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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25435967 | 2015 | Cell line : - Source : 161st Central Hospital of the People's Liberation Army (Wuhan, Hubei, China). Sample Type : CRC Tumor and normal tissue No. of Sample : 102 Stage : TNM Stage I,II,III. | Histopathology, immunohistochemistry, univariate and multivariate analyses | Down-regulation | - | DOK2 may potentially be used as a marker of poor prognosis in patients with colorectal cancer following curative resection. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8p21.3 |
| Start | 21766384 |
| End | 21771290 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4907 |
| OMIM ID | 604997 |
| HGNC ID | HGNC:2991 |
| Unigene ID | Hs.71215 |
| Ensembl ID | ENSG00000147443 |
| PharmGKB ID | PA27457 |
Protein Information
| Protein ID | NP_003965.2 |
|---|---|
| Protein Name | docking protein 2, 56kDa |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 412 |
| Uniprot ID | A4D0S4 |
| Ensembl Protein ID | ENSP00000205386 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 271 |
| Y | Phosphorylation | 299 |
| Y | Phosphorylation | 345 |
| Y | Phosphorylation | 271 |
| Y | Phosphorylation | 271 |
| Y | Phosphorylation | 271 |
| Y | Phosphorylation | 299 |
| Y | Phosphorylation | 299 |
| Y | Phosphorylation | 299 |
| Y | Phosphorylation | 345 |
| Y | Phosphorylation | 345 |
| Y | Phosphorylation | 345 |
| Y | Phosphorylation | 145;- |
| Y | Phosphorylation | 145;- |
| Y | Phosphorylation | 145;- |
| Y | Phosphorylation | 139 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 25 | ABL1 | 1809 | NP_009297.2 | in vitro;in vivo | 12777393 |
| 1956 | EGFR | 579 | NP_005219.2 | in vitro | 10508618 |
| 3635 | INPP5D | 9033 | NP_001017915.1 | in vivo | 10822173 |
| 3932 | LCK | 1080 | NP_005347.3 | in vitro;in vivo | 10799545 |
| 4690 | NCK1 | 2740 | NP_006144.1 | in vitro;in vivo | 1 168 943 210 428 860 |
| 5921 | RASA1 | 745 | NP_002881.1 | in vitro;in vivo | 105 086 181 079 954 000 000 000 |
| 5979 | RET | 1266 | NP_066124.1 | yeast 2-hybrid | 11470823 |
| 7010 | TEK | 2571 | NP_000450.2 | in vivo;yeast 2-hybrid | 9764820 |
| 26128 | KIAA1279 | 13848 | NP_056449.1 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14676 | 7-114 | PH_DOK1,2,3 |
| cl17171 | 7-114 | PH-like superfamily |
| cd01203 | 147-246 | PTB_DOK1_DOK2_DOK3 |
| cl17171 | 147-246 | PH-like superfamily |
| smart00310 | 149-247 | PTBI |
| pfam02174 | 148-247 | IRS |
| cd13164 | 151-244 | PTB_DOK4_DOK5_DOK6 |
| cd01202 | 194-242 | PTB_FRS2 |
| smart00233 | 6-113 | PH |
| cd01257 | 3-109 | PH_IRS |
| cd00821 | 7-109 | PH |
| pfam00169 | 6-110 | PH |
| cd13276 | 7-109 | PH_AtPH1 |
Ontology Information
| HPRD ID | 5537 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.