Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EED | 8726 | embryonic ectoderm development | 11 | WAIT-1, HEED |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23709348 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Genotyping,SNPs | Polymorhpism | - | Allele frequency of g.-1850G>C in the RC patient group was significantly different from that in the control group (p=0.04) and that g.-993G>C may play a role in the lymph node metastatic process of CRC. |
| 25326896 | 2015 | Cell line : - Source : Tumor Hospital of Harbin medical university, Harbin , China. Sample Type : CRC Tumor and normal tissue No. of Sample : 82 Stage : - | qRT-PCR | Up-regulation | - | High expression of EED, SUZ12 and EZH2 might contribute to the CRC development/progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q14.2-q2 |
| Start | 85955586 |
| End | 85989785 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 34200 |
| OMIM ID | 605984 |
| HGNC ID | HGNC:3188 |
| Unigene ID | Hs.503510 |
| Ensembl ID | ENSG00000074266 |
| PharmGKB ID | PA27624 |
Protein Information
| Protein ID | NP_001294936.1 |
|---|---|
| Protein Name | embryonic ectoderm development |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 441 |
| Uniprot ID | Q9H0M0 |
| Ensembl Protein ID | ENSP00000265428 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 25 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 34 |
| T | Phosphorylation | 55 |
| T | Phosphorylation | 57 |
| S | Phosphorylation | 34 |
| T | Phosphorylation | 55 |
| T | Phosphorylation | 57 |
| S | Phosphorylation | 43 |
| T | Phosphorylation | 50 |
| S | Phosphorylation | 43 |
| T | Phosphorylation | 50 |
| S | Phosphorylation | 46 |
| S | Phosphorylation | 46 |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 308 | ANXA5 | 568 | NP_001145.1 | yeast 2-hybrid | 9584197 |
| 2145 | EZH1 | 3397 | NP_001982.2 | in vitro;in vivo;yeast 2-hybrid | 9584197 |
| 2146 | EZH2 | 3342 | NP_004447.2 | in vitro;in vivo;yeast 2-hybrid | 9 584 197 105 810 390 000 000 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vitro;in vivo;yeast 2-hybrid | 10581039 |
| 3066 | HDAC2 | 5521 | NP_001518.2 | in vitro;in vivo;yeast 2-hybrid | 10581039 |
| 3676 | ITGA4 | 1894 | NP_000876.3 | in vitro;in vivo;yeast 2-hybrid | 9765275 |
| 3682 | ITGAE | 5249 | NP_002199.3 | yeast 2-hybrid | 9765275 |
| 3695 | ITGB7 | 948 | NP_000880.1 | in vitro;in vivo;yeast 2-hybrid | 9765275 |
| 5511 | PPP1R8 | 4028 | NP_054829.2 | in vitro;in vivo;yeast 2-hybrid | 12788942 |
| 7528 | YY1 | 2482 | NP_003394.1 | in vitro;in vivo | 11158321 |
| 8841 | HDAC3 | 8950 | NP_003874.2 | yeast 2-hybrid | 10581039 |
| 96764 | TGS1 | 7567 | NP_079107.6 | in vitro;yeast 2-hybrid | 12943661 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 150-438 | WD40 |
| cl02567 | 150-438 | WD40 superfamily |
| cd00200 | 81-264 | WD40 |
| cd00200 | 148-331 | WD40 |
| cd00200 | 232-438 | WD40 |
| pfam00400 | 180-219 | WD40 |
| smart00320 | 179-219 | WD40 |
| pfam00400 | 233-263 | WD40 |
| COG2319 | 79-440 | WD40 |
| COG2319 | 144-438 | WD40 |
| COG2319 | 89-230 | WD40 |
| PTZ00420 | 167-269 | PTZ00420 |
| PTZ00421 | 183-409 | PTZ00421 |
| pfam11715 | 204-300 | Nup160 |
Ontology Information
| HPRD ID | 7486 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Heat shock protein activity (GO:0003773) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.