Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DSC2 | 1824 | Desmocollin 2 | 18 | DG2; DSC3; CDHF2; ARVD11; DGII/III |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17088906 | 2006 | Cell line : - Source : University Hospital, Birmingham and the Royal Free Hospital, London. Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Immunohistochemistry,Western blotting, RT-PCR and Southern blotting. | Down-regulation | - | Loss of Dsc2 (8/19) and de novo expression of Dsc1 (11/19) and Dsc3 (6/19) was found in colorectal adenocarcinomas on a background of colitis. |
| 18819935 | 2008 | Cell line : Colo 205, DLD 1, HT 29, SW 480, LoVo, and T 84 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Western Blotting, real time RT-PCR, Promoter-Reporter Studies, EMSA and ChiP Assay. | Down-regulation | - | Result show that the DSC2 gene is a transcriptional target for Cdx1 and Cdx2. |
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis. | Down-regulation | - | - |
| 21325624 | 2011 | Cell line : S -CO 15 and Caco 2. Source : - Sample Type : - No. of Sample : - Stage : - | Immunoblotting, Immunofluorescence microscopy, beta-Catenin/TCF transcriptional reporter assay | Down-regulation | - | Loss of Dsc2 contributes to the growth of colorectal cancer cells and highlight a novel mechanism by which the desmosomal cadherins regulate B-catenin signaling. |
| 22438068 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 402 Stage : UICC stage II, III | Tissue microarrays, Demethylation test, mRNA expression analysis | Methylation | - | Reduced expression of DSC2, E-cadherin and CDX2 with shorter survival in high-grade carcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] | Chromosome | 18 |
| Location | 18q12.1 |
| Start | 31065974 |
| End | 31102432 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 36459 |
| OMIM ID | 125645 |
| HGNC ID | HGNC:3036 |
| Unigene ID | Hs.95612 |
| Ensembl ID | ENSG00000134755 |
| PharmGKB ID | PA27489 |
mRNA Information
| mRNA ID | NM_024422.4 |
|---|---|
| Exon | join(1..530,8790..8874,10133..10332,11286..11405, 12839..12994,14620..14764,15691..15857,19373..19507, 20010..20195,22081..22337,22444..22586,27526..27750, 30592..30828,31583..31707,33282..33539,34221..36459) | mRNA Sequence | Download Select all |
| Length | 5211 |
CDS Information
| Location | join(462..530,8790..8874,10133..10332,11286..11405, 12839..12994,14620..14764,15691..15857,19373..19507, 20010..20195,22081..22337,22444..22586,27526..27750, 30592..30828,31583..31707,33282..33539,34221..34418) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11892.1 |
Protein Information
| Protein ID | NP_004940.1 |
|---|---|
| Protein Name | Desmocollin 2 |
| Molecular Wt. (Da) | 90512 |
| Protein Sequence | Download Select all |
| Length | 847 |
| Uniprot ID | P25311 |
| Ensembl Protein ID | ENSP00000292401 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 823;- |
| Y | Phosphorylation | 823;- |
| Y | Phosphorylation | 822 |
| Y | Phosphorylation | 822 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 247-351 | Cadherin_repeat |
| cl15786 | 247-351 | CA_like superfamily |
| cd11304 | 359-467 | Cadherin_repeat |
| cl15786 | 359-467 | CA_like superfamily |
| cd11304 | 477-573 | Cadherin_repeat |
| cl15786 | 477-573 | CA_like superfamily |
| cd11304 | 162-239 | Cadherin_repeat |
| cl15786 | 162-239 | CA_like superfamily |
| smart01055 | 31-111 | Cadherin_pro |
| cl07391 | 31-111 | Cadherin_pro superfamily |
| pfam01049 | 785-901 | Cadherin_C |
| cl03079 | 785-901 | Cadherin_C superfamily |
| pfam00028 | 248-345 | Cadherin |
| smart00112 | 267-353 | CA |
| pfam00028 | 360-463 | Cadherin |
| pfam08758 | 33-113 | Cadherin_pro |
| pfam00028 | 476-568 | Cadherin |
| smart00112 | 494-575 | CA |
| pfam00028 | 140-234 | Cadherin |
| smart00112 | 161-241 | CA |
| smart00112 | 377-474 | CA |
| cd00031 | 140-239 | CA_like |
Ontology Information
| HPRD ID | 1910 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.