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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DDB2 | 1643 | damage-specific DNA binding protein 2, 48kDa | 11 | DDBB, UV-DDB2, FLJ34321 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23610444 | 2013 | Cell line : HCT 116, SW 480, SW 620 Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry,Immunofluorescence,Tissue Microarray,real time RT-PCR assays,Chromatin Immunoprecipitation. | Down-regulation | - | A transcriptional regulatory pathway of DDB2 that is directly linked to the mechanisms that suppress metastasis of colon cancer.damaged DNA-binding protein (DDB)-2, is downregulated in high-grade colon cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] | Chromosome | 11 |
| Location | 11p12-p11 |
| Start | 47236493 |
| End | 47260769 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 24277 |
| OMIM ID | 600811 |
| HGNC ID | HGNC:2718 |
| Unigene ID | Hs.700338 |
| Ensembl ID | - |
| PharmGKB ID | PA27188 |
mRNA Information
| mRNA ID | NM_000107.2 |
|---|---|
| Exon | join(1..322,1395..1531,1917..2108,17873..18018, 19632..19731,19816..19993,20329..20471,22896..23060, 23197..23242,23859..24277) | mRNA Sequence | Download Select all |
| Length | 1870 |
Protein Information
| Protein ID | NP_000098.1 |
|---|---|
| Protein Name | damage-specific DNA binding protein 2, 48kDa |
| Molecular Wt. (Da) | 47733 |
| Protein Sequence | Download Select all |
| Length | 427 |
| Uniprot ID | Q99697 |
| Ensembl Protein ID | ENSP00000304169 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 26;- |
| S | Phosphorylation | 24;- |
| K | Acetylation | 278 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1869 | E2F1 | 1806 | NP_005216.1 | in vitro | 9418871 |
| 7507 | XPA | 2045 | NP_000371.1 | in vitro | 19056823 |
| 7508 | XPC | 2046 | NP_004619.3 | in vivo | 15882621 |
| 8450 | CUL4B | 2251 | NP_003579.3 | in vivo | 18593899 |
| 8451 | CUL4A | 7218 | NP_001008895.1 | in vivo | 18593899 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hepatitis B | hsa05161 |
| Nucleotide excision repair | hsa03420 |
| p53 signaling pathway | hsa04115 |
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 115-419 | WD40 |
| cl02567 | 115-419 | WD40 superfamily |
| cd00200 | 203-419 | WD40 |
| cd00200 | 238-427 | WD40 |
| smart00320 | 231-271 | WD40 |
| pfam00400 | 232-271 | WD40 |
| COG2319 | 68-419 | WD40 |
| COG2319 | 98-332 | WD40 |
| COG2319 | 118-328 | WD40 |
| COG2319 | 111-281 | WD40 |
Ontology Information
| HPRD ID | 5987 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.