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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EDA | 1896 | ectodysplasin A | X | EDA1, XLHED, HED, XHED, ED1-A1, ED1-A2, EDA-A1, EDA-A2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23811539 | 2013 | Cell line : SW480 Source : ATCC, Xian-Yi-Lina Biological Technology (China) Sample Type : CRC tumor and normal tissue No. of Sample : 105 CRC and 10 normal tissues Stage : - | ELISA,Immunohistochemistry, immunofluorescence microscopy,Flow cytometry ,Western blotting,Co-immunoprecipitation assay | Up-regulation | - | EDA is essential for the maintenance of the properties of CD133(+)/CD44(+) colon cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tumor necrosis factor (ligand) superfamily |
| Description | The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | X |
| Location | Xq12-q13.1 |
| Start | 68835911 |
| End | 69259322 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 423412 |
| OMIM ID | 300451 |
| HGNC ID | HGNC:3157 |
| Unigene ID | Hs.105407 |
| Ensembl ID | ENSG00000158813 |
| PharmGKB ID | PA27601 |
mRNA Information
| mRNA ID | NM_001399.4 |
|---|---|
| Exon | join(1..638,340961..341066,407152..407175,411791..411970, 413438..413472,414403..414454,417332..417462, 419292..423406) | mRNA Sequence | Download Select all |
| Length | 5296 |
Protein Information
| Protein ID | NP_001390.1 |
|---|---|
| Protein Name | ectodysplasin A |
| Molecular Wt. (Da) | 41163 |
| Protein Sequence | Download Select all |
| Length | 391 |
| Uniprot ID | P61218 |
| Ensembl Protein ID | ENSP00000403852 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 159 |
| R | Proteolytic Cleavage | 159 |
| R | Proteolytic Cleavage | 159 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60401 | EDA2R | 2230 | AAN73210.1 | in vitro | 1 103 993 512 270 930 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00229 | 272-385 | TNF |
| cl00147 | 272-385 | TNF superfamily |
| cd00184 | 249-383 | TNF |
Ontology Information
| HPRD ID | 1351 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Hydrolase activity (GO:0016787) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.