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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ETS1 2113 v-ets avian erythroblastosis virus E26 oncogene homolog 1  11FLJ10768, ETS-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
12731728   2003Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 95

Stage : -

ImmunohistochemistryUp-regulation-The Ets-1 vascular expression may be a prognostic factor forcolorectal cancer.

19499154   2009Cell line : -

Source : Gastrointestinal Surgery Department in Xiangya Hospital, the Second Affiliated Hospital and the Third Affiliated Hospital (Changsha, China),

Sample Type : CRC Tumor and adjecentnormal tissue

No. of Sample : 130

Stage : Duke stage A,B,C,D

Tissue microarrays,In situ hybridization,Immunohistochemistry,real time RT-PCR,Western blotting,Immunofluorescence, luciferase assayUp-regulation-NGX6 expression is lost in the multistep process of human colorectal carcinogenesis. Its overexpression can inhibit the expression of transcription factors AP-1 and Ets-1, and down-regulate the transcriptional activity of the cyclin D1 promoter in human CRC.

21318373   2011Cell line : -

Source : Sao Lucas Hospital,Pontifical catholic University, Rio Grande do sul.

Sample Type : CRC Tumor and adjecentnormal tissue

No. of Sample : 28

Stage : -

real time RT-PCR, immunohistochemistryUp-regulation-ETS may serve as potential markers of colorectal cancer invasiveness and metastasis.

23361474   2013Cell line : -

Source : Tokushima University Hospital of Tokushima.

Sample Type : CRC Tumor and adjecentnormal tissue

No. of Sample : 4

Stage : -

Chromatin immunoprecipitation,real time RT-PCR,Promoter Assay, immunohistochemistryUp-regulation--


Gene Details



NC_000011.9 (128328656..128457453, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]  
Chromosome 11
Location 11q23.3
Start 128328656  
End 128457453  
Strand -  
Gene Sequence

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Length 128798  
OMIM ID 164720   
HGNC ID HGNC:3488   
Unigene ID Hs.369438   
Ensembl ID ENSG00000134954   
PharmGKB ID PA27902   

mRNA Information


mRNA ID NM_001143820.1
Exon join(27..97,14441..14523,31150..31294,97009..97128, 98095..98295,101439..101516,102514..102762,107134..107394, 123958..124076,125009..128824)  
mRNA Sequence

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Length 5143  



CDS Information


   
Location86..1543
CDS Sequence

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CCDS ID CCDS44767.1



Protein Information


      
Protein IDNP_001137292.1
Protein Namev-ets avian erythroblastosis virus E26 oncogene homolog 1
Molecular Wt. (Da)485
Protein Sequence

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Length 55281  
Uniprot IDQ92876
Ensembl Protein ID ENSP00000309148  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation38
TPhosphorylation38
SPhosphorylation251
SPhosphorylation257
SPhosphorylation282
SPhosphorylation285
SPhosphorylation251
SPhosphorylation257
SPhosphorylation282
SPhosphorylation285
YPhosphorylation205;-
YPhosphorylation223;-
KAcetylation2
KAcetylation305
KAcetylation8
KAcetylation15

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1387CREBBP2534NP_004371.2in vitro;in vivo9528793   
2625GATA3572NP_001002295.1in vitro;in vivo10212281   
2908NR3C1679NP_001019265.1in vitro11279115   
4088SMAD34380NP_005893.1in vitro;in vivo1   159   014   515   001   980   
4211MEIS13442NP_002389.1in vitro;in vivo18692240   
4790NFKB11238NP_003989.2in vitro9094628   
6667SP11796NP_612482.2in vitro15001984   
6672SP1006844NP_001073860.1in vitro;in vivo;yeast 2-hybrid1   190   996   215   247   900   
6714SRC1819NP_005408.1in vivo15788656   
6778STAT63302NP_003144.3in vivo15199062   
9611NCOR12911NP_006302.2in vivo15788656   


Pathway Information


                              
Pathway Name Pathway ID
Dorso-ventral axis formation hsa04320
HTLV-I infection hsa05166
Pathways in cancer hsa05200
Ras signaling pathway hsa04014
Renal cell carcinoma hsa05211


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0854251-138  SAM_PNT-ETS-1
cl1575551-138  SAM_superfamily superfamily
pfam00178334-417  Ets
cl02599334-417  Ets superfamily
smart00413334-418  ETS
cd0853366-136  SAM_PNT-ETS-1,2
pfam0219853-135  SAM_PNT
cd0854351-138  SAM_PNT-ETS-2
smart0025153-135  SAM_PNT
cd0820368-134  SAM_PNT
cd0853454-134  SAM_PNT-GABP-alpha
cd0853568-135  SAM_PNT-Tel_Yan
cd0853165-134  SAM_PNT-ERG_FLI-1
cd0853263-131  SAM_PNT-PDEF-like
cd0854157-134  SAM_PNT-FLI-1
cd0854065-134  SAM_PNT-ERG
cd0853668-127  SAM_PNT-Mae
cd0875768-129  SAM_PNT_ESE
cd0853769-130  SAM_PNT-ESE-1-like
cd0853869-117  SAM_PNT-ESE-2-like
cd0853969-133  SAM_PNT-ESE-3-like


Ontology Information


   
HPRD ID1463
Molecular ClassTranscription factor
Molecular FunctionUbiquitin-specific protease activity (GO:0004843)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO