Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EFEMP2 | 30008 | EGF containing fibulin-like extracellular matrix protein 2 | 11 | FBLN4, UPH1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22506683 | 2012 | Cell line : - Source : Sir Run Run Shaw Hospital of Zhejiang University Sample Type : CRC tumor, Blood and healthy sample No. of Sample : 9 CRC Tissues and Paired NC Tissues, 123 paraffin-embedded tissue samples including 88 CRC tissues, 19 colorectal adenoma tissues, and 16 distal NC tissues, blood samples from 79 healthy individuals, 14 individuals with colorectal adenoma, and 122 patients with CRC. Stage : - | Gel Electrophoresis, Nano LC-MS/MS, western blotting, Immunohistochemistry, ELISA | Up-regulation | - | EFEMP2 is a promising serum biomarker for CRC early detection. Expression level of EFEMP2 was dramatically increased in CRC patients, even at the early stage. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fibulins |
| Description | A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. | Chromosome | 11 |
| Location | 11q13 |
| Start | 65866441 |
| End | 65872934 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6494 |
| OMIM ID | 604633 |
| HGNC ID | HGNC:3219 |
| Unigene ID | Hs.731454 |
| Ensembl ID | ENSG00000172638 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_025128.4 |
|---|---|
| Exon | complement(<6492..>6494) | mRNA Sequence | Download Select all |
| Length | 2096 |
CDS Information
| Location | join(581..691,917..965,1572..1778,2277..2399,2698..2814, 2959..3078,4306..4425,4514..4640,4879..5074,5856..6017) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8116.1 |
Protein Information
| Protein ID | NP_058634.4 |
|---|---|
| Protein Name | EGF containing fibulin-like extracellular matrix protein 2 |
| Molecular Wt. (Da) | 46855 |
| Protein Sequence | Download Select all |
| Length | 443 |
| Uniprot ID | P08727 |
| Ensembl Protein ID | ENSP00000355124 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3087 | HHEX | 6829 | NP_002720.1 | yeast 2-hybrid | 16189514 |
| 5359 | PLSCR1 | 8855 | NP_066928.1 | yeast 2-hybrid | 16189514 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 10380882 |
| 8812 | CCNK | 10352 | NP_001092872.1 | yeast 2-hybrid | 16189514 |
| 9747 | FAM115A | 13813 | NP_055534.1 | yeast 2-hybrid | 16189514 |
| 10539 | GLRX3 | 10153 | NP_006532.2 | yeast 2-hybrid | 16189514 |
| 11170 | FAM107A | 9753 | NP_009108.1 | yeast 2-hybrid | 16189514 |
| 26150 | RIBC2 | 11493 | NP_056468.2 | yeast 2-hybrid | 16189514 |
| 27301 | APEX2 | 6442 | NP_055296.2 | yeast 2-hybrid | 16189514 |
| 27332 | ZNF638 | 11736 | NP_055312.2 | yeast 2-hybrid | 16189514 |
| 29979 | UBQLN1 | 5440 | NP_038466.2 | yeast 2-hybrid | 1 618 951 416 713 560 |
| 54557 | SGTB | 18049 | NP_061945.1 | yeast 2-hybrid | 16189514 |
| 55367 | LRDD | 11284 | NP_665893.2 | yeast 2-hybrid | 16189514 |
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
| 57088 | PLSCR4 | 7401 | NP_065086.2 | yeast 2-hybrid | 16189514 |
| 79088 | ZNF426 | 15787 | NP_077011.1 | yeast 2-hybrid | 16189514 |
| 79843 | FAM124B | 8663 | NP_001116251.1 | yeast 2-hybrid | 16189514 |
| 84894 | LINGO1 | 14322 | NP_116197.4 | yeast 2-hybrid | 16189514 |
| 114822 | RHPN1 | 17973 | NP_443156.2 | yeast 2-hybrid | 16189514 |
| 117144 | CATSPER1 | 9396 | NP_444282.3 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00054 | 123-163 | EGF_CA |
| cl21504 | 123-163 | EGF_CA superfamily |
| smart00179 | 123-163 | EGF_CA |
| pfam07645 | 123-161 | EGF_CA |
| smart00179 | 164-197 | EGF_CA |
| cl21504 | 164-197 | EGF_CA superfamily |
| pfam12662 | 183-206 | cEGF |
| pfam14670 | 173-201 | FXa_inhibition |
| cd01475 | 162-200 | vWA_Matrilin |
| cl00057 | 162-200 | vWFA superfamily |
| cd01475 | 241-276 | vWA_Matrilin |
| cl00057 | 241-276 | vWFA superfamily |
| cd01475 | 198-238 | vWA_Matrilin |
| cl00057 | 198-238 | vWFA superfamily |
| cd01475 | 121-155 | vWA_Matrilin |
| cl00057 | 121-155 | vWFA superfamily |
| pfam07645 | 283-310 | EGF_CA |
| cl21504 | 283-310 | EGF_CA superfamily |
| cd00054 | 164-194 | EGF_CA |
| pfam12662 | 224-246 | cEGF |
| cl21504 | 224-246 | EGF_CA superfamily |
| smart00179 | 243-274 | EGF_CA |
| cl21504 | 243-274 | EGF_CA superfamily |
| cd00054 | 203-236 | EGF_CA |
| smart00179 | 203-237 | EGF_CA |
| pfam14670 | 213-241 | FXa_inhibition |
| cd00054 | 243-275 | EGF_CA |
| smart00179 | 283-310 | EGF_CA |
Ontology Information
| HPRD ID | 1125 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.