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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EEF1D | 1936 | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 8 | EF-1D, FLJ20897 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23004678 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : LSCC 7 and RSCC 7 groups Stage : - | 2D electrophoresis coupled with MALDI-TOF-MS, Western blotting,Tissue microarray, immunohistochemistry. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010] | Chromosome | 8 |
| Location | 8q24 |
| Start | 144661867 |
| End | 144679845 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 17979 |
| OMIM ID | 130592 |
| HGNC ID | HGNC:3211 |
| Unigene ID | Hs.333388 |
| Ensembl ID | ENSG00000104529 |
| PharmGKB ID | PA27647 |
mRNA Information
| mRNA ID | NM_001289950.1 |
|---|---|
| Exon | join(1..328,10827..10947,11386..11457,16348..16447, 16522..16622,16949..17170,17470..17664,17846..17979) | mRNA Sequence | Download Select all |
| Length | 1273 |
Protein Information
| Protein ID | NP_001276879.1 |
|---|---|
| Protein Name | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) |
| Molecular Wt. (Da) | 30991 |
| Protein Sequence | Download Select all |
| Length | 281 |
| Uniprot ID | Q03181 |
| Ensembl Protein ID | ENSP00000310928 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 499 |
| S | Phosphorylation | 133 |
| S | Phosphorylation | 499;- |
| S | Phosphorylation | 133;- |
| T | Phosphorylation | 495;- |
| T | Phosphorylation | 129;- |
| S | Phosphorylation | 528;- |
| T | Phosphorylation | 513;- |
| S | Phosphorylation | 162;- |
| T | Phosphorylation | 147;- |
| S | Phosphorylation | 91 |
| S | Phosphorylation | 94 |
| S | Phosphorylation | 484 |
| S | Phosphorylation | 118 |
| S | Phosphorylation | 485 |
| S | Phosphorylation | 119 |
| S | Phosphorylation | 426 |
| S | Phosphorylation | 60 |
| K | Acetylation | 483 |
| K | Acetylation | 117 |
| K | Acetylation | 383 |
| K | Acetylation | 17 |
| K | Acetylation | 473 |
| K | Acetylation | 107 |
| S | Phosphorylation | 431 |
| S | Phosphorylation | 65 |
| S | Phosphorylation | 452 |
| S | Phosphorylation | 86 |
| T | Phosphorylation | 491 |
| T | Phosphorylation | 125 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1400 | CRMP1 | 3913 | NP_001014809.1 | yeast 2-hybrid | 16169070 |
| 1457 | CSNK2A1 | 277 | NP_001886.1 | in vitro | 10094407 |
| 2353 | FOS | 1275 | NP_005243.1 | in vivo;in vitro | 15867431 |
| 3735 | KARS | 3249 | AAG30114.1 | yeast 2-hybrid | 11829477 |
| 84164 | ASCC2 | 16515 | NP_115580.2 | yeast 2-hybrid | 16169070 |
| 118924 | C10orf4 | 12319 | NP_982264.2 | yeast 2-hybrid | 16169070 |
| 284004 | HEXDC | 8677 | NP_775891.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Herpes simplex infection | hsa05168 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00292 | 193-281 | EF1B |
| cl00194 | 193-281 | EF1B superfamily |
| pfam00736 | 195-281 | EF1_GNE |
| smart00888 | 195-281 | EF1_GNE |
| COG2092 | 193-281 | EFB1 |
| pfam10587 | 159-186 | EF-1_beta_acid |
| cl11209 | 159-186 | EF-1_beta_acid superfamily |
| TIGR00489 | 202-275 | aEF-1_beta |
Ontology Information
| HPRD ID | 4187 |
|---|---|
| Molecular Class | Guanine nucleotide exchange factor |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.