144	DAXX_helical_bundle
cl18914	57-144	DAXX_helical_bundle superfamily
pfam03344	1-740	Daxx

Ontology Information

HPRD ID	3973
Molecular Class	Adapter molecule
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of circadian rhythm (GO:0042752)

SNP Information

View SNP Geneview Report

Mechanism	Down-regulation/Mutation
Biomarker	-
Drug Target	-
Biological Process	Cell communication