Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ERG | 2078 | v-ets avian erythroblastosis virus E26 oncogene homolog | 21 | erg-3, p55 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14744775 | 2004 | Cell line : H630, HCT8, DLD1,
HCT116 Source : First Division of General Surgery and Transplantation of Careggi Hospital, Firenze Sample Type : CRC tumor and normal tissue No. of Sample : 11 Stage : - | Cell Invasion Assay,RNase Protection Assay,real time RT-PCR,Western Blotting,Immunohistochemistry | Up-regulation | - | Both the herg1 gene and HERG1 protein were expressed in a high percentage of primary human colorectal cancers, with the highest incidence occurring in metastatic cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014] | Chromosome | 21 |
| Location | 21q22.3 |
| Start | 39739183 |
| End | 40033704 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 294522 |
| OMIM ID | 165080 |
| HGNC ID | HGNC:3446 |
| Unigene ID | Hs.473819 |
| Ensembl ID | ENSG00000157554 |
| PharmGKB ID | PA27858 |
mRNA Information
| mRNA ID | NM_000124.3 |
|---|---|
| Exon | join(1..162,6146..6581,8284..8404,10599..10707, 14347..15091,33112..33240,38428..38586,45872..46007, 55608..55778,56261..56437,60654..60770,62814..62909, 64882..65097,65537..65647,66096..66215,66654..66748, 68004..68149,68235..68942,77568..77772,78673..78751, 79890..84644) | mRNA Sequence | Download Select all |
| Length | 8993 |
Protein Information
| Protein ID | NP_000115.1 |
|---|---|
| Protein Name | v-ets avian erythroblastosis virus E26 oncogene homolog |
| Molecular Wt. (Da) | 168286 |
| Protein Sequence | Download Select all |
| Length | 1493 |
| Uniprot ID | F7VJQ1 |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 86 |
| S | Phosphorylation | 93 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2114 | ETS2 | 1263 | NP_005230.1 | in vitro;yeast 2-hybrid | 9334186 |
| 3725 | JUN | 1302 | NP_002219.1 | in vitro;in vivo | 11278640 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08540 | 134-208 | SAM_PNT-ERG |
| cl15755 | 134-208 | SAM_superfamily superfamily |
| pfam00178 | 317-400 | Ets |
| cl02599 | 317-400 | Ets superfamily |
| smart00413 | 317-400 | ETS |
| cd08541 | 122-205 | SAM_PNT-FLI-1 |
| cd08531 | 134-208 | SAM_PNT-ERG_FLI-1 |
| pfam02198 | 122-204 | SAM_PNT |
| smart00251 | 122-204 | SAM_PNT |
| cd08203 | 137-204 | SAM_PNT |
| cd08534 | 131-205 | SAM_PNT-GABP-alpha |
| cd08533 | 135-203 | SAM_PNT-ETS-1,2 |
| cd08532 | 134-199 | SAM_PNT-PDEF-like |
| cd08543 | 126-199 | SAM_PNT-ETS-2 |
| cd08542 | 126-204 | SAM_PNT-ETS-1 |
| cd08535 | 137-203 | SAM_PNT-Tel_Yan |
| cd08536 | 137-183 | SAM_PNT-Mae |
| cd08757 | 137-204 | SAM_PNT_ESE |
| cd08538 | 138-183 | SAM_PNT-ESE-2-like |
| cd09528 | 141-199 | SAM_Samd9_Samd9L |
| cd08539 | 138-203 | SAM_PNT-ESE-3-like |
| cd09583 | 138-182 | SAM_Atherin-like |
Ontology Information
| HPRD ID | 5115 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Serine-type peptidase activity (GO:0008236) |
| Biological Process | Proteolysis and peptidolysis (GO:0006508) |
Drug Information
No matching records could be found.