Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DPEP1 | 1800 | Dipeptidase 1 (renal)  | 16 | MDP; RDP; MBD1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17912428    | 2007 | Cell line : SW 48, SW 480, SW 620, HT 29, LIM 2412, LIM 1215, LIM 2099, LIM 2405, LIM 1899 and LIM 1863 Source : The Queen Elizabeth Hospital. Sample Type : CRC tumor and Normal tissue No. of Sample : 68 Stage : TNM Stage I-IV | RT-PCR,Focused microarray | Unknown | - | - |
| 15145522    | 2004 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 76 Stage : TNM Stage I-IV | cDNA microarray and RT-PCR | Up-regulation | - | DPEP1 is overexpressed in the majority of colon tumors compared to normal mucosal samples. |
| 20824289    | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : 8 tissue samples and 9 stool samples Stage : - | RT-PCR and Immunohistochemistry | Up-regulation | - | DPEP1 is expressed in the early stages of colon carcinogenesis and affects cancer cell invasiveness. DPEP1 expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer. |
| 21509397    | 2011 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : CRC tumor and Normal tissue No. of Sample : 87 Stage : Duke Stage A-D | MDHB' (Multiplexed Digital-PCR coupled with Hydrogel Bead-array), emulsion PCR | Up-regulation | - | - |
| 22968445    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-freequantitation. | Up-regulation | 54 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]   | Chromosome | 16 |
| Location | 16q24.3 |
| Start | 89613308   |
| End | 89640862   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 27555   |
| OMIM ID | 179780    |
| HGNC ID | HGNC:3002    |
| Unigene ID | Hs.109     |
| Ensembl ID | ENSG00000015413    |
| PharmGKB ID | PA144    |
mRNA Information
| mRNA ID | NM_001128141.2 |
|---|---|
| Exon | join(1..97,16998..17207,22601..22733,22957..23089, 23226..23376,23559..23628,23897..24073,24161..24245, 24325..24400,24529..24664,24745..25124)   | mRNA Sequence |    Download   Select all |
| Length | 1752   |
CDS Information
| Location | join(17104..17207,22601..22733,22957..23089,23226..23376, 23559..23628,23897..24073,24161..24245,24325..24400, 24529..24664,24745..24915) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS10982.1 |    
Protein Information
| Protein ID | NP_001121613.1 |
|---|---|
| Protein Name | Dipeptidase 1 (renal) |
| Molecular Wt. (Da) | 41063 |
| Protein Sequence |    Download   Select all |
| Length | 411   |
| Uniprot ID | Q13535 |    
| Ensembl Protein ID | ENSP00000343741   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Glycosyl phosphatidyl inositol GPI | 385 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 26128 |    KIAA1279 |    13848 |    NP_056449.1 |    yeast 2-hybrid |    16189514    |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1ITQ |
|---|---|
| Resolution | 2.3 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B   |
| Molecule | RENAL DIPEPTIDASE   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01301 | 31-349  | rDP_like |
| cl00281 | 31-349  | metallo-dependent_hydrolases superfamily |
| pfam01244 | 26-352  | Peptidase_M19 |
| COG2355 | 31-354  | COG2355 |
| cd01292 | 33-345  | metallo-dependent_hydrolases |
Ontology Information
| HPRD ID | 8369 |    
|---|---|
| Molecular Class | Protease |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P16444 | DB06211 | Doripenem | SmallMoleculeDrug |
| P16444 | DB01597 | Cilastatin | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
