CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24129181	2013	Cell line : - Source : Kaohsiung University Hospital Sample Type : - No. of Sample : 214 Stage : TNM Stage I-III	Microarray, immunohistochemistry	Up-regulation	-	DVL1 could be a potential prognostic and predictive marker for CRC patients. DVL1 is significantly overexpressed in CRC patients with liver metastasis.

Gene Details

Chromosome 1 - NC_000001.11 (1335278..1349158, complement)
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Gene Type	protein coding
Gene Family	Dishevelled homologs
Description	DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Chromosome	1
Location	1p36
Start	1335278
End	1349158
Strand	-
Gene Sequence	>gi\|568815597:c1349158-1335278 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly CCGGGCGGGGCGCAGGCGGGCGGGCGGGTAGCGCCCCGCGTCCGAGCCCCGGGCCGGGCCCTGAGCGCGC GGGCTCCGCGCCGCCGCCGCGCCATGGCGGAGACCAAGATTATCTACCACATGGACGAGGAGGAGACGCC GTACCTGGTCAAGCTGCCCGTGGCCCCCGAGCGCGTCACGCTGGCCGACTTCAAGAACGTGCTCAGCAAC CGGCCCGTGCACGCCTACAAATTCTTCTTTAAGTCCATGGACCAGGACTTCGGGTCAGTCGGCCGCGAGG CCTGCGCGAGCCTGGCGCGGGCTCGGGGGTCGCACCTGCCCGCGCGGGGACGGGGCGGGGGTCCTGAGCC GTTCGCGCCCCCGGGGACCTGCGACCGCGACGCGCCTCCGCTAGATGCGGCGCGGGTGGCGGCCTCGGCC CGTGTGCGGCGCGCGCCCACCTGTCCGTGGAGCGGGGCGATGGCAGGCGGGGTTCCCGGCGTCCCTGGCC CCAGCTTCCCGGCCCCGAGTCCTGCCTTGGCCCGTGTCAGACTCGGTCGGCCGCATCGCTTCCACCGGGG CTGGCCGGGAGCGCCTGCCGTTGGTGCGGGCTGGGGTCAGGGGCGTGTCAGTGGGAAGGAAGCAGGGTGG GGTTCCCTAGCTGGGATGGGGAGACATGGGGGTACAGGTTCACCAACCTGTCTGCTAGGGTTTGCAGAAG CTTCCCGAGGGTCAAGACAGGTTCTCCTGGCCCCCTTCTGCAGGGTCCTTGTGACAGGGTGGAGGTCAAG GGCCACTGGTGACCATGAAACTTTATTCGCCTACCCGTGTCCTGAGCTTCCTGTGGGCCCCGTCCCCACT GAGCCACAAAGCACTTGCGTTCCCGGAGCAGCCCAGACCATCTGCTGTTTCGGGGCAGCCTGGGTCAGCG TCTCCCTGCTGGGCCTCGGTGGTGGTGTCCCAGGCGAGGAGACCCCTGCTGTGCTGAGCTGGGCCCTCTG GGACAGGGAGCAGGAGCCTGGCGGTCTGCTTGAGGCCTGGCCTGGCCCGGCCCAGCCACCAGTAACCTGA GTCCCTAGTCCCAGCTCAACAGTGCTGGGGGCGGGCTCAGGCCTCGTGGCCCCAGGAGGTGAGCCTCCGG CAAGCGGTGTCCTTGTGTGTGGCCGCTTCTTGGGATTGTGACATTAAGGTTGTTTCTTGGATTCTGTGGT TGCAGGGTCCTCAGGCAGCCCCAGGTCCAGTCAGGCTGGGTCCGCTCTGGAGCTCTCAGGGGGGCCCAAG GGACATCTAGACAGCTGTACTTTCCTTCCCCACCCCCACGACCAGGCAAAGCAGAGAGGGCAGGGTGCGT CCTTGGCAGCCTTTGAAGGCTGGGCGCTCCCCACTCGGCTCAGCGGCCCTCCTGCCCGCTCCGGTCAGGT TGGGCAGGAGGGGGCGGTTTGTTTTCTGAGTCTGGTCCGGGCTCCTCCCCAGCTGGGGCACCTTGCAGTC CCTGCTTCTCTGGGCCTGGGCTGCTTTGGCCTTGAGCATGGGGCATGTGTCAGGTACTTTTGTTTTTGAC TTAGTTTATTATTCTAACGAAAGTTACCAAAGTTACTAATGCTGTTTGTTGCAAATGTGTGCCACCAGGA AATGCGTAGTGAGGAGGTGCCCAGCCCCCAGGTTCTGCTCCTGGACCATGCTCTGGGATGAAGCCCTGGG GGAGTCCGCCTTCTGCTCCTGACACCCACCGGGGGCTGCCCAGGGCAGAGACAGCCTGACTGTTGCCCTA GTGCACTTCTAGCAGTGGCTGCACCTGCTGGGCACATTTGGAGGACGCGTGGGTGCCCGGGCCTGGGAAC AGGGTGGGCAGGTCTGGGTGTCGAGGCAGGCTTGGGGATGCGGCCAGGAAAGAGACAGGGGAGCTTCAGT GTACAGCTTTGGAGGCTGCAGACTTACAGGGGGCTGGGAGTCAGTGGGGCTGCAGAGGTCAGGGCTGGGC TGGGCTGGGCTGTGGGGGTTGGAAAGAATGGACTGGGGTGATGCTGGAGGTCCAAGACGAGGGCCTTGCT CTGTAGCCTCCCAGGTCCTCTGGCTGGGATGGGGGCCTTGCTCTGTGTCCTCCCTGGTCCTCTGGCTGGT GGCCTCAGGAGCCTACGGAGGACCCTCATCAATTACTTCCTTCATCCCTTCCCCTGAGTTCTACCCGCAG ACCTCTCAGCACTGTCTGTTCTGTGGAATAGAACCCCCGTGGGAGGGGCTGGTTGGTCAGTAATACTTTA GCTTAAGCGACTGCTGAACTAGACACTGACCCTGGATGCCAAGCGAATGTAGTTGGAGATGGGGGGAAGA GAAGGCAGGTCCTCGCTGGTCTGGGGTGGCCTTCATAAGAGAGGGAGCTTCAGGCTGGGGACGCTGAGGA GGCCCTGGTGAGTCGGGGGTTCCTGCGCCAGCCCCCGCTGCATTCTCAGCCCAGCCCTGGTTCCCCAGCC TCTGCTCCAGAGCATGACTGACCACCTTGCAGTGCAGGGAGCCTGTGTCATGGCCACAACCACGTGCCCT GGTCTGGACCCCACTCCCCACGCACGGCTTTGGCCCAGTGGGTGAAGGTCCCCCGCCTGTCCTCCACTTT TCATGCCCTGGTCACAGCTATTCTGACCCAAGATCCCCAGGGCTGGGAGGAGGGCAGAATTGGGGAGGGT CTCTGCCTGGTGCTGGGTTTGGTGGTTGGCAGGGGGTCTCGCCCAGCCTTGGGCCGAGGCAGAGGAGGGA GGGTGTTTGGCTCCGGGTCCCCACTGCTGGGTGCGTGGCGGATGCTGGGCCTGCTGGACTTGGCACCGAG GCTGTCTGTTGGGCACAGCTCCCACAGTTCATCTCCGAGGTGGGGGTGACCCAGGCCTGGGACTGGGGGA TGGGTGGAGGCAAGGCTGTGGGCCCAAAGCCCTGGTCCCCAGGGCCGCCTGCCATGGGCCTCGGTGTTGT GACAGCTCCTTGTGTCCTGGGTGGTGCTGTGGGGAGCTATGGAGTTGGGGAGGCTCTGCCTGGCCTGGGC TGTGGGGGGAGTTCCCACTCCGCCCTCCCTGGCTGTGCCACTTGGGGTCTGTGACTCAGCCTCTCTGTGC CCTGAGTGCCTCCCTGGTTTTGGGAGGGTCCAGGCAGTTCACCTACTGCACTCATAGCCATGGCCTAGCA GGGACACTTGAGCCTGTGTGTCCTGAACCGGGGGAGGGGCACAGAGAGATCCCAGGACTCGGCACCACCC AGGGGACAGGCTGGTGGAGAGCCCCTGGCTCTGGGGTCAGGGGTTGGGAGGCCACAGACCCCCAAGGCTG AGGGCCCTGACCTGGGGCGTGCACAGGGGGCTCTGAGGGCACAGGATGGCTCTGCACCGCCTGTCCTGGG CCAGCTACCCCTGCCAGCTTCCTGCTCCGCCTTGGGAGAATGGGGTGCATTCGGGACCACGCCACGTCTA GGGCAGCTGGCTGTGGCCTCTGGGAGTCTGGAGGGTTCTCTGCATCCTGTGTGGCCATGCTGGCTCCCAG GGCGCTGCCTCTGAGTGGATTCCTCCCCGGGGCGGGTCTGTGGGGGCAGCACACAGGTTAGCCAGGCCTC ACAGGGAATCCCAAGGTGGGGGCACAGTGCCGGCAGGGGCGCCCCTGGCAGCTGCCGTGAGTTTCAGCGG AGGCTGCTACAGAGGCGCGGGGACCCCGGGTTGTGGGTACGCCCCCAATGCCTGGCCAGCCTCCAGCACC CTCCCCCATCTGGCTGGGGTGGGGACGGCAGGGCTCTGCCTGGGACCTGGGTAGCTGATCCCTGGAGCCC CAGGCAGACCCCACCCTTCCCTCTGTGCTGTTTGGGTCCTGCTCCCTTTCTCCTGGCCCAGCCAGGCTTG GGTCTGCACCCTGCCACTGGGGGCAGGGGAGGACTTGTTACACCCTGTTGGGCTGAAGAGGGCGGAGTGA GTAGGGCCTCTGGGTCCTGGCTGGACATCTGTGAGGGGGCAGGGGGCAGGGACATCCCAGGCAGCCTGGG GTCTTCGTGAGGCCCTGGCTGGGTGGGCCATGCGGGCTTGGGCCACTCTGGATGGTGGGAGGGGGCAGGG CCCTCTTCCGGTGGAGCCAGGCGGGTGCTGTACTGGGGTGCTGGGTGGCCGAGTCTCCCTCCAGTGAGTC AGAGGGTGCTGGGTGGCCGAGTCTCCCTCCGGTGAGTCAGAGGGTGCTGGGTGACTGAGTGTCTCCCTCA GGTGAGTCAGAGGGTGCTGGGGTTGGGTGTGGCAGGGGAGAAGCTGCCGGCCAGGCCACCTGGGGCCGTG TGTCAGGGACTGAGGTGGGGACCCTGCCAGGGGCTCTGCTGTGGTCAGGTCCATTAGAGACAAGGGCTCA CTGTGGGCCCTGGCCCCCTGGCGGCAGCTAGTGGTGGCCTCGGTGTCCGTGGGGCCCGCCTCACCCTGGG TTGCTCCAGCCTTTCAGGTGTGACAGCCTCTCACTGTGGCGGCCTCAGCCTGGCATGGGGTCATGGTCTT ACCTGGGAAGGCTCCTGTGTGGGGGCAGCAGACGTGGAGGGGTCTGAGAAGTGACCTTCTCTGCTCTTTG GGGGCGTCTACCTCATGGCCTGGCCCTGGGTGGCCTGGGGAGGCAGCTGCAGGACCCCAGAGGGCTAGGT AGGGGTCCCTGCTCCCACCTGGGCTGGCCCTGCCTGCTGTCCACTCTGCCCTGAGGCTTGGGGCCTCTTC CCAGCAAGTGGGTGGGCCAGGGCTTGGGTGAGAGTGTGGGTTTGCCACTTTGCCGGGGGCCTCCTGCTAC CTACTGCTTCGGAGTCTGGCTGAGTCAAGGTGCCCCGGGGTCAGGGGACCTGGAGCGGCCAGTCGGGGTG GCTCTGTAGCTCGCAGTGGGACTAGCAGCCACAAGGCCGCTTCCTGCCAGGTGTGCGGCCAGGCCAAGCC CCGTCTCCGGGCTCCTATTTCTCCACTGGGCCCAAGTCCCGGGCGTGGAAAATGCTGCTGGGCAGGGCAG GGTGCCACGAGGCGGCGTCCAGATCCTACCCAGCCTGCTGCCTGGGCCCTCAGAGGTCACAGTGTGAGTG TCGACCACAGCCCTGCCTGCCTTGCTCCTTGGCCTGGGGACCTGCCCCTGCCCAGCCATCCCCTCTGTGC CGTGTGGGTTGCCACCCTGCCCTCTGAACTCTGAGCTCGGGTCACCCGGCCTCCTCCTGGTTCGTGTCCC CTGACCCTCTGCGGCCTGCCTGGGTGCCCTCTGCCCCGTTCCCAAGCCTATCTGACCTGGGGGTGGACTG GTGAGGCACCTGGCCAGCTTGCTCTCCTGGGGGCCCTGCCGGCTCCGCATCCCCTGCTGCCCCTCTAGGT CCTGAGGTGCAGGGAGGTTTGGTGAGTGGAGGTCTTTGTCTCCCTGGCTAGGTGGACAGGACAGGAGGGT GGTGGGCGGCCTCTGGGGACCTGTGGGCCCTCCCAGCCCACCTACGTCCGTCCGTCGGGTCTGAGAGTCC TTGTAGGTGGACTGTGAGCCTGACTAGGGGTGCAGGGCAGGGGTCAGGCAAAGCCCTGCCCTCACAGAGC CTGACCCTGGGCAGGCAGGCACAGGGCCTGGGACCTGAGGCTGCTCCTGAGACGCCAGGAGGGTGGAGTA GGGCCATAGGGCATGGCTGGCATGATGGAGAGGAGGCTGCTGGGGGATTTGGGCTCCTGGTTGGGAATGA CAGGTCTGAGTGCAGGGGTGGGTGCAGGTGGCCTGATGCCCTGGCTGTTGAGGGGTGGGCGGCTGGTCTG GAGCTGGCTGGGAGGTGGAGCGGTGGACCTGAGGTCTGGGGCAAGGGACAGGGAATAGCCTGGGGAGCCT TGGGGCCCGGTAGGTGCAGCTGCTGCTGCTGAGGAGGCTGGGGCCTGGCCCTGAGGAGTCCCAGTGTGGG GGAAGCCCTGGGGGGGGGGGGCTCCAAGCCCCAGGAACAGATGAGGTGGGGGTGGTTGGAGACAGCGTCT GGGGCCACCACATACATGAACCGAGGGCAGCTGGGCACGGGGGCTTTCCCAAGGAGGCCTCACCCTAGCT GTCCTCCTACCTGGGGGCTGGGGACCAACGCTGCAGGGGACTGAGAGCCTTTGGCTGAGCTGCCCCTGTG AGGATGTCCACAGCCACTGTCCCCATGCTGGGGGGGTGGGGGCCCAGGATGTGACGGAGAGGAAGGACGG TTCCCGAGAGGAGAGTGCGTTAGCAGGGGTGTCCGCAGAGTGACTGGCCCCATGCTGGGGGGGTGGGGGC CCAGGATGTGACGGAGAGGAAGGACGGTTCCCAAGAGGAGAATGCGCTAGCAGGGGTGTCCACAGAGTGA CATTGTGTGGGCAGGAGGAGCGCCTGCTCTCCAGGCCTCACCTCTAGAACCGCAGGGTTGGGCCCCCCAG GTGGGGCCTCACGGCAGCATATGCCCACAGGGTGGTGAAGGAGGAGATCTTTGATGACAATGCCAAGCTT CCCTGCTTCAACGGCCGCGTGGTCTCCTGGGTGAGCCCCTGTGTCTTGGCCCCGAAGGCTCGCCTGGGGA GCATTCCAGGGTGGGGCTCTTCCTGGGGGAGGCGGTGGGTGTGGGGAGGCCCTGGCAGGCTGGGTGCGGA TAGGGCAGCTTGCTGGCCCCCTGTTCCCTGGGTGCCCTGAGGAGGCGTCCTGAAGGCGGGTGGGCTCCCC TGAGCATGCCTGCTCCCTCCACAGCTGGTCCTGGCTGAGGGTGCTCACTCGGATGCGGGGTCCCAGGGCA CGGACAGCCACACAGACCTGCCCCCGCCTCTTGAGCGGACAGGCGGCATCGGGGACTCCCGGCCCCCCTC CTTCCAGTAAGGACACCGTGGGCGCTGGGCCCTGCTACCCCAAGCCTGTCATGGGGGTTGCTGGCCAACA GGGGAGGGAGGCCTGCCTGGGCCAGTAGGCGGGCGTGGCACCTGCTGGGGCTGGGGTCCCACAGGCGAGG GGAGGCTGGGCTGGGCGGCATCTGAGGGGCTGGGGCCACGGCCTCCCCACCCACCCTGCTCTTGTTGCAC AGCCCAAATGTGGCCAGCAGCCGTGACGGGATGGACAACGAGACAGGCACGGAGTCCATGGTCAGTCACC GGCGGGAGCGTGCCCGACGCCGGAACCGCGAGGAGGGTACAGTGGTCATGTCTGCCCAGCTGTGGACCCC CAGCCTCCCTGGGACCCCCATGAGCCATGTTCCTACTACAGCAGTTCCTGTCCCCCAGCCAGTGGCGGTG CTTGGGTGGAGGCACAGGCCCAGCGAGCCTACAGTTGAGCTGCCAGCTCCCAGACCCACAGGCATGCAGC ACTGCCCAGGCAGCCCCAAACCCATGACCTCTGGGAGACCCTGCAGTCAGTTCCCAACCTGCTGCCCCCA CAGCCGCCCGGACCAATGGGCACCCAAGGGGAGACCGACGGCGGGATGTGGGGCTGCCCCCAGACAGCGC GTCCACCGCCCTCAGCAGCGAGCTTGAGTCCAGCAGCTTTGTGGACTCGGACGAGGATGGCAGCACGAGC AGGTGTGTGGGAGTGTCTGTGGGCGTGTATGCCTGTGTGCCCACTTGCAAATGTCTGTACATGATGTGCA TGTGTCTGCATGAGGTGTTTTCACATTGCACGTGTGTGCGTGTGTGTGCATGTGTGTGCCTGCAAATGTC TGTGTACATGATGCACGTGTGCTTGTGCACGTGTTCCACATGAGGTGTTTTCACTGTGCACGTGTGTGCG CGCCTGTGTGTGTGCCCGCGTGCAAACGTGTACATGATGCACGTGTCTGCTTGTGCATGTGTGTCTGTGT GAGGCGTTTTCACATTGCGGATGTGTCTGTGCATGTACCTGTGTGCAAACGTTTATGTACATGATGCGCA TGTCTGTGTGTGCATGTATGTGTGTGTGAGGTGCGTTTTCACAGTGTGCACGTGAGCGTTTTCACAATGC ACGCGTGTGCGCAGGTGTGTGCATGTGTGCGTGTGCGTGTGTGCAGGTGTGCGTGTGCAGATGTGCGTGT GTGCAGGTGTGCTTGTACAGGTGTATGTGAAGGTGTGCGTGCAGGTGTGCATGTGCAGGCGTGCGTGTGC AGGTGTGTGCAGGTGTGCCTGTGTGCAGGGGTGCGTGTGTGCAGGTGTGCATGTGTGTGCAGGGGTGCGT GTGTGCAGGGGTGCATTGTGCAGGGGTGCGTGTGCAGGTGAGTATGCAGGTGTGCATGTGTGCCTGTGCA GGTGTGTAGTGTGCAGGGGTGCGTGTGTGCAGGTGTGCATGCGTGTGCAGGTGTGCGTGTGTTCATGCGT GCGTGTGCAGGGGTGTGCATGTGTGCCTGTGCGCAGGGGTGCATGTGTGCAGGGTTGCGTGTGTGCAGGT GTGTGTGCAGGTGTGTGCATGTGTGCCTTGTGCAGGGGTGCGTGTGTGCAGGTGTGCATGTGTGTGCAGG TGTGCATGTGTGCAGGTGTGTCAGTAGTGGATCTGGCTACATGTGTCTGTGCCCAGTTTGCCTGTCTCTG GGATTTTCGTGTGTGCTCATATGCATATCACGTGTGCAGGGCCTGGGGCGTGGACGTCAGGCACTGAGCC TGCTTTGGAACAAGCCTGGCCTAGACCCCCGATTCCCACTCAGTATTGGGGGAGCGGGTTCCCACCCCCC TACCCATGTCTCCAGCTCCTCTGAGCTCTGACAGTCTGTTCCCAGGCTCAGCAGCTCCACGGAGCAGAGC ACCTCATCCAGACTCATCCGGAAGCACAAACGCCGGCGGAGGAAGCAGCGCCTTCGGCAGGCGGACCGGG TAGGCAGCCGGGTGGAGCAGGGCGGGGCTGGGGAGGCGAAGTCAGTGTCGGGCAGCCCCGTGCCTTTTAC ACACGCCCCCTCTCCTCCATAGGCCTCCTCCTTCAGCAGCATAACCGACTCCACCATGTCCCTCAACATC GTCACTGTCACGCTCAACATGGGTGAGGCCTCGGGGCGAGGGTTGGGGGCAGGGGCAGGGGCTTGGCCGC GGCTCATGGCTCTTCCTGCAGAAAGACATCACTTTCTGGGCATCAGCATCGTGGGGCAGAGCAACGACCG TGGAGACGGCGGCATCTACATTGGCTCCATCATGAAGGGCGGGGCTGTGGCCGCTGACGGCCGCATCGAG CCCGGCGACATGTTGCTGCAGGTGTGTCTGTGGGGGCTGCGGGGTGACATGTAGCTGCGGGTGGGTCCGT GGGGACTTTGGGGTGACGTGCGGCTGCGGGTGGGTCTGTAGGGGCTGCTGGGGGACATGCGGCTGCGGGT GGGTCTGCGGGGGCTGCTGGGGGACATGCGGCTGTGGGTGGGTCTGCGGGGGCGGTGGACTGAGCTGCAC ATCCTGCCTGCACCACCCTAATCCCCACCCCTGCAGGTGAATGACGTGAACTTTGAGAACATGAGCAATG ACGATGCCGTGCGGGTGCTGCGGGAGATCGTTTCCCAGACGGGGTGAGGGCTGGGGGCGCTGGAGCGGGA GGGGCCAGGCAGGGAGGTGGGACCATGGGGGCCTTGCTGTGTGACCACCGTTCCTGCAGGCCCATCAGCC TCACTGTGGCCAAGTGCTGGGACCCAACGCCCCGAAGCTACTTCACCGTCCCACGGGGTGAGTGGCCCTC GGGGCACACGGGGCGGGATGGGGAGGGGGCGCCTACCTAGCCTGAAGGCCTCTCTCCTCTGTGCCCTGCA CCCTGCCCTCCCACCCTGTCCATCTGTCCGCCTGTCATCGCCACGTGGCGGCCACCCAGCTGACCCGGTG CGGCCCATCGACCCCGCCGCCTGGCTGTCCCACACGGCGGCACTGACAGGAGCCCTGCCCCGCTACGGTA CGAGTCCCTGCTCCAGCGCCGTCACGCGCACCAGCTCCTCCTCACTAACCAGCTCCGTGCCTGGTGCTCC ACGTAAGTGGCAGCTCCTGAGGGCCCCAGCAGAAACCGAGGCTTGGAGGGGGCGTCTCTGCCAGCCTCCA GCATGGCCGCCTGTGGCCGTCATGGGGCTGTGACACGTGTGTGTTGCCTGTCCCCAACTCCCTGCACAGA CGTGTGCACAGGCACCCGTGCCCACCTTGTGCAGCCCATCCTGCTCATGGTCTGTGTGTTGGGAACAGGG GATGTACGTAGGGCCCCTATGCGGGGAGCACCCACGGCGTCAGAGGCAGGGGCCAGGTCTCCATTCTGCT TCCTGCCATTAACACGACTAACAGCCTGCGCTCTCGGGTGGGGCATGCGGGGAGGGGAAGGGGCCTGCCC TGTTCTCATTACTTCCTGGTCTGCAGGGTGGGGTGTCAGCCCAGTTTGTGCCTAGGATCCTGATGAAAAG TGTCTGTAGAAGTGGGAGACTAAATGTCCAACCCCCCTGCTCACGCCCCAGCCTCACGGGGGTGCATCCT GCAGTGGGCCGGGGCCCTGCTGTCACGCACCGTCCAGCTTGCGCCCTGGCGCAGGCTCTGCCCAGAGGCT CCCCTGGGGGTGCAGGGCCCTGAGTCCCCCGCCTTCAGATGCTGGGGCTGAAGCGGGGCTGTCTGTGCTT TGCAGAGCTGGAAGAGGCGCCGCTGACGGTGAAGAGTGACATGAGCGCCGTCGTCCGGGTCATGCAGCTG CCAGACTCGGGACTGGAGATCCGCGACCGCATGTGGCTCAAGATCACCATCGCCAATGCCGTCATCGGTG AGTGGCCGTCCCCGCGGGCGGATAGTGCCAGGGGCAGGGCTGCTTGCCTCGAGGCTGCGGGCTGACCGCT GGTGCCGGCCAGGGGCGGACGTGGTGGACTGGCTGTACACACACGTGGAGGGCTTCAAGGAGCGGCGGGA GGCCCGGAAGTACGCCAGCAGCTTGCTGAAGCACGGCTTCCTGCGGCACACGGTCAACAAGATCACCTTC TCCGAGCAGTGCTACTACGTCTTCGGGGATCTCTGCAGCAGTGAGTGGGGGCTTCGGGCTTCAGGGCGGG GGGGAGGGGAACGCCGGAGGCCCCTCCGCGGCCCTCACCTACCCTCCCCCGCCAGATCTCGCCACCCTGA ACCTCAACAGTGGCTCCAGTGGGACTTCGGATCAGGACACGCTGGCCCCGCTGCCCCACCCGGCTGCCCC CTGGCCTCTGGGTCAGGGCTACCCCTACCAGTACCCGGGACCCCCACCCTGCTTCCCGCCTGCCTACCAG GACCCGGGCTTTAGCTATGGCAGCGGCAGCACCGGGAGTCAGCAGAGTGAAGGTGAGAACGCCGCCCCTA CCTGCCCTTCCCCGGCTCCGCCCCCAGCTCCGCCCCACTCCACTGCTGCTCCGCCCCCAGTTCCACCCCA CCCCGCTGCTGCTCCACCCCCAGCTCCACCCCACCCCGCTGCTGCTCCGCCCTGCTTCTCTGCTGACCCC AATCCCATGCTCCTGCTGTGTACTTGGGCCCTGGGTGGGCTCCTTCTGGAAAAGGCAAGTGCCAGGGGGA TCCAGGAGCCAGTGTGAATGGGGAGGACAGGGAAGCGTCTCACACAGGGGCAGCCTGGACCCCACCTCAT CTGGGTGGGATTGGGATGAGGGGCCTCCAGGAGCCTGGCGGCCTGGGCGGCTGTGCCTGGTAGGGGTGGC GGCTGGTGGTTCTCCTATGGTAGAGGCAGGAGGCCCTGAGACCATGTGGCCATGGGCCATGTGACAAGGA CAGGGCAGGGGTGGCCAAGGAGTCTGACAGGGTCACTTTCTAGGCCCCAGGACACAGGAGGGTGGCAGCT GCAGCCCGGGTAGGGAGCCTGACGTGGATGGTGCCGTGCATCCTAGCCTTGTGCCCCTGGCTGGGGTGTG TTTAGGGGCCGGGGATCCAGAGTGTTCCTGAGGTGTTGCCTGGTGGAGCAGAGGCCCCAGTGGGTGGGGT TGGTGAGGCCAGCAGGGGCGTCTGCAGGCCAGGGAGGGGTGCAGGTGGCTTCGTGGAGGGCCCAGGAAGG AGGGCGAGAGAGGAGAGGCGGCCAGAGGGTGTGGGACCGCAGAGAAGCCACGCTGGGTGTCTACTGACCC TCGACCGGCGCTTGCGCCCACTTCAGCCCCGCCCAGCCCGCGGTCAGTCCCCACTGGTGGCGGGTGGGTG CTGGGCAGGTGCCAGGCAGCCGGGCGTGTAACTCGTGCTATCCCTTGTCTTGTGCTAAACAAGCCTTAGA CTGAAGGACTAGCGGAGCGGACCTTGGGCCGGTAAGCCAGGGTCCCGCCCGGGGTCCCTCAGCATGTCCC CAGCCAGCCACGCCCTCCAGCTCCCACTGCGTCTTGGGAGCCCAGGACAGGGCTGAGCTGAGTCATCCGT CGGCCAGGGTCCTGGGCCGGGGGGACAGTGGGGCCTTGGGTGGGGAATCCAGGATGGCCACGGGGGCACC GGGCATGAGGGGCCCTCGCTGGCACCTCAGTCTTTCAGCCGCAAGACCAGGCCCTCAGCTCAAGCATCGG GGTGAGGTGTGGGGGCGCCCAGCTTGCCCCAGGACCCTGCCTGCCTCCCACTGCCCCCACCAGCCCATGC CTGCCGCAGCTGCCCCTGCGACCCTGGGGGTGCCGGCCCTGTCCTCGCGCCTGCATGGCTGCCCCACCCA CCCGTCCTGCACGGGCCACCGTTCCTGCCCGGTCACCTGGCGGGGGCGGTTGTTCTGGACGTGGCCGGGC CTGGTGCTGACAGGCTCCTTCCCCATCCTGTTCTCACTCCCAGGGAGCAAAAGCAGTGGGTCCACCCGGA GCAGCCGCCGGGCCCCGGGCCGTGAGAAGGAGCGTCGGGCGGCGGGAGCTGGGGGCAGTGGCAGTGAATC GGATCACACGGCACCGAGTGGGGTGGGGAGCAGCTGGCGAGAGCGTCCGGCCGGCCAGCTCAGCCGTGGC AGCAGCCCACGCAGTCAGGCCTCGGCTACCGCCCCGGGGCTCCCCCCGCCCCACCCCACGACCAAGGCCT ATACAGTGGTGGGGGGGCCACCCGGGGGACCCCCTGTCCGGGAGCTGGCTGCCGTCCCCCCGGAATTGAC AGGCAGCCGCCAGTCCTTCCAGAAGGCTATGGGGAACCCCTGCGAGTTCTTCGTGGACATCATGTGACTC GTGGCGCATGCCCCAGCCCTGCCTGAGGTGGGGAGCTGGCGGTCCTGCCGCATGCAGAGCTCGCGTGGGC TTGCCTTCGTGGGGGCCAGGACGGGAGGCAGGGTGGGGGGCAGGCTGGACCACCACCATCTGCCCTGGCA GCCTGGCTGCTCCAGCTCCTGACAGCACCTGTGTCTGAGCAGCCGTGTTGGGGGCGCTCCCTCTCTGCCC CTCAGCGAGAGCCTCGGACCTCCCAACCCCTTGTGTCTGGTGGGGATCCCTCCTGGGATGAGGAAGACCC CCTCGGGCTCTCGGCTGACCCCCACCTCCTGCACAGCTGTGCCCAGGCCCCCAGGGTGGTCCATGCGGGG CAACCCCCTGCGGTGCACAGGCCCCCTGTCTGGAGTAGGGATCTAATTTATTTATTTATTGCCTGGCCGG TGACTCGGGGGAGGAGGCGACCCTGTCATCTGTCCCACCTGCTGCTGCCCCTTGGAGCAGCCTGCACCTT CTCTCCTCCCATCCGGCAACAGTCTGAAAGTACGTGGAGGACGGGACCGGAAGACGAGAGAGGGCTGGAC ATCCTGCCCACCGTGTCCCAGCCAGGGCAGGGAGGGACCATGGCCCGCAGGGTCAAGGGGCCCCGATGTG CACAGCTGCCACAGGGAGGGAGGTCTTGGGGAGATGGGCAGTCAGGTGGCCCGTCCTTGGTGAGTGCACA CACTGCGCGCACACATCGCGGCCTTCCTGGCTTCTCTGGCCCCCACGTGTCTGTGCTGTAGATACTGTAT CAAAGTCCCAGCGTTTAGATGGTTAACATAGAGCTGCTTCTGTGTAAATGCTGCTTATTTTAAACACTAA AAAGCGTTTAATTTTATGGGA Download Select all
Length	13881
OMIM ID	601365
HGNC ID	HGNC:3084
Unigene ID	Hs.731450
Ensembl ID	ENSG00000107404
PharmGKB ID	-

mRNA Information

mRNA ID	XM_011542239.1
Exon	complement(<13839..>13881)
mRNA Sequence	>1855 MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIF DDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSR DGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFV DSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNM ERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV LREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYELEEAPL TVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASS LLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQG YPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSG SESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRE LAAVPPELTGSRQSFQKAMGNPCEFFVDIM Download Select all
Length	670

CDS Information

Location	join(94..263,6401..6470,6675..6796,7003..7106,7354..7492, 8656..8749,8843..8912,8982..9121,9347..9423,9510..9577, 9720..9797,10506..10637,10723..10890,10976..11182, 12644..13017)
CDS Sequence	>lcl\|NM_004421.2_cds_NP_004412.2_1 [gene=DVL1] [protein=segment polarity protein dishevelled homolog DVL-1] [protein_id=NP_004412.2] [location=48..2060] ATGGCGGAGACCAAGATTATCTACCACATGGACGAGGAGGAGACGCCGTACCTGGTCAAGCTGCCCGTGG CCCCCGAGCGCGTCACGCTGGCCGACTTCAAGAACGTGCTCAGCAACCGGCCCGTGCACGCCTACAAATT CTTCTTTAAGTCCATGGACCAGGACTTCGGGGTGGTGAAGGAGGAGATCTTTGATGACAATGCCAAGCTT CCCTGCTTCAACGGCCGCGTGGTCTCCTGGCTGGTCCTGGCTGAGGGTGCTCACTCGGATGCGGGGTCCC AGGGCACGGACAGCCACACAGACCTGCCCCCGCCTCTTGAGCGGACAGGCGGCATCGGGGACTCCCGGCC CCCCTCCTTCCACCCAAATGTGGCCAGCAGCCGTGACGGGATGGACAACGAGACAGGCACGGAGTCCATG GTCAGTCACCGGCGGGAGCGTGCCCGACGCCGGAACCGCGAGGAGGCCGCCCGGACCAATGGGCACCCAA GGGGAGACCGACGGCGGGATGTGGGGCTGCCCCCAGACAGCGCGTCCACCGCCCTCAGCAGCGAGCTTGA GTCCAGCAGCTTTGTGGACTCGGACGAGGATGGCAGCACGAGCAGGCTCAGCAGCTCCACGGAGCAGAGC ACCTCATCCAGACTCATCCGGAAGCACAAACGCCGGCGGAGGAAGCAGCGCCTTCGGCAGGCGGACCGGG CCTCCTCCTTCAGCAGCATAACCGACTCCACCATGTCCCTCAACATCGTCACTGTCACGCTCAACATGGA AAGACATCACTTTCTGGGCATCAGCATCGTGGGGCAGAGCAACGACCGTGGAGACGGCGGCATCTACATT GGCTCCATCATGAAGGGCGGGGCTGTGGCCGCTGACGGCCGCATCGAGCCCGGCGACATGTTGCTGCAGG TGAATGACGTGAACTTTGAGAACATGAGCAATGACGATGCCGTGCGGGTGCTGCGGGAGATCGTTTCCCA GACGGGGCCCATCAGCCTCACTGTGGCCAAGTGCTGGGACCCAACGCCCCGAAGCTACTTCACCGTCCCA CGGGCTGACCCGGTGCGGCCCATCGACCCCGCCGCCTGGCTGTCCCACACGGCGGCACTGACAGGAGCCC TGCCCCGCTACGAGCTGGAAGAGGCGCCGCTGACGGTGAAGAGTGACATGAGCGCCGTCGTCCGGGTCAT GCAGCTGCCAGACTCGGGACTGGAGATCCGCGACCGCATGTGGCTCAAGATCACCATCGCCAATGCCGTC ATCGGGGCGGACGTGGTGGACTGGCTGTACACACACGTGGAGGGCTTCAAGGAGCGGCGGGAGGCCCGGA AGTACGCCAGCAGCTTGCTGAAGCACGGCTTCCTGCGGCACACGGTCAACAAGATCACCTTCTCCGAGCA GTGCTACTACGTCTTCGGGGATCTCTGCAGCAATCTCGCCACCCTGAACCTCAACAGTGGCTCCAGTGGG ACTTCGGATCAGGACACGCTGGCCCCGCTGCCCCACCCGGCTGCCCCCTGGCCTCTGGGTCAGGGCTACC CCTACCAGTACCCGGGACCCCCACCCTGCTTCCCGCCTGCCTACCAGGACCCGGGCTTTAGCTATGGCAG CGGCAGCACCGGGAGTCAGCAGAGTGAAGGGAGCAAAAGCAGTGGGTCCACCCGGAGCAGCCGCCGGGCC CCGGGCCGTGAGAAGGAGCGTCGGGCGGCGGGAGCTGGGGGCAGTGGCAGTGAATCGGATCACACGGCAC CGAGTGGGGTGGGGAGCAGCTGGCGAGAGCGTCCGGCCGGCCAGCTCAGCCGTGGCAGCAGCCCACGCAG TCAGGCCTCGGCTACCGCCCCGGGGCTCCCCCCGCCCCACCCCACGACCAAGGCCTATACAGTGGTGGGG GGGCCACCCGGGGGACCCCCTGTCCGGGAGCTGGCTGCCGTCCCCCCGGAATTGACAGGCAGCCGCCAGT CCTTCCAGAAGGCTATGGGGAACCCCTGCGAGTTCTTCGTGGACATCATGTGA Download Select all
CCDS ID	CCDS22.1

Protein Information

Protein ID	NP_004412.2
Protein Name	dishevelled segment polarity protein 1
Molecular Wt. (Da)	72750
Protein Sequence	>1855 MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIF DDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSR DGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFV DSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNM ERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV LREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYELEEAPL TVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASS LLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQG YPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSG SESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRE LAAVPPELTGSRQSFQKAMGNPCEFFVDIM Download Select all
Length	670
Uniprot ID	P09488
Ensembl Protein ID	ENSP00000311469

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	93
S	Phosphorylation	93

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
408	ARRB1	146	NP_004032.2	in vitro;in vivo	11742073
1453	CSNK1D	2920	NP_001884.2	in vitro;in vivo;yeast 2-hybrid	11818547
1454	CSNK1E	2919	NP_001885.1	in vitro;in vivo	1 148 757 811 818 540
1457	CSNK2A1	277	NP_001886.1	in vivo	10806215
1499	CTNNB1	286	NP_001895.1	in vivo	10806215
1857	DVL3	3222	NP_004414.3	in vivo;yeast 2-hybrid	10330181
2059	EPS8	2563	NP_004438.3	in vitro;yeast 2-hybrid	10581192
4088	SMAD3	4380	NP_005893.1	in vitro;yeast 2-hybrid	12650946
4089	SMAD4	2995	NP_005350.1	in vitro	12650946
4092	SMAD7	4241	NP_005895.1	in vitro;yeast 2-hybrid	12650946
5494	PPM1A	16199	NP_808821.2	yeast 2-hybrid	10644691
5879	RAC1	3627	NP_061485.1	in vivo	12533515
6993	DYNLT1	15987	NP_006510.1	yeast 2-hybrid	10644691
8975	USP13	4666	NP_003931.2	yeast 2-hybrid	16169070
57216	VANGL2	2758	Q9ULK5	in vitro	12490194
84064	HDHD2	13640	NP_115500.1	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
Basal cell carcinoma	hsa05217
Hippo signaling pathway	hsa04390
HTLV-I infection	hsa05166
Melanogenesis	hsa04916
Notch signaling pathway	hsa04330
Pathways in cancer	hsa05200
Signaling pathways regulating pluripotency of stem cells	hsa04550
Wnt signaling pathway	hsa04310

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd04438	417-499	DEP_dishevelled
cl02442	417-499	DEP superfamily
cd00992	249-336	PDZ_signaling
cl00117	249-336	PDZ superfamily
smart00021	Jan-85	DAX
cl02426	Jan-85	DIX superfamily
pfam00778	Apr-85	DIX
cd04371	417-495	DEP
smart00049	425-499	DEP
pfam00595	251-336	PDZ
pfam00610	428-497	DEP
smart00228	248-335	PDZ
cd00136	262-335	PDZ
cd04449	416-489	DEP_DEPDC5-like
pfam02377	159-210	Dishevelled
cl03561	159-210	Dishevelled superfamily
cd00988	262-352	PDZ_CTP_protease
cd04443	431-497	DEP_GPR155
cd04437	431-506	DEP_Epac
cd00987	261-335	PDZ_serine_protease
cd00989	260-335	PDZ_metalloprotease
cd04441	444-491	DEP_2_DEP6
pfam12316	503-685	Dsh_C
COG0793	263-363	CtpA

Ontology Information

HPRD ID	7202
Molecular Class	Adapter molecule
Molecular Function	DNA binding (GO:0003677)
Biological Process	DNA repair (GO:0006281)

SNP Information

View SNP Geneview Report