Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ELANE | 1991 | elastase, neutrophil expressed | 19 | NE, HNE, HLE |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24457622 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Western blotting and tumor inhibition assay | Up-regulation | - | NE is not only as a putative diagnostic biomarker of CRC, but also a potential therapeutic target for patients suffered with CRC. More infiltrated neutrophils and an increased NE expression were detected in the cancerous tissues compared to the normal tissues. The serum NE concentration in CRC patients was statistically higher than that in the healthy controls. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. | Chromosome | 19 |
| Location | 19p13.3 |
| Start | 850997 |
| End | 856250 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5254 |
| OMIM ID | 130130 |
| HGNC ID | HGNC:3309 |
| Unigene ID | Hs.99863 |
| Ensembl ID | ENSG00000197561 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011527775.1 |
|---|---|
| Exon | join(1..677,1213..1399,1880..2036,2266..2407,4568..4798, 4962..5254) | mRNA Sequence | Download Select all |
| Length | 938 |
CDS Information
| Location | join(1333..1399,1880..2036,2266..2407,4568..4798, 4962..5168) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12045.1 |
Protein Information
| Protein ID | NP_001963.1 |
|---|---|
| Protein Name | elastase, neutrophil expressed |
| Molecular Wt. (Da) | 23295 |
| Protein Sequence | Download Select all |
| Length | 267 |
| Uniprot ID | P09211 |
| Ensembl Protein ID | ENSP00000381607 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 3.4.21.37 |
|---|---|
| Name | leukocyte elastase lysosomal elastase neutrophil elastase polymorphonuclear leukocyte elastase elastase elaszym serine elastase lysosomal elastase granulocyte elastase |
| Class | Hydrolases; Acting on peptide bonds (peptidases); Serine endopeptidases |
| Sysname | |
| Substrate | |
| Product | |
| Reaction (IUBMB) |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 12 | SERPINA3 | 120 | NP_001076.2 | in vitro | 87 188 498 011 628 |
| 820 | CAMP | 2722 | NP_004336.2 | in vitro | 11389039 |
| 1440 | CSF3 | 736 | NP_000750.1 | in vitro | 14587040 |
| 1441 | CSF3R | 737 | NP_724781.1 | in vitro | 14587040 |
| 2149 | F2R | 1763 | NP_001983.2 | in vitro | 10978167 |
| 2150 | F2RL1 | 2960 | NP_005233.3 | in vitro | 10978167 |
| 2153 | F5 | 1964 | NP_000121.2 | in vitro | 9242537 |
| 3053 | SERPIND1 | 795 | NP_000176.2 | in vitro;in vivo | 2318847 |
| 4018 | LPA | 1063 | NP_005568.2 | in vitro | 88 649 639 111 002 |
| 5345 | SERPINF2 | 2029 | NP_000925.2 | in vitro | 24 371 126 980 881 |
| 6387 | CXCL12 | 2904 | NP_001029058.1 | in vitro | 12068293 |
| 6590 | SLPI | 121 | NP_003055.1 | in vitro | 10702419 |
| 7035 | TFPI | 1064 | NP_006278.1 | in vitro | 15 589 671 211 741 800 000 000 |
| 7412 | VCAM1 | 1888 | NP_001069.1 | in vitro | 11520773 |
| 7852 | CXCR4 | 1217 | NP_001008540.1 | in vitro | 12531874 |
| 8565 | YARS | 9153 | NP_003671.1 | in vitro | 10102815 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Systemic lupus erythematosus | hsa05322 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
| PDB ID | 1B0F |
|---|---|
| Resolution | 3 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | PROTEIN (ELASTASE) |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 30-245 | Tryp_SPc |
| cl21584 | 30-245 | Tryp_SPc superfamily |
| smart00020 | 29-242 | Tryp_SPc |
| pfam00089 | 30-242 | Trypsin |
| COG5640 | 10-243 | COG5640 |
Ontology Information
| HPRD ID | 1804 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P08246 | DB00019 | Pegfilgrastim | BiotechDrug |
| P08246 | DB00058 | Alpha-1-proteinase inhibitor | BiotechDrug |
| P08246 | DB00099 | Filgrastim | BiotechDrug |