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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DICER1 | 23405 | dicer 1, ribonuclease type III  | 14 | Dicer, KIAA0928, K12H4.8-LIKE, HERNA  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21345667    | 2011 | Cell line : - Source : Ludwig Maximilian University of Munich Sample Type : CRC tumor and normal tissue No. of Sample : 237 patients with moderately differentiated adenocarcinoma (G2) of the colon or rectum Stage : - | Tissue microarray and immunohistochemistry | Up-regulation | - | Strong expression of the central microRNA biosynthesis enzyme Dicer predicts poor prognosis in patients with colorectal cancer. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.   | Chromosome | 14 |
| Location | 14q32.13 |
| Start | 95086228   |
| End | 95158010   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 71783   |
| OMIM ID | 606241    |
| HGNC ID | HGNC:17098    |
| Unigene ID | Hs.87889    |
| Ensembl ID | ENSG00000100697    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001291628.1 |
|---|---|
| Exon | join(1..80,24512..24696,25334..25496,26372..26502, 27819..27953,28379..28539,31263..31431,33343..33815, 40257..40389,41316..41558,42190..42344,44787..44919, 45764..45839,46555..46694,49508..49687,49918..50131, 50250..50403,51788..51970,52228..52333,52765..52940, 53885..54665,58076..58231,61298..62186,63855..64123, 66646..66808,66902..66977,67348..71783)   | mRNA Sequence |    Download   Select all |
| Length | 9921   |
CDS Information
| Location | join(24553..24696,25334..25496,26372..26502,27819..27953, 28379..28539,31263..31431,33343..33815,40257..40389, 41316..41558,42190..42344,44787..44919,45764..45839, 46555..46694,49508..49687,49918..50131,50250..50403, 51788..51970,52228..52333,52765..52940,53885..54665, 58076..58231,61298..62186,63855..64123,66646..66808, 66902..66977,67348..67513) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS9931.1 |    
Protein Information
| Protein ID | NP_001182502.1 |
|---|---|
| Protein Name | dicer 1, ribonuclease type III |
| Molecular Wt. (Da) | 208318 |
| Protein Sequence |    Download   Select all |
| Length | 1829   |
| Uniprot ID | O15554 |    
| Ensembl Protein ID | ENSP00000262888   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 664;- |
| Y | Phosphorylation | 664;- |
| S | Phosphorylation | 1016 |
| S | Phosphorylation | 1016 |
| S | Phosphorylation | 1255 |
| S | Phosphorylation | 1255 |
| S | Phosphorylation | 1160 |
| S | Phosphorylation | 1160 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6895 |    TARBP2 |    5446 |    NP_599150.1 |    in vitro;in vivo |    164   249   071   614   221   000   000   000    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer |    hsa05206 |    
Structure Information
| PDB ID | 2EB1 |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B,C   |
| Molecule | Endoribonuclease Dicer   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02843 | 886-1008  | PAZ_dicer_like |
| cl00301 | 886-1008  | PAZ superfamily |
| cd00593 | 1682-1846  | RIBOc |
| cl00258 | 1682-1846  | RIBOc superfamily |
| cd15903 | 271-365  | Dicer_PBD |
| cl17041 | 271-365  | helicase_insert_domain superfamily |
| cd00593 | 1296-1376  | RIBOc |
| cl00258 | 1296-1376  | RIBOc superfamily |
| cd00046 | 58-209  | DEXDc |
| cl21455 | 58-209  | P-loop_NTPase superfamily |
| cd00079 | 444-553  | HELICc |
| cl21455 | 444-553  | P-loop_NTPase superfamily |
| cd00048 | 1850-1912  | DSRM |
| cl00054 | 1850-1912  | DSRM superfamily |
| pfam03368 | 630-722  | Dicer_dimer |
| cl04028 | 630-722  | Dicer_dimer superfamily |
| smart00535 | 1682-1845  | RIBOc |
| cd02825 | 886-1008  | PAZ |
| smart00949 | 925-1065  | PAZ |
| smart00535 | 1296-1387  | RIBOc |
| cd12088 | 271-362  | helicase_insert_domain |
| pfam00636 | 1702-1824  | Ribonuclease_3 |
| pfam02170 | 894-1048  | PAZ |
| pfam14622 | 1679-1826  | Ribonucleas_3_3 |
| pfam00636 | 1313-1366  | Ribonuclease_3 |
| cd02844 | 922-1044  | PAZ_CAF_like |
| pfam00271 | 499-553  | Helicase_C |
| smart00490 | 499-553  | HELICc |
| pfam00270 | 45-221  | DEAD |
| pfam04851 | 41-207  | ResIII |
| pfam14622 | 1293-1369  | Ribonucleas_3_3 |
| cd02845 | 928-1038  | PAZ_piwi_like |
| smart00358 | 1850-1913  | DSRM |
| pfam00035 | 1853-1912  | dsrm |
| cd00268 | 28-177  | DEADc |
| COG0571 | 1666-1918  | Rnc |
| smart00487 | 40-242  | DEXDc |
| COG1111 | 37-553  | MPH1 |
| TIGR02191 | 1669-1912  | RNaseIII |
| PRK00102 | 1666-1915  | rnc |
| PRK13766 | 37-553  | PRK13766 |
| PRK12371 | 1657-1910  | PRK12371 |
| COG0571 | 1293-1366  | Rnc |
| TIGR02191 | 1292-1367  | RNaseIII |
| COG1061 | 42-552  | SSL2 |
| PRK00102 | 1288-1365  | rnc |
| COG0513 | 445-589  | SrmB |
| COG1204 | 47-258  | BRR2 |
| PRK14718 | 1666-1919  | PRK14718 |
| PRK12371 | 1300-1344  | PRK12371 |
| PRK11192 | 444-594  | PRK11192 |
| PTZ00424 | 499-578  | PTZ00424 |
| PRK12372 | 1670-1919  | PRK12372 |
| PRK10917 | 502-539  | PRK10917 |
| COG1200 | 501-539  | RecG |
| COG1197 | 481-532  | Mfd |
| PRK12372 | 1293-1361  | PRK12372 |
| COG0514 | 494-589  | RecQ |
| TIGR00643 | 501-541  | recG |
| PRK14718 | 1293-1361  | PRK14718 |
| PTZ00110 | 499-577  | PTZ00110 |
| PRK11634 | 491-552  | PRK11634 |
| TIGR00580 | 493-532  | mfd |
| COG0556 | 503-587  | UvrB |
| TIGR00614 | 497-553  | recQ_fam |
| PLN00206 | 495-553  | PLN00206 |
| PRK04537 | 499-552  | PRK04537 |
| COG4098 | 483-553  | comFA |
Ontology Information
| HPRD ID | 1867 |    
|---|---|
| Molecular Class | Ribonuclease |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
