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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DICER1 23405 dicer 1, ribonuclease type III  14Dicer, KIAA0928, K12H4.8-LIKE, HERNA 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21345667   2011Cell line : -

Source : Ludwig Maximilian University of Munich

Sample Type : CRC tumor and normal tissue

No. of Sample : 237 patients with moderately differentiated adenocarcinoma (G2) of the colon or rectum

Stage : -

Tissue microarray and immunohistochemistryUp-regulation-Strong expression of the central microRNA biosynthesis enzyme Dicer predicts poor prognosis in patients with colorectal cancer.


Gene Details



Chromosome 14 - NC_000014.9 (95086228..95158010, complement)

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Gene Type protein coding
Gene Family
Description This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.  
Chromosome 14
Location 14q32.13
Start 95086228  
End 95158010  
Strand -  
Gene Sequence

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Length 71783  
OMIM ID 606241   
HGNC ID HGNC:17098   
Unigene ID Hs.87889   
Ensembl ID ENSG00000100697   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001291628.1
Exon join(1..80,24512..24696,25334..25496,26372..26502, 27819..27953,28379..28539,31263..31431,33343..33815, 40257..40389,41316..41558,42190..42344,44787..44919, 45764..45839,46555..46694,49508..49687,49918..50131, 50250..50403,51788..51970,52228..52333,52765..52940, 53885..54665,58076..58231,61298..62186,63855..64123, 66646..66808,66902..66977,67348..71783)  
mRNA Sequence

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Length 9921  



CDS Information


   
Location join(24553..24696,25334..25496,26372..26502,27819..27953, 28379..28539,31263..31431,33343..33815,40257..40389, 41316..41558,42190..42344,44787..44919,45764..45839, 46555..46694,49508..49687,49918..50131,50250..50403, 51788..51970,52228..52333,52765..52940,53885..54665, 58076..58231,61298..62186,63855..64123,66646..66808, 66902..66977,67348..67513)
CDS Sequence

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CCDS ID CCDS9931.1



Protein Information


      
Protein IDNP_001182502.1
Protein Namedicer 1, ribonuclease type III
Molecular Wt. (Da)208318
Protein Sequence

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Length 1829  
Uniprot IDO15554
Ensembl Protein ID ENSP00000262888  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation664;-
YPhosphorylation664;-
SPhosphorylation1016
SPhosphorylation1016
SPhosphorylation1255
SPhosphorylation1255
SPhosphorylation1160
SPhosphorylation1160

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6895TARBP25446NP_599150.1in vitro;in vivo164   249   071   614   221   000   000   000   


Pathway Information


      
Pathway Name Pathway ID
MicroRNAs in cancer hsa05206


Structure Information


PDB ID2EB1
Resolution2
MethodX-RAY DIFFRACTION
Chains A,B,C  
Molecule Endoribonuclease Dicer  
Model View



Domain Information




ID Location Description
cd02843886-1008  PAZ_dicer_like
cl00301886-1008  PAZ superfamily
cd005931682-1846  RIBOc
cl002581682-1846  RIBOc superfamily
cd15903271-365  Dicer_PBD
cl17041271-365  helicase_insert_domain superfamily
cd005931296-1376  RIBOc
cl002581296-1376  RIBOc superfamily
cd0004658-209  DEXDc
cl2145558-209  P-loop_NTPase superfamily
cd00079444-553  HELICc
cl21455444-553  P-loop_NTPase superfamily
cd000481850-1912  DSRM
cl000541850-1912  DSRM superfamily
pfam03368630-722  Dicer_dimer
cl04028630-722  Dicer_dimer superfamily
smart005351682-1845  RIBOc
cd02825886-1008  PAZ
smart00949925-1065  PAZ
smart005351296-1387  RIBOc
cd12088271-362  helicase_insert_domain
pfam006361702-1824  Ribonuclease_3
pfam02170894-1048  PAZ
pfam146221679-1826  Ribonucleas_3_3
pfam006361313-1366  Ribonuclease_3
cd02844922-1044  PAZ_CAF_like
pfam00271499-553  Helicase_C
smart00490499-553  HELICc
pfam0027045-221  DEAD
pfam0485141-207  ResIII
pfam146221293-1369  Ribonucleas_3_3
cd02845928-1038  PAZ_piwi_like
smart003581850-1913  DSRM
pfam000351853-1912  dsrm
cd0026828-177  DEADc
COG05711666-1918  Rnc
smart0048740-242  DEXDc
COG111137-553  MPH1
TIGR021911669-1912  RNaseIII
PRK001021666-1915  rnc
PRK1376637-553  PRK13766
PRK123711657-1910  PRK12371
COG05711293-1366  Rnc
TIGR021911292-1367  RNaseIII
COG106142-552  SSL2
PRK001021288-1365  rnc
COG0513445-589  SrmB
COG120447-258  BRR2
PRK147181666-1919  PRK14718
PRK123711300-1344  PRK12371
PRK11192444-594  PRK11192
PTZ00424499-578  PTZ00424
PRK123721670-1919  PRK12372
PRK10917502-539  PRK10917
COG1200501-539  RecG
COG1197481-532  Mfd
PRK123721293-1361  PRK12372
COG0514494-589  RecQ
TIGR00643501-541  recG
PRK147181293-1361  PRK14718
PTZ00110499-577  PTZ00110
PRK11634491-552  PRK11634
TIGR00580493-532  mfd
COG0556503-587  UvrB
TIGR00614497-553  recQ_fam
PLN00206495-553  PLN00206
PRK04537499-552  PRK04537
COG4098483-553  comFA


Ontology Information


   
HPRD ID1867
Molecular ClassRibonuclease
Molecular FunctionTransmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO