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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24393480 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissue No. of Sample : - Stage : - | Illumina bead chip array, methylation-specific PCR | Methylation | - | hypermethylated genes AKR1B1, CHST10, ELOVL4, SOX5, STK33, and ZNF304 may be potential methylation biomarkers and therapeutic targets of vincristine in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6q14 |
| Start | 80624529 |
| End | 80657315 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 32787 |
| OMIM ID | 605512 |
| HGNC ID | HGNC:14415 |
| Unigene ID | Hs.101915 |
| Ensembl ID | ENSG00000118402 |
| PharmGKB ID | PA27763 |
mRNA Information
| mRNA ID | ?NM_022726.3 |
|---|---|
| Exon | join(1..419,21218..21405,22567..22647,25803..25974, 28052..28179,30716..32787) | mRNA Sequence | Download Select all |
| Length | 3085 |
Protein Information
| Protein ID | NP_073563.1 |
|---|---|
| Protein Name | ELOVL fatty acid elongase 4 |
| Molecular Wt. (Da) | 86112 |
| Protein Sequence | Download Select all |
| Length | 314 |
| Uniprot ID | P78417 |
| Ensembl Protein ID | ENSP00000358724 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Fatty acid elongation | hsa00062 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01151 | 41-278 | ELO |
| cl03120 | 41-278 | ELO superfamily |
| PTZ00251 | 123-279 | PTZ00251 |
Ontology Information
| HPRD ID | 5235 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9GZR5 | DB00132 | Alpha-Linolenic Acid | SmallMoleculeDrug |