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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23902796 | 2013 | Cell line : - Source : Dandong Center Hospital of China Sample Type : - No. of Sample : 109 Colorectal cancer specimens and 52 colorectal adenomas Stage : TNM Stage I-IV | Immunohistochemistry | Up-regulation | - | DEK plays an important role in the progression of colorectal cancers and it is an independent poor prognostic factor of colorectal cancers. The strongly positive rate of DEK protein was 48.62% (53/109) in colorectal cancers, which was significantly higher than that in either adjacent normal colon mucosa (9.17%, 10/109) or colorectal adenomas (13.46%, 7/52). DEK over expression in colorectal cancers was positively correlated with tumor size, grade, lymph node metastasis, serosal invasion, late stage, and disease-free survival- and 5-year survival rates. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. | Chromosome | 6 |
| Location | 6p23 |
| Start | 18224169 |
| End | 18264568 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 40400 |
| OMIM ID | 125264 |
| HGNC ID | HGNC:2768 |
| Unigene ID | Hs.484813 |
| Ensembl ID | ENSG00000124795 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001134709.1 |
|---|---|
| Exon | join(1..184,573..726,6507..6616,8114..8208,8718..8838, 14730..14918,27053..27188,27969..28117,38327..38395, 38839..40400) | mRNA Sequence | Download Select all |
| Length | 2785 |
CDS Information
| Location | join(582..726,6507..6616,8114..8208,8718..8838, 14730..14918,27053..27188,27969..28117,38327..38395, 38839..38850) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS47382.1 |
Protein Information
| Protein ID | NP_001128181.1 |
|---|---|
| Protein Name | DEK proto-oncogene |
| Molecular Wt. (Da) | 38574 |
| Protein Sequence | Download Select all |
| Length | 341 |
| Uniprot ID | P22301 |
| Ensembl Protein ID | ENSP00000412237 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 306;- |
| S | Phosphorylation | 307;- |
| S | Phosphorylation | 301;- |
| S | Phosphorylation | 303;- |
| S | Phosphorylation | 232;- |
| S | Phosphorylation | 227;- |
| S | Phosphorylation | 230;- |
| S | Phosphorylation | 231;- |
| S | Phosphorylation | 32;- |
| S | Phosphorylation | 251;- |
| S | Phosphorylation | 244;- |
| S | Phosphorylation | 51;- |
| T | Phosphorylation | 13;- |
| T | Phosphorylation | 15;- |
| S | Phosphorylation | 296 |
| S | Acetylation | 2 |
| S | Phosphorylation | 243 |
| S | Phosphorylation | 276 |
| K | Acetylation | 326 |
| S | Phosphorylation | 19 |
| T | Phosphorylation | 119 |
| S | Phosphorylation | 121 |
| S | Phosphorylation | 122 |
| S | Phosphorylation | 210 |
| S | Phosphorylation | 211 |
| T | Phosphorylation | 321 |
| T | Phosphorylation | 328 |
| S | Phosphorylation | 335 |
| S | Phosphorylation | 2 |
| T | Phosphorylation | 368 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7020 | TFAP2A | 128 | NP_003211.1 | in vitro;in vivo | 12595566 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1Q1V |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | DEK protein |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam08766 | 321-375 | DEK_C |
| cl07395 | 321-375 | DEK_C superfamily |
| smart00513 | 149-183 | SAP |
| cl02640 | 149-183 | SAP superfamily |
| pfam02037 | 149-183 | SAP |
Ontology Information
| HPRD ID | 1193 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.