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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
EEF2 1938 eukaryotic translation elongation factor 2  19EEF-2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24589652   2014Cell line : SW480

Source : Osaka University Hospital and Osaka Rosai Hospital.

Sample Type : Serum samples

No. of Sample : 79 colorectal and 80 gastric cancer patients, 10 patients with head and neck squamous cell carcinoma (HNSCC) and 40 healthy individuals

Stage : -

Western blotting,Density gradient isoelectric focusing,MALDI-TOF mass spectrometry,ImmunohistochemistryUp-regulation- eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth.


Gene Details



NC_000019.9 (3976054..3985477, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19p13.3
Start 3976054  
End 3985477  
Strand -  
Gene Sequence

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Length 9424  
OMIM ID 130610   
HGNC ID HGNC:3214   
Unigene ID Hs.515070   
Ensembl ID ENSG00000167658   
PharmGKB ID PA27650   

mRNA Information


mRNA ID NM_001961.3
Exon join(1..86,1114..1328,2173..2354,2446..2657,3040..3218, 3412..3517,4012..4125,4485..4623,4755..4950,5398..5656, 6028..6135,7292..7645,7854..8036,8117..8249,8717..9408)  
mRNA Sequence

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Length 3163  



CDS Information


   
Location 84..2660
CDS Sequence

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CCDS ID CCDS12117.1



Protein Information


      
Protein IDNP_001952.1
Protein Nameeukaryotic translation elongation factor 2
Molecular Wt. (Da)95207
Protein Sequence

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Length 858  
Uniprot IDP37231
Ensembl Protein ID ENSP00000287820  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation502
HADP-Ribosylation715
TPhosphorylation54
TPhosphorylation57
TPhosphorylation59
TPhosphorylation57
TDephosphorylation57
TPhosphorylation59
TDephosphorylation59
TDephosphorylation57
CS-Nitrosylation567
YPhosphorylation373;-
TPhosphorylation57;-
TPhosphorylation435;-
SPhosphorylation48
KAcetylation445
KAcetylation239
KAcetylation275
KAcetylation272
KAcetylation857
KAcetylation235
KAcetylation318
DProteolytic Cleavage130
SPhosphorylation399
YPhosphorylation443
SPhosphorylation623
TPhosphorylation724

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
AMPK signaling pathway hsa04152
Oxytocin signaling pathway hsa04921


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0188520-233  EF2
cl2145520-233  P-loop_NTPase superfamily
cd01681574-746  aeEF2_snRNP_like_IV
cl02789574-746  EFG_like_IV superfamily
cd04096742-821  eEF2_snRNP_like_C
cl02785742-821  Elongation_Factor_C superfamily
cd03700394-487  eEF2_snRNP_like_II
cl02787394-487  Translation_Factor_II_like superfamily
cd01683574-747  EF2_IV_snRNP
pfam0000918-221  GTP_EFTU
cd0416720-232  Snu114p
cd0088121-224  GTP_translation_factor
pfam03764623-737  EFG_IV
cd0189020-161  LepA
cd0189118-162  TypA_BipA
cd04098742-821  eEF2_C_snRNP
cd0188621-162  EF-G
smart00889625-737  EFG_IV
cd01514742-821  Elongation_Factor_C
cd0416821-163  TetM_like
pfam00679739-827  EFG_C
cd04090394-487  eEF2_II_snRNP
smart00838740-826  EFG_C
cd0417021-163  EF-G_bact
cd0416920-162  RF3
cd03713742-821  EFG_mtEFG_C
pfam14492503-565  EFG_II
cl20541503-565  EFG_II superfamily
cd01680658-736  EFG_like_IV
cd04097742-808  mtEFG1_C
cd0417127-163  SelB
cd01342394-487  Translation_Factor_II_like
cd0188921-161  SelB_euk
cd0188421-161  EF_Tu
cd0188321-134  EF1_alpha
pfam03144410-480  GTP_EFTU_D2
cd0188821-161  eIF2_gamma
cd03711742-821  Tet_C
cd0188724-194  IF2_eIF5B
cd0088224-162  Ras_like_GTPase
cd0416627-161  CysN_ATPS
cd03698393-485  eRF3_II_like
cd04088412-487  EFG_mtEFG_II
pfam0192631-159  MMR_HSR1
PTZ004161-858  PTZ00416
PLN001161-858  PLN00116
PRK075605-856  PRK07560
COG04809-844  FusA
TIGR004906-845  aEF-2
PRK1335118-822  PRK13351
PRK1274025-823  PRK12740
TIGR0048417-843  EF-G
PRK1273918-821  PRK12739
PRK0000720-821  PRK00007
TIGR0139317-161  lepA
PRK0543313-161  PRK05433
COG048113-161  LepA
TIGR0139419-162  TypA_BipA
COG121718-162  TypA
PRK1021818-162  PRK10218
COG410820-162  PrfC
TIGR0050320-162  prfC
PRK0074120-162  prfC
TIGR0023119-161  small_GTP
COG525612-161  TEF1
COG005021-161  TufB
TIGR0047527-196  selB
COG327626-163  SelB
PLN031264-162  PLN03126
PRK1231713-141  PRK12317
PTZ0014113-134  PTZ00141
TIGR0048313-193  EF-1_alpha
TIGR0048723-162  IF-2
TIGR0368021-161  eif2g_arch
CHL0018923-163  infB
COG525721-161  GCD11
PLN0312721-161  PLN03127
TIGR0048521-161  EF-Tu
PRK1273521-161  PRK12735
PRK1273621-161  PRK12736
COG053224-162  InfB
TIGR0049122-162  aIF-2
PRK0004921-161  PRK00049
PRK0400021-130  PRK04000
CHL0007110-161  tufA
PLN0004321-134  PLN00043
COG289513-161  CysN


Ontology Information


   
HPRD ID4298
Molecular ClassTranslation regulatory protein
Molecular FunctionPhosphatase regulator activity (GO:0019208)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO