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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26097998 | 2015 | Cell line : HCT116 cells Source : - Sample Type : - No. of Sample : - Stage : - | 2Dl protein electrophoresis and mass spectrometry assays (2DE-MS), western blotting and immunohistochemistry | Up-regulation | - | Enolase 1 (ENO1) possesses oncogenic activity and is often overexpressed in various human cancers |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011] | Chromosome | 1 |
| Location | 1p36.2 |
| Start | 8921059 |
| End | 8939151 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 18093 |
| OMIM ID | 172430 |
| HGNC ID | HGNC:3350 |
| Unigene ID | Hs.517145 |
| Ensembl ID | ENSG00000074800 |
| PharmGKB ID | PA27786 |
mRNA Information
| mRNA ID | NM_001428.3 |
|---|---|
| Exon | join(1..513,4176..4269,7107..7202,8583..8641,11036..11105, 11843..11976,12592..12814,13611..13808,15001..15202, 15750..15858,16148..16206,17664..18093) | mRNA Sequence | Download Select all |
| Length | 2204 |
Protein Information
| Protein ID | NP_001419.1 |
|---|---|
| Protein Name | enolase 1, (alpha) |
| Molecular Wt. (Da) | 47038 |
| Protein Sequence | Download Select all |
| Length | 434 |
| Uniprot ID | P54646 |
| Ensembl Protein ID | ENSP00000360290 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 44 |
| Y | Phosphorylation | 287;- |
| S | Phosphorylation | 263;- |
| Y | Phosphorylation | 287;- |
| S | Phosphorylation | 254 |
| Y | Phosphorylation | 57 |
| T | Phosphorylation | 72 |
| K | Acetylation | 71 |
| K | Acetylation | 89 |
| K | Acetylation | 5 |
| K | Acetylation | 64 |
| K | Acetylation | 228 |
| K | Acetylation | 233 |
| K | Acetylation | 285 |
| K | Acetylation | 281 |
| K | Acetylation | 256 |
| K | Acetylation | 193 |
| K | Acetylation | 126 |
| K | Acetylation | 406 |
| K | Acetylation | 60 |
| K | Acetylation | 420 |
| K | Acetylation | 199 |
| K | Acetylation | 221 |
| K | Acetylation | 80 |
| K | Acetylation | 343 |
| S | Phosphorylation | 419 |
| S | Phosphorylation | 27 |
| A | Proteolytic Cleavage | 34 |
| T | Phosphorylation | 100 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 23287 | AGTPBP1 | 8442 | NP_056054.2 | yeast 2-hybrid | 16713569 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Biosynthesis of amino acids | hsa01230 |
| Carbon metabolism | hsa01200 |
| Glycolysis / Gluconeogenesis | hsa00010 |
| HIF-1 signaling pathway | hsa04066 |
| Metabolic pathways | hsa01100 |
| RNA degradation | hsa03018 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03313 | 5-416 | enolase |
| cl21457 | 5-416 | TIM_phosphate_binding superfamily |
| pfam03952 | 3-134 | Enolase_N |
| cl17709 | 3-134 | Enolase_N superfamily |
| cd00308 | 266-388 | enolase_like |
| cd03315 | 266-370 | MLE_like |
| pfam13378 | 322-369 | MR_MLE_C |
| cl15764 | 322-369 | MR_MLE_C superfamily |
| PLN00191 | 2-432 | PLN00191 |
| PTZ00081 | 1-427 | PTZ00081 |
| PRK00077 | 1-433 | eno |
| COG0148 | 1-428 | Eno |
| pfam00113 | 142-432 | Enolase_C |
| TIGR01060 | 3-432 | eno |
| PRK08350 | 16-148 | PRK08350 |
| TIGR01928 | 286-369 | menC_lowGC/arch |
Ontology Information
| HPRD ID | 2105 |
|---|---|
| Molecular Class | Enzyme: Hydratase |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.