CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
10700188	2000	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Mutation	-	EP300 is mutated in epithelial cancers and Provide the first evidence that it behaves as a classical tumour-suppressor gene.
12385008	2002	Cell line : HCT116, HT29, LIM2405, LIM2412 Source : Provided by Dr.Wayne Phillips (Peter MacCallum Cancer Institute, Melbourne, Australia). Sample Type : Colon cancer and normal DNAs No. of Sample : 33 Stage : -	PCR,MSI analysis,SSCP,Western blotting	Mutation	-	Mutations in 4 colon cancer cell lines (HCT116, HT29, LIM2405 and LIM2412)ware found. Silencing of EP300 may be achieved by epigenetic mechanisms such as promoter methylation.
23759652	2013	Cell line : - Source : Korean Patient Sample Type : population based case-control study No. of Sample : 101 Stage : TNM Stage I-IV	SSCP,Immunohistochemistry , PCR	Mutation	-	E1A-binding protein p300 frameshift mutations (4 in exon 27 and 3 in exon 31) in 3 gastric and 4 colorectal cancers that were detected exclusively in cancers with high microsatellite instability

Gene Details

NC_000022.10 (41488614..41576081)
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Gene Type	protein coding
Gene Family	Chromatin-modifying enzymes / K-acetyltransferases
Description	This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Chromosome	22
Location	22q13.2
Start	41488614
End	41576081
Strand	+
Gene Sequence	Download   Select all
Length	87468
OMIM ID	602700
HGNC ID	HGNC:3373
Unigene ID	Hs.517517
Ensembl ID	ENSG00000100393
PharmGKB ID	PA27807

mRNA Information

mRNA ID	NM_001429.3
Exon	join(1..489,24578..25212,33255..33431,34878..35139, 37281..37394,38779..39024,43204..43297,45044..45181, 47531..47648,48439..48613,54130..54207,55228..55337, 56429..56566,57152..57589,59224..59403,59597..59741, 62386..62504,64560..64799,65803..65891,68033..68113, 70114..70170,71444..71521,73990..74057,75840..75990, 76112..76258,76894..77007,77797..77962,79890..80054, 81014..81175,83638..83919,84164..87468)
mRNA Sequence	Download   Select all
Length	8761

CDS Information

   

Location	396..7640
CDS Sequence	Download   Select all
CCDS ID	CCDS14010.1

Protein Information

      

Protein ID	NP_001420.2
Protein Name	E1A binding protein p300
Molecular Wt. (Da)	264031
Protein Sequence	Download   Select all
Length	2414
Uniprot ID	P17252
Ensembl Protein ID	ENSP00000408695

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	89
K	Acetylation	1473
K	Acetylation	1499
K	Acetylation	1542
K	Acetylation	1546
K	Acetylation	1549
K	Acetylation	1550
K	Acetylation	1551
K	Acetylation	1554
K	Acetylation	1555
K	Acetylation	1558
K	Acetylation	1560
K	Acetylation	1637
K	Sumoylation	1020
K	Sumoylation	1024
K	Deacetylation	1020
K	Deacetylation	1024
S	Phosphorylation	1834
T	Phosphorylation	885
S	Phosphorylation	1037
S	Phosphorylation	1038
S	Phosphorylation	285
T	Phosphorylation	887
T	Phosphorylation	1857
T	Phosphorylation	1859
K	Acetylation	1674
K	Acetylation	636
K	Acetylation	1103
K	Acetylation	1583
K	Acetylation	1590
K	Acetylation	977
K	Acetylation	981
K	Acetylation	291
K	Acetylation	1570
K	Acetylation	1528

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
25	ABL1	1809	NP_009297.2	in vivo	16648821
328	APEX1	136	NP_542380.1	in vitro;in vivo	14633989
595	CCND1	1346	NP_444284.1	in vitro	11788592
672	BRCA1	218	NP_009231.2	in vitro;in vivo	10655477
688	KLF5	4212	NP_001721.2	in vitro;in vivo	14612398
864	RUNX3	2565	AAH13362.1	in vivo	15138260
1045	CDX2	2622	NP_001256.2	in vitro;in vivo	10506141
1051	CEBPB	1801	NP_005185.2	in vitro;in vivo	9343424
1108	CHD4	4472	AAH38596.1	in vitro	15189737
1387	CREBBP	2534	NP_004371.2	in vitro	9267036
1840	DTX1	3991	NP_004407.2	in vivo	11564735
1958	EGR1	549	NP_001955.1	in vivo;yeast 2-hybrid	9806899
2002	ELK1	2407	NP_005220.2	in vitro;in vivo	12514134
2099	ESR1	589	NP_000116.2	in vitro;in vivo	11782371
2113	ETS1	1260	NP_001137292.1	in vitro	10942770
2114	ETS2	1263	NP_005230.1	in vitro	10942770
2115	ETV1	2765	NP_004947.2	in vitro;in vivo	12917345
2237	FEN1	2670	NP_004102.1	in vitro;in vivo	11430825
2551	GABPA	11793	NP_002031.2	in vitro	9990060
2956	MSH6	7202	NP_000170.1	in vitro;in vivo	16051665
3150	HMGN1	1231	NP_004956.5	in vitro;in vivo	10753971
3151	HMGN2	1230	NP_005508.1	in vitro;in vivo	1   020   707   010   753   970
3164	NR4A1	744	NP_002126.2	in vitro	12082103
3214	HOXB4	7032	NP_076920.1	in vitro;in vivo	11585930
3621	ING1	3337	NP_005528.3	in vivo	12015309
3622	ING2	5021	NP_001555.1	in vitro;in vivo	1   602   479   916   782   090
3661	IRF3	4769	NP_001562.1	in vitro	9488451
3665	IRF7	5441	NP_004022.2	in vitro	12604599
3725	JUN	1302	NP_002219.1	in vitro;in vivo	11689449
3838	KPNA2	2818	NP_002257.1	in vivo	10801418
4086	SMAD1	3356	NP_005891.1	in vitro;in vivo	10673036
4087	SMAD2	3221	NP_005892.1	in vivo	1   126   418   211   371   640
4088	SMAD3	4380	NP_005893.1	in vivo;yeast 2-hybrid	10497242
4094	MAF	1518	NP_005351.2	in vivo;yeast 2-hybrid	11943779
4193	MDM2	1272	NP_002383.2	in vitro	9809062
4205	MEF2A	2807	NP_005578.2	in vivo	12371907
4255	MGMT	1135	NP_002403.2	in vivo	11564893
4330	MN1	8862	NP_002421.3	in vitro	12569362
4350	MPG	6766	NP_002425.2	in vitro	14761960
4435	CITED1	2146	NP_001138357.1	in vitro;in vivo	10722728
4602	MYB	1810	NP_001123645.1	in vitro;in vivo	10656693
4605	MYBL2	3247	NP_002457.1	in vivo	11733503
4654	MYOD1	1166	NP_002469.2	in vitro;in vivo	900   125   410   944   526
4676	NAP1L4	11873	NP_005960.1	in vitro;in vivo	11073993
4760	NEUROD1	3428	NP_002491.2	in vitro	10545951
4773	NFATC2	2730	NP_775114.1	in vitro;in vivo	9625762
4928	NUP98	3012	NP_057404.2	in vitro;in vivo	9858599
5080	PAX6	6167	NP_001595.2	in vitro;in vivo	10506141
5111	PCNA	1456	NP_002583.1	in vitro;in vivo	11268218
5371	PML	23	NP_150241.2	in vitro	11940591
5454	POU3F2	2734	NP_005595.2	in vitro;yeast 2-hybrid	11029584
5465	PPARA	1369	NP_001001930.1	in vitro;yeast 2-hybrid	9407140
5467	PPARD	2679	NP_006229.1	in vitro	10567538
5629	PROX1	3330	NP_002754.2	in vivo;yeast 2-hybrid	11943779
5757	PTMA	1778	NP_001092755.1	in vitro;in vivo	11967287
5886	RAD23A	7191	NP_005044.1	in vitro;yeast 2-hybrid	11196199
5901	RAN	3109	NP_006316.1	in vitro;in vivo;yeast 2-hybrid	12649209
5970	RELA	1241	NP_068810.3	in vitro;in vivo;yeast 2-hybrid	9   096   323   124   198   060   000   000   000   000   000
6095	RORA	2896	NP_599022.1	in vitro;in vivo	9862959
6418	SET	9023	NP_001116293.1	in vitro;in vivo	11073993
6662	SOX9	6427	NP_000337.1	in vitro;in vivo	12732631
6721	SREBF2	2726	NP_004590.2	in vitro;in vivo	8918891
6760	SS18	2559	AAK21314.1	in vivo	11030627
6774	STAT3	26	NP_644805.1	in vitro;in vivo	1   020   505   415   649   880
6776	STAT5A	3301	NP_003143.2	in vitro;in vivo	998   950   314   726   487
6777	STAT5B	5037	NP_036580.2	in vitro;in vivo	998   950   314   726   487
6778	STAT6	3302	NP_003144.3	in vitro	10454341
6839	SUV39H1	2221	NP_003164.1	in vitro	11252719
6886	TAL1	1753	NP_003180.1	in vitro;in vivo	10490830
6927	HNF1A	800	NP_000536.5	in vitro;in vivo	11978637
6929	TCF3	918	NP_003191.1	in vitro;in vivo	12435739
6996	TDG	3251	NP_003202.3	in vitro;in vivo	11864601
7020	TFAP2A	128	NP_003211.1	in vivo;yeast 2-hybrid	12586840
7157	TP53	1859	NP_000537.3	in vitro;in vivo	164   389   821   272   431   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000
7158	TP53BP1	5569	NP_001135452.1	in vivo	16051665
7161	TP73	3587	NP_005418.1	in vivo	1   064   861   611   804   590
7251	TSG101	3229	NP_006283.1	in vitro;in vivo	10440698
7291	TWIST1	3374	NP_000465.1	in vitro;in vivo	10025406
7392	USF2	2668	NP_003358.1	in vivo	10434034
7528	YY1	2482	NP_003394.1	in vivo	7758944
7704	ZBTB16	11762	NP_005997.2	in vitro;in vivo	15964811
7709	ZBTB17	4968	NP_003434.2	in vitro	12840021
8092	ALX1	3316	NP_008913.2	in vitro;in vivo;yeast 2-hybrid	12929931
8202	NCOA3	3570	NP_858045.1	in vitro	9267036
8626	TP63	4469	NP_003713.3	in vitro;in vivo	15965232
8648	NCOA1	4070	NP_003734.3	in vitro;yeast 2-hybrid	11113179
8925	HERC1	6894	NP_003913.3	in vivo	16051665
9464	HAND2	3872	NP_068808.1	in vitro;in vivo	11994297
9656	MDC1	16252	NP_055456.2	in vitro;in vivo	16051665
10111	RAD50	4950	NP_005723.2	in vivo	16051665
10215	OLIG2	7334	NP_005797.1	in vitro	14576772
10401	PIAS3	9068	NP_006090.2	in vitro;yeast 2-hybrid	14691252
10499	NCOA2	9066	NP_006531.1	in vitro;in vivo	15731352
10579	TACC2	5600	NP_996744.2	in vivo	14767476
10923	SUB1	2737	NP_006704.3	in vitro	11279157
10980	COPS6	16735	NP_006824.2	yeast 2-hybrid	16169070
22938	SNW1	4340	NP_036377.1	in vitro	14985122
23414	ZFPM2	4737	NP_036214.2	in vitro;in vivo	15220332
26471	NUPR1	17814	NP_001035948.1	in vitro	11940591
51176	LEF1	1075	NP_057353.1	in vitro;in vivo	12446687
57062	DDX24	5860	NP_065147.1	in vivo	16051665
65056	GPBP1	16333	NP_001120707.1	in vitro;in vivo	14612417
133418	EMB	13271	NP_940851.1	in vitro	15024082
140628	GATA5	17029	NP_536721.1	in vitro;in vivo	10567378

Pathway Information

                                                                                                                                                      

Pathway Name	Pathway ID
Adherens junction	hsa04520
cAMP signaling pathway	hsa04024
Cell cycle	hsa04110
Epstein-Barr virus infection	hsa05169
FoxO signaling pathway	hsa04068
Glucagon signaling pathway	hsa04922
Hepatitis B	hsa05161
Herpes simplex infection	hsa05168
HIF-1 signaling pathway	hsa04066
HTLV-I infection	hsa05166
Huntington's disease	hsa05016
Influenza A	hsa05164
Jak-STAT signaling pathway	hsa04630
Long-term potentiation	hsa04720
Melanogenesis	hsa04916
MicroRNAs in cancer	hsa05206
Notch signaling pathway	hsa04330
Pathways in cancer	hsa05200
Prostate cancer	hsa05215
Renal cell carcinoma	hsa05211
TGF-beta signaling pathway	hsa04350
Thyroid hormone signaling pathway	hsa04919
Tuberculosis	hsa05152
Viral carcinogenesis	hsa05203
Wnt signaling pathway	hsa04310

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd05495	1051-1158	Bromo_cbp_like
cl02556	1051-1158	Bromodomain superfamily
cd15802	1170-1242	RING_CBP-p300
cl23705	1170-1242	RING_CBP-p300 superfamily
cd02337	1668-1708	ZZ_CBP
cl00295	1668-1708	ZZ superfamily
cd15646	1243-1277	PHD_p300
cl22851	1243-1277	PHD_SF superfamily
pfam08214	1306-1612	KAT11
cl02120	1306-1612	KAT11 superfamily
pfam02172	566-646	KIX
cl03478	566-646	KIX superfamily
pfam09030	1990-2099	Creb_binding
cl07590	1990-2099	Creb_binding superfamily
smart00297	1048-1156	BROMO
cd04369	1054-1153	Bromodomain
cd05498	1074-1151	Bromo_Brdt_II_like
pfam02135	1733-1806	zf-TAZ
cl02660	1733-1806	zf-TAZ superfamily
cd05509	1053-1153	Bromo_gcn5_like
cd05506	1067-1150	Bromo_plant1
pfam06001	1155-1196	DUF902
cl05510	1155-1196	DUF902 superfamily
cd05500	1061-1153	Bromo_BDF1_2_I
smart00551	1729-1807	ZnF_TAZ
cd05497	1056-1155	Bromo_Brdt_I_like
cd05496	1071-1159	Bromo_WDR9_II
cd05502	1049-1151	Bromo_tif1_like
pfam02135	347-416	zf-TAZ
cl02660	347-416	zf-TAZ superfamily
smart00551	347-417	ZnF_TAZ
cd05499	1074-1150	Bromo_BDF1_2_II
pfam00439	1068-1144	Bromodomain
cd05504	1052-1152	Bromo_Acf1_like
cd15557	1244-1275	PHD_CBP_p300
cd05510	1052-1142	Bromo_SPT7_like
smart00291	1664-1706	ZnF_ZZ
cd05512	1057-1147	Bromo_brd1_like
cd05503	1070-1150	Bromo_BAZ2A_B_like
cd15647	1244-1277	PHD_CBP
cd05528	1068-1155	Bromo_AAA
cd05511	1067-1152	Bromo_TFIID
cd02249	1668-1704	ZZ
cd05515	1087-1140	Bromo_polybromo_V
pfam00569	1664-1705	ZZ
cd05524	1087-1158	Bromo_polybromo_I
cd05507	1055-1151	Bromo_brd8_like
cd05505	1050-1149	Bromo_WSTF_like
cd05513	1054-1145	Bromo_brd7_like
cd05521	1053-1141	Bromo_Rsc1_2_I
cd15614	1200-1275	PHD_HAC_like
cl22851	1200-1275	PHD_SF superfamily
cd05516	1086-1154	Bromo_SNF2L2
cd05520	1087-1145	Bromo_polybromo_III
cd05519	1054-1153	Bromo_SNF2
cd05522	1087-1145	Bromo_Rsc1_2_II
cd05518	1076-1139	Bromo_polybromo_IV
cd05529	1052-1153	Bromo_WDR9_I_like
cd05525	1087-1151	Bromo_ASH1
cd02340	1669-1708	ZZ_NBR1_like
cd05517	1087-1151	Bromo_polybromo_II
cd05501	1086-1151	Bromo_SP100C_like
cd02339	1670-1702	ZZ_Mind_bomb
cd05494	1052-1109	Bromodomain_1
cd05508	1052-1153	Bromo_RACK7
cd02341	1668-1707	ZZ_ZZZ3
cd02335	1668-1696	ZZ_ADA2
cd02345	1669-1705	ZZ_dah
pfam08430	124-258	Fork_head_N
cl22540	124-258	Fork_head_N superfamily
cd02338	1669-1706	ZZ_PCMF_like
cd02344	1669-1704	ZZ_HERC2
COG5076	998-1157	COG5076
pfam09606	1937-2412	Med15
pfam09770	640-856	PAT1
pfam09770	659-856	PAT1
pfam09606	432-848	Med15
pfam09770	2034-2343	PAT1
pfam09770	1951-2137	PAT1
pfam09606	1882-2178	Med15
pfam09770	2176-2363	PAT1
pfam09606	98-275	Med15
pfam09606	1881-2294	Med15
pfam09770	677-877	PAT1
pfam03154	661-988	Atrophin-1
TIGR01628	646-796	PABP-1234
pfam09606	62-271	Med15
PRK10263	702-834	PRK10263
PHA03247	593-1042	PHA03247
pfam09606	105-563	Med15
PHA03378	643-856	PHA03378
pfam09606	653-876	Med15
pfam09606	612-854	Med15
pfam09606	88-266	Med15
COG5651	50-217	COG5651
pfam07263	948-1053	DMP1
pfam09606	426-805	Med15
pfam09606	90-275	Med15
PHA03247	661-1077	PHA03247
COG0810	961-1064	TonB
PRK10263	2243-2352	PRK10263
COG5028	675-810	COG5028
pfam09770	2252-2384	PAT1
pfam07271	667-771	Cytadhesin_P30
pfam04503	671-850	SSDP
pfam09770	697-883	PAT1
pfam07223	717-855	DUF1421
TIGR01628	2258-2402	PABP-1234

Ontology Information

   

HPRD ID	3019
Molecular Class	Transcription regulatory protein
Molecular Function	Protein serine/threonine kinase activity (GO:0004674)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report