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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DVL2 1856 dishevelled segment polarity protein 2  17- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20663899   2010Cell line : -

Source : Addenbrookes Hospital, Cambridge

Sample Type : CRC tumor, Mouse

No. of Sample : -

Stage : -

Immunohistochemistry,tissue microarray, Western blotting, real time RT-PCRUp-regulation-Dvl2 and mTOR in the progression of colorectal neoplasia and highlight their potential as therapeutic targets in colorectal cancer.

24427302   2010Cell line : SW620

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 real RT-PCR, RT-PCR,Western blotting, Immunofluorescence microscopy.Up-regulation-CRC cells promote the high expression of IGFBP7 in fibroblasts, most likely through the co-regulation of TGF-? and Wnt signaling in a Smad2/3-Dvl2/3 dependent manner.


Gene Details



NC_000017.10 (7128661..7137867, complement)

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Gene Type protein coding
Gene Family Dishevelled homologs
Description This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17p13.1
Start 7128661  
End 7137867  
Strand -  
Gene Sequence

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Length 9207  
OMIM ID 602151   
HGNC ID HGNC:3086   
Unigene ID Hs.118640   
Ensembl ID ENSG00000004975   
PharmGKB ID PA27542   

mRNA Information


mRNA ID XM_005256502.1
Exon join(1..480,3752..3821,4119..4264,4394..4491,4606..4741, 4871..4961,5102..5171,5275..5414,5504..5580,6505..6572, 6766..6894,7014..7145,7280..7459,7910..8128,8236..9207)  
mRNA Sequence

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Length 3008  



CDS Information


   
Location287..2485
CDS Sequence

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CCDS ID CCDS11091.1



Protein Information


      
Protein IDXP_005256559.1
Protein Namedishevelled segment polarity protein 2
Molecular Wt. (Da)78437
Protein Sequence

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Length 732  
Uniprot IDQ14802
Ensembl Protein ID ENSP00000339499  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation227
SPhosphorylation228
SPhosphorylation211
SPhosphorylation222
SPhosphorylation230

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
408ARRB1146NP_004032.2in vivo;yeast 2-hybrid11742073   
5494PPM1A16199NP_808821.2yeast 2-hybrid10644691   
6993DYNLT115987NP_006510.1yeast 2-hybrid10644691   
8322FZD45203NP_036325.2in vivo12958364   
8907AP1M14639NP_001123996.1yeast 2-hybrid16189514   
9129PRPF37389NP_004689.1yeast 2-hybrid16189514   
9531BAG34860NP_004272.2yeast 2-hybrid16189514   
10127ZNF2635008NP_005732.2yeast 2-hybrid16189514   
10174SORBS311535NP_005766.3yeast 2-hybrid16189514   
10445MCRS111298NP_001012300.1yeast 2-hybrid16189514   
10921RNPS17341NP_006702.1yeast 2-hybrid16189514   
11030RBPMS11870NP_001008712.1yeast 2-hybrid16189514   
11201POLI16094NP_009126.2yeast 2-hybrid16189514   
11267SNF816847NP_009172.2yeast 2-hybrid16189514   
22893BAHD112518NP_055767.3yeast 2-hybrid16189514   
23002DAAM19433NP_055807.1in vivo11779461   
50855PARD6A6316NP_058644.1in vivo19379695   
51224TCEB3B18169NP_057511.2yeast 2-hybrid16189514   
54715-16091NP_665898.1yeast 2-hybrid16713569   
55145THAP115496NP_060575.1yeast 2-hybrid16189514   
57154SMURF16902NP_065162.1in vivo19379695   
58500ZNF25015758NP_066405.1yeast 2-hybrid16189514   
79753SNIP16999NP_078976.2yeast 2-hybrid16189514   
79869CPSF716906NP_079087.3yeast 2-hybrid16189514   
80125CCDC339959NP_079331.3yeast 2-hybrid16189514   
84080C16orf4813151NP_115516.1yeast 2-hybrid16189514   
84904C9orf10012929NP_116207.2yeast 2-hybrid16189514   
90268FAM105B14266NP_612357.4yeast 2-hybrid16189514   
92610TIFA9835NP_443096.1yeast 2-hybrid16189514   
127557$ZBTB8$10315NP_653222.2yeast 2-hybrid16189514   
151871DPPA213248NP_620170.3yeast 2-hybrid16189514   
414301DDI113128NP_001001711.1yeast 2-hybrid16189514   


Pathway Information


                                                
Pathway Name Pathway ID
Basal cell carcinoma hsa05217
Hippo signaling pathway hsa04390
HTLV-I infection hsa05166
Melanogenesis hsa04916
Notch signaling pathway hsa04330
Pathways in cancer hsa05200
Signaling pathways regulating pluripotency of stem cells hsa04550
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04438424-507  DEP_dishevelled
cl02442424-507  DEP superfamily
cd00992265-352  PDZ_signaling
cl00117265-352  PDZ superfamily
smart0002113-93  DAX
cl0242613-93  DIX superfamily
pfam0077814-93  DIX
smart00049433-507  DEP
cd04371430-503  DEP
pfam00610436-505  DEP
pfam00595267-352  PDZ
smart00228264-351  PDZ
cd04449424-497  DEP_DEPDC5-like
cd00136278-351  PDZ
pfam02377168-223  Dishevelled
cl03561168-223  Dishevelled superfamily
cd04443439-505  DEP_GPR155
cd04441428-499  DEP_2_DEP6
cd00987277-351  PDZ_serine_protease
cd04442439-490  DEP_1_DEP6
cd00988278-338  PDZ_CTP_protease
cd04450430-488  DEP_RGS7-like
cd04439439-505  DEP_1_P-Rex
cd04448433-462  DEP_PIKfyve
cd00989277-351  PDZ_metalloprotease
pfam12316515-726  Dsh_C
COG0793279-381  CtpA
TIGR00225277-374  prc


Ontology Information


   
HPRD ID8855
Molecular ClassAdapter molecule
Molecular FunctionProtein binding (GO:0005515)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO