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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DROSHA 29102 drosha, ribonuclease type III  5RNASE3L, Etohi2, HSA242976, RN3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26147304   2015Cell line : -

Source : CHA Bundang Medical Center (Seongnam, South Korea).

Sample Type : Blood sample

No. of Sample : 808 blood samples were collected from the study group, consisting of 408 CRC patients and 400 randomly selected non-CRC (control) subjects

Stage : -

Analysis of miRNA biogenesis gene polymorphisms.Polymorhpism-Variations in RAN rs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC.


Gene Details



NC_000005.9 (31400601..31532282, complement)

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Gene Type protein coding
Gene Family -
Description Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]  
Chromosome 5
Location 5q11.2
Start 31400601  
End 31532282  
Strand -  
Gene Sequence

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Length 131682  
OMIM ID 608828   
HGNC ID HGNC:17904   
Unigene ID Hs.97997   
Ensembl ID ENSG00000113360   
PharmGKB ID PA142671060   

mRNA Information


mRNA ID ?NM_001100412.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS47194.1



Protein Information


      
Protein IDNP_001093882.1
Protein Namedrosha, ribonuclease type III
Molecular Wt. (Da)0
Protein Sequence

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Length 1374  
Uniprot IDQ9BUV8
Ensembl Protein ID ENSP00000341213  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation355;-
SPhosphorylation357;-
SPhosphorylation284;-
SPhosphorylation373
SPhosphorylation796
SPhosphorylation237

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6667SP11796NP_612482.2in vitro;yeast 2-hybrid10976766   
54487DGCR89913NP_073557.3in vitro15574589   


Pathway Information


            
Pathway Name Pathway ID
Proteoglycans in cancer hsa05205
Ribosome biogenesis in eukaryotes hsa03008


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd005931122-1254  RIBOc
cl002581122-1254  RIBOc superfamily
cd00593959-1079  RIBOc
cl00258959-1079  RIBOc superfamily
cd000481260-1331  DSRM
cl000541260-1331  DSRM superfamily
smart005351122-1252  RIBOc
smart00535943-1075  RIBOc
pfam006361144-1233  Ribonuclease_3
pfam14622964-1071  Ribonucleas_3_3
pfam00636966-1055  Ribonuclease_3
pfam146221123-1249  Ribonucleas_3_3
smart003581261-1332  DSRM
pfam000351261-1332  dsrm
pfam12871213-302  PRP38_assoc
cl21734213-302  PRP38_assoc superfamily
PRK001021105-1333  rnc
COG05711105-1332  Rnc
TIGR021911110-1331  RNaseIII
PRK00102879-1070  rnc
COG0571879-1091  Rnc
TIGR02191879-1090  RNaseIII
PRK123711111-1331  PRK12371
PRK147181107-1331  PRK14718
PRK123721107-1331  PRK12372
PRK12372964-1067  PRK12372
PRK14718964-1067  PRK14718
PRK12371879-1062  PRK12371
pfam15502167-277  MPLKIP
pfam08648217-278  DUF1777
TIGR01622220-278  SF-CC1
TIGR01622220-317  SF-CC1
TIGR01642219-277  U2AF_lg
TIGR01622217-277  SF-CC1
TIGR042381260-1331  seadorna_dsRNA
TIGR01642220-317  U2AF_lg
TIGR01642217-314  U2AF_lg
pfam08648250-313  DUF1777


Ontology Information


   
HPRD ID5981
Molecular ClassNot Available
Molecular FunctionAuxiliary transport protein activity (GO:0015457)
Biological ProcessTransport (GO:0006810)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO