Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ERCC1 2067 Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)  19UV20; COFS4; RAD10 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22994779   2012Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 335 primary advanced colorectal carcinoma (including 182 colon and 153 rectal cancer patients)

Stage : -

GenotypingPolymorhpism-GSTP1 Val/Val, ERCC1 C/C and ERCC2 G/G were significantly associated with better survival of colorectal cancer, and these three gene polymorphisms could be used as predictive markers for the prognosis of colorectal cancer.


Gene Details



Chromosome: 19; NC_000019.9 (45910591..45927177, complement)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]  
Chromosome 19
Location 19q13.32
Start 45407333  
End 45478820  
Strand -  
Gene Sequence

   Download   Select all

Length 71488  
OMIM ID 126380   
HGNC ID HGNC:3433   
Unigene ID Hs.435981    
Ensembl ID ENSG00000012061   
PharmGKB ID PA155   

mRNA Information


mRNA ID NM_001297590.1
Exon complement(<68055..70688)  
mRNA Sequence

   Download   Select all

Length 3328  



CDS Information


   
Locationcomplement(<69320..70688)
CDS Sequence

   Download   Select all

CCDS ID CCDS74397.1



Protein Information


      
Protein IDNP_001974.1
Protein NameExcision repair cross-complementing rodent repair deficiency, complementation group 1 (includes over
Molecular Wt. (Da)32431
Protein Sequence

   Download   Select all

Length 297  
Uniprot IDP13688
Ensembl Protein ID ENSP00000161559  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
84993UBL716556NP_116296.1yeast 2-hybrid16189514   


Pathway Information


            
Pathway Name Pathway ID
Fanconi anemia pathway hsa03460
Nucleotide excision repair hsa03420


Structure Information


PDB ID1Z00
Resolution-
MethodSOLUTION NMR
Chains A  
Molecule DNA excision repair protein ERCC-1  
Model View



Domain Information




ID Location Description
TIGR0059799-210  rad10
cl0428399-210  Rad10 superfamily
pfam0383499-166  Rad10
pfam14520239-291  HHH_5
cl22429239-291  ENDO3c superfamily
pfam12826245-292  HHH_2
pfam00633259-288  HHH
COG524195-294  RAD10
PRK00558251-291  uvrC
PRK00024250-282  PRK00024
PRK13766147-293  PRK13766
COG0272245-292  Lig
PRK07956245-292  ligA
PRK14671236-291  uvrC
COG1948101-293  MUS81
PRK14666239-291  uvrC
TIGR00575242-292  dnlj
COG2003250-282  RadC
PRK13482239-283  PRK13482
PRK14668235-285  uvrC


Ontology Information


   
HPRD ID191
Molecular ClassDNA repair protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessSignal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO