Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DTL | 51514 | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | 1 | RAMP, L2DTL, DCAF2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22287560 | 2012 | Cell line : HCT116 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 379 Stage : - | Virus production and viral infection,Real-time cell analysis, real-time PCR,Luciferase reporter assay,Cell cycle analysis, flow cytometry,Western blotting | Up-regulation | - | miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression, which is frequently overexpressed in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | DDB1 and CUL4 associated factors, "WD repeat domain containing" |
| Description | - | Chromosome | 1 |
| Location | 1q32 |
| Start | 212208919 |
| End | 212278187 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 69269 |
| OMIM ID | 610617 |
| HGNC ID | HGNC:30288 |
| Unigene ID | Hs.656473 |
| Ensembl ID | ENSG00000143476 |
| PharmGKB ID | PA142671941 |
Protein Information
| Protein ID | NP_001273158.1 |
|---|---|
| Protein Name | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 730 |
| Uniprot ID | Q9NQC3 |
| Ensembl Protein ID | ENSP00000322147 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 426;- |
| S | Phosphorylation | 485 |
| S | Phosphorylation | 495 |
| S | Phosphorylation | 490 |
| T | Phosphorylation | 508 |
| S | Phosphorylation | 512 |
| T | Phosphorylation | 516 |
| S | Phosphorylation | 510 |
| S | Phosphorylation | 511 |
| S | Phosphorylation | 557 |
| S | Phosphorylation | 676 |
| S | Phosphorylation | 681 |
| T | Phosphorylation | 684 |
| S | Phosphorylation | 679 |
| S | Phosphorylation | 682 |
| S | Phosphorylation | 446 |
| S | Phosphorylation | 558 |
| S | Phosphorylation | 717 |
| T | Phosphorylation | 196 |
| S | Phosphorylation | 410 |
| S | Phosphorylation | 428 |
| S | Phosphorylation | 478 |
| T | Phosphorylation | 522 |
| S | Phosphorylation | 526 |
| T | Phosphorylation | 424 |
| S | Phosphorylation | 539 |
| S | Phosphorylation | 416 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 55-389 | WD40 |
| cl02567 | 55-389 | WD40 superfamily |
| cd00200 | 132-393 | WD40 |
| cd00200 | 40-169 | WD40 |
| pfam00400 | 350-388 | WD40 |
| smart00320 | 349-388 | WD40 |
| cd00200 | 355-397 | WD40 |
| pfam00400 | 130-169 | WD40 |
| smart00320 | 130-169 | WD40 |
| pfam00400 | 88-126 | WD40 |
| smart00320 | 88-126 | WD40 |
| smart00320 | 306-345 | WD40 |
| COG2319 | 37-410 | WD40 |
| COG2319 | 97-398 | WD40 |
| PLN00181 | 231-398 | PLN00181 |
| PLN00181 | 119-383 | PLN00181 |
Ontology Information
| HPRD ID | 8458 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.