Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DKK4 | 27121 | Dickkopf homolog 4 (Xenopus laevis) | 8 | DKK-4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18408752 | 2008 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting, Reporter assays, Chromatin immunoprecipitation assays, Real time RT-PCR | Up-regulation | - | DKK-4 is a new TCF/b-catenin target gene that is upregulated in human colon cancer where it affects the migratory, invasive and angiogenic phenotype of colon cancer cells, most likely through b-catenin-independent mechanisms. |
| 19035286 | 2008 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | DKK-4 is a target of the Wnt/beta-catenin pathway and is up-regulated in colorectal tumours, and it has been shown to increase cell migration and invasion and to promote a proangiogenic phenotype. |
| 21531130 | 2011 | Cell line : - Source : Japanees patients Sample Type : CRC tumor and normal tissue No. of Sample : 113 Stage : - | Peptide Nucleic Acid (PNA)-clamp real-time-PCR TaqMan assay, Gene expression profiles. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8p11.2-p11 |
| Start | 42373194 |
| End | 42391754 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 18561 |
| OMIM ID | 605417 |
| HGNC ID | HGNC:2894 |
| Unigene ID | Hs.159311 |
| Ensembl ID | ENSG00000104371 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011544486.1 |
|---|---|
| Exon | join(1..88,423..714,14583..14820,15925..16075, 16842..16994,17396..18561) | mRNA Sequence | Download Select all |
| Length | 2088 |
CDS Information
| Location | join(14710..14820,15925..16075,16842..16994,17396..17655) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6130.1 |
Protein Information
| Protein ID | NP_055235.1 |
|---|---|
| Protein Name | Dickkopf homolog 4 (Xenopus laevis) |
| Molecular Wt. (Da) | 23093 |
| Protein Sequence | Download Select all |
| Length | 224 |
| Uniprot ID | Q8NB91 |
| Ensembl Protein ID | ENSP00000326819 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04706 | 40-92 | Dickkopf_N |
| cl04692 | 40-92 | Dickkopf_N superfamily |
| pfam06607 | 145-202 | Prokineticin |
| cl05897 | 145-202 | Prokineticin superfamily |
Ontology Information
| HPRD ID | 618 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.