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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DVL3 1857 dishevelled segment polarity protein 3  3KIAA0208 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24427302   2010Cell line : SW621

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 real RT-PCR, RT-PCR,Western blotting, Immunofluorescence microscopy.Up-regulation-CRC cells promote the high expression of IGFBP7 in fibroblasts, most likely through the co-regulation of TGF-? and Wnt signaling in a Smad2/3-Dvl2/3 dependent manner.


Gene Details



NC_000003.11 (183873099..183891314)

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Gene Type protein coding
Gene Family Dishevelled homologs
Description This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3q27
Start 183873099  
End 183891314  
Strand +  
Gene Sequence

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Length 18216  
OMIM ID 601368   
HGNC ID HGNC:3087   
Unigene ID Hs.388116   
Ensembl ID ENSG00000161202   
PharmGKB ID PA27543   

mRNA Information


mRNA ID XM_005247172.1
Exon join(1..486,8347..8416,8957..9078,9182..9291,9486..9621, 9803..9896,10112..10181,10816..10955,11136..11212, 11296..11363,11516..11665,12270..12401,12588..12755, 14696..14911,15009..15419,16257..17550)  
mRNA Sequence

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Length 3744  



CDS Information


   
Location326..2482
CDS Sequence

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CCDS ID CCDS3253.1



Protein Information


      
Protein IDXP_005247229.1
Protein Namedishevelled segment polarity protein 3
Molecular Wt. (Da)78152
Protein Sequence

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Length 718  
Uniprot IDQ14651
Ensembl Protein ID ENSP00000336831  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation192

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1457CSNK2A1277NP_001886.1in vitro;in vivo10806215   
1499CTNNB1286NP_001895.1in vitro;in vivo10806215   
1601DAB23139NP_001334.2in vivo12805222   
4062LY6H4691NP_001123950.1yeast 2-hybrid16169070   
5307PITX13688NP_002644.4yeast 2-hybrid16189514   
5494PPM1A16199NP_808821.2in vivo10644691   
5515PPP2CA8912NP_002706.1in vivo10644691   
8312AXIN14819NP_003493.1in vivo12805222   
8812CCNK10352NP_001092872.1yeast 2-hybrid16189514   
9129PRPF37389NP_004689.1yeast 2-hybrid16189514   
11143MYST27135NP_008998.1yeast 2-hybrid16189514   
22893BAHD112518NP_055767.3yeast 2-hybrid16189514   
59349KLHL1213925NP_067646.1yeast 2-hybrid16189514   
79797ZNF40818338NP_079017.1yeast 2-hybrid16189514   
79856SNX2215412NP_079074.2yeast 2-hybrid16189514   
84708LNX117287NP_001119800.1yeast 2-hybrid16189514   
85362C20orf15812752NP_689515.1yeast 2-hybrid16189514   
85407NKD18482NP_149110.1in vivo;yeast 2-hybrid11274398   
126282TNFAIP8L111314NP_689575.1yeast 2-hybrid16189514   
151871DPPA213248NP_620170.3yeast 2-hybrid16189514   


Pathway Information


                                                
Pathway Name Pathway ID
Basal cell carcinoma hsa05217
Hippo signaling pathway hsa04390
HTLV-I infection hsa05166
Melanogenesis hsa04916
Notch signaling pathway hsa04330
Pathways in cancer hsa05200
Signaling pathways regulating pluripotency of stem cells hsa04550
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04438413-496  DEP_dishevelled
cl02442413-496  DEP superfamily
cd00992247-334  PDZ_signaling
cl00117247-334  PDZ superfamily
smart00021Jan-82  DAX
cl02426Jan-82  DIX superfamily
pfam00778Apr-82  DIX
pfam02377142-204  Dishevelled
cl03561142-204  Dishevelled superfamily
cd04371414-494  DEP
pfam00610425-494  DEP
smart00049422-496  DEP
pfam00595249-334  PDZ
smart00228246-333  PDZ
cd04449413-486  DEP_DEPDC5-like
cd00136260-333  PDZ
cd04443428-494  DEP_GPR155
cd00988260-333  PDZ_CTP_protease
cd04441417-488  DEP_2_DEP6
cd00987259-333  PDZ_serine_protease
cd04450414-477  DEP_RGS7-like
cd04448422-492  DEP_PIKfyve
cd04442428-479  DEP_1_DEP6
cd04439419-494  DEP_1_P-Rex
cd04445411-478  DEP_PLEK1
pfam12316500-706  Dsh_C
COG0793261-363  CtpA


Ontology Information


   
HPRD ID23
Molecular ClassAdapter molecule
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of gene expression, epigenetic (GO:0040029)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO