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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17848589 | 2007 | Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO). Sample Type : - No. of Sample : - Stage : - | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry | Up-regulation | 1.55 | - |
| 22141345 | 2011 | Cell line : - Source : The Queen Elizabeth Hospital Sample Type : - No. of Sample : - Stage : - | 2D DIGE, MS/MS, Immunofluorescence | Up-regulation | - | Pericyte coverage of vasculature is a marker of vessel maturation, hence desmin expression may have use as a marker for microvessel maturation. Desmin expression was significantly increased between stage I and III tumors, (P < 0.0001), and stage II and III tumors, (P < 0.0001). |
| 19460759 | 2009 | Cell line : - Source : Six People's Hospital, Shanghai Jiao Tong University Sample Type : - No. of Sample : - Stage : - | RT-PCR, Western Blotting,Immunohistochemistry, ELISA | Up-regulation | - | desmin can be considered a potential oncofetal serum tumor marker for CRC that may have significance in the detection of patients with CRC. The elevated expression of desmin in CRC tissue and different developmental stages of fetus colon was confirmed by RT-PCR and Western blot analysis. Sample size: 10 fresh CRC and paired tumor-adjacent normal colorectal tissues, Blood from 92 patients with CRC before surgical resections & 45 specimens of healthy individuals. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Intermediate filaments type III |
| Description | This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2q35 |
| Start | 219418377 |
| End | 219426739 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8363 |
| OMIM ID | 125660 |
| HGNC ID | HGNC:2770 |
| Unigene ID | Hs.594952 |
| Ensembl ID | ENSG00000175084 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001927.3 |
|---|---|
| Exon | join(1..664,1719..1779,1875..1970,2119..2280,2452..2577, 2964..3184,5401..5444,7287..7369,7573..8363) | mRNA Sequence | Download Select all |
| Length | 2268 |
CDS Information
| Location | join(87..664,1719..1779,1875..1970,2119..2280,2452..2577, 2964..3184,5401..5444,7287..7369,7573..7614) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS33383.1 |
Protein Information
| Protein ID | NP_001918.3 |
|---|---|
| Protein Name | Desmin |
| Molecular Wt. (Da) | 53405 |
| Protein Sequence | Download Select all |
| Length | 470 |
| Uniprot ID | P36542 |
| Ensembl Protein ID | ENSP00000338568 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 17 |
| T | Phosphorylation | 76 |
| T | Phosphorylation | 77 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 60 |
| K | Acetylation | 240 |
| Y | Phosphorylation | 54 |
| S | Phosphorylation | 68 |
| T | Phosphorylation | 450 |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 32 |
Enzyme Information
| EC | 4.2.1.121 |
|---|---|
| Name | colneleate synthase 9-divinyl ether synthase 9-DES CYP74D CYP74D1 CYP74 cytochrome P-450 DES1 |
| Class | Lyases; Carbon-oxygen lyases; Hydro-lyases |
| Sysname | (8E)-9-[(1E,3E)-nona-1,3-dien-1-yloxy]non-8-enoate synthase |
| Substrate | (9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate |
| Product | (8E)-9-[(1E,3Z)-nona-1,3-dien-1-yloxy]non-8-enoate [CPD:C19827]; H2O |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1832 | DSP | 513 | NP_004406.2 | in vitro;yeast 2-hybrid | 9261168 |
| 4703 | NEB | 1196 | NP_004534.2 | in vitro;yeast 2-hybrid | 12064939 |
| 6462 | SHBG | 1646 | NP_001031.2 | yeast 2-hybrid | 15862967 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Dilated cardiomyopathy | hsa05414 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
Structure Information
| PDB ID | 1A81 |
|---|---|
| Resolution | 3 |
| Method | X-RAY DIFFRACTION |
| Chains | A,C,G |
| Molecule | SYK KINASE |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04732 | 9-106 | Filament_head |
| cl04711 | 9-106 | Filament_head superfamily |
| pfam00038 | 107-415 | Filament |
| TIGR02168 | 103-421 | SMC_prok_B |
| COG1196 | 165-416 | Smc |
| COG1196 | 165-417 | Smc |
| TIGR02168 | 89-360 | SMC_prok_B |
| COG1196 | 89-410 | Smc |
| COG1196 | 186-417 | Smc |
| TIGR02169 | 166-469 | SMC_prok_A |
| TIGR02169 | 108-382 | SMC_prok_A |
| TIGR02168 | 165-418 | SMC_prok_B |
| TIGR02169 | 165-391 | SMC_prok_A |
| COG1579 | 220-395 | COG1579 |
| pfam01576 | 170-413 | Myosin_tail_1 |
| pfam03962 | 305-383 | Mnd1 |
| COG1196 | 201-415 | Smc |
| PRK11281 | 276-411 | PRK11281 |
| COG1196 | 296-436 | Smc |
| TIGR03752 | 111-196 | conj_TIGR03752 |
| TIGR02169 | 105-383 | SMC_prok_A |
| PHA02562 | 165-387 | 46 |
| smart00787 | 294-417 | Spc7 |
| COG2433 | 289-412 | COG2433 |
Ontology Information
| HPRD ID | 156 |
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.