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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DYX1C1 | 161582 | dyslexia susceptibility 1 candidate 1 | 15 | EKN1, FLJ37882, CILD25 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18618141 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR | Splicing | - | Alternatively spliced transcript variants of the DYX1C1 gene could be used as cancer biomarkers to detect colorectal cancer. Semi-quantitative RT-PCR analysis showed the transcriptional activity of V3 and V2 was higher in tumor than in normal tissue samples, especially in the colorectal tissue samples. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tetratricopeptide (TTC) repeat domain containing |
| Description | This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. | Chromosome | 15 |
| Location | 15q21.3 |
| Start | 55417755 |
| End | 55508234 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 90480 |
| OMIM ID | 608706 |
| HGNC ID | HGNC:21493 |
| Unigene ID | Hs.126403 |
| Ensembl ID | ENSG00000256061 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001198784.1 |
|---|---|
| Exon | complement(<89523..90012) | mRNA Sequence | Download Select all |
| Length | 1905 |
CDS Information
| Location | complement(<89665..90012) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS58363.1 |
Protein Information
| Protein ID | NP_001028731.1 |
|---|---|
| Protein Name | dyslexia susceptibility 1 candidate 1 |
| Molecular Wt. (Da) | 43900 |
| Protein Sequence | Download Select all |
| Length | 376 |
| Uniprot ID | Q14766 |
| Ensembl Protein ID | ENSP00000385359 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06469 | Oct-87 | p23_DYX1C1_like |
| cl00175 | Oct-87 | alpha-crystallin-Hsps_p23-like superfamily |
| cd06463 | Oct-86 | p23_like |
| pfam04969 | Aug-77 | CS |
| cd00298 | Oct-77 | ACD_sHsps_p23-like |
| cd06466 | Oct-86 | p23_CS_SGT1_like |
| cd06465 | Oct-83 | p23_hB-ind1_like |
| cd06467 | Aug-86 | p23_NUDC_like |
| cd06468 | May-86 | p23_CacyBP |
| pfam00515 | 367-399 | TPR_1 |
| cl22897 | 367-399 | TPR_1 superfamily |
| cd06489 | Oct-86 | p23_CS_hSgt1_like |
| cd06493 | Aug-86 | p23_NUDCD1_like |
| pfam13414 | 288-353 | TPR_11 |
| pfam13414 | 324-397 | TPR_11 |
| TIGR00990 | 276-396 | 3a0801s09 |
| PLN03088 | 293-398 | PLN03088 |
| TIGR00990 | 216-399 | 3a0801s09 |
Ontology Information
| HPRD ID | 3650 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.