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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ESR2 2100 estrogen receptor 2 (ER beta)  14Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21884200   2011Cell line : -

Source : Japanese population

Sample Type : Population based case-control study and CRC tumor

No. of Sample : 1488 cased

Stage : -

PCR using fluorescein-labelled primers, ImmunohistochemistryPolymorhpism-A role for ESR2 CA repeat polymorphism in the pathogenesis of colorectal cancer among females is suggested.

22759347   2012Cell line : -

Source : Tongji Hospital, Tongji Medical College, Wuhan Eighth Hospital.

Sample Type : Population based case-control study

No. of Sample : 390 CRC and 445 healthy controls

Stage : -

GenotypingPolymorhpism- Endogenous estrogen and genetic variations in ESR2 may individually, or more likely jointly, affect CRC risk in male Han Chinese population.

25376484   2014Cell line : -

Source : The DACHS study conducted in southwest Germany, from University of Heidelberg and Baden-Wuerttemberg and Rhineland-Palatinate, Germany

Sample Type : Population-based case-control study,blood sample or a mouthwash sample

No. of Sample : -

Stage : -

GenotypingPolymorhpism-Higher numbers of ESR2 CA repeats are potentially associated with a small increase in colorectal cancer risk.


Gene Details



NC_000014.8 (64693751..64805268, complement)

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Gene Type protein coding
Gene Family Nuclear hormone receptors
Description This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]  
Chromosome 14
Location 14q23.2
Start 64693751  
End 64805268  
Strand -  
Gene Sequence

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Length 111518  
OMIM ID 601663   
HGNC ID HGNC:3468   
Unigene ID -   
Ensembl ID ENSG00000140009   
PharmGKB ID -   

mRNA Information


mRNA ID ?NM_001040275.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS32096.1



Protein Information


      
Protein ID
Protein Nameestrogen receptor 2 (ER beta)
Molecular Wt. (Da)0
Protein Sequence

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Length 0  
Uniprot IDP49862
Ensembl Protein ID ENSP00000375683  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
190NR0B18362NP_000466.2in vitro;in vivo11053406   
801CALM1241NP_008819.1in vivo11981030   
805CALM2242NP_001734.1in vivo11981030   
808CALM3243NP_005175.2in vivo11981030   
2099ESR1589NP_000116.2in vitro;in vivo9473491   
3275PRMT29060NP_996845.1in vitro;in vivo12039952   
4085MAD2L13274NP_002349.1in vitro;yeast 2-hybrid10706629   
4088SMAD34380NP_005893.1in vitro11555647   
5600MAPK114208AAB05036.1in vitro11579095   
6667SP11796NP_612482.2in vitro10681512   
6776STAT5A3301NP_003143.2in vitro11682624   
7533YWHAH215NP_003396.1in vitro11266503   
7709ZBTB174968NP_003434.2in vitro11117529   
8204NRIP13927NP_003480.2yeast 2-hybrid15604093   
8554PIAS116029NP_057250.1in vitro;in vivo11117529   
10401PIAS39068NP_006090.2in vitro;in vivo11117529   
10891PPARGC1A5155NP_037393.1in vitro;in vivo;yeast 2-hybrid1   578   425   315   604   090   
10957PNRC18412NP_006804.1yeast 2-hybrid15604093   
11214AKAP135253NP_006729.4in vitro;in vivo11579095   
27043PELP110144NP_055204.2in vitro12415108   
55629PNRC217871NP_060231.1yeast 2-hybrid15604093   
135112NCOA714814NP_861447.3in vitro;in vivo119   719   698   197   458   
286827TRIM5915568NP_775107.1in vitro;in vivo;yeast 2-hybrid15941852   


Pathway Information


            
Pathway Name Pathway ID
Estrogen signaling pathway hsa04915
Prolactin signaling pathway hsa04917


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06949263-498  NR_LBD_ER
cl11397263-498  NR_LBD superfamily
cd07171144-225  NR_DBD_ER
cl02596144-225  NR_DBD_like superfamily
cd07068268-497  NR_LBD_ER_like
cd06946268-497  NR_LBD_ERR
cd07155149-223  NR_DBD_ER_like
pfam1249721-124  ERbeta_N
cl1387821-124  ERbeta_N superfamily
pfam00104277-476  Hormone_recep
cd06916149-216  NR_DBD_like
pfam00105147-216  zf-C4
cd07170149-237  NR_DBD_ERR
cd06930297-467  NR_LBD_F2
smart00399149-214  ZnF_C4
cd06157298-466  NR_LBD
smart00430302-468  HOLI
cd06960149-223  NR_DBD_HNF4A
cd07156149-216  NR_DBD_VDR_like
cd06969149-216  NR_DBD_NGFI-B
cd07163149-223  NR_DBD_TLX
cd07167149-223  NR_DBD_Lrh-1_like
cd06964149-227  NR_DBD_RAR
cd07172148-223  NR_DBD_GR_PR
cd07164149-223  NR_DBD_PNR_like_1
cd07168142-223  NR_DBD_DHR4_like
cd06961148-223  NR_DBD_TR
cd06963149-215  NR_DBD_GR_like
cd07154149-220  NR_DBD_PNR_like
cd07173149-214  NR_DBD_AR
cd06943302-476  NR_LBD_RXR_like
cd06956147-223  NR_DBD_RXR
cd06958149-221  NR_DBD_COUP_TF
cd06966148-234  NR_DBD_CAR
cd07165149-223  NR_DBD_DmE78_like
cd07160139-224  NR_DBD_LXR
cd06947269-408  NR_LBD_GR_Like
cd06959149-214  NR_DBD_EcR_like
cd06967148-214  NR_DBD_TR2_like
cd07179149-220  2DBD_NR_DBD2
cd07157149-223  2DBD_NR_DBD1
cd06968149-237  NR_DBD_ROR
cd07074269-408  NR_LBD_PR
cd06955149-216  NR_DBD_VDR
cd06945301-487  NR_LBD_Nurr1_like
cd06957149-223  NR_DBD_PNR_like_2
cd06970149-223  NR_DBD_PNR
cd07166149-227  NR_DBD_REV_ERB
cd07169149-223  NR_DBD_GCNF_like
cd07162149-216  NR_DBD_PXR
cd07161148-214  NR_DBD_EcR
cd07076269-408  NR_LBD_GR
cd07158149-216  NR_DBD_Ppar_like
cd06962148-215  NR_DBD_FXR
cd06953272-484  NR_LBD_DHR4_like
cd06965149-223  NR_DBD_Ppar
cd07075271-408  NR_LBD_MR
cd06944300-497  NR_LBD_Ftz-F1_like
cd07073268-407  NR_LBD_AR
cd07348312-486  NR_LBD_NGFI-B
cd07069298-497  NR_LBD_Lrh-1
cd06931269-494  NR_LBD_HNF4_like
cd07071312-486  NR_LBD_Nurr1
cd07070265-497  NR_LBD_SF-1
cd06950310-480  NR_LBD_Tlx_PNR_like
cd06929293-476  NR_LBD_F1
cd06937285-495  NR_LBD_RAR
cd06954287-483  NR_LBD_LXR
cd07072288-494  NR_LBD_DHR38_like
cd06948297-495  NR_LBD_COUP-TF
cd07349300-495  NR_LBD_SHP
cd06939308-480  NR_LBD_ROR_like
cd06938309-483  NR_LBD_EcR
cd06935277-339  NR_LBD_TR
cd06940309-480  NR_LBD_REV_ERB
cd06933263-341  NR_LBD_VDR
cd06951306-407  NR_LBD_Dax1_like
cd06952310-343  NR_LBD_TR2_like
cd06941297-414  NR_LBD_DmE78_like
cd07350300-343  NR_LBD_Dax1
cd06942310-459  NR_LBD_Sex_1_like
cd06932313-406  NR_LBD_PPAR


Ontology Information


   
HPRD ID4054
Molecular ClassNot Available
Molecular FunctionSerine-type peptidase activity (GO:0008236)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q92731DB00255DiethylstilbestrolSmallMoleculeDrug
Q92731DB00481RaloxifeneSmallMoleculeDrug
Q92731DB00675TamoxifenSmallMoleculeDrug
Q92731DB00783EstradiolSmallMoleculeDrug
Q92731DB01108TrilostaneSmallMoleculeDrug
Q92731DB01196EstramustineSmallMoleculeDrug
Q92731DB04573EstriolSmallMoleculeDrug
Q92731DB04574EstropipateSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO