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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24610677 | 2014 | Cell line : HCT 116 Source : - Sample Type : CRC tumor, normal tissue and blood plasma No. of Sample : - Stage : - | Western blotting,2D-LC and MALDI-TOF/TOF MS,immunohistochemistry | Up-regulation | - | DBN1 is currently believed to be involved in actin cytoskeleton reorganisation and suppresses actin filament cross-linking and bundling. Since actin reorganisation is an important process for tumour cell migration and invasion, DBN1 may have an important role during colorectal cancer metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 5 |
| Location | 5q35.3 |
| Start | 176883613 |
| End | 176900694 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 17082 |
| OMIM ID | 126660 |
| HGNC ID | HGNC:2695 |
| Unigene ID | Hs.130316 |
| Ensembl ID | ENSG00000113758 |
| PharmGKB ID | PA27163 |
mRNA Information
| mRNA ID | XM_011534663.1 |
|---|---|
| Exon | complement(<23636..>23724) | mRNA Sequence | Download Select all |
| Length | 1963 |
Protein Information
| Protein ID | XP_011532965.1 |
|---|---|
| Protein Name | drebrin 1 |
| Molecular Wt. (Da) | 30799 |
| Protein Sequence | Download Select all |
| Length | 274 |
| Uniprot ID | P78337 |
| Ensembl Protein ID | ENSP00000265340 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 143 |
| S | Phosphorylation | 144 |
| S | Phosphorylation | 344 |
| T | Phosphorylation | 348 |
| S | Phosphorylation | 141 |
| S | Phosphorylation | 142 |
| S | Phosphorylation | 342 |
| T | Phosphorylation | 346 |
| S | Phosphorylation | 341 |
| S | Phosphorylation | 339 |
| Y | Phosphorylation | 624;- |
| Y | Phosphorylation | 622;- |
| S | Phosphorylation | 144;- |
| S | Phosphorylation | 142;- |
| T | Phosphorylation | 337;- |
| T | Phosphorylation | 335;- |
| S | Phosphorylation | 566;- |
| S | Phosphorylation | 564;- |
| T | Phosphorylation | 333 |
| T | Phosphorylation | 331 |
| S | Phosphorylation | 339 |
| S | Phosphorylation | 337 |
| S | Phosphorylation | 343 |
| S | Phosphorylation | 341 |
| T | Phosphorylation | 345 |
| T | Phosphorylation | 343 |
| S | Phosphorylation | 347 |
| S | Phosphorylation | 345 |
| T | Phosphorylation | 379 |
| T | Phosphorylation | 377 |
| S | Phosphorylation | 383 |
| S | Phosphorylation | 381 |
| S | Phosphorylation | 603 |
| S | Phosphorylation | 601 |
| S | Phosphorylation | 601 |
| S | Phosphorylation | 599 |
| S | Phosphorylation | 136 |
| S | Phosphorylation | 134 |
| T | Phosphorylation | 243 |
| T | Phosphorylation | 241 |
| S | Phosphorylation | 314 |
| S | Phosphorylation | 312 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5216 | PFN1 | 1452 | NP_005013.1 | in vitro | 9473484 |
| 6829 | SUPT5H | 3655 | NP_003160.2 | yeast 2-hybrid | 16169070 |
| 25836 | NIPBL | 10560 | NP_597677.2 | yeast 2-hybrid | 16169070 |
| 90850 | ZNF598 | 11732 | NP_835461.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11281 | 4-139 | ADF_drebrin_like |
| cl15697 | 4-139 | ADF_gelsolin superfamily |
| smart00102 | 9-134 | ADF |
| pfam00241 | 12-134 | Cofilin_ADF |
| cd11282 | 12-124 | ADF_coactosin_like |
| cd00013 | 28-119 | ADF_gelsolin |
| PHA03247 | 277-565 | PHA03247 |
| PHA03247 | 272-563 | PHA03247 |
Ontology Information
| HPRD ID | 1437 |
|---|---|
| Molecular Class | Cytoskeletal associated protein |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.