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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DGCR8 | 54487 | DGCR8 microprocessor complex subunit | 22 | DGCRK6, Gy1, pasha |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23775303 | 2014 | Cell line : - Source : Dongsan Medical Center (Daegu, Korea). Sample Type : CRC tumor No. of Sample : 60 Stage : - | real-time RT- PCR | Up-regulation | - | DGCR8 mRNA expression level was up-regulated in CRC, suggesting its important role in pathobiology of colorectal carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] | Chromosome | 22 |
| Location | 22q11.2 |
| Start | 20067755 |
| End | 20099400 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 31646 |
| OMIM ID | 609030 |
| HGNC ID | HGNC:2847 |
| Unigene ID | Hs.643452 |
| Ensembl ID | ENSG00000128191 |
| PharmGKB ID | PA27309 |
Protein Information
| Protein ID | NP_001177255.1 |
|---|---|
| Protein Name | DGCR8 microprocessor complex subunit |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 773 |
| Uniprot ID | Q9HAV4 |
| Ensembl Protein ID | ENSP00000265351 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 383;- |
| S | Phosphorylation | 92 |
| S | Phosphorylation | 95 |
| S | Phosphorylation | 109 |
| Y | Phosphorylation | 267 |
| S | Phosphorylation | 275 |
| S | Phosphorylation | 271 |
| T | Phosphorylation | 279 |
| S | Phosphorylation | 377 |
| S | Phosphorylation | 373 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00048 | 513-576 | DSRM |
| cl00054 | 513-576 | DSRM superfamily |
| cd00201 | 304-332 | WW |
| cl00157 | 304-332 | WW superfamily |
| pfam00035 | 513-576 | dsrm |
| smart00358 | 513-576 | DSRM |
| pfam00035 | 620-684 | dsrm |
| cl00054 | 620-684 | DSRM superfamily |
| smart00456 | 302-332 | WW |
| cd00048 | 620-684 | DSRM |
| pfam00397 | 303-332 | WW |
| smart00358 | 624-684 | DSRM |
| PHA03103 | 498-577 | PHA03103 |
| TIGR02191 | 508-574 | RNaseIII |
| PRK00102 | 516-576 | rnc |
| COG0571 | 487-576 | Rnc |
Ontology Information
| HPRD ID | 12204 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell-cell adhesion (GO:0016337) |
Drug Information
No matching records could be found.