Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DCLK1 | 9201 | Doublecortin-like kinase 1  | 13 | CL1; DCLK; CLICK1; DCDC3A; DCAMKL1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24384857    | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Methylation specific PCR and exon arrays | Hypermethylation and down-regulation | - | DCLK1 as a colorectal cancer biomarker for early detection. DCLK1 promoter is hypermethylated in the vast majority of colorectal cancers. DCLK1 is significantly downregulated in human colorectal cancer. |
| 21929751    | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 71 CRC patients, including 18 adenomatous polyps, 40 primary adenocarcinomas, and 14 metastatic lesions Stage : TNM Stage I-IV | real-time RT-PCR, Western blotting, immunohistochemistry, Luciferase Assay | Up-regulation | - | These findings demonstrate that nanoparticle-based Deletionvery of siRNAs directed at critical targets such as DCAMKL-1 may provide a novel approach to treat cancer through the regulation of endogenous miRNAs. |
| 22557932    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | DCLK1 is frequently expressed in colorectal neoplasia and may be associated with poor prognosis. Further studies are necessary to validate the use of DCLK1 as a prognostic marker. DCLK1 immunostaining was performed |
| 23202126    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Potential for developing a therapy for colorectal cancer based on targeting Dclk1-positive Tumor Stem Cells. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]   | Chromosome | 13 |
| Location | 13q13 |
| Start | 35768652   |
| End | 36132020   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 363369   |
| OMIM ID | 604742    |
| HGNC ID | HGNC:2700    |
| Unigene ID | Hs.507755     |
| Ensembl ID | ENSG00000133083    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_004734.4 |
|---|---|
| Exon | join(644..907,5865..6259,19806..20152,184564..184663, 260681..260797,277428..277522,292845..292929, 295880..295988,303714..303771,304267..304386, 309146..309292,321053..321186,322926..323003, 323701..323797,326242..326322,338542..338655, 343736..343809,357322..363369)   | mRNA Sequence |    Download   Select all |
| Length | 8463   |
CDS Information
| Location | join(5884..6259,19806..20152,184564..184663, 260681..260797,277428..277522,292845..292929, 295880..295988,303714..303771,304267..304386, 309146..309292,321053..321186,322926..323003, 323701..323797,326242..326322,338542..338655, 357322..357486) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_001182344.1 |
|---|---|
| Protein Name | Doublecortin-like kinase 1 |
| Molecular Wt. (Da) | 46426 |
| Protein Sequence |    Download   Select all |
| Length | 422   |
| Uniprot ID | P08246 |    
| Ensembl Protein ID | ENSP00000263621   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 352 |
| S | Phosphorylation | 332 |
| S | Phosphorylation | 337 |
| T | Phosphorylation | 336 |
| S | Phosphorylation | 330 |
| S | Phosphorylation | 334 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14183 | 383-650  | STKc_DCKL1 |
| cl21453 | 383-650  | PKc_like superfamily |
| cd01617 | 57-139  | DCX |
| cl00155 | 57-139  | UBQ superfamily |
| cd01617 | 186-265  | DCX |
| cl00155 | 186-265  | UBQ superfamily |
| cd14095 | 389-646  | STKc_DCKL |
| cd14184 | 388-646  | STKc_DCKL2 |
| cd05117 | 389-646  | STKc_CAMK |
| cd14185 | 390-646  | STKc_DCKL3 |
| cd14083 | 386-646  | STKc_CaMKI |
| cd14169 | 386-650  | STKc_CaMKI_beta |
| cd14003 | 389-646  | STKc_AMPK-like |
| cd14167 | 386-647  | STKc_CaMKI_alpha |
| cd14166 | 386-669  | STKc_CaMKI_gamma |
| cd14091 | 390-655  | STKc_RSK_C |
| cd14086 | 388-647  | STKc_CaMKII |
| cd14168 | 386-669  | STKc_CaMKI_delta |
| cd14085 | 386-682  | STKc_CaMKIV |
| cd14663 | 389-646  | STKc_SnRK3 |
| cd14093 | 388-646  | STKc_PhKG |
| cd14007 | 390-647  | STKc_Aurora |
| cd14084 | 383-647  | STKc_Chk2 |
| cd14087 | 389-647  | STKc_PSKH1 |
| cd14092 | 396-650  | STKc_MSK_C |
| cd14105 | 390-647  | STKc_DAPK |
| cd14096 | 388-647  | STKc_RCK1-like |
| cd14089 | 404-646  | STKc_MAPKAPK |
| cd14006 | 396-646  | STKc_MLCK-like |
| cd14088 | 388-647  | STKc_CaMK_like |
| cd14175 | 390-658  | STKc_RSK1_C |
| cd14098 | 389-646  | STKc_Rad53_Cds1 |
| cd14099 | 388-646  | STKc_PLK |
| cd14178 | 387-656  | STKc_RSK3_C |
| cd14097 | 390-647  | STKc_STK33 |
| cd14176 | 387-690  | STKc_RSK2_C |
| cd05123 | 396-646  | STKc_AGC |
| cd14079 | 390-646  | STKc_AMPK_alpha |
| cd14090 | 390-647  | STKc_Mnk |
| cd14008 | 396-647  | STKc_LKB1_CaMKK |
| cd14081 | 390-647  | STKc_BRSK1_2 |
| cd14103 | 396-646  | STKc_MLCK |
| cd14177 | 387-656  | STKc_RSK4_C |
| cd05580 | 390-646  | STKc_PKA_like |
| cd14181 | 388-646  | STKc_PhKG2 |
| cd14194 | 386-647  | STKc_DAPK1 |
| cd14071 | 390-646  | STKc_SIK |
| cd14078 | 386-647  | STKc_MELK |
| cd14196 | 390-647  | STKc_DAPK2 |
| cd08215 | 389-645  | STKc_Nek |
| cd14106 | 383-647  | STKc_DRAK |
| cd14080 | 390-647  | STKc_TSSK-like |
| cd14172 | 386-647  | STKc_MAPKAPK3 |
| cd14195 | 386-647  | STKc_DAPK3 |
| cd14074 | 390-647  | STKc_SNRK |
| cd00180 | 396-645  | PKc |
| cd14075 | 390-647  | STKc_NIM1 |
| cd14182 | 388-646  | STKc_PhKG1 |
| cd05572 | 396-649  | STKc_cGK |
| cd14171 | 385-647  | STKc_MAPKAPK5 |
| cd14069 | 388-647  | STKc_Chk1 |
| cd14094 | 388-649  | STKc_CASK |
| cd14173 | 396-647  | STKc_Mnk2 |
| cd14174 | 396-647  | STKc_Mnk1 |
| cd05581 | 390-646  | STKc_PDK1 |
| cd14014 | 389-640  | STKc_PknB_like |
| cd05122 | 390-647  | PKc_STE |
| cd14073 | 389-647  | STKc_NUAK |
| cd14209 | 388-649  | STKc_PKA |
| cd05612 | 390-646  | STKc_PRKX_like |
| cd14179 | 394-650  | STKc_MSK1_C |
| cd05579 | 396-649  | STKc_MAST_like |
| cd14119 | 396-647  | STKc_LKB1 |
| cd06606 | 389-647  | STKc_MAPKKK |
| cd14009 | 396-646  | STKc_ATG1_ULK_like |
| cd14165 | 390-646  | STKc_TSSK1_2-like |
| cd14180 | 396-651  | STKc_MSK2_C |
| cd14077 | 390-647  | STKc_Kin1_2 |
| cd14170 | 390-648  | STKc_MAPKAPK2 |
| cd14082 | 395-646  | STKc_PKD |
| cd14191 | 390-647  | STKc_MLCK1 |
| cd05571 | 394-646  | STKc_PKB |
| cd14193 | 390-647  | STKc_MLCK4 |
| cd14072 | 389-647  | STKc_MARK |
| cd14190 | 396-647  | STKc_MLCK2 |
| cd14114 | 388-647  | STKc_Twitchin_like |
| cd06623 | 396-648  | PKc_MAPKK_plant_like |
| cd08217 | 390-645  | STKc_Nek2 |
| cd14197 | 387-647  | STKc_DRAK1 |
| cd05578 | 390-646  | STKc_Yank1 |
| cd14002 | 388-647  | STKc_STK36 |
| cd14162 | 390-647  | STKc_TSSK4-like |
| cd14070 | 390-647  | STKc_HUNK |
| cd13999 | 396-643  | STKc_MAP3K-like |
| cd14113 | 396-647  | STKc_Trio_C |
| cd14161 | 389-647  | STKc_NUAK2 |
| cd05118 | 390-646  | STKc_CMGC |
| cd14116 | 388-647  | STKc_Aurora-A |
| cd14192 | 396-647  | STKc_MLCK3 |
| cd05595 | 394-648  | STKc_PKB_beta |
| cd14115 | 396-646  | STKc_Kalirin_C |
| cd14118 | 396-647  | STKc_CAMKK |
| cd13994 | 396-647  | STKc_HAL4_like |
| cd05573 | 388-660  | STKc_ROCK_NDR_like |
| cd06614 | 390-645  | STKc_PAK |
| cd07829 | 390-646  | STKc_CDK_like |
| cd14076 | 390-647  | STKc_Kin4 |
| cd14186 | 388-647  | STKc_PLK4 |
| cd14004 | 390-647  | STKc_PASK |
| cd07830 | 390-646  | STKc_MAK_like |
| cd05570 | 396-645  | STKc_PKC |
| cd14163 | 390-647  | STKc_TSSK3-like |
| cd14109 | 388-647  | PK_Unc-89_rpt1 |
| cd14662 | 389-646  | STKc_SnRK2 |
| cd14198 | 394-647  | STKc_DRAK2 |
| cd14665 | 389-646  | STKc_SnRK2-3 |
| cd06625 | 389-647  | STKc_MEKK3_like |
| cd14199 | 389-647  | STKc_CaMKK2 |
| cd14117 | 390-647  | STKc_Aurora-B_like |
| cd08530 | 389-645  | STKc_CNK2-like |
| cd05584 | 397-646  | STKc_p70S6K |
| cd14104 | 389-647  | STKc_Titin |
| cd14121 | 396-646  | STKc_ULK3 |
| cd05574 | 394-646  | STKc_phototropin_like |
| cd05575 | 394-638  | STKc_SGK |
| cd14107 | 390-646  | STKc_obscurin_rpt1 |
| cd13985 | 389-643  | STKc_GAK_like |
| cd06627 | 389-647  | STKc_Cdc7_like |
| cd05599 | 394-649  | STKc_NDR_like |
| cd14189 | 390-644  | STKc_PLK3 |
| cd14200 | 389-647  | STKc_CaMKK1 |
| cd14137 | 389-649  | STKc_GSK3 |
| cd08224 | 389-643  | STKc_Nek6_7 |
| cd06647 | 388-647  | STKc_PAK_I |
| cd07833 | 388-646  | STKc_CDKL |
| cd14202 | 396-598  | STKc_ULK1 |
| cd06612 | 396-647  | STKc_MST1_2 |
| cd05582 | 394-638  | STKc_RSK_N |
| cd14120 | 396-590  | STKc_ULK1_2-like |
| cd06632 | 389-647  | STKc_MEKK1_plant |
| cd05609 | 394-649  | STKc_MAST |
| cd05585 | 396-649  | STKc_YPK1_like |
| cd06626 | 389-647  | STKc_MEKK4 |
| cd05611 | 396-649  | STKc_Rim15_like |
| cd13993 | 389-638  | STKc_Pat1_like |
| cd14164 | 390-647  | STKc_TSSK6-like |
| cd06609 | 388-647  | STKc_MST3_like |
| cd07831 | 390-646  | STKc_MOK |
| cd07834 | 389-656  | STKc_MAPK |
| cd13996 | 390-584  | STKc_EIF2AK |
| cd06648 | 396-647  | STKc_PAK_II |
| cd05594 | 364-644  | STKc_PKB_alpha |
| cd05593 | 394-646  | STKc_PKB_gamma |
| cd05602 | 394-638  | STKc_SGK1 |
| cd07841 | 389-659  | STKc_CDK7 |
| cd13987 | 396-646  | STKc_SBK1 |
| cd14201 | 396-598  | STKc_ULK2 |
| cd07840 | 390-646  | STKc_CDK9_like |
| cd05603 | 394-638  | STKc_SGK2 |
| cd14010 | 396-646  | STKc_ULK4 |
| cd05590 | 394-649  | STKc_nPKC_eta |
| cd06659 | 383-654  | STKc_PAK6 |
| cd14005 | 389-647  | STKc_PIM |
| cd06610 | 390-645  | STKc_OSR1_SPAK |
| cd05583 | 416-646  | STKc_MSK_N |
| cd05604 | 394-602  | STKc_SGK3 |
| cd14187 | 389-590  | STKc_PLK1 |
| cd14108 | 387-646  | STKc_SPEG_rpt1 |
| cd14188 | 388-644  | STKc_PLK2 |
| cd05601 | 390-649  | STKc_CRIK |
| cd05586 | 396-649  | STKc_Sck1_like |
| cd07832 | 389-646  | STKc_CCRK |
| smart00537 | 52-142  | DCX |
| cd05577 | 396-659  | STKc_GRK |
| cd08225 | 389-647  | STKc_Nek5 |
| cd06656 | 388-647  | STKc_PAK3 |
| cd05592 | 396-668  | STKc_nPKC_theta_like |
| cd05587 | 396-609  | STKc_cPKC |
| cd05598 | 394-649  | STKc_LATS |
| cd05591 | 394-609  | STKc_nPKC_epsilon |
| cd14111 | 397-647  | STKc_SPEG_rpt2 |
| cd06655 | 388-647  | STKc_PAK2 |
| cd07847 | 388-646  | STKc_CDKL1_4 |
| cd08529 | 390-645  | STKc_FA2-like |
| cd05613 | 388-646  | STKc_MSK1_N |
| cd06613 | 390-647  | STKc_MAP4K3_like |
| cd05616 | 396-609  | STKc_cPKC_beta |
| cd07866 | 388-646  | STKc_BUR1 |
| cd08220 | 389-645  | STKc_Nek8 |
| cd06654 | 388-647  | STKc_PAK1 |
| cd05600 | 396-646  | STKc_Sid2p_like |
| cd08218 | 389-647  | STKc_Nek1 |
| cd08228 | 390-635  | STKc_Nek6 |
| cd08219 | 389-642  | STKc_Nek3 |
| cd07838 | 390-647  | STKc_CDK4_6_like |
| cd06611 | 396-651  | STKc_SLK_like |
| cd05615 | 396-625  | STKc_cPKC_alpha |
| cd13997 | 389-645  | PKc_Wee1_like |
| cd13990 | 389-646  | STKc_TLK |
| cd05607 | 394-645  | STKc_GRK7 |
| cd08223 | 389-647  | STKc_Nek4 |
| cd05605 | 394-646  | STKc_GRK4_like |
| cd13989 | 396-587  | STKc_IKK |
| cd08222 | 389-647  | STKc_Nek11 |
| cd06658 | 396-653  | STKc_PAK5 |
| cd07855 | 386-656  | STKc_ERK5 |
| cd05596 | 390-650  | STKc_ROCK |
| cd14110 | 387-647  | STKc_obscurin_rpt2 |
| cd07854 | 386-656  | STKc_MAPK4_6 |
| cd07851 | 388-656  | STKc_p38 |
| cd14133 | 390-647  | PKc_DYRK_like |
| cd07852 | 382-649  | STKc_MAPK15-like |
| cd07846 | 388-646  | STKc_CDKL2_3 |
| cd07835 | 396-646  | STKc_CDK1_CdkB_like |
| cd06657 | 396-653  | STKc_PAK4 |
| cd14046 | 396-644  | STKc_EIF2AK4_GCN2_rpt2 |
| cd07843 | 388-646  | STKc_CDC2L1 |
| cd05627 | 394-646  | STKc_NDR2 |
| cd05614 | 388-649  | STKc_MSK2_N |
| cd05619 | 388-670  | STKc_nPKC_theta |
| cd05618 | 376-609  | STKc_aPKC_iota |
| cd14101 | 390-647  | STKc_PIM2 |
| cd05630 | 394-645  | STKc_GRK6 |
| cd06605 | 394-648  | PKc_MAPKK |
| cd14052 | 389-645  | PTKc_Wee1_fungi |
| cd07856 | 386-647  | STKc_Sty1_Hog1 |
| cd14112 | 387-647  | STKc_Unc-89_rpt2 |
| cd05589 | 396-609  | STKc_PKN |
| cd06652 | 390-647  | STKc_MEKK2 |
| smart00537 | 181-269  | DCX |
| cd05610 | 388-645  | STKc_MASTL |
| cd07857 | 389-656  | STKc_MPK1 |
| cd06917 | 390-647  | STKc_NAK1_like |
| cd07836 | 390-646  | STKc_Pho85 |
| cd05588 | 394-609  | STKc_aPKC |
| cd07878 | 373-656  | STKc_p38beta |
| cd07880 | 373-658  | STKc_p38gamma |
| cd08221 | 434-645  | STKc_Nek9 |
| cd05597 | 394-646  | STKc_DMPK_like |
| cd06608 | 387-647  | STKc_myosinIII_N_like |
| cd14037 | 391-644  | STKc_NAK_like |
| cd05629 | 388-646  | STKc_NDR_like_fungal |
| cd00192 | 394-597  | PTKc |
| cd07877 | 373-656  | STKc_p38alpha |
| cd05617 | 378-609  | STKc_aPKC_zeta |
| cd06628 | 393-647  | STKc_Byr2_like |
| cd05621 | 388-650  | STKc_ROCK2 |
| cd06624 | 396-647  | STKc_ASK |
| cd05628 | 388-643  | STKc_NDR1 |
| cd05606 | 396-649  | STKc_beta_ARK |
| cd05632 | 394-674  | STKc_GRK5 |
| cd08528 | 390-641  | STKc_Nek10 |
| cd14038 | 396-635  | STKc_IKK_beta |
| cd07858 | 385-648  | STKc_TEY_MAPK |
| cd07860 | 396-646  | STKc_CDK2_3 |
| cd05620 | 394-646  | STKc_nPKC_delta |
| cd06653 | 388-647  | STKc_MEKK3_like_u1 |
| cd14210 | 386-647  | PKc_DYRK |
| cd05631 | 394-645  | STKc_GRK4 |
| cd07861 | 396-646  | STKc_CDK1_euk |
| cd05608 | 394-649  | STKc_GRK1 |
| cd07842 | 396-646  | STKc_CDK8_like |
| cd07849 | 386-647  | STKc_ERK1_2_like |
| cd13986 | 389-644  | STKc_16 |
| cd05622 | 388-650  | STKc_ROCK1 |
| cd14050 | 396-645  | PKc_Myt1 |
| cd14058 | 396-644  | STKc_TAK1 |
| cd13982 | 436-645  | STKc_IRE1 |
| cd14102 | 390-647  | STKc_PIM3 |
| cd06631 | 390-647  | STKc_YSK4 |
| cd07845 | 384-653  | STKc_CDK10 |
| cd14134 | 386-646  | PKc_CLK |
| cd14048 | 390-644  | STKc_EIF2AK3_PERK |
| cd07859 | 389-669  | STKc_TDY_MAPK |
| cd07850 | 436-648  | STKc_JNK |
| cd06640 | 396-647  | STKc_MST4 |
| cd06621 | 394-647  | PKc_Pek1_like |
| cd14051 | 395-645  | PTKc_Wee1 |
| cd14036 | 389-643  | STKc_GAK |
| cd14039 | 396-635  | STKc_IKK_alpha |
| cd08229 | 390-635  | STKc_Nek7 |
| cd06641 | 388-647  | STKc_MST3 |
| cd05624 | 388-683  | STKc_MRCK_beta |
| cd14019 | 388-645  | STKc_Cdc7 |
| cd07844 | 396-646  | STKc_PCTAIRE_like |
| cd13983 | 389-646  | STKc_WNK |
| cd06651 | 390-646  | STKc_MEKK3 |
| cd06607 | 388-647  | STKc_TAO |
| cd07865 | 396-646  | STKc_CDK9 |
| cd14047 | 390-644  | STKc_EIF2AK2_PKR |
| cd07879 | 373-656  | STKc_p38delta |
| cd14100 | 390-647  | STKc_PIM1 |
| cd07848 | 389-645  | STKc_CDKL5 |
| cd06642 | 396-587  | STKc_STK25 |
| cd07873 | 396-659  | STKc_PCTAIRE1 |
| cd14065 | 396-582  | PKc_LIMK_like |
| cd05148 | 388-611  | PTKc_Srm_Brk |
| cd13977 | 389-641  | STKc_PDIK1L |
| pfam03607 | 74-138  | DCX |
| cd07839 | 389-646  | STKc_CDK5 |
| cd07863 | 389-646  | STKc_CDK4 |
| cd07870 | 396-646  | STKc_PFTAIRE2 |
| cd06643 | 396-648  | STKc_SLK |
| cd06644 | 396-648  | STKc_STK10 |
| cd14040 | 385-647  | STKc_TLK1 |
| cd07871 | 396-646  | STKc_PCTAIRE3 |
| cd06622 | 396-667  | PKc_PBS2_like |
| cd13979 | 396-598  | STKc_Mos |
| cd07862 | 388-646  | STKc_CDK6 |
| cd14000 | 396-589  | STKc_LRRK |
| cd05041 | 394-594  | PTKc_Fes_like |
| cd07876 | 385-648  | STKc_JNK2 |
| cd07853 | 394-651  | STKc_NLK |
| cd06639 | 379-647  | STKc_myosinIIIB_N |
| cd13988 | 396-598  | STKc_TBK1 |
| cd05623 | 388-679  | STKc_MRCK_alpha |
| cd14022 | 445-646  | PK_TRB2 |
| cd14066 | 396-587  | STKc_IRAK |
| cd05633 | 390-636  | STKc_GRK3 |
| cd06646 | 390-647  | STKc_MAP4K5 |
| cd06645 | 388-647  | STKc_MAP4K3 |
| cd14214 | 386-646  | PKc_CLK3 |
| cd14023 | 445-646  | PK_TRB1 |
| cd06620 | 394-645  | PKc_Byr1_like |
| cd06633 | 396-653  | STKc_TAO3 |
| cd05056 | 388-589  | PTKc_FAK |
| cd14223 | 390-646  | STKc_GRK2 |
| cd14131 | 396-645  | PKc_Mps1 |
| cd14146 | 396-589  | STKc_MLK4 |
| cd07875 | 385-648  | STKc_JNK1 |
| cd07869 | 388-597  | STKc_PFTAIRE1 |
| cd13976 | 407-646  | PK_TRB |
| cd05052 | 396-589  | PTKc_Abl |
| cd14154 | 396-582  | STKc_LIMK |
| cd14041 | 385-663  | STKc_TLK2 |
| cd14132 | 378-645  | STKc_CK2_alpha |
| cd06637 | 383-674  | STKc_TNIK |
| cd14215 | 386-611  | PKc_CLK2 |
| cd05626 | 394-587  | STKc_LATS2 |
| cd14225 | 386-589  | PKc_DYRK4 |
| cd14150 | 394-598  | STKc_A-Raf |
| cd05625 | 394-587  | STKc_LATS1 |
| cd13968 | 396-535  | PKc_like |
| cd13978 | 396-587  | STKc_RIP |
| cd06629 | 389-647  | STKc_Bck1_like |
| cd07872 | 388-655  | STKc_PCTAIRE2 |
| cd14221 | 436-582  | STKc_LIMK1 |
| cd14061 | 396-589  | STKc_MLK |
| cd14062 | 434-598  | STKc_Raf |
| cd07874 | 374-648  | STKc_JNK3 |
| cd14138 | 396-645  | PTKc_Wee1a |
| cd06635 | 394-587  | STKc_TAO1 |
| cd14211 | 390-601  | STKc_HIPK |
| cd05085 | 393-594  | PTKc_Fer |
| cd07837 | 388-646  | STKc_CdkB_plant |
| cd14229 | 390-601  | STKc_HIPK3 |
| cd13974 | 482-644  | STKc_SHIK |
| cd14059 | 434-589  | STKc_MAP3K12_13 |
| cd14222 | 396-582  | STKc_LIMK2 |
| pfam03607 | 203-264  | DCX |
| cd14226 | 386-602  | PKc_DYRK1 |
| cd14145 | 396-611  | STKc_MLK1 |
| cd05084 | 393-578  | PTKc_Fes |
| cd14228 | 381-601  | STKc_HIPK1 |
| cd14148 | 396-588  | STKc_MLK2 |
| cd14155 | 396-576  | PKc_TESK |
| cd14151 | 392-598  | STKc_B-Raf |
| cd05060 | 394-589  | PTKc_Syk_like |
| cd06638 | 372-587  | STKc_myosinIIIA_N |
| cd05038 | 388-581  | PTKc_Jak_rpt2 |
| cd14049 | 390-643  | STKc_EIF2AK1_HRI |
| cd13995 | 396-644  | STKc_MAP3K8 |
| cd14068 | 396-643  | STKc_LRRK2 |
| cd06634 | 394-587  | STKc_TAO2 |
| cd14012 | 398-645  | PK_eIF2AK_GCN2_rpt1 |
| cd06636 | 383-587  | STKc_MAP4K4_6_N |
| cd14149 | 396-648  | STKc_C-Raf |
| cd07864 | 396-647  | STKc_CDK12 |
| cd14033 | 396-644  | STKc_WNK4 |
| cd14135 | 389-585  | STKc_PRP4 |
| cd06619 | 395-651  | PKc_MKK5 |
| cd14227 | 381-647  | STKc_HIPK2 |
| cd14136 | 389-646  | STKc_SRPK |
| cd14156 | 396-582  | PKc_LIMK_like_unk |
| cd14212 | 390-601  | PKc_YAK1 |
| cd05059 | 393-604  | PTKc_Tec_like |
| cd14016 | 389-538  | STKc_CK1 |
| cd14147 | 433-589  | STKc_MLK3 |
| cd14139 | 396-645  | PTKc_Wee1b |
| cd14224 | 386-625  | PKc_DYRK2_3 |
| cd14001 | 421-643  | PKc_TOPK |
| cd06617 | 394-647  | PKc_MKK3_6 |
| cd14213 | 386-646  | PKc_CLK1_4 |
| cd05055 | 388-589  | PTKc_PDGFR |
| cd05112 | 396-578  | PTKc_Itk |
| cd06616 | 396-649  | PKc_MKK4 |
| cd14024 | 471-647  | PK_TRB3 |
| cd05039 | 391-576  | PTKc_Csk_like |
| cd05044 | 417-643  | PTKc_c-ros |
| cd06618 | 379-649  | PKc_MKK7 |
| cd06630 | 393-645  | STKc_MEKK1 |
| cd14205 | 396-635  | PTKc_Jak2_rpt2 |
| cd14067 | 434-589  | STKc_LRRK1 |
| cd05066 | 389-578  | PTKc_EphR_A |
| cd13991 | 396-638  | STKc_NIK |
| cd14158 | 393-597  | STKc_IRAK4 |
| cd14064 | 426-587  | PKc_TNNI3K |
| cd05097 | 388-594  | PTKc_DDR_like |
| cd05065 | 391-578  | PTKc_EphR_B |
| cd05079 | 394-581  | PTKc_Jak1_rpt2 |
| cd05116 | 396-589  | PTKc_Syk |
| cd05095 | 396-611  | PTKc_DDR2 |
| cd05034 | 394-578  | PTKc_Src_like |
| cd06650 | 396-575  | PKc_MEK1 |
| cd05033 | 394-597  | PTKc_EphR |
| cd05068 | 394-589  | PTKc_Frk_like |
| cd05083 | 392-578  | PTKc_Chk |
| cd07868 | 393-593  | STKc_CDK8 |
| cd07867 | 393-593  | STKc_CDC2L6 |
| cd05115 | 396-575  | PTKc_Zap-70 |
| cd05063 | 383-578  | PTKc_EphR_A2 |
| cd14664 | 396-596  | STK_BAK1_like |
| cd05096 | 417-597  | PTKc_DDR1 |
| cd14063 | 391-594  | PK_KSR |
| cd05045 | 392-589  | PTKc_RET |
| cd14159 | 396-583  | STKc_IRAK1 |
| cd14011 | 410-649  | PK_SCY1_like |
| cd14031 | 396-650  | STKc_WNK3 |
| cd05053 | 388-589  | PTKc_FGFR |
| cd05072 | 380-589  | PTKc_Lyn |
| cd14054 | 396-576  | STKc_BMPR2_AMHR2 |
| cd05080 | 388-581  | PTKc_Tyk2_rpt2 |
| cd06649 | 396-586  | PKc_MEK2 |
| cd05082 | 388-578  | PTKc_Csk |
| cd14017 | 389-537  | STKc_TTBK |
| cd14060 | 397-589  | STKc_MLTK |
| cd05048 | 409-610  | PTKc_Ror |
| cd05036 | 394-597  | PTKc_ALK_LTK |
| cd14056 | 435-562  | STKc_TGFbR_I |
| cd14030 | 396-650  | STKc_WNK1 |
| cd05101 | 388-589  | PTKc_FGFR2 |
| cd05067 | 436-589  | PTKc_Lck_Blk |
| cd06615 | 396-574  | PKc_MEK |
| cd05073 | 377-589  | PTKc_Hck |
| cd13998 | 396-576  | STKc_TGFbR-like |
| cd05081 | 396-581  | PTKc_Jak3_rpt2 |
| cd05032 | 388-594  | PTKc_InsR_like |
| cd14032 | 396-650  | STKc_WNK2_like |
| cd05113 | 394-578  | PTKc_Btk_Bmx |
| cd14203 | 436-604  | PTKc_Src_Fyn_like |
| cd14018 | 480-638  | STKc_PINK1 |
| cd05075 | 392-589  | PTKc_Axl |
| cd05062 | 388-642  | PTKc_IGF-1R |
| cd05057 | 389-589  | PTKc_EGFR_like |
| cd05074 | 388-589  | PTKc_Tyro3 |
| cd05069 | 375-640  | PTKc_Yes |
| cd14025 | 394-589  | STKc_RIP4_like |
| cd05054 | 388-595  | PTKc_VEGFR |
| cd05098 | 388-627  | PTKc_FGFR1 |
| cd05049 | 394-576  | PTKc_Trk |
| cd05100 | 389-589  | PTKc_FGFR3 |
| cd05061 | 388-643  | PTKc_InsR |
| cd13981 | 390-535  | STKc_Bub1_BubR1 |
| cd14013 | 495-647  | STKc_SNT7_plant |
| cd14027 | 399-598  | STKc_RIP1 |
| cd05058 | 439-588  | PTKc_Met_Ron |
| cd14218 | 389-647  | STKc_SRPK3 |
| cd05071 | 377-604  | PTKc_Src |
| cd05040 | 396-536  | PTKc_Ack_like |
| cd05035 | 391-592  | PTKc_TAM |
| cd14207 | 388-611  | PTKc_VEGFR1 |
| cd05099 | 388-589  | PTKc_FGFR4 |
| cd08216 | 433-587  | PK_STRAD |
| cd13980 | 493-643  | STKc_Vps15 |
| cd05090 | 413-597  | PTKc_Ror1 |
| cd14204 | 392-605  | PTKc_Mer |
| cd14216 | 389-606  | STKc_SRPK1 |
| cd05051 | 436-597  | PTKc_DDR |
| cd05114 | 394-596  | PTKc_Tec_Rlk |
| cd13975 | 463-583  | PKc_Dusty |
| cd05091 | 417-628  | PTKc_Ror2 |
| cd05093 | 394-578  | PTKc_TrkB |
| cd14144 | 459-562  | STKc_BMPR1 |
| TIGR03724 | 398-537  | arch_bud32 |
| COG3642 | 384-537  | Bud32 |
| smart00220 | 390-647  | S_TKc |
| pfam00069 | 390-647  | Pkinase |
| PTZ00263 | 390-646  | PTZ00263 |
| COG0515 | 390-656  | SPS1 |
| PTZ00426 | 388-649  | PTZ00426 |
| PLN00034 | 393-659  | PLN00034 |
| smart00219 | 391-597  | TyrKc |
| smart00221 | 391-597  | STYKc |
| PHA03390 | 398-648  | pk1 |
| pfam07714 | 393-589  | Pkinase_Tyr |
| PTZ00283 | 350-645  | PTZ00283 |
| PTZ00267 | 434-643  | PTZ00267 |
| PTZ00036 | 343-649  | PTZ00036 |
| PLN00009 | 388-649  | PLN00009 |
| PTZ00266 | 390-653  | PTZ00266 |
| PTZ00024 | 382-659  | PTZ00024 |
| PHA03211 | 407-578  | PHA03211 |
| TIGR03903 | 412-613  | TOMM_kin_cyc |
| PHA03210 | 346-611  | PHA03210 |
| PHA03212 | 375-578  | PHA03212 |
| PRK13184 | 388-642  | pknD |
| PHA03209 | 366-581  | PHA03209 |
| PHA03207 | 363-578  | PHA03207 |
Ontology Information
| HPRD ID | 1268 |    
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
