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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21364582 | 2011 | Cell line : HT 29, LoVo, Caco-2, WiDr, SW480, HCT116, HRT 18 Source : ATCC Sample Type : - No. of Sample : - Stage : - | RT-PCR and western blotting,methylation-specific PCR, and bisulphite sequencing | Methylation | - | DNA methylation contributes to downregulation of DSC3 in CRC cell lines. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] | Chromosome | 18 |
| Location | 18q12.1 |
| Start | 28570052 |
| End | 28622781 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 52730 |
| OMIM ID | 600271 |
| HGNC ID | HGNC:3037 |
| Unigene ID | Hs.41690 |
| Ensembl ID | ENSG00000134762 |
| PharmGKB ID | PA164741482 |
mRNA Information
| mRNA ID | NM_001941.4 |
|---|---|
| Exon | join(1..224,10540..10624,11644..11843,13188..13307, 16901..17056,18323..18467,20314..20480,24016..24150, 24560..24745,34291..34547,34658..34800,35685..35909, 38450..38674,41077..41198,45768..46025,48444..53451) | mRNA Sequence | Download Select all |
| Length | 7656 |
Protein Information
| Protein ID | NP_001932.2 |
|---|---|
| Protein Name | desmocollin 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 896 |
| Uniprot ID | O00168 |
| Ensembl Protein ID | ENSP00000343314 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 93;- |
| S | Phosphorylation | 93;- |
| Y | Phosphorylation | 817 |
| Y | Phosphorylation | 817 |
| S | Phosphorylation | 407 |
| T | Phosphorylation | 408 |
| T | Phosphorylation | 412 |
| S | Phosphorylation | 418 |
| Y | Phosphorylation | 425 |
| S | Phosphorylation | 407 |
| T | Phosphorylation | 408 |
| T | Phosphorylation | 412 |
| S | Phosphorylation | 418 |
| Y | Phosphorylation | 425 |
| S | Phosphorylation | 823 |
| S | Phosphorylation | 823 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vivo | 10769211 |
| 3728 | JUP | 1414 | NP_002221.1 | in vivo | 10769211 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 247-351 | Cadherin_repeat |
| cl15786 | 247-351 | CA_like superfamily |
| cd11304 | 477-573 | Cadherin_repeat |
| cl15786 | 477-573 | CA_like superfamily |
| cd11304 | 360-464 | Cadherin_repeat |
| cl15786 | 360-464 | CA_like superfamily |
| smart01055 | 27-111 | Cadherin_pro |
| cl07391 | 27-111 | Cadherin_pro superfamily |
| pfam01049 | 780-896 | Cadherin_C |
| cl03079 | 780-896 | Cadherin_C superfamily |
| pfam08758 | 27-113 | Cadherin_pro |
| pfam00028 | 248-346 | Cadherin |
| smart00112 | 267-353 | CA |
| smart00112 | 494-575 | CA |
| pfam00028 | 360-462 | Cadherin |
| pfam00028 | 478-568 | Cadherin |
| pfam00028 | 140-234 | Cadherin |
| cl15786 | 140-234 | CA_like superfamily |
| smart00112 | 159-241 | CA |
| cd00031 | 140-239 | CA_like |
| cd11304 | 162-239 | Cadherin_repeat |
| smart00112 | 380-469 | CA |
| pfam00028 | 596-669 | Cadherin |
| cl15786 | 596-669 | CA_like superfamily |
Ontology Information
| HPRD ID | 4110 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.