CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
ERBB2	2064	V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	17	NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
9927187	1999	Cell line : HT 29 Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 80 Stage : TNM Stage I-IV	-	Phosphorylation	-	In colorectal cancer cells are constitutively phosphorylated on tyrosine residues and form heterodimeric complexes. NDF-treatment of colorectal cancer cells was accompanied by increased tyrosine phosphorylation and heterodimerization of HER3 with HER2.
20056314	2010	Cell line : DiFi, LS 174T, CaCo 2, SW 480, HT 29, SW 613 and HCT 116 Source : - Sample Type : - No. of Sample : - Stage : -	Cell viability and apoptosis assays, Western blotting , Immuno fluorescence and confocal microscopy	Phosphorylation	-	Tephrosin could exert antitumor effects by inducing internalization and degradation of inactivated EGFR and ErbB2 in human colon cancer cells. Treatment of HT-29 cells with tephrosin inhibited both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3.
22200761	2012	Cell line : HT 29, HCT 116, and SW 620 Source : ATCC Sample Type : - No. of Sample : - Stage : -	Immunohistochemistry, RT-PCR and western blotting	Up-regulation	-	Overexpressed ERBB2 may constitute a potential target for colorectal cancer therapy. ERBB2-depleted HT-29 cells exhibited increased sensitivity to radiation compared to control cells, likely due to enhanced G0/G1 phase cell cycle arrest and apoptosis. ERBB2 may be involved in the malignancy and metastasis of colorectal cancer.
24819100	2014	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 142 Stage : TNM Stage I-IV	Immunohistochemistry, FISH	Up-regulation	-	HER-2 overexpression could be a predictive biomarker of distant metastasis in rectal cancer patients after preoperative radiotherapy, especially patients showing a poor response to neoadjuvant radiotherapy.
23985256	2013	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : TNM Stage IV	Tissue microarray and immunohistochemistry	Up-regulation	-	Both univariate and multivariate analyses showed that VEGFR-3, HER-2, and TIMP-1 were significant predictors of lymph node metastasis. VEGFR-3, HER2 and TIMP-1 are independent factors for lymph node metastasis in stage T1 and T2 colorectal cancers.

Gene Details

Chromosome: 17; NC_000017.10 (37844393..37884915)
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Gene Type	protein coding
Gene Family	CD molecules
Description	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Chromosome	17
Location	17q12
Start	39688084
End	39728662
Strand	+
Gene Sequence	>gi\|568815581:39688084-39728662 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly AAGTTCCTGTGTTCTTTATTCTACTCTCCGCTGAAGTCCACACAGTTTAAATTAAAGTTCCCGGATTTTT GTGGGCGCCTGCCCCGCCCCTCGTCCCCCTGCTGTGTCCATATATCGAGGCGATAGGGTTAAGGGAAGGC GGACGCCTGATGGGTTAATGAGCAAACTGAAGTGTTTTCCATGATCTTTTTTGAGGTAGGGCTGTTTACT GTCACCACCCCTGTCGGATTTTACTTCCTAAACGTACCTGTAACTATCCACTTCTCTCCATCTCTTCTGG CACCACCCTGGTTAAAGACACCATCATGTGTCGCCAAGACAGCCGCAGTAGCTTCTTAATGGCTCTCCCT GCCTCTACTTTTGCCTCTTCCAACCTGCGCTCCATTTTGAAAAATTAAAATTTGCCCATATCACTTTTTT TTTCTTAAAATTATTTACTGGCTCCCAATTACCTTGGGTAAAATACAGTCTCCACAAACCCTGCCTGATT TGGCCCCTGTCCACTGGTCTCCCTCACTCCCTTGCTCCAGACCCGCTTCAGAGGGCTATGTCCCTCAAGC TTCCTGACTGCCTGGCCTGGTCTGAATCACTCACTCTTCTTTTTTCTTCTAGTCGCAATTGAAGTACCAC CTCCCGAGGGTGATTGCTTCCCCATGCGGGGTAGAACCTTTGCTGTCCTGTTCACCACTCTACCTCCAGC ACAGAATTTGGCTTATGGTAGGCGCTAACTGCGTTTGTTTGTTCTTCTGTTTAATGAATGAACAGCATAC ATCAACATAAGAACTTGACAAATCCAGGGCTGTAAAATCATCAGTATGGTTCTGCACTGAGATCGGAGAG AAGTAATATTTCTAGGAAAATTAGGAACCCTGGGAACAGGACGCTTGCTTTAGTATCCTCTCCCTGCTCA CCTCCCCTGCACTCCCATCAGCACCGACCCACACCCAATCTCATAGAAGCCTTGTAGCTAAGGATCACCC TTTCTCCTCCCCCACTCTCCTCACCCCTTGTCAACTTTTCTTTTTCGTCCTGGGGGTTGGAATGAGTAAG AAGTAGCCTGGGATTCCATTCACTCACTTAACAAACATTTCTGAGTCCTTAGCTCTAGCACCTTGCTAAG CAAGGCAAAATCTCCAGGAGGCACCATTCACATTGCATTTTCTGTGAATGGTGCTCTGGGGAGCAGCATT CACATTGCCTTTTCTGTGAATGGCAAATTCTTCCAGTTAAATATAACATGAATAGTGTCCCCTGGAGTTG ACCACCCAACTGATACTGACTGAGAAGCTGAAATGAACAAAACAACCCCTTAGCCCTCCAGGAGCTGACC GGAAATCCAGTGCTAATACTACTTTGCATCTTACAGATTAGTTCTTTTACAATACTGTTTTTTTTTCTTT TTTCATTTCATTTTGTCCTTTCTGTGACTCTGGGATGAGTCTTTTTATGAGGATCCTCATATAAAGATGG ACATTTAGGATTAAAGAGGATGAAATCCTGACAAAATAGGGAGTCTCCCCTTTAGAAAATTCCTAAGTAA GGCTGGGGGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGACGGATCACCTGAGG TTAGGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGTTGG GTGTGGTGGTGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGG AGGCAGAGGTTGTGGTGAGCCAAGATTGCGCCATCGCACTCCAGCCTGGGCAACAAGAGCGAAACTCAAA AAAAAAAAAAAAAAGAAAAAGAAAATTCCAATTTTGAAGGCCTCATCCTATATTATGTCAAACATACTGA AATGCAGTAACGCCCCACATTAAATAAGATTTATAAATAACTATACATATATATAATTCAATCTAATTGC TGTTAATAGTTGACATATTGCTACATTTATATACATTTAGTTAAAAAAAATTTTTTTTCCCAGACAGCCT CTCACTCTTTCACCTAGACTGAAGTGCAGTGGCATGATCACGACTCACTGCAACCTCAACCTCCCAGACT CAAGTGATCCTTCCATCTCAGCCTCCTGAGTAGCTGGGACTGCAGCATGCGCCACTATGCCCTGCTAATT TTTTTAATTTTTTGTAGAGACACGGTCTTGCTATGTTGCCTAGACTGGTCTCCAATTCCTGGGCTCGAGT GATCCTCCCGCCTCAACCTCCCAAAGTGCTGGGATTACGGGCGTGAGCCATGCCACACGGCCATAAAATA TTAATTTTCGCAGCTTTCTTATATTTTAGAACTAACAATGGAAATTTGTTCGGGTCTAAAGTATTTCAGA GGTCCTTGAAAACCCATGCCTACATACCTGATGGAAAAAGCAATCCTAGGTTAATGGTGGAAGTGGGAGT AGAGACTTCTGTTCTGTTGACTTCTTGGAAGATGGGGTACTGTCTCTCTGGGACAGCTCTTGAGAATTTC CCTGCCAGCACAGCCCCAGATAACAATCTCTAGATGGCGATTACCTGGCCTCTCTTCCCAACTTTCTAGC CTGGAGCCCCTAGTTCTCCCCTGAGCCTCCTTAGCTTGTCCTTCTTCCTAACTTGTATTTGGCTTCAGAT GTGATCCACAGTCTGAAAAGTCACTAATTCATTCCTTCAACTCAGGCTTATTGAGTCCTCCTGTGTATCA GCCATTGTACTCATGGGGGAAAAAAAAGACAAAGCATATGTTAATAGTAGAGTGTGCTGGACAGGCACAG TGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGGCGAGGCAGGTGGATCATCTGAGGTCAGGAGTTCGA GACCAGCCTGACCTAACATGGAGAAACTCCTGAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGC AAAACTCCGTTTCAAAAAAAAAAAAAAAAGTATAGTGTGCTAAAGGCTCAACGGCAAGCTGACCATGTTC TTAGATCAAAATTGGTAGAGAGTCTACAATGTGGGTTCCTTATTCATCAAATGTTTATTAAGTTTACCAT GTGCAAGTCTCTGGGAACAGAGTGATGAACAAGGCACTGTACTTTTCATGGTCAGAGGAGGGAAACAGGC CATAAACAAGTGTCAAACAAAAGACTGAAGCCAGGTGCGGTGGCTCACATCTGTAATCCCAGCACTGTGG GAGGCCAAGGCAGGCGGATCATGAGATCAGGAGATCGAGACCATCCTAGCCAACATGGTGAAACCCCATC TCTACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACGTGCCTGTAATCCCAGCTACTCCGGAAGC TGAGGCAGGAGAATTGCTTGAACCAGGGAGTTGGAGGTTGCAGTGAGCCTGGATTATGCCACTGCACTCC AGCCTGGTGACAGAGCGAGACTCCATCTACATTAAAAAAAAAAATATATATATATATATATACACACACA CACACACACACACACACATACCCTCTAACCCAGGAATTTCACTCCTAGGTATACCTACATAAGCTCCAGT ATACCTAAACAAGTGCAAATTTGTTTAAGTACAGTTATTTGTGGTAGCATTAGTCATTGTTTTCAATAGC AAGAAGAAAAAGGAAACAACTAAATGTCCATCAATAGGGAATGAATTATATTAATGGAGGGAGAGCCATA CAATGGAAGGCTGAACAGAAATTAATAGGAATGGGGCAGATTTGTAATGTACTAGCATGGTAAAACCTTC ATGATAGATATAGATATAGATATAGATATAGATATAGATATATATACATATACATATACATATACATATA CATATATATATATATATATATATATCTCTTGTGTCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTG CCACCACATCCGGCTAATTTTTGTATTTTTTAGTAGAGACAGGGCTTCACCATGTTGGTAAGGCTGTCTT GAACTCCCGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCATC ACACCTGGCCAAATATTTTTGATAAGTATCAAGTGCACAGTGCAGAACAAAATATGTGTGTGTGTATGCA TGTGTATGTACACCTATACACTTATATACAGTACCCCATGTGAAGAAAAATAAGGGTACGTGTTATGCGC GTAGTATTATGGTTGTTATTTTTGAGAATATATCTAGAAAGATAAAAAAGAAAGTGGAAATAGTTCTTGC CTCTGGTGGGAAGTGGGACTATGTGCCTGATCAATAGGGAAGTAAGGAACACTTTTTTTTTTTTTTTTTA AACGGAGTTTTTGCTCTTGTTACCCAGGTTGGAGTGCAATGGCGCGATCTTAGCTCACTGCAACCTCTGC CTCCCAGGTTCAAGCGATTCTGCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCATGCGCCTCCACG CCTGGCTAATTTTGTATTTTTAGTAAAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTTGAACTCCCC ACCTCAGGTGATCCGTCCGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGTGCCTGGC CAGGAACGCTTTTTATTTTTGTACCTTTAAAAGTGTGTACCGTCTGTGTATATAATCAGTTAAAAACAAA GAAAAGCTGAGTGTGGTGGCTCATGCCTGTAATCCCAGCCCTTAAGGAGGCCGAGGCCGGCGGCAGATCA CCTGAGGTCAGGAGTTCAAGACCGGCCTGACCAAAACGGTGAAAACTCATCTCTACAAAAACATAAAAAT TAGCCAGGCATGATGGCAAGTGCCTGTAATCCCAGCTGGTTGGGAGGCTGAGGTGGGAGACTTGCTTGAA CCTAGGAGGCAGAGATTGCAGTGAGCCAAGACTGTACCACTGCACTCCAGCCTGGGCAACAGAGCAAGTC TCTGTCTCAAAACAAAAACAAAAACACAAAGAAAAAATGTAAAACAATTTCATGCAGTAGCAAGCATCGA GTTAAATACAGTTGACCCTTGAACAACACAGGTTTGAATTGCACGGGTCCATTTATACTCACATTTCTTC CACCTCTGCCACCCCCAAAATAGCAAGACCAACCCCATCTCTTTTCCTTTCTCTTCCCCCTCCTCAGCCT ACTCAATGTGAAGATGATGAGGATGAAAACCTTTGTGATGATCCACTTCCACTTAATGAATGGTAAATAT GTTTTTTCTTACTTATGATTTTCTTAGTAGCATTTTCTTTTCTCTAGCTTCCTTTATTGTAAAAATACAG TATATAACACATATCACATACAAAATGTGTGTAAATGGACTGTTTGCTATTGATAAGTATTCTGGTAAAC AGTAGACTATTAGTTTTTTTTGTTTTGTGACAAGGTCTCCCTCTGTCGCCCAGCCTGGAATGCCGTGGTG TGATCATGGCTCACTGCAGCCAAAAACTTCTGGGCTAAAGCAATCCTCTACTAAAAATACAAAAATTAGC CAGGCATGGTGGTGCGCTTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCG GGAGGCAGAGGTTGCAGTGAGCTGAGATTGCACCGTTGCATTCCAGCCTGGACAACAGAGCGAGACTCCA TCTCGAAAATAAAATAATAATAATAATAATAATAATAATAATAATAATAATAGGGCTGGGTGTGGTGGCT CATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGACAGATCACCTGAGGTCAGGAGTCTCAATTAA AAAATAAATAGGCCGGGCACAGTGGCTCATGCCCATAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGA TCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACGGAGAAACGCTGCCTCTATCAAAAATACAA AAATTAGCTGGATGTGGTGGTGCATGCTATAATCCCAGTAATACCAGCTACTCGGAAGGCTGAGGCAGGA GAATCACTCGAATCCGGGACACGGAGGTTGCAGTGAGCCGACATCATGCCACTGCGCTCCAGCCTGGGTG ACAGTGAGACTCTGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATATATATATATATATA TATATATATATATATATATATATATGTGTGTATATATATATATATACACATATATATGTGTATATATATA TACACACACACATATATATGTGTATATATAAAATAAAATAAATAATAATAAAACATTTACTTTGGCTGCT GTTGCTGCGGGGAGAATTGCAGGGTGTCAAAAGTAGCACTGGTGGAGGGGTAGTGATCAAAGTCTGGTGC TTTAGCCCAAAGGAGAAATGATAGAGACTCAGACTAGCTGGTGATGGAGGTAGAATAAGCATAAATGTAT CAAAAAGAGGAGTTGATAGATCTTAAAGAATGATTGGATTTGAAGGGCAAAGGAAGAGAAGAATCAACCA GGTGGGTTCAGTGAATGAAACCATCAGAAACGAATTGTCCCCTGAAATCAAGACTTTGTGATTGCCATAG TTGTATGCTTCTCAAAGGTTCCTCGTCTCCTCTTCCTTGGACCAAAAGTCAGAGGCAAGAATGCCCTCAT TCATACCCCAGTGGTCTATACCTCCAGCAGCAAGTCGAGTGAGCAAGTGATGTCCTGAAAGGCCCAGTGG ATCAGTGGAATGAAGCGGGCAGGAAGACTTAGTGCTCCTGAAACAAGGAATCCAGAATCCAGGAGAAGGA TGGCTCAGTGGGGCTTTCAAGGGACAAGTATGGGGGTTGAAGGGGTCACTGTCCCTATACCAAATCCGAA AATATTGTGACCAGGAACCATTCTGTCCAACTCTTCTATTTCAGGTGGCAAAGCAAAGCTATATTCAAGA CCACATGCAAAGCTACTCCCTGAGCAAAGAGTCACAGATAAAACGGGGGCACCAGTAGAATGGCCAGGAC AAACGCAGTGCAGCACAGAGACTCAGACCCTGGCAGCCATGCCTGCGCAGGCAGTGATGAGAGTGACATG TACTGTTGTGGACATGCACAAAAGTGAGGTGAGTCGCAGGACAGAAGAGTGCTTTTTGTTTCAGCAGAGC AGCCTGGGGAGAGATAAAAGCTACTCCTGGGGCCTGGGCCTGCATTCCTGAGATGTGGGTAAGAGGGGCC CAGGGTCAGAGTGTCTGGCAAGCTTGGCTCTGCCCCTTTGCTGTCCTGGAGACTAGGGCTAATCCTGGGC TCAGGGAGTGGCCTCCCCATGGTTAGGATACAAGTGCTCATCAAGGGCCACCCCTAGGAAGGACCAATTT TCCTATCAGAAGCTTCTAAGTTATCCTCCTTTGGCCCAAAGGGACACCTCAAGCCTACTCTGAGGAACTC TTTCCAATGAACTAATTCCTACAGTCACTTCCCCAGCAACCTGTGCCTCAGCCTCAAGGCACTGTGGGGT AGGCCTCAGTTTGTGGCCTGGACATCGGACTGTGGACCAGACGACTCCTCCCGATTTCTGTTTGTTTTCA GTCCTCTGACCCCAAGCTGGCTGGTGAAGTAGGTAGAGGGAGGAGACTTTGGTGCATGCATACACACACA CACACACACACACACACACACACACACACACACACACACACACACGTCTCCTGTGCCCCCCAGTCTCCAT GGCTGGTCAATGATTGACTGGCATTTCACAGGCCGCTGGTTGCAGCCCCAGCCTGTTGACTTAGAGGTCA CCCTCGGAAGCTAGAGCCCTGTCCTGCCTCTTCAGTGTCAGTGGTCACTCCACTGCCCACAGGCTGGGGT CTTGGGCAAAACACACGCATCTGCCCTGATCTGAGTTTGCTGCCCTCTGTCCCGCAGTCAGCCCCACTCT GTTCCCACTCCCTCTCCCCAGCCCCCTAGCTAGACCCCTCTCACCAGCACCCCTTTCCCTTCCCTGAGGG TCCCCCTCGCTGTCTTTGTCCCTCAGACATCCTCTTTCCTGGGCTCTCCTGCCAGGCCCTGCTGGAGGGA CAGTTAAGGAGGAAATCGAATCAGCAGCGCCCACCCCTGCCCCCCTTCCTCTCCTCTTGTCAGACACCAG ACGAGGTTTTTTCCTCTGGCTTCCCAGCTCTGAATGGGCTCATTCTTTTTCAGAGGCTCGGCCCCTCTCG AGCCTCCTCCCCAGGGCGTGAGTTCTGACCCCAGCTCCTCCCCCCATCCCCACTCCAGCCCCCTCTCCAG CTTGCTCCACCCTCTCTACCGCCCACCGGGACTGGGCATTGTCTGCCAGTCCGGGTTTCTTCCTGGGATT TGGGATGCAGAGAGGATGGGTTTGCTTGGGCGGGGGGGTGGAGAGTGAAGGGGGGAAGCAGGATCTTTGT AGAGGGAGGGACCTACAGTTACCTGGACTTCTTTCCTCTGTCTCCCCTCTTGGTACCCTTGACTGGGGCT CTTGAGGGTAATGGGTGAAGCCAAATCTGCCATGGCTCAGTTCCCAGCTCAGCTCTGTGACCTTGGGAAA GTTCCTTTAGCTCGTGGAATCTCAAGGCTCAAGGTTCCTCTTCTGCAAAATGGGGAATGATAACACCTGC CTCCTCTGGAGTCTTGGGGACTCAGTGTTCTGAGGAACGTGGCTGTAGGTCAGAGTGGCACAGAGTAGGG TCCAATGAAGCATGGCGTCCACAGTAGCTTTCCTGACTGGACTAACCTTTCCGGACACAACAGCAGGGCA GGGGTGGGGCCTGGGGAGAAAGGACACCTCTAACCCTGATCCTAACATCCCGATGGCCTCTAAGGCTGCC TGCACACTCATCCAGGTGCAAGCCCTCCAAGGTGTGGTGTGATGAACCAGTGACTCCTGGAGCCAGGTCA GCGCATCCTCTTCCCGCAGGGCTGTAAGCTGCAGGACTGAGAGGCAGGTTGACCAGGTCCTGGGCTGGAT GATGGGGTGAGAGTAAGGGGTCAGTTTTGATACATGCCCAACTTTTCTCTCTAGCCCTAAGACATCCTGG GCAAATTGCTTACCTCAGTTCCCCTGATCCTCACCCTAACCCTAACACCAGCTCAAGAGAAAATAGGGAT ATTGATGGCCATCCAGAAGGGCTGCTGTGTTCCATACACAGCAATATTTCTCGAATGTTTGTGACAGCGG TCCAAGGAATAAGTTAATTTTACATTATCACTCTGGATACCTGTACAAAACTCCACCTTATCCTTACTAT ATGAATGTGCTAGGGTTGTTTTTTTGTTTTGTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGT TGCCCAGGCTGGAGTACAATGGCGCGATCTTGGCTCACCGCAACCTCCGCTTCCCAGGTTCAAGCGATTC ACCTGCCTCAGCCTTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCATGCCCGGCTAATTTTGTGTTT TTAGTAGAGACAGGGTTTCTCCATGTTGGTCAGGCTGGTACCAAACTCCCGACCTCAGGTGATCCACCTG CCTTGGCCTCCCAAAGTGCTGCAATTACAGGCATGAGCCACCGCACCCAGCCGTGCTAGGGTCTTTTTCT GTTCAATTCCTTTCTCTCTCTTGCTCTCTTTCTTTCTTTCAATGGAGTCTTACTCTGTCACCCAGGCTGG AGTGCAGTGGCAAGATCTCAGCTCACTGCAACCTCTGCCCTCTGAGTTCAAGCAATTCTCCTGCCTCAGC CTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACCACACCTAGTTAATTTTTGTACTTTTAGTAGAGATG GGGTTTTGTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCTGCCTGTCTTGGCCTCCCAA AGTGCTGGGATTACAGGCATGAGCCGCCATACTCGGCCAACTTTGTATTACTTTCTTAAAGAGAGTTTCC CAAATTATATAAGCTTCAGGCCCCACAAAACCTAGATCTGCCCCAGTATAACTAAATCTGGGACCATTTA TTGAGCAATTATTATGTGCCAAGTATTGCGCTGAGTGCTTCCAGAGCATTATCTCCTTTAACCCCAGCAT AGTATGTCAGATGCTGTTTTACAGATGAGCCAACTGAGACCAGAGATGCTCAGTCACTTGCCCAAGGTGA CATGACTGATATGGAATAGAGTCAAGATTTTTTTTTTTTTTTTTGACACGGAGTCTCACTCTGTCTCCCA GGCTGGAGTGCAGAGGCGCAATCTCAGCTCACTGCAAGCTCTGCCTCCCAGGTTCACGCCATTCTCCTGC CTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTGTATTTTTAGC AGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTCGGC CTCCCAAAGTGCTGGAATTACAGGTGTGAGCCACCGCGACTGGCCAGATTCAAGATTTGAACCCAGGTCC TCTTGGTCCCAGAGGCCCCTGTTTCTCAACTCCCTAGGATGGCATAGCAACCTGTCCCACAAGAGGTGCC TGCTTTAAGTGTGCTCAGCACATGGAAGCAAGTTTAGAAATGCAAGTGTATACCTGTAAAGAGGTGTGGG AGATGGGGGGGAGGGAAGAGAGAAAGAGATGCTGGTGTCCTTCATTCTCCAGTCCCTGATAGGTGCCTTT GATCCCTTCTTGACCAGTATAGCTGCATTCTTGGCTGGGGCATTCCAACTAGAACTGCCAAATTTAGCAC ATAAAAATAAGGAGGCCCAGTTAAATTTGAATTTCAGATAAACAATGAATAATTTGTTAGTATAAATATG TCCCATGCAATATCTTGTTGAAATTAAAAAAAAAAAAAAAAGTCTTCCTTCCATCCCCACCCCTACCACT AGGCCTAAGGAATAGGGTCAGGGGCTCCAAATAGAATGTGGTTGAGAAGTGGAATTAAGCAGGCTAATAG AAGGCAAGGGGCAAAGAAGAAACCTTGAATGCATTGGGTGCTGGGTGCCTCCTTAAATAAGCAAGAAGGG TGCATTTTGAAGAATTGAGATAGAAGTCTTTTTGGGCTGGGTGCAGTTGCTCGTGGTTGTAATTCCAGCA CTTTGGGAGGCTGAGGCGGGAGGATCACCTGAGGTTGGGAGTTCAAGACCAGCCTCACCAACGTGGAGAA ACCCTGTCTTTACTAAAAATACAAAAAATTAGCTGGTCATGGTGGCACATGCCTGTAATCCCAGCTGCTC GGGAGGCTGAGGCAGGAGAATCACTTGAACCAGGGAGGCAGAGGTTGTGGTGAGCAGAGATCGCGCCATT GCTCTCCAGCCTGGGCAACAAGAGCAAAAGTTCGTTTAAAAAAAAAAAAAAGTCCTTTCGATGTGACTGT CTCCTCCCAAATTTGTAGACCCTCTTAAGATCATGCTTTTCAGATACTTCAAAGATTCCAGAAGATATGC CCCGGGGGTCCTGGAAGCCACAAGGTAAACACAACACATCCCCCTCCTTGACTATCAATTTTACTAGAGG ATGTGGTGGGAAAACCATTATTTGATATTAAAACAAATAGGCTTGGGATGGAGTAGGATGCAAGCTCCCC AGGAAAGTTTAAGATAAAACCTGAGACTTAAAAGGGTGTTAAGAGTGGCAGCCTAGGGAATTTATCCCGG ACTCCGGGGGAGGGGGCAGAGTCACCAGCCTCTGCATTTAGGGATTCTCCGAGGAAAAGTGTGAGAACGG CTGCAGGCAACCCAGGCGTCCCGGCGCTAGGAGGGACGCACCCAGGCCTGCGCGAAGAGAGGGAGAAAGT GAAGCTGGGAGTTGCCACTCCCAGACTTGTTGGAATGCAGTTGGAGGGGGCGAGCTGGGAGCGCGCTTGC TCCCAATCACAGGAGAAGGAGGAGGTGGAGGAGGAGGGCTGCTTGAGGAAGTATAAGAATGAAGTTGTGA AGCTGAGATTCCCCTCCATTGGGACCGGAGAAACCAGGGGAGCCCCCCGGGCAGCCGCGCGCCCCTTCCC ACGGGGCCCTTTACTGCGCCGCGCGCCCGGCCCCCACCCCTCGCAGCACCCCGCGCCCCGCGCCCTCCCA GCCGGGTCCAGCCGGAGCCATGGGGCCGGAGCCGCAGTGAGCACCATGGAGCTGGCGGCCTTGTGCCGCT GGGGGCTCCTCCTCGCCCTCTTGCCCCCCGGAGCCGCGAGCACCCAAGGTGGGTCTGGTGTGGGGAGGGG ACGGAGCAGCGGCGGGACCCTGCCCTGTGGATGCCCCGCCGAGGTCCCGCGGCCGGCGGGGCCAGAGGGG CCCGGACGAGCTCTCCTATCCCGAAGTTGTGGACAGTCGAGACGCTCAGGGCAGCCGGGCCCTGGGGCCC TCGGGCGGGAGGGGGCAGTTACACGGCAGCGGCTCGAGATGGCCCATCCAAGAGACTGGCGCTTTCCAGG CTCCGAGGGGCTCCGGGAACTTGTCAAAGAAGTTCTCTGAAATTGTTCAGAAAGTTTTCCCGCAAAGGGT GTATTGCGTAGAGCGCGCGCGCGCGTTTCCCCCCTTCTTGAGCCCCCTCAAGCTTTCTCAAAGCCTTTCC AGTTGGCAGCCTCCGCCTCCGGACTGGCCTGGGCTGGATTCCTTGGGGGGGTCCTCTGCCCTGCCCCTCC TCCAGCCCCTCCCCGCTCCCCTTCAGACGATTTTGGTTTGGTTGCTCCTGCTTCTGGCGGGGTCGGGTGT GTGTGTGTGTGGTGGAGTGGAGGGTGGCATAGCAACCTGTCCCAACCAGAGCCGGGGAGGAAAGGGTGGC CCGGAGGGTGGCCTCTTGCTGGGGTCTGGGTTGGGGGCGGGGGAGACGTTTGCTTTGAACAGATTCTTGG GGCCAGCTTAGGGACTGTGCTCTGTGACTTTTGGAGCGCGTGGACCATGGAGGGGTGGGGGTGGGTTTCT TGGGGTGTAAAGTGGGAGAGTTCCCAGAGAAGGAAGCTAAGAAATAAGGCCAGATGGGAGCCTAGGGAGG GCTGCGTTGTTCTGCTGCCTTTTCCTTGGTGCTGTGCGTGGGGAAGGGTGAGTGGGGGCAGTGTGTATCC TGACCCATCTGTCCACCTGTGTGCATTAATCATAAAAGCTAACATATAGCCTGGGCCAGGTATACTCTGC CAGGAACTGTTTGTGGTGTTTTGCATGCATTCTCCTTTAATCCTAGAACACCCCTATAGTGGAAGTTCTG CCAGCATTCTGGACTGAGTAGCAGTCCAGAGGTTGAGTAGCAGCTAGTAAGTGGTGGGGTCAAGATGGGA CCCCAGGCAGTGCGACCCCCAACCATGCATTCGAAATCGCTATATGGATGAGTGCACCTGGAGCAATGAG GGACACTGCTCCCTGAGTCACTGGGCTGCAGGGGAGACAAAATGAAAGTGTTCTGGGAGTCGTGGGTGGT CTCCATAGGTCAGAGGGTCTGGGGAGGGAGTGGGTGTCATCGTGGCTGTGTGTTGCCCGAGGGGCCCTCT GTGAGTGAGTGCATGGCCGTGTTATCTCTGCAGGTCTACGCCAGGGTGTTCCTCAGTTGTGTGGTCTTTG TATTTGTGTGTCTGGGCTTTGTGTTGCCAAACAGCAGTCTCTCTGCTGACTTGGGGACACAGGCTGAACT CTGTCCTCTGCAGGAACTCCCTTAAGGTGCTGGGCCAGATCTGCCATAAACAGAGGGAGGTAGCCTTCTA TGGCCACGCCTTCTTGCTGAGGAAGAAGGTTCCTCTCTTCCAGGGAGTACATCCTTGCCCTCCCTGTTTC CCAGACAAGCATCTTCACCTCTCATCTTCTGATGAGAAGGGTGAGGCCATACTGAGCTGTCAGGCTGAGC TGCTGCCCTTCCTCACCTTGGGCTGGGAGTTGATCAGGGAATGGCAGTTGCTGCAGAGCTGGATTTGAGG GCTGGGTTCTCTGGATGGGGCCTCCTCATGTCCTCACCCCTCAACCTGCACTATTGATTGTGTTGTGCAG GAGTTAGTTAAAAAGTCATTGCACAGCCTGGGCAACAAGGCAAAACTCTGTACAAAAAATACAAAAATTA GTTGGATGTGATTACACGTGCCTGTAGTCCCAGCTACTCCGGAGGCTGAGGCAGGAGGATCACCTGAGCC CAGGAAGTTGAGGCTTGCAGTGAGCTGTGATTGCAAATGCTCTCCAGCCTGGGTGACAGTGTGAGACTCC GTTTCAGAAAAAAAGTATACCACCCAGCTGCCTCCAGCACCCAGATTTTACCCAAGGGGTGAGGTCTGGG GCAGGAATGTGGGGGAAGGGGAGGCCTAGGGGGAGCCCCAGAGGGGTCAGGATTTTTCTGAAATCCTTTC TTAGAGGTATGGGTTTTACAAATTGCAGCAAATACATCCTTTTAATCTTGCAGAACTCCTTCATATTTTA ATTCCAGTATGATTCTTCCAACAGCCTCCTCTCTTTACTATACTTGGGGAAAGTACTCATTTTATTTGTC AAGAAAAAAACAATTGAAAAGATAGGGATCAAATGTAAAAAGAAAAAATACGTGGCATTCCAAAGTCAAA CACAAAGCATGTTTAATTTTCTCGTGGTTTGGGATTACCCATATTCCTGCTGTATGAACCTGTCTTGTCT TAACTTTTAAGAAATGTACGGTGTACTTCCTATATGCTAGGTTTTTATCCATGCTTTCATTTAATCTCTG TGACAGTCCTGTGAAGTAGGTGCACAGATGAGAAAATGGAAGTTCAGAGAAATGAAGCAACTTATCCAAG GCTCCCAGCTACCCAGTAATGTCCAGGGAATTTTTGGACTCTGAAGAGGAGGCATTAAGAGGTGGTTAGA GTCTTATTCCAGCCAACAATAATGGGTTGAACAAAGCCTTAGGGGCAGGCAGGTGGCCAGATGGGAGGAG AAGCGCTCCTCTTGTTCAGGCGAATGACCTTTCCATCCACTTCTCTAGGCTGTAGAAAGTGGAGCTGAGC TGGGGGCCCTGAGGTTCCCTCTTGACTTCAGAGTCCTCTCCCTTCCTGTCCAGCCAATGCCTGTCTTCCT TTTGGGCCCTACCAGCATGACAGGGGGCTGCGGGCAGGAGGGGACAGAGGCCACGTTGACACACAGGGCT GTGGGTGAGAGAGACAGCTGAAGTGTCAGCGTGAGGGGCCAGTGTGGGGCTGCGGCTGGGAGGGCTGGGG TGGGGCCCAGGGTAGTTGTGCCTGTCCTTGGGTGATGGAATGATCTGGAAAGAGATTCCTTCCCTGCCCT CCACCTGTGAGAAGCCCCTCTAGAGTGACATCTCCATCTTATGTTTGGCCACCCATCCTCCCCCTGGGAA GAGAGCCGAGGTGGGGTAAGGGATGTGTACTCTTTCAAGGAGTGGGAGAATTATTCTAGCGAATGTTTGT GTTGTCCCAGTTCTGTTTACAAAGCCTCGTCATGTTTACAGATGGCTGCGCAATTCATTACCTCATTTAA CTCTCATGTACCTCCTCTGAGGGAGTAAGAGCTGTTACAGCCAAGTTTAGGTCAGTAAATATTCACCAAG TTGCAGGTACTGCAGGGCATAGAGATGAATCCGATTTAGCTTCTGCCCTGGAGGTCTGGGAACTTGCTCA AGATCACTCAGTGAGCAGCTGAGCTAGGGTTCTCAACTAAAGACCCTGGGCCCAGGCCCTGGTCTGATGT CAGGCCTGATACACCAGGTGTTTGTGGTCGGGGAATCCCAGTGTCACTTGAATGGGCTGTGACATTATGG GTCTGGGAGAGCTGAGCTTTGGGGACACAGGTCATTTTACTGTAGTATTCATGGAAACCAAGGGAAGTAT TGGCTTTTCTGCTGTGAGCAAGAGGAGCAGCTGGGGCTGCAAGCTGGTGGGGAGGAGAGAACCCACCTGA GAGAAACCTCAGGACTGGGGTCAAGTCCTGACCACCAGAGTCCAGAGAGACATGAAGGACTGTGACCAGC TCTGAGCAGAGAGATGGATTCCATGACCTCAACTGGTCCCTTTTGTTCGGAGACTCGTGACTGGACTTCA TTCATCCACTCATTCATTCATTCACTCAGCAGACACTTATCTAGCGCTCCCTGTGGCTGGTCCTGCCTCA TACTGTCTTTGCTCTGGAGAATTGGAGGTTGGGGTTCCTGAGGGGCAGGGTCCTGGAGACAAGGACACTC CTGGGTAGAATTAGGACCTACCCCCCAGGAAATCAACGGGGACCAGGTGCCGTGGCTCACACCTGTAATC CCAGCACTTTGGGAGGCCGAGACGGGCGGATCACAAGGTCAGCAGTTCAGGACCAGCCTGGCCAACATGG TGAAACCCGCCTCAACTAAAAATACAAAAATTAGCCAGGTGTGGTGTCAGGCACCCGTAATCCCAGCTAC TGAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCA CTGCACTCCAGCCTGGCGACAGGGCGAGACTCCATCTCAAAAAAAGAAAACCAATGGGACAGGGCAGATA TGGGGACAATGGTAAGGAGATGGGAGAGTGGGAGGGAGGTGTCAGGAAGACCTTCTTGACTTCATGTAGG CTGGTGGGGGTGTTAGCCAGCAAGCCTCCAGTTCCCTGGGAACCGTTCTCAGGGTACCAATTTTACCACC TGTCTGCAAACACTTTAAGATTCTTAATCAGACTCAAATTGGCCACAAATCAGGTAAACAAACTCACTAG TGGGGTGGGGCTACCACCCGTTCTGACCCTCCAGCCCAACCCAGCCCAGCCACCCTGCCCTCCGTAGAGC CTGTGGTGTTTATCGGTGGCATTGGGAGAATTAGTGTGTATTTATGTTGGCGTGGGGTGTGGGGTGGATT TGTGTGTGTGCAGTTAGGCCTAGTGGAAGGAATGTGGGATCTGAAGGCAGGCCAGCCTGAGTTCCAGTCC TGCCTGTTGCTCACAAGCTTTATGAGGCGAGAGCTAACCCCTGCCAGCCTCAGTTGTCTTCTTTGCAAGA TGGAGGTTGCAGCCCCAGTCTCTGGAGCATGTTATGCAGATCCACCGAGAGTGCCTGCCAGGCACACAGT AGGTGCTCAGCTCAGTTACTGTGGCGGCCCCCACTCCCCATTGTTGTTGTTTTCCTATTGCCTGGCGGCC ACAGCTGGTATCCCTTGAAAAGGGCTACAGGGGGTGGAGTCGGACCCTGCCCCAGCCCTGTGGAGACCCT GGGCTTGGGCCAGGGCCTGGGGTCTGGGCCTGCAGACAGCTGTGTCTATAAAGCAGCTGAAGGGCTGAGG CCGGGGGAGGTCCTGGCAGCAGGGCGTTATTTTGGGCCTGGCCTGCCACCCCCAGCTCCTGTTTCTCTTG GGAGTCTGTTGGGGGAGGAAGTGTGGGGAAGAGGAGGGGGTGCAAGTGGGTGAGGCATGGAGTGGGGAGG CCTCCCTCAGGGACATGGACCCTTGAGTTCTATTTCTGTTCCTCCCTCCTGTTCCTCCCTCTTTGTCCTT ATCTGCCTAGAGAGGTGGGAATAGAGGCCATTCTGAGTATCACTAGGAGACCACCAGTTTGTGGCCACTG GCCACTGGCCCAGGCAGGGAACCTGGGGGCTTGCCCTACCAGCCTCTCCCAGCAATCTGAAGGCAGGGGG TACCTCGTATTACCCCCTAGGATTTGACCTTAGGCTCCAACTTGCTGGGAGAGCAGTGCCTCTGGTGTCA GACCCCAAGCCAGCCCTTGTGCTGTCCCTGAATCTGCATGTAGCCTGTGGGAGGCGGAGCAGTGACCGGC AGGAATTCTGGGCAGCTCAGGCACCTGTGGGCCTGAGGGTGCCCTCTGCCCCCACCCTTCCGATCTCCTG GGCAAGACACGCCAGGTGATTCATCTCACCAGAGCAGAAAAACAAGTTCAACTGGGCACTTTAATCTCCC CTCACTGGCAGGCCTGGTGTGAGCTGCTACCCCGGCGCCCCTCACCAGGGGTGCTTTACCTCCTCTAGTA TTCCTGACCTTAGTGGGCATTTCTGGTCTCAGGGATACCAGGCTGGGGTCCAAGTGGGCCAGGTGTGGCA GTTCAGCCCTATGCCCCATGGCTGATGGCTCGCGCTGGGCAGGTATGCAGGGCTGACGTAGTGCCTTTGT GGCAGCAGTTTCGTGGCACACATTCTGCCAGCTGGTTCTGGAGTCTTGCCCTGAGGAGGTGGCCAGGGTG AGGGTGCCAGCGCAGGAACCTTTGGCGCATGCTTCACCCTGGCCTGGGATCTGCAGCCTGGGTCCAGATG CCCACAACTGGAATCTGACGCTCCTTTTCTCTTCATGGGGGACTCCCAGAGGTCTCTGCAATGACCAGAG CCCCGGTTGTCCCATGCCTCAGCTGCAACTCCAGCTGACCCTCCTTCCCCACTCTCTGGGTGGCATTACG GGGGTGTGGATCCCTTGCCAAGAGGTTGGCATGTGGGTGTGCTGGAATGGCATAGGGAGAATGCACCGAG TTTGTTTGCTTGGGAGAGGGGCAGGGGGTATCCAGAAGATTCATGATTCGTCATCGCCTCTCTTGGGGGA TTTTTACCCCTTTGCCCTGAGTTGTGCCTTTGGGACAAAGGAAGCCTTTCTTTGCCAGCCAACACCCTGT ACTGGCGGGCGAGCTCCCCAGGGCTGGCACGCTGGGGCAGCCTCTGAATGCACAGGGTGGGCCTAGTCAG AAGAAGCCTTTCCCCTGAAATCCCTCTACTTCCCAAGCACGCAAGCTTTCTCCTGCTGTTAAACCTGCAG TGTGCAAGGGACATGGGCGGAGGGGTCCTTCAGTCAGGCTTCTCCCTGTCTGAGGTGGCATGACTTGGAG TGAGTTTGGATGGGGTGGCCAGGTCTGAGAAGGTCCCCCGCCAGTGTCCTCTGACCCATCTGCTCTCTCC TGCCAGTGTGCACCGGCACAGACATGAAGCTGCGGCTCCCTGCCAGTCCCGAGACCCACCTGGACATGCT CCGCCACCTCTACCAGGGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAATGCC AGCCTGTCCTTCCTGCAGGTGAGGCCCGTGGGCAACCCAGCCAGGCCCTGCCTCCAGCTGGGCTGAGCCC TCTGTTTACAGGTGGGTGGCAGAAGAAGGTGCCCTGCCCTTCTGTTTCCTCTCTTGTTGTGGTTTCTCAA CCAGGAAGTCCTTTCTAACATCTAACCCCCATTCATTTTACTGCAGAATCAGTTGACTCTCTCTATAACG TGGCTGGCCGAGGTCATGTCTGGATGGGATGCGTCTGTGTTTCCGCTAAATCTTGTGCTCTCTTGCCAGC ATGATCATGTCCCCTGTCCACCTGCTCCAGCCACTATCCCTCTCCCACTTACAGCAGAAGAAAGGGCTGG TGAGAAAGGTGGATTACAGGCCCACTTCTGCCACTGACGAGCCCTATGAATGTGGCCTACACCCCCTTAG CTTCACTGGGTCTCAGTTTCCCTATCTGTATATTGGGAGCAGTTGTGAAGCTCAGAAGAGAAATGTCTGT GAAAAGGTTATGAACAGGAGGGAGAGTGGAAACCAACCTGCTGGATCGTGTCCACAGACCCTGGAATGGG GCCACATGCTTGGTTTGTCAAATTGCAGACGCCGGCCGGGTGCGATGGCTCATGCCTGTAATCCCAGCAC TTTGGGAGGCCGAGGCGGACAGATCACTTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAA CCCCGTCTCTACTGAAAATACAAAATTAGCCAGGCATGGTGGCACATGCCTATAATCCCAGCTACTTGGG AAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGACGGAGGTTGTGGTGAGCCTAGATCGTGCCATTGT ACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAAAAATTTGCAGACGCCATCCCATCCA GGCCTTTGCTTTCACTGATGAAGAAACTGAGATACAGAGAGGGCAGGGCACCTGTTCGGAGTTTATGAAA TGCCCCCCCACCATTATCTTTCTTGATCATATAAGAATCTGGTGAGGCAAGGTAGGGCGTGATCTTTATC TCTATTTTATCGTTTTATTTAAGCGGGAACAGGACTGCTCAGTGGCTGGGGGCCTTGCCCAAGATCTCCA AGTACTGGGGAACCCCAGGGAGGCCCTGGGGGGTGGCAGTGTTCCTATTTCAGCCCCACTCTGCTTCCCC CTCCCAGGATATCCAGGAGGTGCAGGGCTACGTGCTCATCGCTCACAACCAAGTGAGGCAGGTCCCACTG CAGAGGCTGCGGATTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCTAGACAATG GAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTCCCCAGGAGGCCTGCGGGAGCTGCAGCTTCG AAGCCTCACAGGTGGCCTTCACCGTCATTGAAACCTTCTCTTGGTTATTCAGAGCTGACCAGGGCCACTG CTAACCAGGGGGAGGCTTTGTGTGCATTAGAAATGGTGTCCCTTCTGGGCAGACGCAGGCAGAGCCCGGG AAGACGCCCTCAGAAGATTGGAAAAAGATTCCCCTTCTTCCTGGGAAGTTGTAGCTTGCGTCAGCACATA TAATTCAATCGTGAGAATGCAGGCTGGGTTTTTGCCCCCACTTGGCTGAGTGAAGTGTACAGTGAACAAC CTATGTAACTATTTGCTGGCCCTGGAGCCGACTCTGCCCCAGAGTCTGGGTGCCAGGTGCTTTGCCCGCA TGGCCCATTTCAGTCACGCTGCAGTCCTGTCAGGAAAAAATCAGTGTTATTCTCATTCTACATATGAGAA AACTGAGGCTTGCAGATATAAGGGCCAAAAGTTACACAGCTAGTGAGTGATGGGGCTGAGTTTCAGACTC CACAGTCTCTTAACCACCAAGCAGCATGCCCAGAGTAGAGGTGAGAAGGAAGGAGAGAGCTGCGGTCCAC ATGAGCATCTGGACCTAGCATGGACAACTCACTCCTCCCTGGCTCTCGCTTTGTTCTTGTTGCGGGTGTG GTGGTGGTGGGACTCAAAGACGGTAAAGATAGCTTTCTCTCCTCCCTGGGGAATCTGGGGGTTGTTTAAA AGGCCTGCTCCTCTTTTAGAAGGCAGGAGGGCCCCAAGGGAAGCAGAAGGTGACAGAAGGGGAAAGGGTC CTCTGATCATTGCTCACCCCACAGAGATCTTGAAAGGAGGGGTCTTGATCCAGCGGAACCCCCAGCTCTG CTACCAGGACACGATTTTGTGGAAGGACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGAC ACCAACCGCTCTCGGGCCTGTAAGCCATGCCCCTCCCTGCTGCCTCTTCTCTCAGACAGCCTGACCCCAG CCGCAAACTCCCAACTTACAACCCAGTGCCTGCCCGCCACTGCCCCAGCCGCCTACACCACCCATTTCCT CCCTCTCTGTCCCTCCTGCCATCTCCCTGTGCCTCTTCATCTCTGGGGTTCTCTGTCTTGTCTCCCTCTG CTTATAGGTTGTGCCTCTGGTTTGGGGGCCTCTCAGCCTGTCTGGGTCCCTCCCTTGCTGTGCAGTTGGC CTCGTGGCCTCTGCTGCTGTTTGTGCCTCTCTCTGTTACTAACCCGTCCTCTCGCTGTTAGACATCTCTC TCACTGCCTGTCTCTGGTTCTGTCCTCAGGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCTGG GGAGAGAGTTCTGAGGATTGTCAGAGCCGTGAGTCTCAGGGAGGCCTGGAGTCAGGGAAGGGGAGGGCTG GGGCCGGGTGGAATGCAGGTGTCATACAGGTGACATGGGAGGGGTGGGATAACAGGCTTGGGATGTCTCC CCTGGGCCAGGTAGTCTCCCTAGAAGGTGATGCTGATGAGGGTCTGGTGCCCAGGGCGCCACTCAGCCCT CATCCTGCCCTTTGCCCAACAGTGACGCGCACTGTCTGTGCCGGTGGCTGTGCCCGCTGCAAGGGGCCAC TGCCCACTGACTGCTGCCATGAGCAGTGTGCTGCCGGCTGCACGGGCCCCAAGCACTCTGACTGCCTGGT ATGTGCCTCTGCTTTGTGCCCAATGTGCTCTACCCCCCAGGATGCAAGGGGTGGGCACCCTGCCTGGTAC TGCCCTATTGCCCCTGGCACACCAGGGCAAAACAGCACAGTGAAAGCCAGCCACCTGTCCCCCCAGGCCT GCCTCCACTTCAACCACAGTGGCATCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAACACAGACAC GTTTGAGTCCATGCCCAATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTGT GAGTGCCAGGGAGAAACACAGTTTTCTCATTTTGGTGGGGAGGTTTGTTTCTGTAAATGGGAGCATATGG GGAGCACTGTCTGCATCTTGCTTTGAGAGCTGGTCATGACAGTTCCTGCCGAGCTGCCTTGTTCTTTCAA CAGCTGTGGAGCAGGTGGCAGTAAGGAGAGGCAGCTAAGAGCCCAGACTTGGGAGCCAGACTGCCTGGGT TTGAAACCCAGCTCTATCAATTAGTAGGCACGTGACCCTCTTGCTGTGCCTCAGTTTCCTCATCAGTAAA ATGGGGGCAAGAATAGTCCCAACTGCATAAGATGGTTATAACATTTGAAAGAGTTAATATTTGTAAAGCT CTTAGAACGGTGCCTGGTATGTACTAAGTGCTCCTAAATGTTAGCTTTTATTCTATAGCCTGGTGAGGTC AGTTTTACCTTTCGTTTTGTTTTTGAGACCGAATTTAGTTAGCTCTATCGCAGTGGCGCGATCTCGGCTC ACTGCAACCTCCGCCTCCCAGGTTCGTGCTATTCTCGTGTCTCAGCCTCCTGAGTAGCTGGGATTACAGG CGCCCACCACCATGCCTCGCTAAATTTTGTATTTTTAGTAGAGACAGGGTTTCACCACGTTGGCCAGACT GGTCTCGAACTCCTGACTTCAGGCGATCCACCTGCCTCGGCCTCTGAAAGTGCTGGGATTACAGGCGTGA GCCACTGCACCCGGACTTTTTTTTTTTTGGCAGAGTCTCGCTCCATTGCCCAGGCTGGAGTGCAGTGGTG CAATTTTGGCTCACTGCAACCTCTGCCTTCCGCATTCAAGCAATTCTTGTGCCTCAGACTCTTGAGTAGG TGGAACTACAGGCATGCACCACCATGGCTGGGTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACTAT GTTGGCCAAGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGTCTCCCAAAGTGCTGGGA TTACAGGCATGAGCCATCGTGCCTGGCCTAGCTCAGTTTTATTTAACAGATCACCTATTTACTGATGGGC GTTTATGGACTGGGCTCAGACCTGGGGAACCTCTTTCCTCCTCTCACAGGAACAGGAGTGGGCCTTCAGA TCCTGGCTGACTGTGTTAGGGAGAGGACAAAATGTAGAGCCAGACCATTTGGGTTCAAATCCTCGCTCCT CCACTCACTAGCACAATGACCTTGAATAATTTACAGAACTCTCTGCTTTGGTCTCCCTTTTTGCAAAATG GGAATCTCACAGTGCTGATCCCGTCTGGTTGTTGTGAGGGGTAAATGGATGTCAGGTGCTGATGCGTGGT AGGGCATTTAAGTATTGGTTGATATTATTCTTCTTGTGCCTGGGCACGGTAATGCTGCTCATGGTGGTGC ACGAAGGGCCAGGGTATGTGGCTACATGTTCCTGATCTCCTTAGACAACTACCTTTCTACGGACGTGGGA TCCTGCACCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGATGGAACACAGCGGTGTGAGA AGTGCAGCAAGCCCTGTGCCCGAGGTACCCACTCACTGCCCCCGAGGCCAGCTGCAGTTCCTGTCCCTCT GCGCATGCAGCCTGGCCCAGCCCACCCTGTCCTATCCTTCCTCAGACCCTCTTGGGACCTAGTCTCTGCC TTCTACTCTCTACCCCTGGCCCCCCTCAGCCCTACAAGTGTCCCTATATCCCCTGTCAGTGTGGGGAGGG GCCCGGACCCTGATGCTCATGTGGCTGTTGACCTGTCCCGGTATGAAGGCTGAGACGGCCCCTTCCCCAC CCACCCCCACCTCCTCAGTGTGCTATGGTCTGGGCATGGAGCACTTGCGAGAGGTGAGGGCAGTTACCAG TGCCAATATCCAGGAGTTTGCTGGCTGCAAGAAGATCTTTGGGAGCCTGGCATTTCTGCCGGAGAGCTTT GATGGGTAAGAGTGGGCACGATGACCTGAGACAGTGTCAGGGCAGACAGAGTCCTGAGGATCCAGATGTG GCAGCATCTCTTGGGGATGGCAGGAGACAGAAGTGGGGGGATCAAGAATGCAAAGAAAGCAGATGGGAGA CCAGAGGAGCAGGGCCTTTGGTGGGTGGGGGTGATTATTTTTGTAAATGACATGCTATCCGTGAACAAGG ACTTGTATGGAGGTCAGACCATCTAGATAAAGTAAAATTCCCTTTGAGTTCATAGCAGCTTTATTCAAAA TATCCCCAAATTGGAAATAACTCAAATGTGCATCACTAGGTGAAGGAATAAACAAGTGGCAGTGTATCCA TTTGGTGAAGTTCTACTTAGCAACCAAAGGAAATGAACTACCGATACAACATAAATGAATCTCAGAAACA TTACATTGAGCAAAAGAAGCCAGAGACAAGATTCCATACTGTCTGATCCCCTTTATGTGAGGCTCTGAAC CGAAAAAACCACTCTGTGGTGGGAGAGATCAGAACGGTGGTTGCCCCAGGGTGGGGGGCTTCAAAAGGGA GGCACACAAGGACATTTCTGGGGTAATAGAAATGCTCTGTATAGTGATTGGGGTAGTGGATACATGAGCG AATCCATTTGTCAAAACTCATCAAACTGTGTGATAAGAGTCTGTGCATTTTATTTATTTCATTTTATTTT TTGAGATAGAGTCTCACTCTGTCAGCAGGCTGGAGTGCAGTGGTACGATCTTGGCTCACTGCAACCTCTG CCTCCTGGATTCAAGCAATTCTCCTGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGTGTGTGCCACCAT GCCCAGCTAATTTTTGTATTTTTAATAGAGATGGGGTTTCACCATGTTGGCAAGGATGGTCTCGATCTCT TGACGTCGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCCGGT GCATTTTATTGTATATAAGTTATACTTCAATAAGAAATGAATTGGGGCCAGGCACGGTGGCTCACGCCTG TAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCC AACATGGTGAAACCCCATCTCTACTAAAAAATATAAAAAATTAGCCAGGCTTCCTGGCATGCGCCTATCA TCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCATGAACTCGGGAGGTGGAGGTTGTAGTGAGCTGA GATTTCGCTATTGCACTCCAGCCTGGGCGACAGAGTGAGACCCTGTCTCAAAAAGAAAAAAAAAAAAAAG GGTCAGGCGCCGTGGTGCACACCTGTAATCCCAGCACTTTGGGAGGCTGAAGCAGGAAGATTGCTTGAGC CCAGGAATTCAAGAACAGCGTGGGCAACATAGTGAGATCCCATCTCTACAAAAAAACACAAAAAATTAGC CGGGCATGGTGGTACGCACCTGTAGTCTCAGCTACTAGGGAGACTGAGGTGGGAGAATCACCTGAGCCTG GGAGGTGGAGGTTGCAGTGGGTTGAAATCATGTCACTGTACTCCAGCCTGGGTGACAGAATGAGACCCTG TCTCAAAAAAAAAAAAAAAAAAAAAATTCCCTTTCACACTTCCTTTACCTCCACTCCCCTTTCCAGAGGG GGCCATGGTTAACAGTGTGTGTGTTCACCTAGACCGTTTATGCATCTGTAGACACACACACAGTGAAGTG TGGTTTTCGTCGTTTTGGTGGGGAGGTTGGTTTCTGTAAATGGGAACATATAGGGAGCACTGTCTGCACC TTGCTTTGAGAGCCGGTCATGACAGTTCCCATTGAACTGCCTTGTTCTTTCAATAGCTGCAGAGCAGGTG GCGGCAAGGAGAGGCAGCTAAGAGCCCAGACTTGGGAGCCAGACTGCCTGGGTTTGAAACCCGGCTCTAC CACTTACTAGGCATGTGACCCTTGTGCTGTGCCTCAGTTTCTTCATCTGTAAAGTGGGGGCAAGAACAGT CCCAACTTCATAAGATGGTTATACCACCATGCCTGGCCAGATGATTATAAAGTTTGAATGAGTTAATATT TGTAAAGCTCTTAGAACAGTGCCTGGCAGATACTAGGTGCTCCTAAATGTTGGTTTTTATTATGTGGCTG GGTGGCTCGGGGTTTTATTTAACAGCTCCCCTATTTACTAATAGACATTTAGATCATGTTCCATTTTCAC TCTTACAAACAGTTCCACTTTGTGTGTGGCTCTGGGAACATGGGCCAGTGTCTCCCTAGGCCACATTCCT AGAAATAAGATTTCTTTTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTTTATCGCCAGGCTGGTGTG CAGTAGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCT CGAGTAACTGGGACTATAGGCGCGCGGCACCACACCCAGCTAATTTTTGTATTTGTAGTAGAGATGGGGT TTCACCATGTTGGCCAGGATGGTCTCCATCTCTTGACTTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTG CTGGGATTACAGGCGTGAGCCACTGAGCCCAGGCAGAAATAAGATTTCTAGATCAAAGGATATAAATACT GTTTTGATAGATGTTGCCGAACTAAGGCCTGGGCTTTGAAGCCCAGGATGGGAACAGCTGGGCTCGATGG GCAAAGGGTTTGAGTGAAGGCATTCATGGTGGGGAGTGGCTGGCATGGCCAGTGCTGGGAGTGATGTCCA CCCTGTTCCTGGCCCTGCTGACTCCTCTCCTGACCCCTCCAGGGACCCAGCCTCCAACACTGCCCCGCTC CAGCCAGAGCAGCTCCAAGTGTTTGAGACTCTGGAAGAGATCACAGGTGGGCTCTGTCTCTGCATCCTGT TCTGCAGGGGCTGGGAGTCCTTGTCCTGTCCCCACTCCTTTAATCTCACCCTCTGCCTGCAGGTTACCTA TACATCTCAGCATGGCCGGACAGCCTGCCTGACCTCAGCGTCTTCCAGAACCTGCAAGTAATCCGGGGAC GAATTCTGCACAAGTGAGCACTGAGAAAGAGGGGGCCTGATGGGGAGGAGTCCCAGGGAGGAGTCCCTGT GGGAAGCTTTGGGCCTGAGGGAGTACTCCTGTAGCAGTAACCTTTCCATGAAAGTCTGCAGAGTGTGCTG GGGATGGAGGAAGATGAGAATAGCCTTTGCTGACCGGGAAGGGGTCCGTGGTAAGGTGCCCACCTTTCTC CCATAGTGGCGCCTACTCGCTGACCCTGCAAGGGCTGGGCATCAGCTGGCTGGGGCTGCGCTCACTGAGG GAACTGGGCAGTGGACTGGCCCTCATCCACCATAACACCCACCTCTGCTTCGTGCACACGGTGCCCTGGG ACCAGCTCTTTCGGAACCCGCACCAAGCTCTGCTCCACACTGCCAACCGGCCAGAGGACGAGTGTGGTAA GACAGGGAGCCCAGTGTGCGCACTCCCCATCTGCCAGCACACAGCAGTGCCCAGGGGGCCCTGGCAGCAG CGTTCTTGGACTTGTGCAGACTGCCCGTCTCTGTGCACCCTTCTTGACTCAGCACAGCTCTGGCTGGCTT GGCCTCTTGGCATGGCTTCTCTAGCTGGGTCCTACCTGCCTTGGCATCCTTCCCTCCCCCTCTGTTTCTG AAATCTCAGAACTCTTCCTCTCCCTACATCGGCCCCACCTGTCCCCACCCCTCCAGCCCACAGCCATGCC CACAGCCAGTTCCCTGGTTCACTTGGACCTGGGGCCTCCCCTAAAAGTCCCCTGCGGTCCCTTCCTCCTC ACTGCAGTGGGCGAGGGCCTGGCCTGCCACCAGCTGTGCGCCCGAGGGCACTGCTGGGGTCCAGGGCCCA CCCAGTGTGTCAACTGCAGCCAGTTCCTTCGGGGCCAGGAGTGCGTGGAGGAATGCCGAGTACTGCAGGG GTATGAGGGGCGGAGGAGAGGGTGGCTGGAGGGGTGCATGGGGCTCCTCTCAGACCCCCTCACCACTGTC CCTTCTCTCAGGCTCCCCAGGGAGTATGTGAATGCCAGGCACTGTTTGCCGTGCCACCCTGAGTGTCAGC CCCAGAATGGCTCAGTGACCTGTTTTGGACCGGTGAGCTGCTGGCGGGCTCAGAGCTGGGTGGAGGGGGG CAGCGAGGGGGATTGCCAGGGACTTGGCAGGATGGCGAGATGCAGTAGGGTGTGCTATCTGGTAAAATAT CCCTGGAGAGGGCTCAGCGCTCAGACCTGAACAGCAACAGAGTGGCAGAAAAGGGGCCTGGGGGACACTG GGGCCCTTCAGACTATGAAAAGGTTCTAAGGAGGTCTGTGTTGGTGGCTGTGACTGTGGCTGTGCTAGGG TGGTGAGCCCTGTGGGCTCAGGCGTCAGACTACCTGGATTCAGACCCAGCTCCTGCTTCCAACCTTGGTT TTTTATTCCTAAAATGGGTATTGTAATAATACCTACCTTGCTGGGGTGTGGCAAGAATGAAATTAAACAG GGCTTGGCACAGTGAAGCACGGGAAAGGCTTTCTACAGAGCAGTGACTGTTGTTACTCGCTGTTACACCT TAGGTAATGCGTTTTCCTCTCTGGGTGCCTCCCATTTTCTGGCTCAAGTCCCTGCCCAGGATCAAGCTTG GAGGAGGGCCCCGAGGGAGGGGCCACAGAGACTGGGTGAAGAGCAAGGGTGTTTGTCCCAGGAGCATGGC GAAAATTGCTGCTGGGTGGCCTTGGGAAGCACAAAGGGGACCCAACTAAGGGCCTGATCCTACTGCCCTG GGGGTGTCAGTGCCAGCCCCCCACAAATCTTTTCTGCCCCCCCCAGGAGGCTGACCAGTGTGTGGCCTGT GCCCACTATAAGGACCCTCCCTTCTGCGTGGCCCGCTGCCCCAGCGGTGTGAAACCTGACCTCTCCTACA TGCCCATCTGGAAGTTTCCAGATGAGGAGGGCGCATGCCAGCCTTGCCCCATCAACTGCACCCACTCGTG AGTCCAACGGTCTTTTCTGCAGAAAGGAGGACTTTCCTTTCAGGGGTCTTTCTGGGGCTCTTACTATAAA AGGGGACCAACTCTCCCTTTGTCATATCTTGTTTCTGATGACAAAAATAACACATTGTTAAAATTGTAAA ATTAAAACATGAAATATAAATTAATGCCCTAGCAGTTCTATCCCCACTGTTAATAATTTGAAATATTTTT CCTCTAGTTATTTTTGTCTGTGCACATTCTAATATGTATATATAAGTTAACATATATTAATATTATTCTC CAGTTATTTTTATCTGTGCACATTTTAACACACACACACACACACACACACACACACATATGTATTTTTA GACGGAGTTTCACTCTGTCGCCCAGGCTGGAGTGCAGTAGTACAATCTTGGCTCACTGCAGCCTCCACCT CCTGGGTTTAAGCAATTCTCCTGCTTCCGCCTCCTGAGTAGCTGGGATTACGGGAACGTGCTACCTTGCC TGGCTAATTTTTGTATTTTTAGTACATAGGATTTCACCATGTTGGCCAGGCTGGTCTCGAACCCCTGACC TCAGGTGATCTGCCAGCCTCGGTCCCCCAAAGTGTTGGGATTACAGCGGTGAGCCACCATGCCCAGTCAT ATATTTCTTTTTAACAAATAGAATCATAGATCATACATATTGTTTGCAAATTGCTTTTTCTCACTTTCCA GAACCTTGAAATGTTTTTCCATGTTCTAACATGGTGATCTACCTTATTCTTTTAATTTTTCTTATTTAGT TGTCTTTACACATGAAACACATGAATACATCCTTGTGATAAACATTTTCAGTAACATAAAAGTATAAATG TTACAAAGCCAACGTGCCCTTTCACTCAACTCCCTGTCCACCCAGTCTCTCCTGTCTGCTGGGAGAACCA CCGCATTGACTTGTGTGTTCACCCTTCCAGGCTCTTTTCTGCACACTTATATAGACATACTACATTTATA TTAGGTCGAGTCAAATAAGATTGCTGTTTGTGTAAACCAAAAAGTGTCAAGAGCCTGGGCGCAGTGACTC ACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACTTGAGATCAGGAGTTCGAGACCAA TCTGGCCAACATAGCGAGACCCCGTCTCTACTAAAAATACAAAAACTAGCCAGGTGTGGTGATGCTGTTC TGCACTTTGCTTTCCCCCCGACTTGAGGTATCCTTTCTTGTGAGTACAGACGGATCTACCACCTTTATTT TTTTTTTAATTACTCAACCTGTAACATGGATGTAATTTCACTTTGTTTTTGAGGGATATTGAGCTTGTTT CCCTGTTTTTGCAGTTTATTGCAATTGAGCTCCACACACAAGTGAGCCCTCTTTTGTATGCCCCCTAGTG GGAATACAGTGCTGGCAATGTTTATCACAAGGATATATTCATGCATTTCAATTTAAAGACAACTAAATGA GAAAAATTAAAAGAATATGGATCCAGGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAG GCCGAGGCAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCGTCT CTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTATTTGAGAGGTTGA GACAGGAGAATTGCTTGAACCTGGGCAGCGGAGGTTGCAGTGAGACGAGATTGCACCAGTGCACTCCAAC CTGGGCAACACAGTGCAACTCCTTCTCAAGAAAAAAAAGAAAAAAAAAAAGAATATGGGTCCAGATCCAT ATGGATCCTAGATCCAGATCACGGTGTTAGAACATGGAAAAACATTGCAAGATTCTGCTAAGTGAAAAAA GCATTTGCAAACAGTATGTACAGTCTATATTCAGAGGAGGAACTGCTGGGTCATAGATGATATTTCATAG GTATTGCCAAACCGTTCTCTGGAGAAGTGGTATGGGTTTACCCTGGGATTCTTCTATGGAGGGAATAGTT GAGCTCCCGGGCTTGCTCTTCTGGGTGCCCCTCCCCGCTTCCTATCCACCACAAGGAGCTGCAGGGGAGC GGGGCATGCCGGTTCCTTGGCTGGAGAAGGAGTCTCCTTGTGAGGTGGTAGAAGGAGCACTGACGGCCTT GAGCCCAGTTTCTGCCTTTGTCAAATGGGGATAATGACCCAGCCACACCCCTCCCAGGGTTGTTGTGAGG CTGGAAAGGTGGTTCCCAAGAGGGTGGTTCCCAGAATTGTTGATGAGACTGTTTCTCCTGCAGCTGTGTG GACCTGGATGACAAGGGCTGCCCCGCCGAGCAGAGAGCCAGGTTGGCCTGGACCCCAGGATGTACCCTTC ATTGCCCTTCACTCCCCCACTGGATGCTGGGTGGTCACTGCTGTAGGGAGGGGACCCCCTGACATATGTC CCTTCCCACCCACTCTTCCACTGTGGAACCTCCTGTCATTTTCCACTTCACCAAGTGACAGAGGACCTGC TCAGATGCTGAGGGGAGGGGACTGCAAGGAAAGATGGCTAGGAAACCCAGTCCCTCCACACCCTAGAGTA ACTTGATGCCTTGTGAGGGACACAGGCAAAGTTCAATTCCTTGGAAGTCAAGGGAGACTGAGAAGAGTAC AGCTGCAGCACTGAGGGAGTGATGAATTCTTAACTGGGGATGGTGGGAGGCTTCGAGTGGGAGGTGGCAT TTGAGCTAGGCTTTGAGAGAGGAGCAGGTATTGCACTTGCATTTAGGTAGAAAGCATTGGGGTGCAAGGT GACACTGGAGGGGGAGGCATCAGGAAATCCAGGATGTCTTCAAAGTTCTGGTGTCGGGGGCTGTTGAGTA AGCACAGGAATAAGGGGGTCAAGTTAGAGTCAGGGTGGGGTCTGACCTGGATGCCATAGGACCTGATCCC CAAGCCACAGGGTGGGACTTGACTGGGCAGTGGGGACCTTTGGAAAGGACTTTGGGGAGAAAAACAGACT GGAGTCTGTCTTAGGCGATCATCGGTCCGTGAAATGAGCATGTGTTACAGGCTTGGTATGTACCAGACCC TGTGCTAAGCAAGGGGGTATGGAGAGGAGAGGGTGACAAGAATATTGGATCAACACCCGGGAGCTCCATC TATCCCAGGATGCACTATCTTTTTTTTATTTTTTTGAGACGGAGTCTCACTCTGCCTGCAGGCTGGAGTG CAGTGGCTCCATCTCGGTTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGCTTCTTGTGCCTCAGCCTCC CAAGTAGCTGGGATTACAGGCACATGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGT TTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCAAGATCCGCCCACCTTGGCCTCCCAAAGTG CTGGGATTACAGACATGAGCCACCGTGCCCAGCCAGATACGCTATCTTTTTATTGAGTGATTGAGACAGG GTCTTGCTCTCTTGTCCAGTCTTGAATGTGGTGGTGTAATCACAGGCTCACTGCAGCCTTGACCTCCTGG GCTCAAGTTACCCTTCTGCAGTAGCTGGGACTATAGGAGCGTGCCACCACGCCTGGGTAATTTAAAAAAT TTTTTTTGTATAGACAGGGTCTCACTATGTTGCCCGAGCTGGTCTCAAACTCGTGGGCTCAAGTGATCCT CCAGTTTTGGCCTCCCAAAATGTTGGGATCACAGGAGTGAGCCACCACTCCTGGCGATGAGCCAAGTCTT TTTTTTTTTTTTTTTTTTTTGATATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAATGACACGATCT TGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCAGTTCAAGCAATCCTCCTGTCTCAGCCCCCCAGTA GCTGGGATTACAGGCATGCGCTACCACGTCCGGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTTGCC ATGTTGGCCAGGCTGGTCTTGAACTGCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGG GATTACAGGTGTGAGCCATCGTGCCTGGCGGAGCCGAGTCTTAAAAGATGACCCTGTGGAGAAATGGTGG TCCAGGCTGAAGGGACAGCCTATGCAAACACTGGGAGGTGTGGAAAATCATGACCTGTGGGTGGAAATTT TGGCTAGAACATCAAAATCATCAGGTGTACATTCCTGTACCCATGCAGCAGTCAGAATCTCTGGGGGTGG GGCCCCAAAATTGTATGCATACAGACTGTGTGCTGATTTGTGATATTACTTAGGATTTTTTGACTTTACA ATGGTGGAAAAGCAATAATATACATTCAGTATAAACCGTACTTTGAATACCCATACAGCCATTCTGTTTT TCACTTTTATTTTTATTTATTTATTTATTTATTATTTATTTTGAGATGTCATTTTGCTGTTGTTACCCAG GCTGGAGTGCAATGGCGCAGTCTTGGCTCACCGCAACCTCCACCTCTCAGGTTCAAACGATTCTCCTGCT TCAGCCTCCAGAGTGGCTGGGATTACAGGCAGGCACCACCACACCCGGCTAATTTTGTATTTTTAGTAGA GACGGGGTTTCTCCATGTTAGTCAGGCTGGTCTCGAACTCGAGAGCTCAGGTGATCTGCCCATCTCAGCC TCAAGCCACCATGCCCAGCCCTACTTTCAGTATTCAATAAATTACATAGCCAGGCACCGTGGCTCACACC TGTAATCCCAGCACTTTAGGAGGCCAAGGTGGGAGGATCCTTTGAGGCCAGAAGCTCGAGACCAGCCTGG GCAACATAGTGAGACCCCATTTCTACAAAAAATAAAAAAACTAGCTGAGTGTGGTGGCGTGTGTCTGTAG TCCCAGCTACTTGGGCAGCTGAGGTGGAAAGACTGCTTGAGCCCAGAGGTCAGGGCTGCAGTGGGCCATG ATCTCACCACTGCACTCAGCCTGGGCAACACAGCAAGGCCCTGTCTCAAAAATAAATAAATAAATAACAC AAACTTATTTAACAGTTTACTATAAAATAGGCTTTGTGTCAGATGATTCTGCCCAACTGTAAGCTGCTGG CAGTGTAAATGTTCTGAGCACGTGTAAGCCAGGCTAGGTGTCTTAAATGCATTTTCAGTTTCAACTTAGA ATTGGTTTATCAGGACGTAGCCCCTTGGTGTTGAGGGGCATGTGTATTAACAGTCTCCTTAGTGACTTTT TTTTTTTTGAGATGGAGTCTTGCACTGGCCGTAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTTG TCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGTCTCCCAAGTAGCTGGGATTACAGGCACCCACACCACG CCCAGCTAATTTTTGTGTGTGTGTATTTTTAGTAGAGACGGGGGTTTCACTATGTTGGCCAGGCTGGTCT CGAACTCCTGACCTTGTGATCTGCCCACCTCAGACTCTCAAAGTGCTAGGATTCCAGGCATGAGCCACCG CGCCCAGAGTCCTTAGTGATTTTTACACCATGAATTGTTGAAGCCCTAAGCCAGAGCCAAGGGCAAGAGT ATAGAGAATCTGGAGATGCGGAGAGGGTTCTGATTGCCTACAAGGAGTTTGGACTTTATTGTGGAGGCAG CGGGGAGCCAAGGCAGGTTTTAGAGTAGGAGAGGGTCCAAGCCTGTGGGTCACCCTTCCGACTTCCCTTT CCGAATGCCAAACACCTTCATGTCCCCCGTGGGCCCCCTTTGTCCCTCCCACCCCAAACTAGCCCTCAAT CCCTGACCCTGGCTTCCGCCCCCAGCCCTCTGACGTCCATCATCTCTGCGGTGGTTGGCATTCTGCTGGT CGTGGTCTTGGGGGTGGTCTTTGGGATCCTCATCAAGCGACGGCAGCAGAAGATCCGGAAGTACACGATG CGGAGACTGCTGCAGGAAACGGAGGTGAGGCGGGGTGAAGTCCTCCCAGCCCGCGTGGGGTCTGCACCGG CCCCCGGCACTGACCCACCACCCCCTCACCCCAGCTGGTGGAGCCGCTGACACCTAGCGGAGCGATGCCC AACCAGGCGCAGATGCGGATCCTGAAAGAGACGGAGCTGAGGAAGGTGAAGGTGCTTGGATCTGGCGCTT TTGGCACAGTCTACAAGGTCAGGGCCAGGTCCTGGGGTGGGCGGCCCCAGAGGATGGGGGCGGTGCCTGG AGGGGTGTGGTCGGCAGTTCTGATGGGAGGGGCAAGAGCTGGAGGCAGTGTTTGGGGGAGGGCAGTTACA GCGGAGAAGGGAGCGGGGCCAAGCCCTAGGGTGGTGAAGGATGTTTGGAGGACAAGTAATGATCTCCTGG AAGGCAGGTAGGATCCAGCCCACGCTCTTCTCACTCATATCCTCCTCTTTCTGCCCAGGGCATCTGGATC CCTGATGGGGAGAATGTGAAAATTCCAGTGGCCATCAAAGTGTTGAGGGAAAACACATCCCCCAAAGCCA ACAAAGAAATCTTAGACGTAAGCCCCTCCACCCTCTCCTGCTAGGAGGACAGGAAGGACCCCATGGCTGC AGGTCTGGGCTCTGGTCTCTCTTCATTGGGGTTTGGGGAGATATGACTCCCGCAAACCTAGACTATTTTT TTGGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTTATCTCGGCTCACTGCAACCTC CACCTCCTGGACTCAAGCGATTTTCATGCCTCAGGCTCCTGAGTAGCTGGGATTACAAGCGCCCGCTAAT TTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTAGAGTGAAATGGTGCGGTCTCAGCT CAGCCTCCCAGGTTAAAGCGATTCTTCTCCCTCAGTCTCCTGAGTAGCTGGGATTACAGGCGCGAGCCAC CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGATTTCACCATGTTGGCCAGGTTGGTGTCAAAC TCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCC GGCCTAATCTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGTCCAGGCTGGTACTTTGAGCCTTC ACAGGCTGTGGGCCATGGCTGTGGTTTGTGATGGTTGGGAGGCTGTGTGGTGTTTGGGGGTGTGTGGTCT CCCATACCCTCTCAGCGTACCCTTGTCCCCAGGAAGCATACGTGATGGCTGGTGTGGGCTCCCCATATGT CTCCCGCCTTCTGGGCATCTGCCTGACATCCACGGTGCAGCTGGTGACACAGCTTATGCCCTATGGCTGC CTCTTAGACCATGTCCGGGAAAACCGCGGACGCCTGGGCTCCCAGGACCTGCTGAACTGGTGTATGCAGA TTGCCAAGGTATGCACCTGGGCTCTTTGCAGGTCTCTCCGGAGCAAACCCCTATGTCCACAAGGGGCTAG GATGGGGACTCTTGCTGGGCATGTGGCCAGGCCCAGGCCCTCCCAGAAGGTCTACATGGGTGCTTCCCAT TCCAGGGGATGAGCTACCTGGAGGATGTGCGGCTCGTACACAGGGACTTGGCCGCTCGGAACGTGCTGGT CAAGAGTCCCAACCATGTCAAAATTACAGACTTCGGGCTGGCTCGGCTGCTGGACATTGACGAGACAGAG TACCATGCAGATGGGGGCAAGGTTAGGTGAAGGACCAAGGAGCAGAGGAGGCTGGGTGGAGTGGTGTCTA GCCCATGGGAGAACTCTGAGTGGCCACCTCCCCACAACACACAGTTGGAGGACTTCCTCTTCTGCCCTCC CAGGTGCCCATCAAGTGGATGGCGCTGGAGTCCATTCTCCGCCGGCGGTTCACCCACCAGAGTGATGTGT GGAGTTATGGTGTGTGATGGGGGGTGTTGGGAGGGGTGGGTGAGGAGCCATGGCTGGAGGGAGGATGAGA GCTGGGATGGGGAGAATTACGGGGCCACCTCAGCATGTGAAGGGAGGGAAGGGGCTGCCTGTGCCCCACC TTGCAGGGTCTGTGCACTTCCCAGGATTAGGGAAAGACCGGGTAGGGTCTGTCTCCTGGCATCACATCTC CCCCTGCTACCTGCCATGATGCTAGACTCCTGAGCAGAACCTCTGGCTCAGTACACTAAAGCTCCCTCTG GCCCTCCCACTCCTGACCCTGTCTCTGCCTTAGGTGTGACTGTGTGGGAGCTGATGACTTTTGGGGCCAA ACCTTACGATGGGATCCCAGCCCGGGAGATCCCTGACCTGCTGGAAAAGGGGGAGCGGCTGCCCCAGCCC CCCATCTGCACCATTGATGTCTACATGATCATGGTCAAATGTGCGTGGCTGAGCTGTGCTGGCTGCCTGG AGGAGGGTGGGAGGTCCTGGGTGGAGGAGCCCACAAGGGGCATGAAAGGGGACCAGGATGTATGTAGACC CAGGAGCCCTAGTATGTTAGGAGCCTCAAAACCTTCTTGTATCCCTTTTACAGTCAAAGTCCAAAGCCAC TCTTGAGGAACACTCTTGTACAAAATTAAGCTGGGCACAGTGGCTCATGCCTGTAATCCCAGTACTTTTG GAGGCTGAGGTGGGAGGATCCCTTGAAGCCAGGAGTTCAAGACCAGCCTGGGCAACATAGTGAGATCCTA TCTCTACAAAAAATAAAAAAATTATCTGGGTGTGGTGGTGTGTGCCAGTAGTCCCAGCTACTCAGGAGAG GCTGAGGCAGGAAGATCACTTGAGCCTAGTTTAAGGTTGCAGTAAGCTATGATTGCACCACTGAAATCCA GCCTGGGTGACAGAGCGAAACCTCATCTCAAAAAAATAAAAAAGCAAACAAAAAGAAAAAAAAAATTAAA AGGGAAACTAGAAGAGATGCCAAAGGTTCTGGCTGAAGACCCCAGAGTCTGGTGCTACTTCTCTACCACC TGAGGGCTTTGGGCTGTCCCTTGGGACTGTCTAGACCAGACTGGAGGGGGAGTGGGAGGGGAGAGGCAGC AAGCACACAGGGCCTGGGACTAGCATGCTGACCTCCCTCCTGCCCCAGGTTGGATGATTGACTCTGAATG TCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTC ATCCAGGTACTGGGCCTCTGTGCCCCATCCCTGCCTGTGGCTAAGAGCACCCTCCTGCAGAGGGTGGGAA GGAGAGATGAGTCCAGTATGCCAGGCCCCTCACGGAAGGCTGCATGCTGGGCTGGGGAGGGGCCACCATC CTGCCTCTCCTTCCTCCACAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCT CACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTT CTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGG GTCAGTGCCCTCGGTCACACTGTGTGGCTGTCTGCTTACCTCCCCCAACCCCGGTGGACTAGGGTCCCTT TCTCTGATGTTCCCTCAACTGTCACCTCTCAAGGAAACCCCATTATCCCTACAAAAAATTCTTACTGCCT TCCAACCCCTGTGACCCCATTCTCTCCACGGTGACTGTGTCATACCCCAAAGGTGACCTCTGTTTTTCTC CTGTGACCCTGTCACCTTCCATGGAGTCCCCATCCCAGATCCGTGAGTGACCCCCATCATGACTTTCTTT CTTGTCCCCAGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTC TCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAAG GGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCC TGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGGTATGGAGTCCAGTCT AAGCAGAGAGACTGATGGGCAGGGGAGGTGGGACCTTCAGCCCAGGGTCCACTGTGGGGGCAGAGGGAGT GGCAGAGACACCGGGGTTCCTTCCCCTAATGGGTCACCTTCTCTTGACCTTTCAGAATATGTGAACCAGC CAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCAC TCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGT GCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCT TCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCAC CTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGG CCAAGTCCGCAGAAGCCCTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGG TGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTTC CTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTTT GTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTC CTTCCAGATCCTGGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGT CTAAGAACAAAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACA GCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGTT TTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCT TCTCCACACCCACTTTGTCCATTTGCAAATATATTTTGGAAAACAGCTA Download Select all
Length	40579
OMIM ID	164870
HGNC ID	HGNC:3430
Unigene ID	Hs.446352
Ensembl ID	ENSG00000141736
PharmGKB ID	PA27844

mRNA Information

mRNA ID	NM_001289936.1
Exon	join(1..195,613..717,5178..5242,6905..7098,11454..11504, 18907..19058,20238..20451,21235..21369,21730..21798, 22003..22118,22257..22398,23845..23964,24239..24365, 27203..27276,27363..27453,27657..27856,28218..28350, 28432..28522,29237..29397,31704..31751,35236..35374, 35455..35577,35829..35927,36643..36828,36966..37121, 37244..37319,37624..37770,38479..38576,38732..38920, 39212..39464,39606..40579)
mRNA Sequence	>2064 GGAGGAGGTGGAGGAGGAGGGCTGCTTGAGGAAGTATAAGAATGAAGTTGTGAAGCTGAGATTC CCCTCCATTGGGACCGGAGAAACCAGGGGAGCCCCCCGGGCAGCCGCGCGCCCCTTCCCACGGG GCCCTTTACTGCGCCGCGCGCCCGGCCCCCACCCCTCGCAGCACCCCGCGCCCCGCGCCCTCCC AGCCGGGTCCAGCCGGAGCCATGGGGCCGGAGCCGCAGTGAGCACCATGGAGCTGGCGGCCTTG TGCCGCTGGGGGCTCCTCCTCGCCCTCTTGCCCCCCGGAGCCGCGAGCACCCAAGTGTGCACCG GCACAGACATGAAGCTGCGGCTCCCTGCCAGTCCCGAGACCCACCTGGACATGCTCCGCCACCT CTACCAGGGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAATGCCAGC CTGTCCTTCCTGCAGGATATCCAGGAGGTGCAGGGCTACGTGCTCATCGCTCACAACCAAGTGA GGCAGGTCCCACTGCAGAGGCTGCGGATTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGC CCTGGCCGTGCTAGACAATGGAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTCCCCA GGAGGCCTGCGGGAGCTGCAGCTTCGAAGCCTCACAGAGATCTTGAAAGGAGGGGTCTTGATCC AGCGGAACCCCCAGCTCTGCTACCAGGACACGATTTTGTGGAAGGACATCTTCCACAAGAACAA CCAGCTGGCTCTCACACTGATAGACACCAACCGCTCTCGGGCCTGCCACCCCTGTTCTCCGATG TGTAAGGGCTCCCGCTGCTGGGGAGAGAGTTCTGAGGATTGTCAGAGCCTGACGCGCACTGTCT GTGCCGGTGGCTGTGCCCGCTGCAAGGGGCCACTGCCCACTGACTGCTGCCATGAGCAGTGTGC TGCCGGCTGCACGGGCCCCAAGCACTCTGACTGCCTGGCCTGCCTCCACTTCAACCACAGTGGC ATCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAACACAGACACGTTTGAGTCCATGCCCA ATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTACAACTACCTTTC TACGGACGTGGGATCCTGCACCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGAT GGAACACAGCGGTGTGAGAAGTGCAGCAAGCCCTGTGCCCGAGTGTGCTATGGTCTGGGCATGG AGCACTTGCGAGAGGTGAGGGCAGTTACCAGTGCCAATATCCAGGAGTTTGCTGGCTGCAAGAA GATCTTTGGGAGCCTGGCATTTCTGCCGGAGAGCTTTGATGGGGACCCAGCCTCCAACACTGCC CCGCTCCAGCCAGAGCAGCTCCAAGTGTTTGAGACTCTGGAAGAGATCACAGGTTACCTATACA TCTCAGCATGGCCGGACAGCCTGCCTGACCTCAGCGTCTTCCAGAACCTGCAAGTAATCCGGGG ACGAATTCTGCACAATGGCGCCTACTCGCTGACCCTGCAAGGGCTGGGCATCAGCTGGCTGGGG CTGCGCTCACTGAGGGAACTGGGCAGTGGACTGGCCCTCATCCACCATAACACCCACCTCTGCT TCGTGCACACGGTGCCCTGGGACCAGCTCTTTCGGAACCCGCACCAAGCTCTGCTCCACACTGC CAACCGGCCAGAGGACGAGTGTGTGGGCGAGGGCCTGGCCTGCCACCAGCTGTGCGCCCGAGGG CACTGCTGGGGTCCAGGGCCCACCCAGTGTGTCAACTGCAGCCAGTTCCTTCGGGGCCAGGAGT GCGTGGAGGAATGCCGAGTACTGCAGGGGCTCCCCAGGGAGTATGTGAATGCCAGGCACTGTTT GCCGTGCCACCCTGAGTGTCAGCCCCAGAATGGCTCAGTGACCTGTTTTGGACCGGAGGCTGAC CAGTGTGTGGCCTGTGCCCACTATAAGGACCCTCCCTTCTGCGTGGCCCGCTGCCCCAGCGGTG TGAAACCTGACCTCTCCTACATGCCCATCTGGAAGTTTCCAGATGAGGAGGGCGCATGCCAGCC TTGCCCCATCAACTGCACCCACTCCTGTGTGGACCTGGATGACAAGGGCTGCCCCGCCGAGCAG AGAGCCAGCCCTCTGACGTCCATCATCTCTGCGGTGGTTGGCATTCTGCTGGTCGTGGTCTTGG GGGTGGTCTTTGGGATCCTCATCAAGCGACGGCAGCAGAAGATCCGGAAGTACACGATGCGGAG ACTGCTGCAGGAAACGGAGCTGGTGGAGCCGCTGACACCTAGCGGAGCGATGCCCAACCAGGCG CAGATGCGGATCCTGAAAGAGACGGAGCTGAGGAAGGTGAAGGTGCTTGGATCTGGCGCTTTTG GCACAGTCTACAAGGGCATCTGGATCCCTGATGGGGAGAATGTGAAAATTCCAGTGGCCATCAA AGTGTTGAGGGAAAACACATCCCCCAAAGCCAACAAAGAAATCTTAGACGAAGCATACGTGATG GCTGGTGTGGGCTCCCCATATGTCTCCCGCCTTCTGGGCATCTGCCTGACATCCACGGTGCAGC TGGTGACACAGCTTATGCCCTATGGCTGCCTCTTAGACCATGTCCGGGAAAACCGCGGACGCCT GGGCTCCCAGGACCTGCTGAACTGGTGTATGCAGATTGCCAAGGGGATGAGCTACCTGGAGGAT GTGCGGCTCGTACACAGGGACTTGGCCGCTCGGAACGTGCTGGTCAAGAGTCCCAACCATGTCA AAATTACAGACTTCGGGCTGGCTCGGCTGCTGGACATTGACGAGACAGAGTACCATGCAGATGG GGGCAAGGTGCCCATCAAGTGGATGGCGCTGGAGTCCATTCTCCGCCGGCGGTTCACCCACCAG AGTGATGTGTGGAGTTATGGTGTGACTGTGTGGGAGCTGATGACTTTTGGGGCCAAACCTTACG ATGGGATCCCAGCCCGGGAGATCCCTGACCTGCTGGAAAAGGGGGAGCGGCTGCCCCAGCCCCC CATCTGCACCATTGATGTCTACATGATCATGGTCAAATGTTGGATGATTGACTCTGAATGTCGG CCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGG TCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCT GGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTTC TTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTA CCAGGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTC TCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCA GCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACC CCACAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCC TGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCT GCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGG TCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGG AGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTAC TGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGGACACCTACGGCAG AGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCC CTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCC TCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTTCCTGCT TGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTT TGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGG CCCTTTCCTTCCAGATCCTGGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGC CCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGC CCCCCATGAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTT TAGTTTTTACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGT GTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTCTCCACACCCACTTTGTCCATTTGCAAATATA TTTTGGAAAACAGCTA Download Select all
Length	4624

CDS Information

Location	join(11477..11504,18907..19058,20238..20451,21235..21369, 21730..21798,22003..22118,22257..22398,23845..23964, 24239..24365,27203..27276,27363..27453,27657..27856, 28218..28350,28432..28522,29237..29397,31704..31751, 35236..35374,35455..35577,35829..35927,36643..36828, 36966..37121,37244..37319,37624..37770,38479..38576, 38732..38920,39212..39464,39606..39961)
CDS Sequence	>gi\|54792095:239-4006 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1, mRNA ATGGAGCTGGCGGCCTTGTGCCGCTGGGGGCTCCTCCTCGCCCTCTTGCCCCCCGGAGCCGCGAGCACCC AAGTGTGCACCGGCACAGACATGAAGCTGCGGCTCCCTGCCAGTCCCGAGACCCACCTGGACATGCTCCG CCACCTCTACCAGGGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAATGCCAGC CTGTCCTTCCTGCAGGATATCCAGGAGGTGCAGGGCTACGTGCTCATCGCTCACAACCAAGTGAGGCAGG TCCCACTGCAGAGGCTGCGGATTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCT AGACAATGGAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTCCCCAGGAGGCCTGCGGGAGCTG CAGCTTCGAAGCCTCACAGAGATCTTGAAAGGAGGGGTCTTGATCCAGCGGAACCCCCAGCTCTGCTACC AGGACACGATTTTGTGGAAGGACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGACACCAA CCGCTCTCGGGCCTGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCTGGGGAGAGAGTTCTGAG GATTGTCAGAGCCTGACGCGCACTGTCTGTGCCGGTGGCTGTGCCCGCTGCAAGGGGCCACTGCCCACTG ACTGCTGCCATGAGCAGTGTGCTGCCGGCTGCACGGGCCCCAAGCACTCTGACTGCCTGGCCTGCCTCCA CTTCAACCACAGTGGCATCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAACACAGACACGTTTGAG TCCATGCCCAATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTACAACTACC TTTCTACGGACGTGGGATCCTGCACCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGATGG AACACAGCGGTGTGAGAAGTGCAGCAAGCCCTGTGCCCGAGTGTGCTATGGTCTGGGCATGGAGCACTTG CGAGAGGTGAGGGCAGTTACCAGTGCCAATATCCAGGAGTTTGCTGGCTGCAAGAAGATCTTTGGGAGCC TGGCATTTCTGCCGGAGAGCTTTGATGGGGACCCAGCCTCCAACACTGCCCCGCTCCAGCCAGAGCAGCT CCAAGTGTTTGAGACTCTGGAAGAGATCACAGGTTACCTATACATCTCAGCATGGCCGGACAGCCTGCCT GACCTCAGCGTCTTCCAGAACCTGCAAGTAATCCGGGGACGAATTCTGCACAATGGCGCCTACTCGCTGA CCCTGCAAGGGCTGGGCATCAGCTGGCTGGGGCTGCGCTCACTGAGGGAACTGGGCAGTGGACTGGCCCT CATCCACCATAACACCCACCTCTGCTTCGTGCACACGGTGCCCTGGGACCAGCTCTTTCGGAACCCGCAC CAAGCTCTGCTCCACACTGCCAACCGGCCAGAGGACGAGTGTGTGGGCGAGGGCCTGGCCTGCCACCAGC TGTGCGCCCGAGGGCACTGCTGGGGTCCAGGGCCCACCCAGTGTGTCAACTGCAGCCAGTTCCTTCGGGG CCAGGAGTGCGTGGAGGAATGCCGAGTACTGCAGGGGCTCCCCAGGGAGTATGTGAATGCCAGGCACTGT TTGCCGTGCCACCCTGAGTGTCAGCCCCAGAATGGCTCAGTGACCTGTTTTGGACCGGAGGCTGACCAGT GTGTGGCCTGTGCCCACTATAAGGACCCTCCCTTCTGCGTGGCCCGCTGCCCCAGCGGTGTGAAACCTGA CCTCTCCTACATGCCCATCTGGAAGTTTCCAGATGAGGAGGGCGCATGCCAGCCTTGCCCCATCAACTGC ACCCACTCCTGTGTGGACCTGGATGACAAGGGCTGCCCCGCCGAGCAGAGAGCCAGCCCTCTGACGTCCA TCATCTCTGCGGTGGTTGGCATTCTGCTGGTCGTGGTCTTGGGGGTGGTCTTTGGGATCCTCATCAAGCG ACGGCAGCAGAAGATCCGGAAGTACACGATGCGGAGACTGCTGCAGGAAACGGAGCTGGTGGAGCCGCTG ACACCTAGCGGAGCGATGCCCAACCAGGCGCAGATGCGGATCCTGAAAGAGACGGAGCTGAGGAAGGTGA AGGTGCTTGGATCTGGCGCTTTTGGCACAGTCTACAAGGGCATCTGGATCCCTGATGGGGAGAATGTGAA AATTCCAGTGGCCATCAAAGTGTTGAGGGAAAACACATCCCCCAAAGCCAACAAAGAAATCTTAGACGAA GCATACGTGATGGCTGGTGTGGGCTCCCCATATGTCTCCCGCCTTCTGGGCATCTGCCTGACATCCACGG TGCAGCTGGTGACACAGCTTATGCCCTATGGCTGCCTCTTAGACCATGTCCGGGAAAACCGCGGACGCCT GGGCTCCCAGGACCTGCTGAACTGGTGTATGCAGATTGCCAAGGGGATGAGCTACCTGGAGGATGTGCGG CTCGTACACAGGGACTTGGCCGCTCGGAACGTGCTGGTCAAGAGTCCCAACCATGTCAAAATTACAGACT TCGGGCTGGCTCGGCTGCTGGACATTGACGAGACAGAGTACCATGCAGATGGGGGCAAGGTGCCCATCAA GTGGATGGCGCTGGAGTCCATTCTCCGCCGGCGGTTCACCCACCAGAGTGATGTGTGGAGTTATGGTGTG ACTGTGTGGGAGCTGATGACTTTTGGGGCCAAACCTTACGATGGGATCCCAGCCCGGGAGATCCCTGACC TGCTGGAAAAGGGGGAGCGGCTGCCCCAGCCCCCCATCTGCACCATTGATGTCTACATGATCATGGTCAA ATGTTGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCC AGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCT TCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCA GCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCA TCTACCAGGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTC CACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAAGGG GCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTG CCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAG ATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCT GGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCC GTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCA GCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTT CAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGA Download Select all
CCDS ID	CCDS74052.1

Protein Information

Protein ID	NP_001005862.1
Protein Name	V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homol
Molecular Wt. (Da)	134725
Protein Sequence	>2064 MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQV PLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRN PQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAG GCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPE GRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHL REVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISA WPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVH TVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVE ECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKP DLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVV FGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTV YKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVT QLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKIT DFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGI PAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQ NEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRS GGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTV PLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVK DVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENP EYLGLDVPV Download Select all
Length	1225
Uniprot ID	P23560
Ensembl Protein ID	ENSP00000320002

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	1196
Y	Phosphorylation	1248
Y	Phosphorylation	1166
Y	Phosphorylation	1248
Y	Phosphorylation	1218
Y	Phosphorylation	1023
Y	Phosphorylation	1139
Y	Phosphorylation	1221
Y	Phosphorylation	1222
Y	Phosphorylation	1248
Y	Phosphorylation	1109
Y	Phosphorylation	1191
Y	Phosphorylation	1192
Y	Phosphorylation	1218
Y	Phosphorylation	993
Y	Dephosphorylation	1248
Y	Dephosphorylation	1218
Y	Phosphorylation	877
Y	Phosphorylation	735
Y	Phosphorylation	923
Y	Phosphorylation	1005
S	Phosphorylation	1054
S	Phosphorylation	1024
S	Phosphorylation	1134
S	Phosphorylation	1151
S	Phosphorylation	1104
S	Phosphorylation	1121
Y	Phosphorylation	876
Y	Phosphorylation	846
Y	Phosphorylation	1004
Y	Phosphorylation	974
Y	Phosphorylation	1126
Y	Phosphorylation	1096
Y	Phosphorylation	1247
Y	Phosphorylation	1217
S	Phosphorylation	998
S	Phosphorylation	968
S	Phosphorylation	1107
S	Phosphorylation	1077

Enzyme Information

EC	2.7.10.1
Name	receptor protein-tyrosine kinase AATK AATYK AATYK2 AATYK3 ACH ALK anaplastic lymphoma kinase ARK ATP:protein-tyrosine O-phosphotransferase (ambiguous) AXL Bek Bfgfr BRT Bsk C-FMS CAK CCK4 CD115 CD135 CDw135 Cek1 Cek10 Cek11 Cek2 Cek3 Cek5 Cek6 Cek7 CFD1 CKIT CSF1R DAlk DDR1 DDR2 Dek DKFZp434C1418 Drosophila Eph kinase DRT DTK Ebk ECK EDDR1 Eek EGFR Ehk2 Ehk3 Elk EPH EPHA1 EPHA2 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EphB5 ephrin-B3 receptor tyrosine kinase EPHT EPHT2 EPHT3 EPHX ERBB ERBB1 ERBB2 ERBB3 ERBB4 ERK Eyk FGFR1 FGFR2 FGFR3 FGFR4 FLG FLK1 FLK2 FLT1 FLT2 FLT3 FLT4 FMS Fv2 HBGFR HEK11 HEK2 HEK3 HEK5 HEK6 HEP HER2 HER3 HER4 HGFR HSCR1 HTK IGF1R INSR INSRR insulin receptor protein-tyrosine kinase IR IRR JTK12 JTK13 JTK14 JWS K-SAM KDR KGFR KIA0641 KIAA1079 KIAA1459 Kil Kin15 Kin16 KIT KLG LTK MCF3 Mdk1 Mdk2 Mdk5 MEhk1 MEN2A/B Mep MER MERTK MET Mlk1 Mlk2 Mrk MST1R MTC1 MUSK Myk1 N-SAM NEP NET Neu neurite outgrowth regulating kinase NGL NOK nork novel oncogene with kinase-domain Nsk2 NTRK1 NTRK2 NTRK3 NTRK4 NTRKR1 NTRKR2 NTRKR3 Nuk NYK PCL PDGFR PDGFRA PDGFRB PHB6 protein-tyrosine kinase (ambiguous) protein tyrosine kinase (ambiguous) PTK PTK3 PTK7 receptor protein tyrosine kinase RET RON ROR1 ROR2 ROS1 RSE RTK RYK SEA Sek2 Sek3 Sek4 Sfr SKY STK STK1 TEK TIE TIE1 TIE2 TIF TKT TRK TRKA TRKB TRKC TRKE TYK1 TYRO10 Tyro11 TYRO3 Tyro5 Tyro6 TYRO7 UFO VEGFR1 VEGFR2 VEGFR3 Vik YK1 Yrk
Class	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases
Sysname	ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
Substrate	ATP [CPD:C00002]; [protein]-L-tyrosine
Product	ADP [CPD:C00008]; [protein]-L-tyrosine phosphate
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
12	SERPINA3	120	NP_001076.2	in vivo	10829039
1499	CTNNB1	286	NP_001895.1	in vitro;in vivo	770 260 511 245 482
1950	EGF	578	NP_001954.2	in vitro	12093292
2885	GRB2	150	NP_002077.1	in vitro	116 065 751 117 392 000 000 000
3105	HLA-A	826	NP_002107.3	in vitro	10593938
3320	HSP90AA1	777	NP_001017963.2	in vivo	11071886
3691	ITGB4	946	NP_000204.3	in vivo	11375975
3717	JAK2	993	NP_004963.1	in vivo	11940572
4582	MUC1	1152	P15941	in vivo	1 127 886 812 939 400
5286	PIK3C2A	4672	NP_002636.2	in vivo	10805725
5287	PIK3C2B	4160	NP_002637.3	in vivo	10805725
5781	PTPN11	1470	NP_002825.3	in vitro;in vivo	16729043
83442	SH3BGRL3	15332	NP_112576.1	in vitro;in vivo	16729043

Pathway Information

Pathway Name	Pathway ID
Adherens junction	hsa04520
Bladder cancer	hsa05219
Calcium signaling pathway	hsa04020
Central carbon metabolism in cancer	hsa05230
Endometrial cancer	hsa05213
ErbB signaling pathway	hsa04012
Focal adhesion	hsa04510
HIF-1 signaling pathway	hsa04066
MicroRNAs in cancer	hsa05206
Non-small cell lung cancer	hsa05223
Pancreatic cancer	hsa05212
Pathways in cancer	hsa05200
Prostate cancer	hsa05215
Proteoglycans in cancer	hsa05205

Structure Information

PDB ID	1N8Z
Resolution	2.52
Method	X-RAY DIFFRACTION
Chains	A
Molecule	Herceptin Fab (antibody) - light chain
Model	View

Domain Information

ID	Location	Description
cd05109	712-990	PTKc_HER2
cl21453	712-990	PKc_like superfamily
cd12094	641-684	TM_ErbB2
cl17045	641-684	TM_EGFR-like superfamily
cd00064	235-280	FU
cl00066	235-280	FU superfamily
cd00064	562-607	FU
cl00066	562-607	FU superfamily
cd00064	510-544	FU
cl00066	510-544	FU superfamily
cd05057	712-990	PTKc_EGFR_like
cd05108	712-1023	PTKc_EGFR
cd05110	712-1013	PTKc_HER4
cd05111	713-990	PTK_HER3
cd00192	724-976	PTKc
cd05060	726-984	PTKc_Syk_like
cd05056	724-977	PTKc_FAK
cd05040	724-977	PTKc_Ack_like
cd05034	724-976	PTKc_Src_like
cd05038	720-980	PTKc_Jak_rpt2
cd05053	715-979	PTKc_FGFR
cd05033	723-979	PTKc_EphR
cd05068	718-972	PTKc_Frk_like
cd05039	715-978	PTKc_Csk_like
cd05044	724-970	PTKc_c-ros
cd05032	726-974	PTKc_InsR_like
cd05059	719-974	PTKc_Tec_like
cd05052	726-979	PTKc_Abl
cd05058	724-977	PTKc_Met_Ron
cd05041	726-975	PTKc_Fes_like
cd05148	719-977	PTKc_Srm_Brk
cd05063	722-979	PTKc_EphR_A2
cd05116	726-969	PTKc_Syk
cd05065	724-979	PTKc_EphR_B
cd05115	726-969	PTKc_Zap-70
cd05045	724-979	PTKc_RET
cd05112	718-977	PTKc_Itk
cd13999	726-976	STKc_MAP3K-like
cd05036	720-969	PTKc_ALK_LTK
cd05066	724-979	PTKc_EphR_A
cd05048	720-972	PTKc_Ror
cd05099	724-979	PTKc_FGFR4
cd14203	724-974	PTKc_Src_Fyn_like
cd05114	715-973	PTKc_Tec_Rlk
cd05082	715-972	PTKc_Csk
cd05051	717-972	PTKc_DDR
cd05035	724-979	PTKc_TAM
cd05067	720-974	PTKc_Lck_Blk
cd14204	724-972	PTKc_Mer
cd05085	724-977	PTKc_Fer
cd05055	724-980	PTKc_PDGFR
cd05113	715-974	PTKc_Btk_Bmx
cd05101	724-979	PTKc_FGFR2
cd05083	724-979	PTKc_Chk
cd05098	724-979	PTKc_FGFR1
cd05081	716-972	PTKc_Jak3_rpt2
cd05100	715-979	PTKc_FGFR3
cd05074	714-976	PTKc_Tyro3
cd05049	723-972	PTKc_Trk
cd05075	724-982	PTKc_Axl
cd05043	725-974	PTK_Ryk
cd05061	723-973	PTKc_InsR
cd05054	720-977	PTKc_VEGFR
cd05084	726-969	PTKc_Fes
cd05072	720-974	PTKc_Lyn
cd05070	720-984	PTKc_Fyn
cd14205	715-972	PTKc_Jak2_rpt2
cd00180	726-974	PKc
cd05047	725-979	PTKc_Tie
cd05089	725-987	PTKc_Tie1
cd05079	720-979	PTKc_Jak1_rpt2
cd05071	714-972	PTKc_Src
cd05050	720-972	PTKc_Musk
cd05064	724-979	PTKc_EphR_A10
cd05073	720-974	PTKc_Hck
cd05069	726-984	PTKc_Yes
cd05046	714-977	PTK_CCK4
cd05090	718-972	PTKc_Ror1
cd05092	726-978	PTKc_TrkA
cd05080	720-979	PTKc_Tyk2_rpt2
cd05062	726-974	PTKc_IGF-1R
cd05088	714-987	PTKc_Tie2
cd14207	720-973	PTKc_VEGFR1
cd05095	726-972	PTKc_DDR2
cd05102	720-973	PTKc_VEGFR3
cd05097	719-972	PTKc_DDR_like
cd05103	720-973	PTKc_VEGFR2
cd05091	716-972	PTKc_Ror2
cd05096	750-972	PTKc_DDR1
cd05094	726-972	PTKc_TrkC
cd05093	726-981	PTKc_TrkB
cd14060	727-979	STKc_MLTK
cd05107	817-979	PTKc_PDGFR_beta
cd14061	725-979	STKc_MLK
cd05106	718-981	PTKc_CSF-1R
cd05104	817-973	PTKc_Kit
cd05105	817-972	PTKc_PDGFR_alpha
cd14145	718-977	STKc_MLK1
cd14059	726-974	STKc_MAP3K12_13
cd14148	725-969	STKc_MLK2
cd14147	719-979	STKc_MLK3
cd14146	725-977	STKc_MLK4
cd14014	721-946	STKc_PknB_like
cd13978	726-971	STKc_RIP
cd14058	726-974	STKc_TAK1
pfam01030	52-173	Recep_L_domain
cl08303	52-173	Recep_L_domain superfamily
cd06606	719-923	STKc_MAPKKK
cd14066	726-924	STKc_IRAK
cd05122	719-923	PKc_STE
cd14063	719-981	PK_KSR
cd06623	719-974	PKc_MAPKK_plant_like
cd14064	726-973	PKc_TNNI3K
cd06627	726-974	STKc_Cdc7_like
cd14151	726-982	STKc_B-Raf
cd14150	719-981	STKc_A-Raf
cd06612	717-928	STKc_MST1_2
cd14062	726-972	STKc_Raf
cd05037	726-975	PTK_Jak_rpt1
cd14003	723-937	STKc_AMPK-like
cd06605	719-972	PKc_MAPKK
cd05117	724-939	STKc_CAMK
cd14065	726-975	PKc_LIMK_like
cd08215	721-946	STKc_Nek
cd14664	726-924	STK_BAK1_like
pfam01030	366-486	Recep_L_domain
cl08303	366-486	Recep_L_domain superfamily
cd14149	726-974	STKc_C-Raf
cd14206	726-972	PTKc_Aatyk3
cd14027	764-976	STKc_RIP1
cd05087	723-972	PTKc_Aatyk1
cd06642	717-973	STKc_STK25
cd06609	719-934	STKc_MST3_like
cd06632	721-936	STKc_MEKK1_plant
cd05042	724-972	PTKc_Aatyk
cd14154	726-982	STKc_LIMK
cd06641	717-946	STKc_MST3
cd06614	724-923	STKc_PAK
cd06610	725-931	STKc_OSR1_SPAK
cd06620	715-973	PKc_Byr1_like
cd08529	726-972	STKc_FA2-like
cd14162	724-925	STKc_TSSK4-like
cd14080	724-937	STKc_TSSK-like
cd13983	725-923	STKc_WNK
cd08530	724-946	STKc_CNK2-like
cd14000	725-977	STKc_LRRK
cd05118	721-917	STKc_CMGC
cd06625	721-976	STKc_MEKK3_like
cd13979	719-967	STKc_Mos
cd06640	717-915	STKc_MST4
cd14098	723-946	STKc_Rad53_Cds1
cd13996	723-876	STKc_EIF2AK
cd07832	726-916	STKc_CCRK
cd14221	726-972	STKc_LIMK1
cd06650	715-950	PKc_MEK1
cd05581	724-917	STKc_PDK1
cd06628	722-974	STKc_Byr2_like
cd14009	726-947	STKc_ATG1_ULK_like
cd06619	719-923	PKc_MKK5
cd06630	722-974	STKc_MEKK1
cd06917	718-942	STKc_NAK1_like
cd14099	721-974	STKc_PLK
cd13992	737-979	PK_GC
cd14070	724-945	STKc_HUNK
cd14208	726-977	PTK_Jak3_rpt1
cd06631	721-922	STKc_YSK4
cd05123	726-943	STKc_AGC
cd14158	726-936	STKc_IRAK4
cd06647	721-973	STKc_PAK_I
cd08225	723-973	STKc_Nek5
cd05579	728-931	STKc_MAST_like
cd08222	721-917	STKc_Nek11
cd06621	718-944	PKc_Pek1_like
cd14068	725-967	STKc_LRRK2
cd14025	726-975	STKc_RIP4_like
cd06626	724-923	STKc_MEKK4
cd07834	723-917	STKc_MAPK
cd05580	718-923	STKc_PKA_like
cd14155	726-981	PKc_TESK
cd14002	725-923	STKc_STK36
cd14663	724-924	STKc_SnRK3
cd05582	724-925	STKc_RSK_N
cd05086	723-972	PTKc_Aatyk2
cd14222	726-980	STKc_LIMK2
cd07838	726-915	STKc_CDK4_6_like
cd14121	726-937	STKc_ULK3
cd14055	724-972	STKc_TGFbR2_like
cd06654	716-981	STKc_PAK1
cd05078	726-977	PTK_Jak2_rpt1
cd14048	718-916	STKc_EIF2AK3_PERK
cd14054	725-917	STKc_BMPR2_AMHR2
cd06617	718-972	PKc_MKK3_6
cd14042	750-982	PK_GC-A_B
cd06656	716-981	STKc_PAK3
cd14008	726-946	STKc_LKB1_CaMKK
cd07841	722-923	STKc_CDK7
cd14081	724-937	STKc_BRSK1_2
cd05613	723-925	STKc_MSK1_N
cd14082	724-913	STKc_PKD
cd14137	716-917	STKc_GSK3
cd06652	718-917	STKc_MEKK2
cd06655	726-981	STKc_PAK2
cd14202	719-945	STKc_ULK1
cd07830	723-922	STKc_MAK_like
cd06651	721-974	STKc_MEKK3
cd14026	723-917	STKc_RIP2
cd14156	726-980	PKc_LIMK_like_unk
cd14056	724-967	STKc_TGFbR_I
cd14077	723-924	STKc_Kin1_2
cd05572	726-925	STKc_cGK
cd06616	726-979	PKc_MKK4
cd07870	723-937	STKc_PFTAIRE2
cd14072	721-942	STKc_MARK
cd06615	718-936	PKc_MEK
cd14097	726-939	STKc_STK33
cd06636	723-931	STKc_MAP4K4_6_N
cd14153	724-985	PK_KSR2
cd14120	726-923	STKc_ULK1_2-like
cd06629	722-975	STKc_Bck1_like
cd14087	725-924	STKc_PSKH1
cd05611	723-933	STKc_Rim15_like
cd13998	725-915	STKc_TGFbR-like
cd06618	709-972	PKc_MKK7
cd14209	723-924	STKc_PKA
cd14076	726-928	STKc_Kin4
cd06624	725-923	STKc_ASK
cd06643	726-915	STKc_SLK
cd14053	724-971	STKc_ACVR2
cd05578	725-925	STKc_Yank1
cd14006	726-931	STKc_MLCK-like
cd06608	723-915	STKc_myosinIII_N_like
cd14186	725-924	STKc_PLK4
cd06653	721-917	STKc_MEKK3_like_u1
cd06644	726-915	STKc_STK10
cd08219	723-918	STKc_Nek3
cd14031	726-923	STKc_WNK3
cd07862	723-922	STKc_CDK6
cd06638	723-973	STKc_myosinIIIA_N
cd14152	726-986	STKc_KSR1
cd07829	721-924	STKc_CDK_like
cd14161	723-956	STKc_NUAK2
cd14096	718-937	STKc_RCK1-like
cd07851	721-917	STKc_p38
cd08220	722-975	STKc_Nek8
cd13982	724-942	STKc_IRE1
cd14071	747-925	STKc_SIK
cd14142	723-915	STKc_ACVR1_ALK1
cd08228	724-946	STKc_Nek6
cd05584	724-950	STKc_p70S6K
cd07863	723-922	STKc_CDK4
cd06637	723-931	STKc_TNIK
cd14079	724-937	STKc_AMPK_alpha
cd05612	719-923	STKc_PRKX_like
cd06622	719-923	PKc_PBS2_like
cd14113	722-923	STKc_Trio_C
cd08218	721-917	STKc_Nek1
cd08217	723-972	STKc_Nek2
cd06649	715-931	PKc_MEK2
cd14046	717-867	STKc_EIF2AK4_GCN2_rpt2
cd08221	723-973	STKc_Nek9
cd07879	722-945	STKc_p38delta
cd13989	726-923	STKc_IKK
cd08224	724-918	STKc_Nek6_7
cd14045	750-979	PK_GC_unk
cd14167	724-923	STKc_CaMKI_alpha
cd14201	719-946	STKc_ULK2
cd14166	724-923	STKc_CaMKI_gamma
cd14075	726-875	STKc_NIM1
cd07869	716-937	STKc_PFTAIRE1
cd14069	723-924	STKc_Chk1
cd14100	725-924	STKc_PIM1
cd14007	724-931	STKc_Aurora
cd08223	804-921	STKc_Nek4
cd14190	724-925	STKc_MLCK2
cd07866	726-922	STKc_BUR1
cd05616	723-925	STKc_cPKC_beta
cd06613	726-915	STKc_MAP4K3_like
cd13990	726-923	STKc_TLK
cd05630	720-939	STKc_GRK6
cd14116	724-924	STKc_Aurora-A
cd05614	723-923	STKc_MSK2_N
cd14192	719-925	STKc_MLCK3
cd05592	724-925	STKc_nPKC_theta_like
cd14131	722-972	PKc_Mps1
cd13986	723-976	STKc_16
cd13997	719-973	PKc_Wee1_like
cd14191	726-925	STKc_MLCK1
cd07840	721-871	STKc_CDK9_like
cd07836	721-917	STKc_Pho85
cd14032	726-917	STKc_WNK2_like
cd14073	724-925	STKc_NUAK
cd14017	723-868	STKc_TTBK
cd05602	716-923	STKc_SGK1
cd05604	723-923	STKc_SGK3
cd13985	719-967	STKc_GAK_like
cd08229	724-979	STKc_Nek7
cd14165	726-950	STKc_TSSK1_2-like
cd14110	761-938	STKc_obscurin_rpt2
cd14105	726-925	STKc_DAPK
cd05615	715-925	STKc_cPKC_alpha
cd14193	720-925	STKc_MLCK4
cd05077	726-975	PTK_Jak1_rpt1
cd14084	719-910	STKc_Chk2
cd13994	726-917	STKc_HAL4_like
cd14033	726-923	STKc_WNK4
cd14043	804-981	PK_GC-2D
cd06611	726-977	STKc_SLK_like
cd07842	727-917	STKc_CDK8_like
cd05620	724-925	STKc_nPKC_delta
cd05570	724-925	STKc_PKC
cd14038	726-923	STKc_IKK_beta
cd14044	829-979	PK_GC-C
cd05573	722-923	STKc_ROCK_NDR_like
cd05076	771-977	PTK_Tyk2_rpt1
cd13988	726-923	STKc_TBK1
cd14001	815-917	PKc_TOPK
cd06607	718-915	STKc_TAO
cd07880	721-917	STKc_p38gamma
cd05631	720-923	STKc_GRK4
cd14194	726-930	STKc_DAPK1
cd06659	800-923	STKc_PAK6
cd06648	796-923	STKc_PAK_II
cd05583	725-923	STKc_MSK_N
cd13993	720-923	STKc_Pat1_like
cd14164	726-931	STKc_TSSK6-like
cd14067	752-975	STKc_LRRK1
cd14093	725-923	STKc_PhKG
cd14106	724-925	STKc_DRAK
cd05632	720-925	STKc_GRK5
cd14197	724-925	STKc_DRAK1
cd07877	726-917	STKc_p38alpha
cd14005	724-917	STKc_PIM
cd07833	722-917	STKc_CDKL
cd14103	726-910	STKc_MLCK
cd14030	726-917	STKc_WNK1
cd05619	724-931	STKc_nPKC_theta
cd06658	764-927	STKc_PAK5
cd06639	723-973	STKc_myosinIIIB_N
cd07878	720-916	STKc_p38beta
cd07853	828-916	STKc_NLK
cd14107	726-917	STKc_obscurin_rpt1
cd14101	719-973	STKc_PIM2
cd14010	796-945	STKc_ULK4
cd14083	724-910	STKc_CaMKI
cd14114	726-925	STKc_Twitchin_like
cd13987	726-917	STKc_SBK1
cd14143	725-915	STKc_TGFbR1_ACVR1b_ACVR1c
cd08528	726-918	STKc_Nek10
cd14196	726-925	STKc_DAPK2
cd05577	726-923	STKc_GRK
cd14050	722-974	PKc_Myt1
cd07864	828-917	STKc_CDK12
cd14102	725-924	STKc_PIM3
cd05587	724-931	STKc_cPKC
cd06646	723-945	STKc_MAP4K5
cd07835	722-917	STKc_CDK1_CdkB_like
cd07856	726-916	STKc_Sty1_Hog1
cd07831	726-918	STKc_MOK
cd14144	724-915	STKc_BMPR1
cd14199	812-923	STKc_CaMKK2
cd14078	714-924	STKc_MELK
cd14181	725-923	STKc_PhKG2
cd14085	724-923	STKc_CaMKIV
cd14052	721-967	PTKc_Wee1_fungi
cd05607	724-923	STKc_GRK7
cd14665	723-924	STKc_SnRK2-3
cd05603	724-923	STKc_SGK2
cd14198	724-930	STKc_DRAK2
cd07858	828-922	STKc_TEY_MAPK
cd05608	724-916	STKc_GRK1
cd07852	828-922	STKc_MAPK15-like
cd14011	827-924	PK_SCY1_like
cd05593	723-923	STKc_PKB_gamma
cd06645	717-931	STKc_MAP4K3
cd07849	725-923	STKc_ERK1_2_like
cd14189	807-930	STKc_PLK3
cd14057	732-979	PK_ILK
cd05605	721-923	STKc_GRK4_like
cd07857	828-922	STKc_MPK1
cd14138	718-973	PTKc_Wee1a
cd07860	721-917	STKc_CDK2_3
cd07871	722-917	STKc_PCTAIRE3
cd06635	718-915	STKc_TAO1
cd07855	723-909	STKc_ERK5
cd07876	721-916	STKc_JNK2
cd13975	827-967	PKc_Dusty
cd05595	724-923	STKc_PKB_beta
cd14179	717-939	STKc_MSK1_C
cd14169	726-923	STKc_CaMKI_beta
cd06633	726-915	STKc_TAO3
cd14133	723-917	PKc_DYRK_like
cd14016	721-868	STKc_CK1
cd06634	718-915	STKc_TAO2
cd14041	725-975	STKc_TLK2
cd07854	721-917	STKc_MAPK4_6
cd13991	726-907	STKc_NIK
cd05589	721-933	STKc_PKN
cd05575	724-926	STKc_SGK
cd13968	726-865	PKc_like
cd14118	829-975	STKc_CAMKK
cd14040	723-975	STKc_TLK1
cd14200	829-923	STKc_CaMKK1
cd07873	722-917	STKc_PCTAIRE1
cd14176	794-927	STKc_RSK2_C
cd14119	828-925	STKc_LKB1
cd14175	794-937	STKc_RSK1_C
cd14086	726-916	STKc_CaMKII
cd06657	764-927	STKc_PAK4
cd05610	723-869	STKc_MASTL
cd14089	724-916	STKc_MAPKAPK
cd14662	723-924	STKc_SnRK2
cd14177	794-927	STKc_RSK4_C
cd05600	715-868	STKc_Sid2p_like
cd07861	722-917	STKc_CDK1_euk
smart00261	557-603	FU
cd14168	724-923	STKc_CaMKI_delta
cd14187	828-975	STKc_PLK1
cd14184	724-923	STKc_DCKL2
cd14140	724-966	STKc_ACVR2b
cd05618	792-943	STKc_aPKC_iota
cd14178	794-927	STKc_RSK3_C
cd14094	725-929	STKc_CASK
cd14074	724-868	STKc_SNRK
cd05609	832-925	STKc_MAST
cd14195	726-930	STKc_DAPK3
cd14049	719-916	STKc_EIF2AK1_HRI
cd14012	793-976	PK_eIF2AK_GCN2_rpt1
cd05586	726-923	STKc_Sck1_like
cd07845	718-917	STKc_CDK10
cd07872	722-915	STKc_PCTAIRE2
cd07850	724-916	STKc_JNK
cd14136	828-917	STKc_SRPK
cd05585	725-923	STKc_YPK1_like
cd13981	724-919	STKc_Bub1_BubR1
cd14188	807-930	STKc_PLK2
cd14039	726-923	STKc_IKK_alpha
cd14172	724-943	STKc_MAPKAPK3
cd14095	723-867	STKc_DCKL
cd14111	813-931	STKc_SPEG_rpt2
cd14091	793-923	STKc_RSK_C
cd14047	726-916	STKc_EIF2AK2_PKR
cd14141	724-915	STKc_ACVR2a
cd14183	718-925	STKc_DCKL1
cd14092	796-870	STKc_MSK_C
cd14180	796-925	STKc_MSK2_C
cd07844	722-917	STKc_PCTAIRE_like
cd05598	722-923	STKc_LATS
cd14088	762-923	STKc_CaMK_like
cd14171	714-932	STKc_MAPKAPK5
cd07843	828-917	STKc_CDC2L1
cd05617	792-943	STKc_aPKC_zeta
cd07875	828-919	STKc_JNK1
cd07848	801-915	STKc_CDKL5
cd14174	724-925	STKc_Mnk1
cd05621	715-923	STKc_ROCK2
cd07837	722-915	STKc_CdkB_plant
cd14134	723-917	PKc_CLK
cd14090	796-925	STKc_Mnk
cd13995	729-923	STKc_MAP3K8
cd07874	828-916	STKc_JNK3
cd05571	724-916	STKc_PKB
cd05588	796-943	STKc_aPKC
cd07859	724-922	STKc_TDY_MAPK
cd14117	726-924	STKc_Aurora-B_like
cd14159	726-939	STKc_IRAK1
cd14220	724-915	STKc_BMPR1a
cd05590	724-936	STKc_nPKC_eta
cd05629	719-867	STKc_NDR_like_fungal
cd14109	806-930	PK_Unc-89_rpt1
cd07839	722-937	STKc_CDK5
cd05594	723-916	STKc_PKB_alpha
cd14135	827-917	STKc_PRP4
cd14125	721-868	STKc_CK1_delta_epsilon
cd07846	806-917	STKc_CDKL2_3
cd14115	726-923	STKc_Kalirin_C
cd14163	794-942	STKc_TSSK3-like
cd14019	726-966	STKc_Cdc7
cd05599	842-923	STKc_NDR_like
cd05574	720-925	STKc_phototropin_like
cd14128	721-878	STKc_CK1_alpha
cd14004	723-937	STKc_PASK
cd07847	722-917	STKc_CDKL1_4
cd14170	724-923	STKc_MAPKAPK2
cd14229	726-926	STKc_HIPK3
smart00261	509-544	FU
cd07865	721-868	STKc_CDK9
cd14182	796-923	STKc_PhKG1
cd14108	828-925	STKc_SPEG_rpt1
cd14173	796-925	STKc_Mnk2
cd14185	751-945	STKc_DCKL3
cd14223	724-923	STKc_GRK2
smart00261	235-270	FU
cd14219	719-915	STKc_BMPR1b
pfam07714	720-976	Pkinase_Tyr
pfam14843	511-643	GF_recep_IV
pfam00757	189-343	Furin-like
smart00219	720-976	TyrKc
smart00221	720-976	STYKc
smart00220	721-972	S_TKc
pfam00069	720-973	Pkinase
COG0515	719-984	SPS1
PLN00034	699-914	PLN00034
PHA03209	707-928	PHA03209
PHA03212	756-917	PHA03212
PTZ00024	710-917	PTZ00024
PTZ00263	715-943	PTZ00263
PTZ00426	715-923	PTZ00426
pfam00757	502-603	Furin-like
PTZ00267	828-996	PTZ00267
TIGR03903	750-917	TOMM_kin_cyc
PTZ00283	724-945	PTZ00283
PRK13184	723-990	pknD
PLN00009	828-917	PLN00009
pfam14843	194-270	GF_recep_IV
COG3170	1063-1192	FimV
pfam14843	236-271	GF_recep_IV

Ontology Information

HPRD ID	214
Molecular Class	Receptor tyrosine kinase
Molecular Function	Receptor binding (GO:0005102)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P04626 DB00072 Trastuzumab BiotechDrug
P04626 DB01259 Lapatinib SmallMoleculeDrug
P04626 DB05773 ado-trastuzumab emtansine SmallMoleculeDrug
P04626 DB06366 Pertuzumab BiotechDrug
P04626 DB08916 Afatinib SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Uniprot ID	DrugBank ID	Name	Type
P04626	DB00072	Trastuzumab	BiotechDrug
P04626	DB01259	Lapatinib	SmallMoleculeDrug
P04626	DB05773	ado-trastuzumab emtansine	SmallMoleculeDrug
P04626	DB06366	Pertuzumab	BiotechDrug
P04626	DB08916	Afatinib	SmallMoleculeDrug

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO