Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EML4 | 27436 | echinoderm microtubule associated protein like 4 | 2 | ROPP120, ELP120 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19737969 | 2009 | Cell line : - Source : Genentech's Human Tissue Bank. Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 83 Stage : - | Exon Array, RT-PCR, FISH | Gene Fusion | - | Recurrence of EML4-ALK fusion in multiple solid tumors and further substantiate its role in tumorigenesis. |
| 24200637 | 2013 | Cell line : - Source : ILSbio (Chestertown, Oncogenic driver genes in CRC and NSCLC 331 MD) and Asterand (Detroit, MI). Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 61 CRC and 6 normal colon Stage : Stage I-III | DNA Sequencing,FISH,Sanger sequencing | Gene Fusion | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015] | Chromosome | 2 |
| Location | 2p21 |
| Start | 42396490 |
| End | 42559688 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 163199 |
| OMIM ID | 607442 |
| HGNC ID | HGNC:1316 |
| Unigene ID | Hs.713173 |
| Ensembl ID | ENSG00000143924 |
| PharmGKB ID | PA27769 |
Protein Information
| Protein ID | NP_001138548.1 |
|---|---|
| Protein Name | echinoderm microtubule associated protein like 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 981 |
| Uniprot ID | Q8IX12 |
| Ensembl Protein ID | ENSP00000265872 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 899 |
| Y | Phosphorylation | 226;- |
| S | Phosphorylation | 146;- |
| Y | Phosphorylation | 226;- |
| S | Phosphorylation | 144;- |
| T | Phosphorylation | 897;- |
| S | Phosphorylation | 895;- |
| S | Phosphorylation | 87;- |
| S | Phosphorylation | 138;- |
| S | Phosphorylation | 134;- |
| T | Phosphorylation | 889 |
| S | Phosphorylation | 903 |
| T | Phosphorylation | 909 |
| S | Phosphorylation | 919 |
| S | Phosphorylation | 938 |
| T | Phosphorylation | 921 |
| S | Phosphorylation | 934 |
| S | Phosphorylation | 942 |
| S | Phosphorylation | 946 |
| S | Phosphorylation | 978 |
| S | Phosphorylation | 981 |
| T | Phosphorylation | 201 |
| S | Phosphorylation | 16 |
| S | Phosphorylation | 980 |
| S | Phosphorylation | 150 |
| S | Phosphorylation | 200 |
| S | Phosphorylation | 7 |
| T | Phosphorylation | 17 |
| S | Phosphorylation | 11 |
| S | Phosphorylation | 13 |
| S | Phosphorylation | 61 |
| S | Phosphorylation | 176 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Non-small cell lung cancer | hsa05223 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03451 | 223-298 | HELP |
| cl04081 | 223-298 | HELP superfamily |
| cd00200 | 502-863 | WD40 |
| cl02567 | 502-863 | WD40 superfamily |
| cd00200 | 456-749 | WD40 |
| cd00200 | 303-656 | WD40 |
| cl02567 | 303-656 | WD40 superfamily |
| cd00200 | 294-620 | WD40 |
| cd00200 | 587-864 | WD40 |
| pfam00400 | 717-749 | WD40 |
| smart00320 | 717-749 | WD40 |
| pfam00400 | 589-620 | WD40 |
| smart00320 | 589-620 | WD40 |
| pfam00400 | 302-347 | WD40 |
| pfam00400 | 826-863 | WD40 |
| COG2319 | 280-742 | WD40 |
| COG2319 | 502-864 | WD40 |
| COG2319 | 711-864 | WD40 |
| PTZ00420 | 690-752 | PTZ00420 |
Ontology Information
| HPRD ID | 11054 |
|---|---|
| Molecular Class | Structural protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.