CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
25970543	2015	Cell line : - Source : Loannina University Hospital, Papageorgiou� Hospital, University Hospital of Patras, Henry Dunant� Hospital, Agii AnargiriCancer Hospital, Alexandra� Hospital, Sotiria Hospital, Attikon Hospital. Sample Type : CRC tumor No. of Sample : 441 Stage : TNM stage II, III	real time RT-PCR, multivariable analysis,Immunohistochemistry	Down-regulation	-	In localised CRC, mRNA-based CD3Z/CD8 profiling of tumour immune response may have stage, site and tissue-specific prognostic significance, along with ESR1 expression.

Gene Details

NC_000006.11 (152011631..152424409)
View Larger Image   

Gene Type	protein coding
Gene Family	Nuclear hormone receptors
Description	This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Chromosome	6
Location	6q24-q27
Start	152011631
End	152424409
Strand	+
Gene Sequence	Download   Select all
Length	412779
OMIM ID	133430
HGNC ID	HGNC:3467
Unigene ID	Hs.208124
Ensembl ID	ENSG00000091831
PharmGKB ID	PA156

mRNA Information

mRNA ID	NM_001122742.1
Exon	join(1..169,11380..11510,117348..117869,152102..152292, 190160..190276,253678..254013,321161..321299, 370496..370629,403890..404073,408237..412779)
mRNA Sequence	Download   Select all
Length	6466

CDS Information

   

Location	371..2158
CDS Sequence	Download   Select all
CCDS ID	CCDS5234.1

Protein Information

      

Protein ID	NP_001116214.1
Protein Name	estrogen receptor 1
Molecular Wt. (Da)	66085
Protein Sequence	Download   Select all
Length	595
Uniprot ID	Q92786
Ensembl Protein ID	ENSP00000261454

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	537
S	Phosphorylation	167
S	Phosphorylation	167
Y	Dephosphorylation	537
Y	Dephosphorylation	537
S	Phosphorylation	118
Y	Phosphorylation	537
S	Phosphorylation	167
T	Phosphorylation	311
S	Phosphorylation	118
S	Phosphorylation	167
S	Phosphorylation	305
S	Phosphorylation	102
S	Phosphorylation	104
S	Phosphorylation	106
S	Phosphorylation	118
S	Glycosylation	10

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
190	NR0B1	8362	NP_000466.2	in vitro	11053406
547	KIF1A	3156	NP_004312.2	yeast 2-hybrid	15604093
627	BDNF	214	NP_001137282.1	in vitro	11923430
672	BRCA1	218	NP_009231.2	in vitro;in vivo	103   349   891   124   450   000   000   000
801	CALM1	241	NP_008819.1	in vivo	11981030
805	CALM2	242	NP_001734.1	in vivo	11981030
808	CALM3	243	NP_005175.2	in vivo	11981030
902	CCNH	9059	NP_001230.1	in vivo	12527756
904	CCNT1	3938	NP_001231.2	in vitro;in vivo	15940264
994	CDC25B	307	NP_068660.1	in vitro;in vivo	11689696
1026	CDKN1A	298	NP_510867.1	in vitro	17911387
1499	CTNNB1	286	NP_001895.1	in vitro	15304487
1854	DUT	3165	P33316	yeast 2-hybrid	15604093
1956	EGFR	579	NP_005219.2	in vitro	11887937
2063	NR2F6	583	NP_005225.2	in vitro	10713182
2064	ERBB2	1281	NP_004439.2	in vitro;in vivo	15173068
2101	ESRRA	7210	NP_004442.3	in vitro	9058380
2274	FHL2	4026	NP_001441.4	yeast 2-hybrid	15666801
2309	FOXO3	4061	NP_001446.1	in vitro;yeast 2-hybrid	11435445
2770	GNAI1	756	NP_002060.4	in vitro;in vivo	11369763
2959	GTF2B	8928	NP_001505.1	in vitro	76   416   939   841   876
3172	HNF4A	2612	CAA89989.1	in vitro;yeast 2-hybrid	9717844
3276	PRMT1	4257	NP_001527.3	in vitro	11050077
3308	HSPA4	9025	NP_002145.3	in vivo	15556606
3480	IGF1R	932	NP_000866.1	in vivo	1   074   988   916   113   100
3726	JUNB	1303	NP_002220.1	in vitro	11477071
3727	JUND	1304	NP_005345.3	in vitro	11477071
4088	SMAD3	4380	NP_005893.1	in vitro;in vivo	11555647
4089	SMAD4	2995	NP_005350.1	in vivo;yeast 2-hybrid	1   155   564   712   576   470
4350	MPG	6766	NP_002425.2	in vitro;in vivo	14761960
4435	CITED1	2146	NP_001138357.1	in vitro;in vivo	11581164
4790	NFKB1	1238	NP_003989.2	in vitro	7651415
4878	NPPA	164	NP_006163.1	yeast 2-hybrid	15604093
5433	POLR2D	16191	NP_004796.1	yeast 2-hybrid	15604093
5457	POU4F1	3379	NP_006228.3	in vitro;in vivo;yeast 2-hybrid	9448000
5458	POU4F2	220	NP_004566.2	in vitro;yeast 2-hybrid	9448000
5566	PRKACA	3382	NP_002721.1	in vitro	9891036
5595	MAPK3	3479	NP_002737.2	in vitro;in vivo	12118371
5705	PSMC5	3400	NP_002796.4	in vitro;in vivo;yeast 2-hybrid	859   819   314   702   340
5914	RARA	6769	NP_000955.1	in vitro;yeast 2-hybrid	971   784   417   641   689
5970	RELA	1241	NP_068810.3	in vitro	7651415
6047	RNF4	4167	NP_002929.1	in vitro;in vivo	11696545
6256	RXRA	1577	NP_002948.1	in vitro	9717844
6654	SOS1	1681	NP_005624.2	in vitro	15173068
6667	SP1	1796	NP_612482.2	in vitro;in vivo	1   563   714   710   446   910
6670	SP3	3483	NP_003102.1	in vitro;in vivo	10816575
6720	SREBF1	1701	NP_001005291.1	in vitro;in vivo	12021179
7025	NR2F1	584	NP_005645.1	in vitro;in vivo;yeast 2-hybrid	12093745
7067	THRA	7185	NP_003241.2	in vitro;yeast 2-hybrid	9717844
7068	THRB	7521	NP_000452.2	in vitro	9717844
7249	TSC2	1850	NP_000539.2	in vitro;in vivo	15851513
7329	UBE2I	9045	NP_003336.1	yeast 2-hybrid	15666801
7391	USF1	1880	NP_009053.1	in vitro	15111769
7533	YWHAH	215	NP_003396.1	in vitro	11266503
7709	ZBTB17	4968	NP_003434.2	in vitro	11117529
8085	MLL2	3664	NP_003473.3	in vitro	16603732
8503	PIK3R3	5831	NP_003620.3	in vivo	15001646
8861	LDB1	9144	NP_001106878.1	in vitro;in vivo	19117995
9564	BCAR1	4248	NP_055382.2	in vivo	15020686
10155	TRIM28	3445	NP_005753.1	in vitro	9774463
10273	STUB1	6232	NP_005852.2	in vivo	16037132
10376	TUBA1B	3960	NP_006073.2	in vivo	15556606
10401	PIAS3	9068	NP_006090.2	in vitro;in vivo	11117529
10463	SLC30A9	6858	NP_006336.3	in vitro;in vivo	15988012
10524	KAT5	3245	NP_874369.1	in vitro;in vivo	16260778
10614	HEXIM1	9544	NP_006451.1	in vivo	15940264
10987	COPS5	6888	NP_006828.2	in vivo	15899841
11331	PHB2	17843	NP_009204.1	in vitro	1   093   809   915   140   870
22899	ARHGEF15	10535	NP_776089.2	yeast 2-hybrid	15604093
23788	MTCH2	14788	NP_055157.1	yeast 2-hybrid	15604093
51132	RLIM	2304	NP_899196.1	in vitro;in vivo	19117995
55147	RBM23	15227	NP_001070819.1	in vitro	15694343
203068	TUBB	1852	NP_001060.1	in vivo	15556606
286827	TRIM59	15568	NP_775107.1	in vitro;in vivo;yeast 2-hybrid	15941852

Pathway Information

                              

Pathway Name	Pathway ID
Endocrine and other factor-regulated calcium reabsorption	hsa04961
Estrogen signaling pathway	hsa04915
Prolactin signaling pathway	hsa04917
Proteoglycans in cancer	hsa05205
Thyroid hormone signaling pathway	hsa04919

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd06949	310-547	NR_LBD_ER
cl11397	310-547	NR_LBD superfamily
cd07171	180-261	NR_DBD_ER
cl02596	180-261	NR_DBD_like superfamily
cd07068	315-546	NR_LBD_ER_like
pfam02159	42-181	Oest_recep
cl23520	42-181	Oest_recep superfamily
cd06946	315-546	NR_LBD_ERR
cd07155	185-259	NR_DBD_ER_like
cd06930	343-517	NR_LBD_F2
cd06916	185-256	NR_DBD_like
pfam00105	183-252	zf-C4
cd07170	183-272	NR_DBD_ERR
cd06157	345-517	NR_LBD
pfam00104	325-529	Hormone_recep
smart00399	185-252	ZnF_C4
cd07167	185-263	NR_DBD_Lrh-1_like
cd06960	185-259	NR_DBD_HNF4A
cd07156	185-252	NR_DBD_VDR_like
cd06964	182-263	NR_DBD_RAR
smart00430	350-517	HOLI
cd06943	316-529	NR_LBD_RXR_like
cd07168	177-263	NR_DBD_DHR4_like
cd06969	185-256	NR_DBD_NGFI-B
cd06961	185-263	NR_DBD_TR
cd07172	183-254	NR_DBD_GR_PR
cd07163	185-259	NR_DBD_TLX
cd07164	185-259	NR_DBD_PNR_like_1
cd07169	180-263	NR_DBD_GCNF_like
cd07173	181-262	NR_DBD_AR
cd06963	185-254	NR_DBD_GR_like
cd07154	185-256	NR_DBD_PNR_like
cd07074	314-528	NR_LBD_PR
cd07165	185-264	NR_DBD_DmE78_like
cd06958	185-257	NR_DBD_COUP_TF
cd06968	185-275	NR_DBD_ROR
cd06967	184-260	NR_DBD_TR2_like
cd06955	183-280	NR_DBD_VDR
cd06947	314-456	NR_LBD_GR_Like
cd06959	185-250	NR_DBD_EcR_like
cd07076	315-517	NR_LBD_GR
cd06956	185-259	NR_DBD_RXR
cd06966	183-269	NR_DBD_CAR
cd06957	185-266	NR_DBD_PNR_like_2
cd06965	185-271	NR_DBD_Ppar
cd07179	185-256	2DBD_NR_DBD2
cd07166	185-271	NR_DBD_REV_ERB
cd06970	185-260	NR_DBD_PNR
cd07157	185-260	2DBD_NR_DBD1
cd07160	185-250	NR_DBD_LXR
cd07158	185-256	NR_DBD_Ppar_like
cd07162	185-258	NR_DBD_PXR
cd07161	185-271	NR_DBD_EcR
cd06962	185-251	NR_DBD_FXR
cd06945	314-529	NR_LBD_Nurr1_like
cd07075	316-529	NR_LBD_MR
cd06944	328-546	NR_LBD_Ftz-F1_like
cd07069	341-548	NR_LBD_Lrh-1
cd07348	315-535	NR_LBD_NGFI-B
cd06931	316-543	NR_LBD_HNF4_like
cd07073	323-508	NR_LBD_AR
pfam12743	552-595	ESR1_C
cl15062	552-595	ESR1_C superfamily
cd07070	314-546	NR_LBD_SF-1
cd07071	315-535	NR_LBD_Nurr1
cd06953	321-523	NR_LBD_DHR4_like
cd06950	358-529	NR_LBD_Tlx_PNR_like
cd06937	347-545	NR_LBD_RAR
cd07072	315-535	NR_LBD_DHR38_like
cd06948	316-544	NR_LBD_COUP-TF
cd06929	341-525	NR_LBD_F1
cd06933	308-486	NR_LBD_VDR
cd06954	347-532	NR_LBD_LXR
cd06940	357-529	NR_LBD_REV_ERB
cd06938	329-545	NR_LBD_EcR
cd06952	350-526	NR_LBD_TR2_like
cd06941	342-397	NR_LBD_DmE78_like
cd06939	356-529	NR_LBD_ROR_like
cd06942	343-517	NR_LBD_Sex_1_like
cd06932	361-454	NR_LBD_PPAR
cd07349	349-544	NR_LBD_SHP
cd06936	320-536	NR_LBD_Fxr
PRK10263	113-167	PRK10263

Ontology Information

   

HPRD ID	4037
Molecular Class	Transcription factor
Molecular Function	Serine-type peptidase activity (GO:0008236)
Biological Process	Protein metabolism (GO:0019538)

SNP Information

View SNP Geneview Report