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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| E2F5 | 1875 | E2F transcription factor 5, p130-binding | 8 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26103003 | 2015 | Cell line : SW620, SW480, HCT116, HT29, LoVo,
LS174T. Source : Cell Bank of Type Culture Collection (Shanghai City, China) Sample Type : - No. of Sample : - Stage : - | Luciferase assays,Real time RT-PCR,Western blotting, Proliferation, cell cycle, apoptosis and cell invasion assays | Up-regulation | - | miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8q21.2 |
| Start | 86089619 |
| End | 86126753 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 37135 |
| OMIM ID | 600967 |
| HGNC ID | HGNC:3119 |
| Unigene ID | Hs.445758 |
| Ensembl ID | ENSG00000133740 |
| PharmGKB ID | PA27577 |
mRNA Information
| mRNA ID | XM_011517477.1 |
|---|---|
| Exon | join(1..599,25092..25201,26039..26200,29117..29165, 30370..30434) | mRNA Sequence | Download Select all |
| Length | 985 |
Protein Information
| Protein ID | XP_011515779.1 |
|---|---|
| Protein Name | E2F transcription factor 5, p130-binding |
| Molecular Wt. (Da) | 18863 |
| Protein Sequence | Download Select all |
| Length | 174 |
| Uniprot ID | P54821 |
| Ensembl Protein ID | ENSP00000239461 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo;yeast 2-hybrid | 776 080 412 789 259 |
| 4088 | SMAD3 | 4380 | NP_005893.1 | in vitro;in vivo | 12150994 |
| 5933 | RBL1 | 312 | NP_002886.2 | in vivo;yeast 2-hybrid | 7892279 |
| 5934 | RBL2 | 1576 | NP_005602.3 | in vivo | 11756542 |
| 7027 | TFDP1 | 1792 | NP_009042.1 | in vitro;in vivo | 7760804 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14660 | 128-232 | E2F_DD |
| cl22411 | 128-232 | E2F_DD superfamily |
| pfam02319 | 50-116 | E2F_TDP |
| cl03534 | 50-116 | E2F_TDP superfamily |
Ontology Information
| HPRD ID | 7517 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | DNA-directed DNA polymerase activity (GO:0003887) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.