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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EIF3I | 8668 | eukaryotic translation initiation factor 3, subunit I | 1 | TRIP-1, eIF3-beta, eIF3-p36, eIF3i |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24056964 | 2014 | Cell line : - Source : IUSCC Tissue Procurement and Distribution Core at Indiana University School of Medicine, Indianapolis, IN Sample Type : Frozen and paraffin embedded surgical specimens No. of Sample : - Stage : - | real-time RT-PCR, luciferase reporter assay,Colony formation, anchorage-independent growth, and xenograft tumor formation assays,RNA/protein pull-down assay,EMSA | Up-regulation | - | Found that eIF3i expression was upregulated in both human colon adenocarcinoma and adenoma polyps as well as in model inducible colon tumorigenic cell lines. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | - | Chromosome | 1 |
| Location | 1p34.1 |
| Start | 32687971 |
| End | 32697205 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 9235 |
| OMIM ID | 603911 |
| HGNC ID | HGNC:3272 |
| Unigene ID | Hs.530096 |
| Ensembl ID | ENSG00000084623 |
| PharmGKB ID | PA162384875 |
Protein Information
| Protein ID | NP_003748.1 |
|---|---|
| Protein Name | eukaryotic translation initiation factor 3, subunit I |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 325 |
| Uniprot ID | Q16891 |
| Ensembl Protein ID | ENSP00000387262 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 308;- |
| Y | Phosphorylation | 308;- |
| K | Acetylation | 264 |
| S | Phosphorylation | 207 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1981 | EIF4G1 | 6774 | NP_886553.2 | in vivo | 16541103 |
| 2099 | ESR1 | 589 | NP_000116.2 | yeast 2-hybrid | 10706629 |
| 7040 | TGFB1 | 1821 | NP_000651.3 | in vitro;in vivo | 9813058 |
| 7048 | TGFBR2 | 1823 | NP_001020018.1 | in vitro;in vivo | 756 615 611 781 097 |
| 8661 | EIF3A | 3618 | NP_003741.1 | in vivo | 8995409 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| RNA transport | hsa03013 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 6-311 | WD40 |
| cl02567 | 6-311 | WD40 superfamily |
| cd00200 | 45-311 | WD40 |
| cd00200 | 6-216 | WD40 |
| cd00200 | May-80 | WD40 |
| cd00200 | 184-312 | WD40 |
| pfam00400 | 42-80 | WD40 |
| smart00320 | 41-80 | WD40 |
| pfam00400 | 282-311 | WD40 |
| smart00320 | 282-312 | WD40 |
| pfam00400 | 178-216 | WD40 |
| smart00320 | 177-216 | WD40 |
| COG2319 | 6-311 | WD40 |
| COG2319 | 1-311 | WD40 |
| COG2319 | 2-240 | WD40 |
| COG2319 | Jan-83 | WD40 |
| PLN00181 | 31-216 | PLN00181 |
Ontology Information
| HPRD ID | 15624 |
|---|---|
| Molecular Class | Translation regulatory protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.