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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19846965 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 97 Stage : - | Immunohistochemistry | Up-regulation | - | The relationship of Bak with EPO and EPOR is evidence of their co-expression suggesting competition between EPO mediated cell survival and Bak associated apoptosis in colorectal carcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fibronectin type III domain containing |
| Description | This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] | Chromosome | 19 |
| Location | 19p13.3-p1 |
| Start | 11487881 |
| End | 11495018 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7138 |
| OMIM ID | 133171 |
| HGNC ID | HGNC:3416 |
| Unigene ID | Hs.631624 |
| Ensembl ID | - |
| PharmGKB ID | PA27834 |
mRNA Information
| mRNA ID | NM_000121.3 |
|---|---|
| Exon | join(1..250,1111..1246,2238..2413,2494..2651,3134..3287, 3372..3459,5565..5652,5748..7138) | mRNA Sequence | Download Select all |
| Length | 2459 |
Protein Information
| Protein ID | NP_000112.1 |
|---|---|
| Protein Name | erythropoietin receptor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 508 |
| Uniprot ID | P46734 |
| Ensembl Protein ID | ENSP00000319139 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 368 |
| Y | Phosphorylation | 426 |
| Y | Phosphorylation | 454 |
| Y | Phosphorylation | 456 |
| Y | Phosphorylation | 468 |
| Y | Phosphorylation | 485 |
| Y | Phosphorylation | 489 |
| Y | Phosphorylation | 504 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 867 | CBL | 1320 | NP_005179.2 | in vivo | 11443118 |
| 2056 | EPO | 586 | NP_000790.2 | in vivo | 103 188 349 808 045 |
| 2549 | GAB1 | 5116 | NP_997006.1 | in vivo | 10455108 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo | 7534299 |
| 3635 | INPP5D | 9033 | NP_001017915.1 | in vivo;yeast 2-hybrid | 1 066 061 115 644 410 |
| 4486 | MST1R | 2545 | NP_002438.2 | in vivo | 14982882 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vivo | 1 532 933 815 953 600 |
| 5336 | PLCG2 | 2570 | AAH11772.1 | in vivo;yeast 2-hybrid | 1 595 360 115 644 410 |
| 6777 | STAT5B | 5037 | NP_036580.2 | in vitro;in vivo;yeast 2-hybrid | 897 723 215 644 415 |
| 10603 | SH2B2 | 16097 | NP_066189.3 | in vitro;in vivo | 10374881 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Hematopoietic cell lineage | hsa04640 |
| Jak-STAT signaling pathway | hsa04630 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00063 | 146-244 | FN3 |
| cl21522 | 146-244 | FN3 superfamily |
| pfam09067 | 37-140 | EpoR_lig-bind |
| cl21522 | 37-140 | FN3 superfamily |
| smart00060 | 146-223 | FN3 |
| pfam00041 | 146-223 | fn3 |
Ontology Information
| HPRD ID | 3155 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Signal transduction (GO:0007165); Regulation of cell cycle (GO:0000074) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P19235 | DB00012 | Darbepoetin alfa | BiotechDrug |
| P19235 | DB00016 | Epoetin alfa | BiotechDrug |
| P19235 | DB08894 | Peginesatide | SmallMoleculeDrug |
| P19235 | DB08923 | Epoetin Zeta | BiotechDrug |