Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| E2F4 | 1874 | E2F transcription factor 4, p107/p130-binding | 16 | E2F-4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24100580 | 2013 | Cell line : SW480 Source : - Sample Type : - No. of Sample : - Stage : - | Luciferase assays, Sequencing , soft-agar assays | Mutation | - | cancer-associated E2F4 mutations enhance the capacity of colorectal cancer cells to grow without Anchorage, thereby contributing to tumor. progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008] | Chromosome | 16 |
| Location | 16q22.1 |
| Start | 67226068 |
| End | 67232821 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6754 |
| OMIM ID | 600659 |
| HGNC ID | HGNC:3118 |
| Unigene ID | Hs.108371 |
| Ensembl ID | ENSG00000205250 |
| PharmGKB ID | PA27576 |
mRNA Information
| mRNA ID | NM_001950.3 |
|---|---|
| Exon | join(1..198,597..706,845..1006,1308..1351,2234..2295, 2522..2816,3618..3842,5435..5482,5703..5747,5844..6754) | mRNA Sequence | Download Select all |
| Length | 2100 |
Protein Information
| Protein ID | NP_001941.2 |
|---|---|
| Protein Name | E2F transcription factor 4, p107/p130-binding |
| Molecular Wt. (Da) | 43829 |
| Protein Sequence | Download Select all |
| Length | 413 |
| Uniprot ID | P54278 |
| Ensembl Protein ID | ENSP00000265849 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vitro;in vivo | 9244350 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vivo | 8657117 |
| 5933 | RBL1 | 312 | NP_002886.2 | in vitro;in vivo | 12 150 994 115 732 000 000 000 |
| 5934 | RBL2 | 1576 | NP_005602.3 | in vivo | 1 157 320 217 159 890 |
| 7027 | TFDP1 | 1792 | NP_009042.1 | in vitro | 10540350 |
| 9221 | NOLC1 | 3864 | AAH01883.1 | in vitro;in vivo | 8657117 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14660 | 95-198 | E2F_DD |
| cl22411 | 95-198 | E2F_DD superfamily |
| pfam02319 | 17-83 | E2F_TDP |
| cl03534 | 17-83 | E2F_TDP superfamily |
Ontology Information
| HPRD ID | 4025 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell adhesion (GO:0007155) |
Drug Information
No matching records could be found.