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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ERCC5 2073 excision repair cross-complementation group 5  13- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23626689   2013Cell line : -

Source : Newfoundland Colorectal Cancer Registry (NFCCR)

Sample Type : Population based case control study

No. of Sample : 532

Stage : TNM stage I -IV

Sequenom MassArray platform, TaqMan SNP genotyping assays and gel electrophoresis of PCR-amplified fragments. Polymorhpism-ERCC5 His46His polymorphism with DFS were identified in two colorectal cancer patient cohorts.

26225711   2015Cell line : -

Source : PubMed, Embase and Web of Science

Sample Type : -

No. of Sample : -

Stage : -

Meta analysisPolymorhpism-ERCC5 rs17655 polymorphism might contribute to genetic susceptibility to colorectal cancer.


Gene Details



NC_000013.10 (103498191..103528351)

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Gene Type protein coding
Gene Family -
Description This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]  
Chromosome 13
Location 13q22-q34
Start 103498191  
End 103528351  
Strand +  
Gene Sequence

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Length 30161  
OMIM ID 133530   
HGNC ID HGNC:3437   
Unigene ID Hs.258429   
Ensembl ID ENSG00000134899   
PharmGKB ID PA27851   

mRNA Information


mRNA ID NM_001204425.1
Exon join(<6278..6453,7917..8032,8448..8534,10212..10272, 12435..12578,15667..15874,16190..17263,19827..20071, 20422..20541,20792..21005,22273..22417,26358..26558, 27419..27503,29467..30161)  
mRNA Sequence

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Length 5143  



CDS Information


   
Location 123..5045
CDS Sequence

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CCDS ID CCDS32004.1



Protein Information


      
Protein IDNP_001191354.1
Protein Nameexcision repair cross-complementation group 5
Molecular Wt. (Da)184521
Protein Sequence

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Length 1640  
Uniprot IDO14733
Ensembl Protein ID ENSP00000381066  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation338
SPhosphorylation341
SPhosphorylation355
SPhosphorylation356
SPhosphorylation357
SPhosphorylation384
SPhosphorylation428
SPhosphorylation526
SPhosphorylation563
SPhosphorylation526;-
SPhosphorylation562;-
SPhosphorylation563;-
SPhosphorylation384;-
SPhosphorylation724;-
SPhosphorylation156;-
SPhosphorylation157;-
SPhosphorylation558;-
SPhosphorylation559;-
SPhosphorylation382
SPhosphorylation423
SPhosphorylation424
KAcetylation8
TPhosphorylation567
SPhosphorylation100
SPhosphorylation363
TPhosphorylation920
TPhosphorylation924
TPhosphorylation738

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2068ERCC2530NP_000391.1in vitro8652557   
2130EWSR1592NP_053733.2yeast 2-hybrid16713569   
2968GTF2H43456NP_001508.1in vivo16246722   
5430POLR2A8916NP_000928.1in vivo16246722   


Pathway Information


      
Pathway Name Pathway ID
Nucleotide excision repair hsa03420


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd098681-130  PIN_XPG
cl148121-130  PIN_SF superfamily
cd09868750-982  PIN_XPG
cl14812750-982  PIN_SF superfamily
cd09904849-943  H3TH_XPG
cl22433849-943  H3TH_StructSpec-5'-nucleases superfamily
cd09856763-979  PIN_FEN1-like
pfam00752Feb-98  XPG_N
cl02628Feb-98  XPG_N superfamily
smart00485Jan-98  XPGN
cd09856May-88  PIN_FEN1-like
pfam00867777-861  XPG_I
cl22865777-861  XPG_I superfamily
smart00484777-837  XPGI
cd098691-108  PIN_GEN1
cd098701-113  PIN_YEN1
cd09867711-847  PIN_FEN1
cd098675-108  PIN_FEN1
cd09869771-835  PIN_GEN1
cd09870772-830  PIN_YEN1
cd098571-120  PIN_EXO1
cd0012820-146  PIN_FEN1_EXO1-like
cd09900849-906  H3TH_XPG-like
cd09857711-842  PIN_EXO1
cd09852750-821  PIN_SF
cd09897849-937  H3TH_FEN1-XPG-like
cd00128740-830  PIN_FEN1_EXO1-like
cd09905848-939  H3TH_GEN1
smart00279848-881  HhH2
cd09906848-942  H3TH_YEN1
cd0985326-115  PIN_StructSpec-5'-nucleases
cd0985228-95  PIN_SF
cd00080849-904  H3TH_StructSpec-5'-nucleases
TIGR006001-1029  rad2
PTZ00217711-1033  PTZ00217
TIGR03674711-997  fen_arch
PRK03980711-997  PRK03980
PTZ002171-121  PTZ00217
TIGR036741-127  fen_arch
COG0258746-998  Exo
COG025815-96  Exo
PRK0398043-95  PRK03980
pfam09528277-698  Ehrlichia_rpt


Ontology Information


   
HPRD ID1453
Molecular ClassDNA repair protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessMetabolism (GO:0008152)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO