CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
DUT	1854	deoxyuridine triphosphatase	15	dUTPase

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
19052026	2009	Cell line : - Source : Department of Surgery of Kurume University Sample Type : CRC tumor and Normal tissue No. of Sample : 55 Stage : TNM Stage IV	Immunohistochemistry	Up-regulation	-	dUTPase may be a predictive biomarker for the metastatic potential of colorectal cancer. primary tumours showed a significantly higher expression of dUTPase in patients with metastasis when compared with dUTPase expression in patients without metastasis

Gene Details

Chromosome 15 - NC_000015.10 (48331100..48343373)
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Gene Type	protein coding
Gene Family
Description	This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Chromosome	15
Location	15q21.1
Start	48331100
End	48343373
Strand	+
Gene Sequence	>gi\|568815583:48331100-48343373 Homo sapiens chromosome 15, GRCh38.p2 Primary Assembly AACTGTCACCGGCGCCGAGATGCGGTTCCGGCGCTTAGGGCGCCGCTAAACTCAGAGCCCGGGAGTCATG GCTGCGGGCGGTGCCGCCCCAGGTAAATCAGTCCAGGAGCAGGGCCCGGGCCTGGCGTACACTCTCGGAA AAATGGGGGCCAGAGCAAACAAGAAGAGCGAAAGCAAGAGGGCTAGGCAGCCAGAGGCGGCAGCAAGACT CAAGACGCCAACGGCGCCGTCTTCCTGGGGCCCCAGGGCCTGCGCCATCCCTGGGCTGCCGGGGCACCGC CTCTCCACGCCCCTCGTCCGGCGGCGGCTGCGACTGCTTCCGAGGTCATGTTCCCAGGACGGGCGCGTCT TCAGGGTGGAAGCCTGGCGCACGTCCGGAGGTGCCGAGGACCCAACCAGCCCAAACTCTGGGGGAAATGA CTCCCCTCTGCCCTCGCCCCGCGCTCTGCTACCATTTCCTTACGTCTCTGCTTCGCTCAGCGATGCAAAA CGCGCGAGGCGCACGGCAGAGGGCCGAAGCCGCGGTACTCTCCGGGCCAGGCCCGCCCCTCGGCCGCGCC GCGCAGCACGGGATTCCCCGGCCGCTGTCCAGCGCTGGCCGCCTGAGCCAAGGCTGCCGCGGAGCCAGTA CAGTCGGGGCCGCTGGCTGGAAGGGCGAGCTTCCTAAGGCGGGGGGAAGCCCGGCGCCGGGGCCGGGTAG GAAAGGCGGGGGAGGGGCTCCGGCCGTCTGGAAGGAATCCACGCGGCTTGAGGCTGTGGGGGAAGTAGGG TGGCGAGCGGTCCTTCTGCGCGCGGGGGGCGGGGGGGGTGGGGTGGTCCATTAGGGTCCCCTGGCGAGGG GGCGGCTTTCTAGTGTGTGAGGGCGACGCCCTAGAAGCTCCCCTTCAAAGTTGGCCCCACGCGCTGAATG TGGAAAGTTGACTGGGACCCAGTAGTTTCCCATCCCAAACCTGCTTTCCGAGAAGGGCTTCAAACCCAAA ATGTGAATCCCGCCTCCCCTCTCAGCCAGAACTGTGGACTCGTCCCGGGGAGGGGCGGTGGGTGGGGCGG GGCTGGCGGGAAATTTCGGTTTTGGCGCGCTCCCTGCGGCGACGCTCATCGTGCGCTCTCCTCTTCCCCC GGTGGTCTCCTCGCTCGCCTTCTGGCTCTGCCATGCCCTGCTCTGAAGAGACACCCGCCATTTCACCCAG TAAGCGGGCCCGGCCTGCGGAGGTGGGCGGCATGCAGCTCCGCTTTGCCCGGCTCTCCGAGCACGCCACG GCCCCCACCCGGGGCTCCGCGCGCGCCGCGGGCTACGACCTGTACAGGTGAGCGGGGACCTGCCGGCGAG GAGGCTGGGAAGGGCCGGCCGTCCGCTGCCACAGCTAGAAACAGTCACCGGAGAGATCACAGGAACACAC TAGCTATAAATAGGATTTCTGCCTTTTTCGTGTTTAAAATTTTAGCTTTCATCTTTGGCATAAATTAAAT AGAGATTTGGGCAAAGACTGCAGAATAAGTAAAATAGCTATACGGTGTCTAGCAAGGCGTTACTTTGCAA CGTTTATTGTGCCCTTCCTAAATAGAAGATAGAGAGGAAGGCCCATGGTGGCTTTCGAGTGGCCCGAGGG TGATGCTGTGCTCAATAGAAAAACCAAGGTGAGAGCCTAGATGTGAGCGTGAAAATACCTAAGAAGGATG AACGAAGATGCATCTGCCTTAAAAAGTTATTTTCTATACATTCATCCGGCCCAGGGCGGAATTTGAGAAG GCATCTGAAAACGAAAGGCAGAGCTGCCTGTAATCTACCACACTTTCATCTCTACAGCACGTTTTACCTG TACTAAAAACTTTCCGTATGCTGTTGTATTTAGTCCTCACAACAATCCTTAACTAGATAAGTGTTACTTT TTACACAGGCAGGAGTTTGTGAAGAGCTGAATTGATTTCCCCAGAGGCTTGAAGATGATATAATTTTTTA TCCCGAATTTTGGGCTTTTTTTTTTTCATCTGACTACTGTGCCCAGTTCTTAGAACCATTAAGGTAGGAG AAAAGTAATGCTGAGAGGGAAGGAGATTTTATACTAAATCCCAAGCATTGGGATTTATTTTAAAGTATCT CAGATAATTCAAACATGAGAACTATTAGTCTAAGCACAGGAGAAGAGAAAGTAGTGCCTGATGATAGCAA CAGAAAAAAAAGGAAAAGGAAAGTAGGTATGGACAATTGTAGCTGGAAAAACTACAGTCTCTTAATTTTG ATGAATAAAAGTAGAGTGATATAGTTTGACTAGACCTTTCCAAAGTATATTTTGGAGCACTTTCTTGAGT CCTAGGGGAGTCCTTGATTTAAGATACCTTAAGTAGACTCCTAATAAACACAGGTGACTTTCTGTATACT GAAATTGACATGGAAATAATGGATCAGCAATAAATTAGGGCTTAACTGTTTAAAGAGGGATTTCAGTGAA AGAAGGGGTAGTACTGCTTTACCAGAGTTAATTAAGGTCTCCAAAGTAAACTTCCGGTTCTGCTCATTGT AAAATCTCTTAAATTTCTACCCAGGAGAGGGCCACAGTAATATCAAGAGTAGCAGCATTTGCTATGTGGA CTTTAGAGGAATTCTGTTCCTAAGCAAGGTCCATCTCCAGGGGCCGTTCACGGTGATCAGCTGTCTCCCT CAGCCAGGAAATTCATAGCCTAAGCTTGGTAAACTACCAAGCCCTGCCTGACAGATACAACACAGTTCTT TATCTCTTATTTTGTCCACCCGTTTTTCTCCTTTCCTTCTGCATATTTTCCCTAATCACACAGATCATTG TGAGAATAAAATGGGTTAATATATGTAAACCAATTAGAACTGTTCCTGGCACACAGTAAAGGCTTAATCA ATGATAGCTAGTATTATTAGTAGTATTTGGCCTTTTTTCTTTGTTCTTTCTTCATTTTTTTCCTTTTCAA ACTATGGTTGTAAAGCATCCACCTTTTGAAAGTTTGCCTTTCTGCCCTTTCACGCTGATAAGTACCTCAG TTTCCAATAAACTTTTGTTCAGGGGCAAACATTTACAATGTTGACATCTCTTCACACCACCAAAAATATT CATGGAGAATTATTTTATCTAAAGCTGTCTTTTTAATAATAAAATAGCCACCTCTACCTTCTTCATAAAC TTTTAAGATGAATTGGTAATTCATCATAGCAAGGTTGATTTTAGAAACTAAAGTTGCATTAATTCATTAA ATACACTGAAAGTAATTTTGTATGCTTGGTCACAAAGAAAATATAAAAACAATTTTATAAATAGATTTGC AGTTATTTTCTTTCAATATTTTCTTAGTGCCTATGATTACACAATACCACCTATGGAGAAAGCTGTTGTG AAAACGGACATTCAGATAGCGCTCCCTTCTGGGTGTTATGGAAGAGTGGGTAAGTCATTTAAGAAACAGG TAACTATTTGTCAAGTTCTCCTTTGTGATAGATTCTTCATGTTTCATTTGGGGTAATAAGCAGGCAATAT TGCTTGGGCTGTGTCCTAAAAGAAGCACCATTTGTGATAGCAAATGCACTCTTTGAAAGGCTTTATTTAC ATCTCTGCTTTGCCTCTTTTTGACCCTTTTATTTTTCTCCTTCCTCACTGGAGCTTTTAGGCTCACACTG GCCTAGAAGGCTGTTCTCAGAACATGGCATTTTATATTATGAGAGTAAAACTTCTGACCTGTTGGTCCCA GAATGTGTAAGCCTACTTAACCTTTTCTTGTTTGGCCATGGGGTTAGGGTAAGGGATACTCTTCAGTGTT GTAGAGGCACTGGGAGGAGCTAGGACAAAATGGAGTACACGTCAACAGGTTTGATTTTTCTGGAGCGGAT CAGTTGTTACCAGACAGTTCTTTGCAAGAGCGTAAGTTCTTTTTGACTAACTTCAGAGTAAACATAAAGG AGGCAATGGAGCTGTGACGCCCTCCTCCAGGGAAAGGAGCTAGACTGGCACTATATTATTAGCCATGAGT GAGGAAACTGCCAGTACTTCAGCCCTTAAAAGATAACAAGATGGGCTCTCATCTCATCTCTTGAGCATCA TTGACTCCATTTTTTAGAATTTTTTCAGGGGAAGGGGCAGGAGATGGAGTGAAATAAAGGTTAGTACAGA AAGAGGCAGCATTATTGACAAAGTGCCTGATTTAAATTATTCTAAAATAAAATGCTGGAAGTTAGGATAA TTAATTATAGGCCTGATGCTTGAGTCTGCAATAATAAGGTGTAACCTTAGCTTTTTATTTTTTTCATTTT TTAGGATTAAAAAGTATACTAGCATTGAATCATTGAGACTTAGTTTTTGGCATTTTTACTTAACTGATAT TAGCCCATTTATCTTACTCTGGTTCATGTGTTTCCTACAGGCATGTCTTTTGGCATCTGAATCATGAATA GTGGGGTCCCAAGTTGTAGGCTATGGTCTGCTACTATTTGGTTAGGTTTGTTTCCCTCTCCCTTCCTCTT CCTTTCCCTTCCCATCTGCATTGTACATGTTGTGGTGTCCCATCTTAAAACCAAAGTCTTCTTCCTCAGT AGTGTGTTCCTGCTGGCCATACTTCTCTTTCTTCCCCTTTGAGGCTTAACTTCTTGAAAGAGCAGCCTAC AGTTGTTCCCGCTTGCTCACCTTTCAGCTCATTCTAGCAGTCCTTCTCCCCTGTCTGCAGCACCACAAAT TCTGACTGAAGTCACATGGGAGTGGTTTAAGTTAGTTTTGAATTAAAACCTTGTGGAATTTTTCTAAACT AGTCTTTCCAACTTTGGTAATGCAGTATGATGAATATATATTCTTTAATTCAAAACCATGTGCTAAAGTT AAGATGAAGATATAGATATTATAGGTGAAGAGAATGACATGCTTAAATTGCATCAGTTATCTCTGATATA GCCCTTCCCCCTTAAAATAACCAATGTCTCCTTTTTTGTTTTTTAGCTCCACGGTCAGGCTTGGCTGCAA AACACTTTATTGATGTAGGAGGTAATATATTTCCTTTTTTATTCTGTAAATGTTTGCAAGTATTTACTTT GTCTTTAAAAGGTAATATTCAAATGACAGATTTTATTTTTAAGAAAAGAAAATGATTAGAGGAAAGCTTG TTATAATAGGAGGAAAAGCTTTGTGGTTATTTTAAGTAATTATATTTTGTTTAACTACTAACTTAATTTT TAAAATAATGATTACCTAATTAATAATGACAGATTTAATGATATAATAATTAAGTAATTATTTAAGCAAC AAAAGTTCTAGAAAACACAGGTCTATCTTGTAAGAATTTTCTTCATAAGAGAGCTATCTGTCTTTAGCAA AATTTAAGAAGAAAATCTTTCCCTGAAGTCAGGAGAGAAAACACTTTTCTCTAAATTTGTTAAGACAGTC CTCTGTGTTACCTGTTTCCCTTATAATAAAGCCTTTCTCATGTTTGTCTCAAAGTTAACCCTACCTCATG TGGTACCTTTCATGAAGAACCCTCAGTGTCCTCTGCTAACTACTCTTGATACAGAGCTACTCCTCTTATT GTAAGGAAATTTCTACTTTCCTGATGTGGTTTCCTTGTTTCAGGTCCGCTCCAACTGGGATTCAGACCCC ACTTATGTGGTCCTTACATACTGACCCTTTATCCCATCAGTAGTGAATCTTTCACTTAACAAGATACCTT GGCCCCCACATAAGTAGGTGTGCTAGATCTCCTCCTCCACCCGTTTTTACAGAGCTGCTTTATGGAGGCT TGTTAACAGATCAGGAAAACTGGCTTAGAAATGAGCCCACATGGATATGTGGTAAAAACTGGAGTCTCTG TGTGATTCCAGCCTCCTTGTTCTTTCCACTGCAATTAATTGTGGAGATTACCCTGCTGCATCCCCCTCAC CAACTAAACACGTCCAGAATTAGCTCACTTTTATGTGCCACTGCAAGGGCTAACTAAGCACTTAATGAAA CCTGGCTATCCTAGACCTGCCCCTTAGTCTAACATTTGGTGGGTGTGGTGTCTCTCCATAGTGTCACCAG GTGGTGCTGTGGGACAAGACAGGACCCCAAAAGTACACCCTTTAGGGACTAAAGGGGAGCTGAGTTTTAC ATAGCAGGGTGGACATTGACAGCCCACTCTTGGGTTGAGGATTCCTTGGGCTCTGTAAGTTATGCCCGAT GTTCAAAAATGCTTTTACAAGGTCAACTGTGGTCATTTTGGGACAGTAACTTAAGGATATAAATAATTGT ATATATTTTCAATGAAGTTTCAAATGATTGTTCAAGGAACGGGAGCTTTGGAATAACAACTGGATGTAGG TCCCAGCTCTGTCATTAACTAGTTATTACTTAACCTTTCTGAGCCTGTTTCCTCATTTTACAATGGAAAT TAGTGTGCCTGCCTCTAGAGGTAGGAGGATTAAATGATAATGTGTATGAAATACCTAATATAGTACTTGG CACATATTAGATTCTGTGAGATATAATTTCTGTCCTTAGGGACTTCACAGATTGTTTTTATGTGGAAACT TTTTCTTTTATTCGACTTTGTTACTAATTTTTGCTCTGTTTAAAACAACTTTCTGGAAAAAAATTCATGT AAAAGAATGGAAAGTTAGTTTGCCTAGTGGTTGGTATGGTGTTATTCATAAAATCACATTGTGGTGTGTT CTTGGATGCAGAGAATCTTAACAATCTCCCTTAGGCACAAGTTTATCATAGTTGGCAACAGTTTTTATTT CTGAAGAGAGATGTTGTTAGAAATCCCAGGCTCTAAATAAGGGTCAAAGGGAAAAGTTGAGCATTCAGGA TTCTGTTCAGAATTCACATCTGGTAGGTGTGGATAGTTTTTCACTAAAAAAGGTTTCCAACAAATGACAT GCCAAACTCTTGACACAGTAAAACTTTTGCCTGAAGTCAGTTAATCACTCTGCCAGTTCCAATGCATGAT TTTTCCAGTGATAACTTCAAGTTACTTTCTGCTTTCTCTGAGGAGAAATATCCCTGATACTTATATCCTG TAGGCAGAGAAGGCTTTTCTTGGAGGTCGAATGGCAATTGGGTGGTAAATGAATTTGGAACTACTGAAAT TTTTATACCGTCAACATTCATGCAAAAAAAAAAACTATTGAGGGCCTTTTTTTCTGCCATACATTTGAAT TGACTTCAAACTTCTTAATTTCTTTTAGTCACTTAAAGGTTTTTCACATTTTCGTGGCCCAAGCATAAAG ATCACCTATCTGCAGGATTCAAGACACCCAATCATTTGAGTAGTTCTGATAGGACTGCTTTACAGATACG TTAGCAGAGGCCTTTCAAAAAGGGAGTGTTTTTGTATGTTAGAAGATACTATAAAGCCAACAAGCAAATA TTTGCAACTTATATGAAAAAGAACAAATGAGAAAAAAACATACACAAAATATAGACAAGGACATGCAAAT GTCCAACAAATGGGAGGAAAAAAATCCAGCCTCACTAGTCATCAGGGAATGAAAAGTAAGGCAATGAGAT AGCCATTTTGTACTCATCATATTGGCCAGAATGTAAGAGATTGTTGCCATCAAATATTGGCAAGGATTTT GGAAATGGGCATTCTCAAATATTGCTGATGGAAGTTTGAGTGGCTACACCTTTTTTGCAACCTATTTGAT GAAAATAAAAAGCATTCATATACAAGGATATACTTAAAGGGCTGCTTCATTTATTATAGCAAAATGTAAA AGCAGCCTGTGTCTGATATTATGCAAGAGAATAGTTACATAGAAACAATGGTACAGGTTGGGCGTTGTGG CTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACAGGCAGATTGCTTGAGCCCAGGAGTTTGAGGC TTATTTGAGCAACATAGGGATACTTTCTCTCTACAAGAAATACAAAAATTAGCCAGGTGTGGTGGTGCCT TTGTACCTGGAGGCTGAGGTGGGAGAATCACTTGAGGTTGAGGCTATAGTGAGTTGTGATCATACCACTA TACTCCTGCCTGGGCTATAAGAGTGAGACCCTGCCAAAAAAAGAAAGAGAAGGAGAGAGAGAACCCATAT TTCCATATCTTGTATCTAAAAAGAATGGCTAACATTTACATATATTAATCTCAAAGGATAAAAAGAAAAA AATAAAGTAGTATGTAAGATATATTTCTGTAACATTAGCTATCTCAGGGAGGGTAAGAGAATATTATAAG CTTTTACTTTATATGTATTTGTATTGTTTTAGTTATTTAAAAATTTTTGAATAAAGTAGAAACAATAGTT CAGAAGTCAGTCCATGTCTTTCTCTAACTCATTCAAGATAGATGAATTATTAGCTTGTACCTCAAAATCT CCCAGCATGGAAGTTCTCTAGCCTACTGTGGCCATTTTTTCTAGCATGGAACAACATGCTATGTTGAGGG ATTTCTTCATTAAATCTAATTTAAATTGTCCCTGCAGTCAAAATTTTTTCCATATAGATAATATGGAAAA CAGCTGGTTTCATCTTTATATCAAATTTTTTCATAAATATTAAGGTGTAAATTAATGGTCAACTGACGGT GGAGAAATAAAGCAGGGTTTGGTATTGGAATTGGTCAAGTTCAATAATGGATTGTTTCCTTCAGGCCCGA CAGGAGATGAACTGCCTTTGCTGCTTTTCTGCCCAGTTTTATACTCACTCTTCTCGTAAAAGTGTTGCAT CAGGAACCTTTTAAGAAGTGCTTAAATTCAGATTCACTTGTCCCTAGTAATTCATTCATAAAGCACAGGG GTTCATTTAAACGTATGTTGTAATCCATTCGGAAAATCTAAAATGTTGTTTTTGCTGAATATTTTTCCCC GTGGTGGACCTAAGGGTTTGCTTTTTTCCCCCCATTATATGAGAAAATTGAAAGGATATGCTTAGGAATT ACCCTTGTTCTTAAAAAATGGGGGGTGGGTATGCTTTGGGGTTTTTTTGTCTGTTTTCTCAGCTTTCAAA TAATGAGGAGTATGGGCAAATAGCATTACTGCCCATTGAGCTGAACACAGGATTATTTTTATTTCCATAT TTTTTCCTTCATCAGGGCTTTTGTTTGGGGTAGAGTATTAATAACAAGTAAGATGTGACATGGAGCTGTC TTCAGTTAGATTCACGTGAGTCTTATCCAGCCTTTCACAAACTGAGGAGAAAGAATTAACGTGTATAGCA GGAAATTGGGGGTGGGAGGAGGAAGGGGAGTGACTGCTAATAAGGTAGGGGATTTTTGGAGGGAGGGTAA TGTAAATGTGCTATAATTGACTGTGACGATAGTTGGCCAACTCTGATACACTATGAACTGTGGAATTGTA ACACTTCAAATGGATAAATTGTATGCTTTGTGAATTATTTATCAATATAAAAAAATGAAAAGGCCCGGTG CACCTGTATTATCTGTGCTTGTGCTTATGGAAATATTTTAAATTATTGGCTCAAAGATAAATGCTAGCAA GTCTGGTAAGTATAACTCTCTGGGCTATGTCAGGGACCTGGCTCAAGTCTCCCCTGCAAAGATCTTCTCC CCCTGTGTTCATAATCTTAAACAAGTATTAATTACACAAAAAAAGTTGTACTCATGAAGCCTATGTGCTA CAGTCTTCTGAGAAACCATGCTCTAAGAAAGGATGGTGGTTCAGATTAAAAGGAGAGGAAGATTATGAAC TGAAAAATACAGCTTCATTTTTAGTGTAAAAATGGAATATTCTAATATTTGCAAGACTGCTGCTTAACAA TGTCAGCGTTGATTTACTCCACTGCAGAGCTTTAGGCTTTTTGACATTTTTATTTATGACTCAATCGTAT TTCAATCTGGGTATTAGCGGGAAGCTGATACCAGGAAAAACCTTTAAAACCCAAATCGTAATTTTCTCCT AGTCTTTTTGGCAAGTGTGCCGTGGGTAGACAGTAGGTTGGAGATGGCCATTGCTACTGCCAGCTTAAAA TAGGAAATGGTCGCCATTTGATAAAGAGTGACAGGTTGGAAAATTAGGACCTGTTTTCTAAATTTTTATT TGTATTTTAGTAATGTCATTTCTTGGTTTTGAGGCTTTACATAGTACCAGGGCAAGATTCACTTATTCAA TTGTAAGAATACAAATCTCAGAGCTACATGATAATGATTTTGAGATAATCTTACACCTCTAGTATTCCAA TAGCAAAAATTGAGATAATATTACTTTTCTTTTCTCTAGCTGGTGTCATAGATGAAGATTATAGAGGAAA TGTTGGTGTTGTACTGTTTAATTTTGGCAAAGAAAAGTTTGAAGGTATGTTAAATATATACATTCACATA ATTTTAGTGAATTTTCAGAGTCATGTATGTGTAAATTAATATTGACTCCTTTAATTCTCATTGAATAAGA CAGGATATGGCGAATGTGTCAGTAACGTCAGTAATAAACTATTCTTTCTTTGAAGTCAAAAAAGGTGATC GAATTGCACAGCTCATTTGCGAACGGATTTTTTATCCAGAAATAGAAGAAGTTCAAGTAAGTATTACAAA GGAAGATACAGAATAAGTAATATAACATCTTAAGTGAAGAAATATATATAATCTTGAGAATTTAATATGC TGTTTGTAACTAAATAGTATATATGACTAAACTTATTTTAAGCAAATTTAAAATACTAGTTTTAGAATTT CTTTAAATGTTTTTCATGTAGCTATTATGTAGTATTACTTTGGATAATAAGTTATTTAAACATACTGTGA ACTTCTAATATTTTATTAGAATTTTTTAAAGTTATCCAGTATTCTAATTTATGGAGCTTTTTAGAATTTA ATTTTCTTTCTGTAATCTCCCTTTTGAAAAGATGATATAGCAAGAGTAGAATTCTGGCTGTATTTTTCTT AGGAGCTGGAGAGGAAAACTGAAAGAGGCTCTTAAAAAAAACTGTGAAGCTTACTACCTTTCTATCTTTC AGGCCTTGGATGACACCGAAAGGGGTTCAGGAGGTTTTGGTTCCACTGGAAAGAATTAAAATTTATGCCA AGAACAGAAAACAAGAAGTCATACCTTTTTCTTAAAAAAAAAAAAAAAGTTTTTGCTTCAAGTGTTTTGG TGTTTTGCACTTCTGTAAACTTACTAGCTTTACCTTCTAAAAGTACTGCATTTTTTACTTTTTTTTATGA TCAAGGAAAAGATCATTAAAAAAAAACACAAAGAAGTTTTTCTTTGTGTTTGGATCAAAAAGAAACTTTG TTTTTCCGCAATTGAAGGTTGTATGTAAATCTGCTTTGTGGTGACCTGATGTAAACAGTGTCTTCTTAAA ATCAAATGTAAATCAATTACAGATTAAAAAAAAAAGCCTGTATTTAACTCATATGATCTCCCTTCAGCAA CTTATTTTGCTTTAATTGCTTTAAATCTTAAGCAATATTTTTTATTCAGTAAACAAATTCTTTCACAAGG TACAAAATCTTGCATAAGCTGAACTAAAATAAAAATGAAAAGGAGAGATTAAAGGTATTCCTTGTTCTTC CCTTCTCTTCACTAGTCTAAAAACTTCTTTTTAATCTTAAGATTCTTTGTGATGAGGGTGAGAAAAAGAA TCCTCAGTTTATTTTTCCACTATTAATCTTTCTTTTGATAAATCCTCTATTGACTGGGTAGAGGTATGTT TGTGAAAGACATGTAACTTGGGGATTTGTTACTTTAGGTTTGTTCCCTTGAATTTCATCTCATCAGGCAA ATTGTACTAGTTGTAGTTACGAGTTTTCCCTCAGTGAAGTAGCAATAGGCTGTAATCAAGAAAATATGCC ATTTATAGAGATAAGATAAATGAAATAATACTTCAGCCACCAGGTTTTTCTGTCTCACATACATAAGCAG CATTTCATTGCAGATATGGGACTGATTCTGTGGCTTACCTTGATTAACATCTTTTGGAAGTTTTGCTAGT GTGCTTTCCTTTCTTTACTATGTTTCTCAGATTCCTTTGTATCAGGGTTTTGGGTGTCACTTAGGTTTTG TCCATCAGATTCTGTGAGACACCAGGCATCGTTTTGAGGATGTGGGTTATACACATGGAGTGCTTCTGGA ACTATCAGCCCACTTGACCACCCAGTTTGTGGAAGCACAGGCAAGAGTGTTCTTTTCTGGTGATTCTCCA GGCCATTTAATACCCTGCAATGTAATTGTCCCTCTGTGGCTCACATTTCATTAGTGAGCCATGAAATCAA CTCAGTGGGACATAGCCAGCATTTTTGCATACCAGGTTGGGCTATAAAATATTTCTGTTGTCAATAAATT TTAAATGTTTTCCTGCTAAACTAA Download Select all
Length	12274
OMIM ID	601266
HGNC ID	HGNC:3078
Unigene ID	Hs.527980
Ensembl ID	ENSG00000128951
PharmGKB ID	-

mRNA Information

mRNA ID	XM_011521315.1
Exon	join(1..92,1169..1307,3318..3409,4947..4991,10190..10264, 10416..10486,10923..11463)
mRNA Sequence	>1854 GTCATGTTCCCAGGACGGGCGCGTCTTCAGGGTGGAAGCCTGGCGCACGTCCGGAGGTGCCGAG GACCCAACCAGCCCAAACTCTGGGGGAAATGACTCCCCTCTGCCCTCGCCCCGCGCTCTGCTAC CATTTCCTTACGTCTCTGCTTCGCTCAGCGATGCAAAACGCGCGAGGCGCACGGCAGAGGGCCG AAGCCGCGGTACTCTCCGGGCCAGGCCCGCCCCTCGGCCGCGCCGCGCAGCACGGGATTCCCCG GCCGCTGTCCAGCGCTGGCCGCCTGAGCCAAGGCTGCCGCGGAGCCAGTACAGTCGGGGCCGCT GGCTGGAAGGGCGAGCTTCCTAAGGCGGGGGGAAGCCCGGCGCCGGGGCCGGAGACACCCGCCA TTTCACCCAGTAAGCGGGCCCGGCCTGCGGAGGTGGGCGGCATGCAGCTCCGCTTTGCCCGGCT CTCCGAGCACGCCACGGCCCCCACCCGGGGCTCCGCGCGCGCCGCGGGCTACGACCTGTACAGT GCCTATGATTACACAATACCACCTATGGAGAAAGCTGTTGTGAAAACGGACATTCAGATAGCGC TCCCTTCTGGGTGTTATGGAAGAGTGGCTCCACGGTCAGGCTTGGCTGCAAAACACTTTATTGA TGTAGGAGCTGGTGTCATAGATGAAGATTATAGAGGAAATGTTGGTGTTGTACTGTTTAATTTT GGCAAAGAAAAGTTTGAAGTCAAAAAAGGTGATCGAATTGCACAGCTCATTTGCGAACGGATTT TTTATCCAGAAATAGAAGAAGTTCAAGCCTTGGATGACACCGAAAGGGGTTCAGGAGGTTTTGG TTCCACTGGAAAGAATTAAAATTTATGCCAAGAACAGAAAACAAGAAGTCATACCTTTTTCTTA AAAAAAAAAAAAAAGTTTTTGCTTCAAGTGTTTTGGTGTTTTGCACTTCTGTAAACTTACTAGC TTTACCTTCTAAAAGTACTGCATTTTTTACTTTTTTTTATGATCAAGGAAAAGATCATTAAAAA AAAACACAAAGAAGTTTTTCTTTGTGTTTGGATCAAAAAGAAACTTTGTTTTTCCGCAATTGAA GGTTGTATGTAAATCTGCTTTGTGGTGACCTGATGTAAACAGTGTCTTCTTAAAATCAAATGTA AATCAATTACAGATTAAAAAAAAAAGCCTGTATTTAACTCATATGATCTCCCTTCAGCAACTTA TTTTGCTTTAATTGCTTTAAATCTTAAGCAATATTTTTTATTCAGTAAACAAATTCTTTCACAA GGTACAAAATCTTGCATAAGCTGAACTAAAATAAAAATGAAAAGGAGAGATTAAAGGTATTCCT TGTTCTTCCCTTCTCTTCACTAGTCTAAAAACTTCTTTTTAATCTTAAGATTCTTTGTGATGAG GGTGAGAAAAAGAATCCTCAGTTTATTTTTCCACTATTAATCTTTCTTTTGATAAATCCTCTAT TGACTGGGTAGAGGTATGTTTGTGAAAGACATGTAACTTGGGGATTTGTTACTTTAGGTTTGTT CCCTTGAATTTCATCTCATCAGGCAAATTGTACTAGTTGTAGTTACGAGTTTTCCCTCAGTGAA GTAGCAATAGGCTGTAATCAAGAAAATATGCCATTTATAGAGATAAGATAAATGAAATAATACT TCAGCCACCAGGTTTTTCTGTCTCACATACATAAGCAGCATTTCATTGCAGATATGGGACTGAT TCTGTGGCTTACCTTGATTAACATCTTTTGGAAGTTTTGCTAGTGTGCTTTCCTTTCTTTACTA TGTTTCTCAGATTCCTTTGTATCAGGGTTTTGGGTGTCACTTAGGTTTTGTCCATCAGATTCTG TGAGACACCAGGCATCGTTTTGAGGATGTGGGTTATACACATGGAGTGCTTCTGGAACTATCAG CCCACTTGACCACCCAGTTTGTGGAAGCACAGGCAAGAGTGTTCTTTTCTGGTGATTCTCCAGG CCATTTAATACCCTGCAATGTAATTGTCCCTCTGTGGCTCACATTTCATTAGTGAGCCATGAAA TCAACTCAGTGGGACATAGCCAGCATTTTTGCATACCAGGTTGGGCTATAAAATATTTCTGTTG TCAATAAATTTTAAATGTTTTCCTGCTAAACTAA Download Select all
Length	2146

CDS Information

Location	join(68..92,1169..1307,3318..3409,4947..4991,10190..10264, 10416..10486,10923..10979)
CDS Sequence	>lcl\|NM_001025248.1_cds_NP_001020419.1_1 [gene=DUT] [protein=deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 1 precursor] [protein_id=NP_001020419.1] [location=93..851] ATGACTCCCCTCTGCCCTCGCCCCGCGCTCTGCTACCATTTCCTTACGTCTCTGCTTCGCTCAGCGATGC AAAACGCGCGAGGCGCACGGCAGAGGGCCGAAGCCGCGGTACTCTCCGGGCCAGGCCCGCCCCTCGGCCG CGCCGCGCAGCACGGGATTCCCCGGCCGCTGTCCAGCGCTGGCCGCCTGAGCCAAGGCTGCCGCGGAGCC AGTACAGTCGGGGCCGCTGGCTGGAAGGGCGAGCTTCCTAAGGCGGGGGGAAGCCCGGCGCCGGGGCCGG AGACACCCGCCATTTCACCCAGTAAGCGGGCCCGGCCTGCGGAGGTGGGCGGCATGCAGCTCCGCTTTGC CCGGCTCTCCGAGCACGCCACGGCCCCCACCCGGGGCTCCGCGCGCGCCGCGGGCTACGACCTGTACAGT GCCTATGATTACACAATACCACCTATGGAGAAAGCTGTTGTGAAAACGGACATTCAGATAGCGCTCCCTT CTGGGTGTTATGGAAGAGTGGCTCCACGGTCAGGCTTGGCTGCAAAACACTTTATTGATGTAGGAGCTGG TGTCATAGATGAAGATTATAGAGGAAATGTTGGTGTTGTACTGTTTAATTTTGGCAAAGAAAAGTTTGAA GTCAAAAAAGGTGATCGAATTGCACAGCTCATTTGCGAACGGATTTTTTATCCAGAAATAGAAGAAGTTC AAGCCTTGGATGACACCGAAAGGGGTTCAGGAGGTTTTGGTTCCACTGGAAAGAATTAA Download Select all
CCDS ID	-

Protein Information

Protein ID	NP_001020419.1
Protein Name	deoxyuridine triphosphatase
Molecular Wt. (Da)	19346
Protein Sequence	>1854 MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLS QGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTR GSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDED YRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN Download Select all
Length	252
Uniprot ID	Q16772
Ensembl Protein ID	ENSP00000211122

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	99
S	Phosphorylation	11
T	Phosphorylation	239
S	Phosphorylation	248
T	Phosphorylation	151
S	Phosphorylation	160
T	Phosphorylation	239
S	Phosphorylation	248
T	Phosphorylation	128
S	Phosphorylation	137
K	Acetylation	179
K	Acetylation	91
K	Acetylation	179
K	Acetylation	68
T	Phosphorylation	7
S	Phosphorylation	13
S	Phosphorylation	99
S	Phosphorylation	88
S	Phosphorylation	88
S	Phosphorylation	243
S	Phosphorylation	155
S	Phosphorylation	243
S	Phosphorylation	132
T	Phosphorylation	249
T	Phosphorylation	161
T	Phosphorylation	249
T	Phosphorylation	138

Enzyme Information

EC	3.6.1.23
Name	dUTP diphosphatase deoxyuridine-triphosphatase dUTPase dUTP pyrophosphatase desoxyuridine 5'-triphosphate nucleotidohydrolase desoxyuridine 5'-triphosphatase
Class	Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides
Sysname	dUTP nucleotidohydrolase
Substrate	dUTP [CPD:C00460]; H2O [CPD:C00001]
Product	dUMP [CPD:C00365]; diphosphate [CPD:C00013]
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
5465	PPARA	1369	NP_001001930.1	in vitro;in vivo;yeast 2-hybrid	8910358
5467	PPARD	2679	NP_006229.1	in vitro;in vivo	8910358
9825	SPATA2	9636	NP_006029.1	yeast 2-hybrid	16189514
79873	NUDT18	7992	NP_079091.3	yeast 2-hybrid	16189514

Pathway Information

Pathway Name	Pathway ID
Metabolic pathways	hsa01100
Pyrimidine metabolism	hsa00240

Structure Information

PDB ID	1Q5H
Resolution	2
Method	X-RAY DIFFRACTION
Chains	A, B,
Molecule	dUTP pyrophosphatase
Model	View

Domain Information

ID	Location	Description
cd07557	134-221	trimeric_dUTPase
cl00493	134-221	trimeric_dUTPase superfamily
TIGR00576	114-251	dut
PHA02703	114-250	PHA02703
PLN02547	100-250	PLN02547
PHA03094	114-252	PHA03094
pfam00692	121-250	dUTPase
COG0756	118-251	Dut
PRK00601	112-252	dut
PTZ00143	135-252	PTZ00143
PRK13956	126-251	dut
COG0717	143-224	Dcd
TIGR02274	146-224	dCTP_deam
PHA03124	134-251	PHA03124
PHA03131	134-221	PHA03131
PRK12727	17-163	PRK12727

Ontology Information

HPRD ID	2701
Molecular Class	Enzyme: Hydrolase
Molecular Function	Glutathione transferase activity (GO:0004364)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO