Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ERCC1 | 2067 | Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)  | 19 | UV20; COFS4; RAD10  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22994779    | 2012 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 335 primary advanced colorectal carcinoma (including 182 colon and 153 rectal cancer patients) Stage : - | Genotyping | Polymorhpism | - | GSTP1 Val/Val, ERCC1 C/C and ERCC2 G/G were significantly associated with better survival of colorectal cancer, and these three gene polymorphisms could be used as predictive markers for the prognosis of colorectal cancer. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]   | Chromosome | 19 |
| Location | 19q13.32 |
| Start | 45407333   |
| End | 45478820   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 71488   |
| OMIM ID | 126380    |
| HGNC ID | HGNC:3433    |
| Unigene ID | Hs.435981     |
| Ensembl ID | ENSG00000012061    |
| PharmGKB ID | PA155    |
mRNA Information
| mRNA ID | NM_001297590.1 |
|---|---|
| Exon | complement(<68055..70688)   | mRNA Sequence |    Download   Select all |
| Length | 3328   |
CDS Information
| Location | complement(<69320..70688) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS74397.1 |    
Protein Information
| Protein ID | NP_001974.1 |
|---|---|
| Protein Name | Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes over |
| Molecular Wt. (Da) | 32431 |
| Protein Sequence |    Download   Select all |
| Length | 297   |
| Uniprot ID | P13688 |    
| Ensembl Protein ID | ENSP00000161559   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 84993 |    UBL7 |    16556 |    NP_116296.1 |    yeast 2-hybrid |    16189514    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Fanconi anemia pathway |    hsa03460 |    
| Nucleotide excision repair |    hsa03420 |    
Structure Information
| PDB ID | 1Z00 |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A   |
| Molecule | DNA excision repair protein ERCC-1   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| TIGR00597 | 99-210  | rad10 |
| cl04283 | 99-210  | Rad10 superfamily |
| pfam03834 | 99-166  | Rad10 |
| pfam14520 | 239-291  | HHH_5 |
| cl22429 | 239-291  | ENDO3c superfamily |
| pfam12826 | 245-292  | HHH_2 |
| pfam00633 | 259-288  | HHH |
| COG5241 | 95-294  | RAD10 |
| PRK00558 | 251-291  | uvrC |
| PRK00024 | 250-282  | PRK00024 |
| PRK13766 | 147-293  | PRK13766 |
| COG0272 | 245-292  | Lig |
| PRK07956 | 245-292  | ligA |
| PRK14671 | 236-291  | uvrC |
| COG1948 | 101-293  | MUS81 |
| PRK14666 | 239-291  | uvrC |
| TIGR00575 | 242-292  | dnlj |
| COG2003 | 250-282  | RadC |
| PRK13482 | 239-283  | PRK13482 |
| PRK14668 | 235-285  | uvrC |
Ontology Information
| HPRD ID | 191 |    
|---|---|
| Molecular Class | DNA repair protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
