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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22874640 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 130 CRC and 25 healthy control Stage : - | PCR | Alternative cleavage and polyadenylation | - | - |
| 20652332 | 2010 | Cell line : - Source : Department of pathology of the University medical center (VUmc), Amsterdam, the Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : 26 CRC, 26 colorectal adenomas, and 15 healthy control Stage : - | real time RT-PCR and immunohistochemistry | Up-regulation | - | Serum DK-?/? is the most promising of the existing tumor biomarkers for the diagnosis of early-stage colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010] | Chromosome | 19 |
| Location | 19q13.12 |
| Start | 35988119 |
| End | 36004560 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 16442 |
| OMIM ID | - |
| HGNC ID | HGNC:25063 |
| Unigene ID | Hs.417795 |
| Ensembl ID | ENSG00000161249 |
| PharmGKB ID | PA145149020 |
Protein Information
| Protein ID | NP_001119528.2 |
|---|---|
| Protein Name | dermokine |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 476 |
| Uniprot ID | Q8N119 |
| Ensembl Protein ID | ENSP00000357798 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 450 |
| S | Phosphorylation | 461 |
| T | Phosphorylation | 64 |
| S | Phosphorylation | 75 |
| S | Phosphorylation | 459 |
| S | Phosphorylation | 460 |
| S | Phosphorylation | 73 |
| S | Phosphorylation | 74 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 13614 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Glutathione transferase activity (GO:0004364) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.