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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DPEP1 1800 Dipeptidase 1 (renal)  16MDP; RDP; MBD1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17912428   2007Cell line : SW 48, SW 480, SW 620, HT 29, LIM 2412, LIM 1215, LIM 2099, LIM 2405, LIM 1899 and LIM 1863

Source : The Queen Elizabeth Hospital.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 68

Stage : TNM Stage I-IV

RT-PCR,Focused microarrayUnknown--

15145522   2004Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 76

Stage : TNM Stage I-IV

cDNA microarray and RT-PCRUp-regulation-DPEP1 is overexpressed in the majority of colon tumors compared to normal mucosal samples.

20824289   2011Cell line : -

Source : -

Sample Type : -

No. of Sample : 8 tissue samples and 9 stool samples

Stage : -

RT-PCR and ImmunohistochemistryUp-regulation-DPEP1 is expressed in the early stages of colon carcinogenesis and affects cancer cell invasiveness.

DPEP1 expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer.

21509397   2011Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 87

Stage : Duke Stage A-D

MDHB' (Multiplexed Digital-PCR coupled with Hydrogel Bead-array), emulsion PCR Up-regulation--

22968445   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-freequantitation.Up-regulation54-


Gene Details



Chromosome: 16; NC_000016.9 (89679716..89704839)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]  
Chromosome 16
Location 16q24.3
Start 89613308  
End 89640862  
Strand +  
Gene Sequence

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Length 27555  
OMIM ID 179780   
HGNC ID HGNC:3002   
Unigene ID Hs.109    
Ensembl ID ENSG00000015413   
PharmGKB ID PA144   

mRNA Information


mRNA ID NM_001128141.2
Exon join(1..97,16998..17207,22601..22733,22957..23089, 23226..23376,23559..23628,23897..24073,24161..24245, 24325..24400,24529..24664,24745..25124)  
mRNA Sequence

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Length 1752  



CDS Information


   
Location join(17104..17207,22601..22733,22957..23089,23226..23376, 23559..23628,23897..24073,24161..24245,24325..24400, 24529..24664,24745..24915)
CDS Sequence

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CCDS ID CCDS10982.1



Protein Information


      
Protein IDNP_001121613.1
Protein NameDipeptidase 1 (renal)
Molecular Wt. (Da)41063
Protein Sequence

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Length 411  
Uniprot IDQ13535
Ensembl Protein ID ENSP00000343741  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SGlycosyl phosphatidyl inositol GPI385

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
26128KIAA127913848NP_056449.1yeast 2-hybrid16189514   


Pathway Information


No matching records could be found.

Structure Information


PDB ID1ITQ
Resolution2.3
MethodX-RAY DIFFRACTION
Chains A,B  
Molecule RENAL DIPEPTIDASE  
Model View



Domain Information




ID Location Description
cd0130131-349  rDP_like
cl0028131-349  metallo-dependent_hydrolases superfamily
pfam0124426-352  Peptidase_M19
COG235531-354  COG2355
cd0129233-345  metallo-dependent_hydrolases


Ontology Information


   
HPRD ID8369
Molecular ClassProtease
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P16444DB06211DoripenemSmallMoleculeDrug
P16444DB01597CilastatinSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO