Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EPHX1 | 2052 | epoxide hydrolase 1, microsomal (xenobiotic) | 1 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22352736 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 68 CRC and 116 controls Stage : - | PCR-RFLP | Polymorhpism | - | Investigated the polymorphisms in exon 3 (T>C, Tyr113His) and exon 4 (A>G, His139Arg) of the EPHX1 gene in 68 CRC patients and 116 controls. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008] | Chromosome | 1 |
| Location | 1q42.1 |
| Start | 225997797 |
| End | 226033264 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 35468 |
| OMIM ID | 132810 |
| HGNC ID | HGNC:3401 |
| Unigene ID | Hs.89649 |
| Ensembl ID | ENSG00000143819 |
| PharmGKB ID | PA27829 |
mRNA Information
| mRNA ID | NM_001136018.3 |
|---|---|
| Exon | join(1..96,18652..18839,21706..21886,28581..28808, 29144..29273,29756..29964,32293..32401,34425..34550, 35073..35490) | mRNA Sequence | Download Select all |
| Length | 1699 |
Protein Information
| Protein ID | NP_001129490.1 |
|---|---|
| Protein Name | epoxide hydrolase 1, microsomal (xenobiotic) |
| Molecular Wt. (Da) | 52818 |
| Protein Sequence | Download Select all |
| Length | 455 |
| Uniprot ID | P45984 |
| Ensembl Protein ID | ENSP00000345524 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 422 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bile secretion | hsa04976 |
| Chemical carcinogenesis | hsa05204 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam06441 | 49-161 | EHN |
| cl05773 | 49-161 | EHN superfamily |
| pfam00561 | 178-395 | Abhydrolase_1 |
| COG0596 | 121-449 | MhpC |
| pfam12697 | 144-302 | Abhydrolase_6 |
| TIGR03056 | 138-240 | bchO_mg_che_rel |
| PRK00870 | 142-231 | PRK00870 |
| TIGR01249 | 124-248 | pro_imino_pep_1 |
| PRK03204 | 143-248 | PRK03204 |
Ontology Information
| HPRD ID | 3816 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.