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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DOT1L 84444 DOT1-like histone H3K79 methyltransferase  19KIAA1814, DOT1, KMT4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24816405   2014Cell line : -

Source : 2nd Department of General Surgery in Medical University of Lublin

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Cell isolation and FACS analysis,Cell culture and sphere formation,Lentiviral transduction,Cytokine detection,RT-PCR,Western Blotting,In vitro and in vivo migration assays,Chromatin immunoprecipitation,Immunohistochemistry,In vivo tumor formationUp-regulation-The DOT1L complex induced the core stem cell genes NANOG, SOX2, and Pou5F1, resulting in increased cancer stemness and tumorigenic potential.


Gene Details



NC_000019.9 (2164148..2232577)

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Gene Type protein coding
Gene Family Chromatin-modifying enzymes / K-methyltransferases
Description The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]  
Chromosome 19
Location 19p13.3
Start 2164148  
End 2232577  
Strand +  
Gene Sequence

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Length 68430  
OMIM ID 607375   
HGNC ID HGNC:24948   
Unigene ID Hs.713641   
Ensembl ID ENSG00000104885   
PharmGKB ID PA134993717   

mRNA Information


mRNA ID ?NM_032482.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS42460.1



Protein Information


      
Protein IDNP_115871.1
Protein NameDOT1-like histone H3K79 methyltransferase
Molecular Wt. (Da)0
Protein Sequence

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Length 1739  
Uniprot IDQ969G5
Ensembl Protein ID ENSP00000307292  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation984;-
SPhosphorylation374
SPhosphorylation471
TPhosphorylation480
SPhosphorylation775
SPhosphorylation786
SPhosphorylation822
SPhosphorylation834
SPhosphorylation899
TPhosphorylation900
SPhosphorylation902
SPhosphorylation1001
SPhosphorylation1009
SPhosphorylation1104
SPhosphorylation1259
SPhosphorylation1035
SPhosphorylation826
SPhosphorylation297
SPhosphorylation1246
SPhosphorylation596
YPhosphorylation78
SPhosphorylation84
SPhosphorylation285
TPhosphorylation289
SPhosphorylation302
SPhosphorylation304
TPhosphorylation306
SPhosphorylation572
YPhosphorylation771
SPhosphorylation997
SPhosphorylation1007
SPhosphorylation1008
SPhosphorylation1059
SPhosphorylation1100
SPhosphorylation1213
SPhosphorylation448
SPhosphorylation1348
SPhosphorylation1355

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
Lysine degradation hsa00310
Transcriptional misregulation in cancer hsa05202


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd02440159-267  AdoMet_MTases
cl17173159-267  AdoMet_MTases superfamily
pfam08123115-317  DOT1
TIGR02473510-635  flagell_FliJ
cl21477510-635  FliJ superfamily
COG2882507-626  FliJ
PRK05689509-634  fliJ
pfam03280506-661  Lipase_chap
cl19941506-661  Lipase_chap superfamily
pfam02050520-635  FliJ
cd00176506-660  SPEC
cl02488506-660  SPEC superfamily
smart00935500-598  OmpH
cl21485500-598  OmpH superfamily
pfam07218898-998  RAP1
cl12344898-998  RAP1 superfamily
smart00502508-640  BBC
cl17972508-640  BBC superfamily
pfam14932541-662  HAUS-augmin3
cl22400541-662  HAUS-augmin3 superfamily
COG2959554-657  HemX
cl19375554-657  HemX superfamily
pfam10473567-654  CENP-F_leu_zip
cl22858567-654  CENP-F_leu_zip superfamily
pfam15175508-595  SPATA24
cl21040508-595  SPATA24 superfamily
cd00176511-658  SPEC
pfam03938500-598  OmpH
pfam06188508-703  HrpE
cl19405508-703  FliH superfamily
pfam14723437-617  SSFA2_C
cl20656437-617  SSFA2_C superfamily
COG0419483-658  SbcC
pfam13514476-715  AAA_27
COG0419484-661  SbcC
TIGR02168506-660  SMC_prok_B
pfam07926508-641  TPR_MLP1_2
pfam15035503-660  Rootletin
pfam05622507-688  HOOK
TIGR02168506-656  SMC_prok_B
pfam12795509-661  MscS_porin
TIGR02169500-661  SMC_prok_A
TIGR04523506-661  Mplasa_alph_rch
pfam15450506-660  DUF4631
pfam00038484-660  Filament
COG0419484-661  SbcC
TIGR02168508-660  SMC_prok_B
pfam12128484-684  DUF3584
TIGR04523512-661  Mplasa_alph_rch
TIGR04523488-661  Mplasa_alph_rch
TIGR04211509-611  SH3_and_anchor
pfam05622511-670  HOOK
pfam12128506-718  DUF3584
COG1196508-661  Smc
TIGR04211564-654  SH3_and_anchor
pfam04111563-661  APG6
TIGR02169508-660  SMC_prok_A
PRK11281479-656  PRK11281
COG1579511-660  COG1579
PHA03307792-1124  PHA03307
pfam13851537-676  GAS
TIGR02169508-660  SMC_prok_A
TIGR00618485-656  sbcc
pfam10174504-658  Cast
COG1196509-661  Smc
TIGR02168534-712  SMC_prok_B
pfam12795504-657  MscS_porin
COG4372538-655  COG4372
TIGR04523508-660  Mplasa_alph_rch
TIGR00618469-661  sbcc
COG0419481-658  SbcC
pfam09731503-688  Mitofilin
pfam13868519-659  Trichoplein
TIGR04523540-661  Mplasa_alph_rch
TIGR02499529-688  HrpE_YscL_not
TIGR02168537-661  SMC_prok_B
TIGR02169483-698  SMC_prok_A
TIGR04523484-661  Mplasa_alph_rch
PHA03247811-1260  PHA03247
pfam05622509-660  HOOK
pfam04849510-655  HAP1_N
pfam09789483-617  DUF2353
PRK11281509-655  PRK11281
PRK03918511-658  PRK03918
COG3264511-683  MscK
COG0419483-632  SbcC
TIGR00618502-658  sbcc
pfam01576484-661  Myosin_tail_1
pfam01576509-711  Myosin_tail_1
PHA03247884-1236  PHA03247
pfam13868518-655  Trichoplein
pfam07888506-658  CALCOCO1
pfam13863513-636  DUF4200
COG1196484-655  Smc
pfam11559562-661  ADIP
COG4717538-693  YhaN
TIGR02169569-659  SMC_prok_A
pfam01576518-659  Myosin_tail_1
COG1196538-661  Smc
COG4372518-779  COG4372
COG1196541-656  Smc
pfam04111485-636  APG6
pfam08317511-653  Spc7
TIGR02168500-695  SMC_prok_B
COG1196508-635  Smc
COG4717513-661  YhaN
smart00787541-653  Spc7
COG1196506-647  Smc
PRK12704515-658  PRK12704
pfam13166484-687  AAA_13
COG4717483-682  YhaN


Ontology Information


   
HPRD ID12261
Molecular ClassEnzyme: Methyltransferase
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO